Vern L. Schramm
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Why Is Vern L. Schramm Influential?
(Suggest an Edit or Addition)According to Wikipedia, Vern L. Schramm is a professor and Ruth Merns Chair in Biochemistry at the Albert Einstein College of Medicine of Yeshiva University. Schramm was elected to the National Academy of Sciences in 2007. His laboratory's research focuses on the elucidation of enzymatic mechanisms and transition state structure.
Vern L. Schramm's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The biochemistry of sirtuins. (2006) (691)
- Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions. (2001) (286)
- Enzymatic transition states and transition state analog design. (1998) (235)
- Enzymatic transition states and dynamic motion in barrier crossing. (2009) (224)
- Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry. (2003) (212)
- One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase. (1998) (204)
- Enzymatic transition states, transition-state analogs, dynamics, thermodynamics, and lifetimes. (2011) (180)
- Transition state structure of purine nucleoside phosphorylase and principles of atomic motion in enzymatic catalysis. (2001) (166)
- Purine nucleoside phosphorylase. Catalytic mechanism and transition-state analysis of the arsenolysis reaction. (1993) (155)
- Transition state analogues of 5′-methylthioadenosine nucleosidase disrupt quorum sensing (2009) (153)
- Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition. (2005) (152)
- Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes (2001) (149)
- The 2.0 Å structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor (1999) (142)
- Femtomolar Transition State Analogue Inhibitors of 5′-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase from Escherichia coli* (2005) (121)
- The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor. (1999) (121)
- Transition state analysis for human and Plasmodium falciparum purine nucleoside phosphorylases. (2004) (118)
- Purine and pyrimidine pathways as targets in Plasmodium falciparum. (2011) (118)
- Transition States, analogues, and drug development. (2013) (117)
- Enzymatic Transition State Theory and Transition State Analogue Design* (2007) (109)
- Targeting a Novel Plasmodium falciparum Purine Recycling Pathway with Specific Immucillins* (2005) (108)
- Femtosecond dynamics coupled to chemical barrier crossing in a Born-Oppenheimer enzyme (2011) (107)
- Structural insights into intermediate steps in the Sir2 deacetylation reaction. (2008) (107)
- The reaction mechanism for CD38. A single intermediate is responsible for cyclization, hydrolysis, and base-exchange chemistries. (1998) (105)
- Purine-less Death in Plasmodium falciparumInduced by Immucillin-H, a Transition State Analogue of Purine Nucleoside Phosphorylase* (2002) (102)
- Transition-state analysis of nucleoside hydrolase from Crithidia fasciculata. (1991) (102)
- Transition state structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli and its similarity to transition state analogues. (2005) (100)
- Nucleoside hydrolase from Crithidia fasciculata. Metabolic role, purification, specificity, and kinetic mechanism. (1991) (99)
- Achieving the Ultimate Physiological Goal in Transition State Analogue Inhibitors for Purine Nucleoside Phosphorylase* (2003) (99)
- Enzymatic transition states and transition state analogues. (2005) (97)
- Mechanism of 3-mercaptopicolinic acid inhibition of hepatic phosphoenolpyruvate carboxykinase (GTP). (1976) (96)
- Enzymatic transition states: thermodynamics, dynamics and analogue design. (2005) (92)
- Nucleoside Hydrolase from Leishmania major (1999) (91)
- Transition-state analogs as inhibitors of human and malarial hypoxanthine-guanine phosphoribosyltransferases (1999) (91)
- Weak coupling of ATP hydrolysis to the chemical equilibrium of human nicotinamide phosphoribosyltransferase. (2008) (88)
- Inosine-uridine nucleoside hydrolase from Crithidia fasciculata. Genetic characterization, crystallization, and identification of histidine 241 as a catalytic site residue. (1996) (88)
- Transition State Analogue Inhibitors of Purine Nucleoside Phosphorylase from Plasmodium falciparum * (2002) (86)
- Determination of free and bound manganese(II) in hepatocytes from fed and fasted rats. (1982) (82)
- Atomic detail of chemical transformation at the transition state of an enzymatic reaction (2008) (80)
- Plasmodium falciparum Purine Nucleoside Phosphorylase (2004) (78)
- Transition-state structures for N-glycoside hydrolysis of AMP by acid and by AMP nucleosidase in the presence and absence of allosteric activator. (1987) (77)
- SIR2: the biochemical mechanism of NAD(+)-dependent protein deacetylation and ADP-ribosyl enzyme intermediates. (2004) (77)
- Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase. (2003) (76)
- Enzymatic transition state poise and transition state analogues. (2003) (75)
- Transition State Structure for the Hydrolysis of NAD Catalyzed by Diphtheria Toxin. (1997) (74)
- Trypanosomal nucleoside hydrolase. A novel mechanism from the structure with a transition-state inhibitor. (1998) (73)
- Ricin A-chain: kinetics, mechanism, and RNA stem-loop inhibitors. (1998) (72)
- Pre-steady-state transition-state analysis of the hydrolytic reaction catalyzed by purine nucleoside phosphorylase. (1995) (72)
- Promoting vibrations in human purine nucleoside phosphorylase. A molecular dynamics and hybrid quantum mechanical/molecular mechanical study. (2004) (71)
- Enzymatic transition-state analysis and transition-state analogs. (1999) (71)
- Development of transition state analogues of purine nucleoside phosphorylase as anti-T-cell agents. (2002) (69)
- Mass-dependent bond vibrational dynamics influence catalysis by HIV-1 protease. (2011) (68)
- Three-dimensional structure of the inosine-uridine nucleoside N-ribohydrolase from Crithidia fasciculata. (1996) (67)
- Binding isotope effects: boon and bane. (2007) (67)
- Structural Rationale for the Affinity of Pico- and Femtomolar Transition State Analogues of Escherichia coli 5′-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase*♦ (2005) (66)
- Transition state analysis and inhibitor design for enzymatic reactions. (1994) (66)
- Third-generation immucillins: syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase. (2009) (66)
- A Transition State Analogue of 5′-Methylthioadenosine Phosphorylase Induces Apoptosis in Head and Neck Cancers* (2007) (66)
- Detecting ricin: sensitive luminescent assay for ricin A-chain ribosome depurination kinetics. (2009) (65)
- A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT (2009) (65)
- Structural and kinetic characterization of Escherichia coli TadA, the wobble-specific tRNA deaminase. (2006) (64)
- Purine nucleoside phosphorylase. Inosine hydrolysis, tight binding of the hypoxanthine intermediate, and third-the-sites reactivity. (1992) (64)
- Synthesis of a transition state analogue inhibitor of purine nucleoside phosphorylase via the Mannich reaction. (2003) (64)
- Growth and Metastases of Human Lung Cancer Are Inhibited in Mouse Xenografts by a Transition State Analogue of 5′-Methylthioadenosine Phosphorylase* (2010) (63)
- Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae. (2006) (62)
- Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins (2009) (61)
- Addition of lithiated 9-deazapurine derivatives to a carbohydrate cyclic imine: convergent synthesis of the aza-C-nucleoside immucillins. (2001) (61)
- A Covalent Intermediate in CD38 Is Responsible for ADP-Ribosylation and Cyclization Reactions (2000) (60)
- Electronic nature of the transition state for nucleoside hydrolase. A blueprint for inhibitor design. (1993) (60)
- Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase. (2003) (60)
- Synthesis of nucleotides with specific radiolabels in ribose. Primary 14C and secondary 3H kinetic isotope effects on acid-catalyzed glycosidic bond hydrolysis of AMP, dAMP, and inosine. (1984) (60)
- Iminoribitol transition state analogue inhibitors of protozoan nucleoside hydrolases. (1999) (59)
- Plasmodium falciparum Parasites Are Killed by a Transition State Analogue of Purine Nucleoside Phosphorylase in a Primate Animal Model (2011) (59)
- Kinetic mechanism of phosphoenolpyruvate carboxykinase (GTP) from rat liver cytosol. Product inhibition, isotope exchange at equilibrium, and partial reactions. (1978) (59)
- Syntheses and bio-activities of the L-enantiomers of two potent transition state analogue inhibitors of purine nucleoside phosphorylases. (2006) (59)
- Plasmodium falciparum Purine Nucleoside Phosphorylase Is Critical for Viability of Malaria Parasites* (2008) (59)
- Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases. (2008) (58)
- Remote mutations and active site dynamics correlate with catalytic properties of purine nucleoside phosphorylase. (2008) (58)
- A new class of C-nucleoside analogues. 1-(S)-aryl-1,4-dideoxy-1,4-imino-D-ribitols, transition state analogue inhibitors of nucleoside hydrolase (1993) (58)
- Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases. (2007) (58)
- Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A. (2004) (58)
- Synthesis of transition state analogue inhibitors for purine nucleoside phosphorylase and N-riboside hydrolases (2000) (57)
- Synthesis of 5'-methylthio coformycins: specific inhibitors for malarial adenosine deaminase. (2007) (53)
- Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase. (2005) (53)
- Ricin A-Chain: Kinetic Isotope Effects and Transition State Structure with Stem-Loop RNA† (2000) (53)
- Molecular Electrostatic Potential Analysis for Enzymatic Substrates, Competitive Inhibitors, and Transition-State Inhibitors (1996) (53)
- Electrophilic aromatic selenylation: new OPRT inhibitors. (2010) (53)
- Acyclic immucillin phosphonates: second-generation inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. (2012) (53)
- Protein Mass-Modulated Effects in the Catalytic Mechanism of Dihydrofolate Reductase: Beyond Promoting Vibrations (2014) (53)
- Transition-state analysis for depurination of DNA by Ricin A-chain (2000) (52)
- Four generations of transition-state analogues for human purine nucleoside phosphorylase (2010) (51)
- Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase. (2004) (50)
- A kinetic isotope effect study and transition state analysis of the S-adenosylmethionine synthetase reaction. (1987) (50)
- Atomic motion in enzymatic reaction coordinates. (2001) (50)
- Transition States and transition state analogue interactions with enzymes. (2015) (50)
- Guanosine-inosine-preferring nucleoside N-glycohydrolase from Crithidia fasciculata. (1994) (50)
- Mass Modulation of Protein Dynamics Associated with Barrier Crossing in Purine Nucleoside Phosphorylase. (2012) (50)
- Transition states of Plasmodium falciparum and human orotate phosphoribosyltransferases. (2009) (49)
- Neighboring group participation in the transition state of human purine nucleoside phosphorylase. (2007) (47)
- Promoting Vibrations and the Function of Enzymes. Emerging Theoretical and Experimental Convergence. (2018) (47)
- Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase. (2002) (46)
- Synthesis of transition state inhibitors for N-riboside hydrolases and transferases (1997) (46)
- A picomolar transition state analogue inhibitor of MTAN as a specific antibiotic for Helicobacter pylori. (2012) (46)
- Molecular Cloning and Expression of a Purine-specific N-Ribohydrolase from Trypanosoma brucei brucei (1998) (46)
- Altered enthalpy-entropy compensation in picomolar transition state analogues of human purine nucleoside phosphorylase. (2009) (45)
- Human DNMT1 transition state structure (2016) (45)
- Erythrocytic Adenosine Monophosphate as an Alternative Purine Source in Plasmodium falciparum* (2008) (44)
- Purine nucleoside phosphorylase from Mycobacterium tuberculosis. Analysis of inhibition by a transition-state analogue and dissection by parts. (2001) (44)
- Immucillin‐H binding to purine nucleoside phosphorylase reduces dynamic solvent exchange (2000) (44)
- Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces. (2001) (43)
- Regulation of adenosine monophosphate levels as a function of adenosine triphosphate and inorganic phosphate. A proposed metabolic role for adenosine monophosphate nucleosidase from Azotobacter vinelandii. (1973) (43)
- Design and synthesis of potent "sulfur-free" transition state analogue inhibitors of 5'-methylthioadenosine nucleosidase and 5'-methylthioadenosine phosphorylase. (2010) (42)
- 8-Aza-immucillins as transition-state analogue inhibitors of purine nucleoside phosphorylase and nucleoside hydrolases. (2003) (42)
- Mammalian and avian liver phosphoenolpyruvate carboxykinase. Alternate substrates and inhibition by analogues of oxaloacetate. (1990) (42)
- Structural analysis of adenine phosphoribosyltransferase from Saccharomyces cerevisiae. (2001) (42)
- Immucillins in Infectious Diseases. (2017) (41)
- Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase. (2003) (41)
- Enzymatic Transition States and Drug Design. (2018) (41)
- Pertussis toxin: transition state analysis for ADP-ribosylation of G-protein peptide alphai3C20. (1997) (41)
- Inhibitors of ADP-ribosylating bacterial toxins based on oxacarbenium ion character at their transition states. (2004) (41)
- A beta-fluoroamine inhibitor of purine nucleoside phosphorylase. (2008) (41)
- Phosphoribosyltransferase mechanisms and roles in nucleic acid metabolism. (2004) (41)
- Nucleophilic participation in the transition state for human thymidine phosphorylase. (2004) (41)
- Transition state structure for ADP-ribosylation of eukaryotic elongation factor 2 catalyzed by diphtheria toxin. (2004) (41)
- Transition-state analysis of S. pneumoniae 5'-methylthioadenosine nucleosidase. (2007) (40)
- Imino-sugar-based nucleosides. (2003) (40)
- Correlation of the molecular electrostatic potential surface of an enzymatic transition state with novel transition-state inhibitors. (1993) (40)
- Altered thermodynamics from remote mutations altering human toward bovine purine nucleoside phosphorylase. (2008) (39)
- Crystal structures of Giardia lamblia guanine phosphoribosyltransferase at 1.75 A(,). (2000) (39)
- Transition-state structure for the ADP-ribosylation of recombinant Gialpha1 subunits by pertussis toxin. (1998) (39)
- Modulating Enzyme Catalysis through Mutations Designed to Alter Rapid Protein Dynamics. (2016) (38)
- Characterizing DNA methyltransferases with an ultrasensitive luciferase-linked continuous assay. (2011) (38)
- Acyclic ribooxacarbenium ion mimics as transition state analogues of human and malarial purine nucleoside phosphorylases. (2007) (38)
- Energetic Mapping of Transition State Analogue Interactions with Human and Plasmodium falciparum Purine Nucleoside Phosphorylases*♦ (2005) (38)
- Introduction: Principles of Enzymatic Catalysis (2006) (38)
- Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36 (2016) (37)
- Catalytic and allosteric mechanism of AMP nucleosidase from primary, beta-secondary, and multiple heavy atom kinetic isotope effects. (1987) (37)
- A transition-state analogue reduces protein dynamics in hypoxanthine-guanine phosphoribosyltransferase. (2001) (36)
- Catalytic mechanism of yeast adenosine 5'-monophosphate deaminase. Zinc content, substrate specificity, pH studies, and solvent isotope effects. (1993) (36)
- Inhibition of ricin A-chain with pyrrolidine mimics of the oxacarbenium ion transition state. (2004) (36)
- Kinetic isotope effect characterization of the transition state for oxidized nicotinamide adenine dinucleotide hydrolysis by pertussis toxin. (1997) (36)
- The catalytic site of AMP nucleosidase. Substrate specificity and pH effects with AMP and formycin 5'-PO4. (1979) (36)
- Spontaneous epimerization of (S)-deoxycoformycin and interaction of (R)-deoxycoformycin, (S)-deoxycoformycin, and 8-ketodeoxycoformycin with adenosine deaminase. (1985) (36)
- Mechanistic Diagnoses of N-Ribohydrolases and Purine Nucleoside Phosphorylase (1996) (35)
- Insight into catalytically relevant correlated motions in human purine nucleoside phosphorylase. (2006) (35)
- Recycling nicotinamide. The transition-state structure of human nicotinamide phosphoribosyltransferase. (2013) (35)
- Mechanism-based inhibitors of CD38: a mammalian cyclic ADP-ribose synthetase. (2002) (35)
- Action of magnesium ion on diphosphopyridine nucleotide-linked isocitrate dehydrogenase from bovine heart. Characterization of the forms of the substrate and the modifier of the reaction. (1974) (34)
- Transition states and inhibitors of the purine nucleoside phosphorylase family. (2005) (34)
- Closed Site Complexes of Adenine Phosphoribosyltransferase fromGiardia lamblia Reveal a Mechanism of Ribosyl Migration* (2002) (34)
- Isozyme-specific transition state inhibitors for the trypanosomal nucleoside hydrolases. (1997) (34)
- Transition-state structure of neisseria meningitides 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. (2007) (33)
- Characterization of AMD, the AMP deaminase gene in yeast. Production of amd strain, cloning, nucleotide sequence, and properties of the protein. (1989) (33)
- New Antibiotic Candidates against Helicobacter pylori. (2015) (32)
- The pathway of adenylate catabolism in Azotobacter vinelandii. Evidence for adenosine monophosphate nucleosidase as the regulatory enzyme. (1975) (32)
- Inhibition and structure of Trichomonas vaginalis purine nucleoside phosphorylase with picomolar transition state analogues. (2007) (32)
- Primate genome gain and loss: a bone dysplasia, muscular dystrophy, and bone cancer syndrome resulting from mutated retroviral-derived MTAP transcripts. (2012) (32)
- 5'-Deoxyadenosine contacts the substrate radical intermediate in the active site of ethanolamine ammonia-lyase: 2H and 13C electron nuclear double resonance studies. (2001) (32)
- Transition-state analysis of AMP deaminase. (1993) (32)
- Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. (2013) (32)
- Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases. (2003) (31)
- Transport of purines and purine salvage pathway inhibitors by the Plasmodium falciparum equilibrative nucleoside transporter PfENT1. (2010) (31)
- Hydride Transfer in DHFR by Transition Path Sampling, Kinetic Isotope Effects, and Heavy Enzyme Studies. (2016) (31)
- Transition state structure of the solvolytic hydrolysis of NAD (1997) (31)
- AMP deaminase from yeast. Role in AMP degradation, large scale purification, and properties of the native and proteolyzed enzyme. (1989) (31)
- Mn2+-sensitive and -insensitive forms of phosphoenolpyruvate carboxykinase (GTP). (1981) (30)
- Activating the phosphate nucleophile at the catalytic site of purine nucleoside phosphorylase: a vibrational spectroscopic study. (2004) (30)
- The rate constant describing slow-onset inhibition of yeast AMP deaminase by coformycin analogues is independent of inhibitor structure. (1990) (30)
- Binding modes for substrate and a proposed transition-state analogue of protozoan nucleoside hydrolase. (1995) (30)
- Circular DNA and DNA/RNA hybrid molecules as scaffolds for ricin inhibitor design. (2007) (30)
- Effect of dietary p-aminobenzoic acid on murine Plasmodium yoelii infection. (2003) (30)
- Transition-state variation in human, bovine, and Plasmodium falciparum adenosine deaminases. (2007) (29)
- Adenylate degradation in Escherichia coli. The role of AMP nucleosidase and properties of the purified enzyme. (1980) (29)
- Remote mutations alter transition-state structure of human purine nucleoside phosphorylase. (2008) (29)
- Transition state analogue discrimination by related purine nucleoside phosphorylases. (2006) (29)
- Structural and metabolic specificity of methylthiocoformycin for malarial adenosine deaminases. (2009) (29)
- Transition state analogues in quorum sensing and SAM recycling. (2008) (28)
- Ricin A-chain inhibitors resembling the oxacarbenium ion transition state. (2001) (27)
- Mn2(+)-binding properties of a recombinant protein-tyrosine kinase derived from the human insulin receptor. (1990) (27)
- Incorporation of extracellular 8-oxodG into DNA and RNA requires purine nucleoside phosphorylase in MCF-7 cells (2007) (27)
- Transition-state inhibitors of purine salvage and other prospective enzyme targets in malaria. (2013) (27)
- Transition state analogue inhibitors of protozoan nucleoside hydrolases. (1999) (26)
- Tryptophan-free human PNP reveals catalytic site interactions. (2008) (26)
- Transition states of native and drug-resistant HIV-1 protease are the same (2012) (26)
- Evaluation of the relationship between the intra- and extramitochondrial [ATP]/[ADP] ratios using phosphoenolpyruvate carboxykinase. (1983) (25)
- Conformational dynamics in human purine nucleoside phosphorylase with reactants and transition-state analogues. (2010) (25)
- Malaria parasite type 4 equilibrative nucleoside transporters (ENT4) are purine transporters with distinct substrate specificity. (2012) (24)
- Transition state structure of E. coli tRNA-specific adenosine deaminase. (2008) (24)
- Transition State Analogues of Plasmodium falciparum and Human Orotate Phosphoribosyltransferases* (2013) (24)
- Transition state analysis of the arsenolytic depyrimidination of thymidine by human thymidine phosphorylase. (2011) (24)
- Transition state analysis of thymidine hydrolysis by human thymidine phosphorylase. (2010) (24)
- Amidrazone analogues of D-ribofuranose as transition-state inhibitors of nucleoside hydrolase. (1994) (24)
- Conformational states of human purine nucleoside phosphorylase at rest, at work, and with transition state analogues. (2010) (23)
- Transition-state structure of human 5'-methylthioadenosine phosphorylase. (2006) (23)
- Binding causes the remote [5'-3H]thymidine kinetic isotope effect in human thymidine phosphorylase. (2004) (23)
- Triple Isotope Effects Support Concerted Hydride and Proton Transfer and Promoting Vibrations in Human Heart Lactate Dehydrogenase. (2016) (23)
- Catalytic-site design for inverse heavy-enzyme isotope effects in human purine nucleoside phosphorylase (2017) (22)
- Determinants of sensitivity of human T-cell leukemia CCRF-CEM cells to immucillin-H. (2008) (22)
- Isotope-specific and amino acid-specific heavy atom substitutions alter barrier crossing in human purine nucleoside phosphorylase (2015) (22)
- Transition-state analysis of a Vmax mutant of AMP nucleosidase by the application of heavy-atom kinetic isotope effects. (1991) (22)
- Enzymatic N-riboside scission in RNA and RNA precursors. (1997) (22)
- The mechanism of soluble peptidoglycan hydrolysis by an autolytic muramidase. A processive exodisaccharidase. (1984) (22)
- L-Enantiomers of transition state analogue inhibitors bound to human purine nucleoside phosphorylase. (2008) (21)
- Femtomolar inhibitors bind to 5'-methylthioadenosine nucleosidases with favorable enthalpy and entropy. (2012) (21)
- Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing. (2011) (21)
- Immucillins as Antibiotics for T‐Cell Proliferation and Malaria (2004) (21)
- Transition States (2009) (21)
- Luciferase-based assay for adenosine: application to S-adenosyl-L-homocysteine hydrolase. (2012) (21)
- Kinetic studies of the interaction of substrates, Mn2+, and Mg2+ with the Mn2+-sensitive and -insensitive forms of phosphoenolpyruvate carboxykinase. (1981) (21)
- Purification, properties, and allosteric activation of nucleoside diphosphatase. (1968) (20)
- Subcellular location of phosphoenolpyruvate carboxykinase in hepatocytes from fed and starved rats. (1986) (20)
- Covalent modification of the beta-1,4-N-acetylmuramoylhydrolase of Streptococcus faecium with 5-mercaptouridine monophosphate. (1988) (20)
- Transition state analogues rescue ribosomes from saporin-L1 ribosome inactivating protein. (2009) (20)
- Inhibition of ricin by an rna stem-loop containing a ribo-oxycarbonium mimic (1996) (20)
- Ground-state destabilization in orotate phosphoribosyltransferases by binding isotope effects. (2011) (20)
- Kinetic properties of allosteric adenosine monophosphate nucleosidase from Azotobacter vinelandii. (1974) (20)
- Structure and regulation of the AMP nucleosidase gene (amn) from Escherichia coli. (1989) (20)
- Ricin A-chain activity on stem-loop and unstructured DNA substrates. (2005) (20)
- Transition state variation in enzymatic reactions. (2001) (20)
- Detection of an abasic site in RNA with stem-loop DNA beacons: application to an activity assay for Ricin Toxin A-Chain. (2008) (19)
- Catalytic and regulatory site composition of yeast AMP deaminase by comparative binding and rate studies. Resolution of the cooperative mechanism. (1990) (19)
- Entropy-driven binding of picomolar transition state analogue inhibitors to human 5'-methylthioadenosine phosphorylase. (2011) (19)
- Inactivation of chicken mitochondrial phosphoenolpyruvate carboxykinase by o-phthalaldehyde. (1991) (19)
- Comparison of initial velocity and binding data for allosteric adenosine monophosphate nucleosidase. (1976) (19)
- Salmonella enterica MTAN at 1.36 Å resolution: a structure-based design of tailored transition state analogs. (2013) (17)
- AMP nucleosidase: kinetic mechanism and thermodynamics. (1986) (17)
- Genetic resistance to purine nucleoside phosphorylase inhibition in Plasmodium falciparum (2018) (17)
- Transition-state analysis of Trypanosoma cruzi uridine phosphorylase-catalyzed arsenolysis of uridine. (2011) (17)
- Hydrolysis of soluble, linear, un-cross-linked peptidoglycans by endogenous bacterial N-acetylmuramoylhydrolases (1984) (17)
- Transition Path Sampling Study of the Reaction Catalyzed by Purine Nucleoside Phosphorylase (2008) (17)
- Trypanosomal nucleoside hydrolase. Resonance Raman spectroscopy of a transition-state inhibitor complex. (1996) (17)
- Transition-state interactions revealed in purine nucleoside phosphorylase by binding isotope effects. (2008) (17)
- Pyrophosphate interactions at the transition states of Plasmodium falciparum and human orotate phosphoribosyltransferases. (2010) (16)
- A high-affinity adenosine kinase from Anopheles gambiae. (2011) (16)
- Loop-tryptophan human purine nucleoside phosphorylase reveals submillisecond protein dynamics. (2009) (16)
- Ricin A-chain substrate specificity in RNA, DNA, and hybrid stem-loop structures. (2004) (16)
- Electrostatic potential surface analysis of the transition state for AMP nucleosidase and for formycin 5'-phosphate, a transition-state inhibitor. (1994) (16)
- Pyrophosphate activation in hypoxanthine--guanine phosphoribosyltransferase with transition state analogue. (2010) (15)
- Crystal structure of formycin 5'-phosphate: an explanation for its tight binding to AMP nucleosidase. (1988) (15)
- Inverse enzyme isotope effects in human purine nucleoside phosphorylase with heavy asparagine labels (2018) (15)
- Arsenate and phosphate as nucleophiles at the transition states of human purine nucleoside phosphorylase. (2011) (15)
- Active site contacts in the purine nucleoside phosphorylase--hypoxanthine complex by NMR and ab initio calculations. (2004) (15)
- Heat Capacity Changes for Transition-State Analogue Binding and Catalysis with Human 5'-Methylthioadenosine Phosphorylase. (2017) (15)
- The effect of a novel transition state inhibitor of methylthioadenosine phosphorylase on pemetrexed activity (2006) (15)
- Second-sphere amino acids contribute to transition-state structure in bovine purine nucleoside phosphorylase. (2008) (14)
- Structural and Biochemical Characterization of Chlamydia trachomatis Hypothetical Protein CT263 Supports That Menaquinone Synthesis Occurs through the Futalosine Pathway* (2014) (14)
- Methylthioadenosine deaminase in an alternative quorum sensing pathway in Pseudomonas aeruginosa. (2012) (14)
- Ribocation transition state capture and rebound in human purine nucleoside phosphorylase. (2009) (14)
- Immucillins ImmA and ImmH Are Effective and Non-toxic in the Treatment of Experimental Visceral Leishmaniasis (2015) (14)
- Effects of allosteric activation on the primary and secondary kinetic isotope effects for three AMP nucleosidases. (1984) (13)
- Prediction of inhibitor binding free energies by quantum neural networks. Nucleoside analogues binding to trypanosomal nucleoside hydrolase. (1999) (13)
- Inhibition and Structure of Toxoplasma gondii Purine Nucleoside Phosphorylase (2014) (13)
- The Transition-State Structure for Human MAT2A from Isotope Effects. (2017) (13)
- Immucillins in custom catalytic-site cavities. (2008) (13)
- Anopheles gambiae purine nucleoside phosphorylase: catalysis, structure, and inhibition. (2007) (13)
- Transition-State Analysis of 2-O-Acetyl-ADP-Ribose Hydrolysis by Human Macrodomain 1 (2014) (12)
- Transition State Structure and Inhibition of Rv0091, a 5'-Deoxyadenosine/5'-methylthioadenosine Nucleosidase from Mycobacterium tuberculosis. (2016) (12)
- Catalytic site conformations in human PNP by 19F-NMR and crystallography. (2013) (12)
- Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics. (2012) (12)
- The Immucillins: Design, Synthesis and Application of Transition- State Analogues. (2015) (12)
- Transition State Analogue Inhibitors of 5'-Deoxyadenosine/5'-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis. (2017) (12)
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- The role of adenosine monophosphate nucleosidase in the regulation of adenine nucleotide levels in Azotobacter vinelandii during aerobic-anaerobic transitions. (1978) (12)
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- The structural gene for AMP nucleosidase. Mapping, cloning, and overproduction of the enzyme. (1984) (11)
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- Active site and remote contributions to catalysis in methylthioadenosine nucleosidases. (2015) (10)
- Kinetic Isotope Effects and Transition State Structure for Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase from Plasmodium falciparum. (2017) (10)
- Transition State Analysis of Adenosine Triphosphate Phosphoribosyltransferase. (2017) (10)
- Leaving group activation and pyrophosphate ionic state at the catalytic site of Plasmodium falciparum orotate phosphoribosyltransferase. (2010) (10)
- Enzyme homologues have distinct reaction paths through their transition states. (2015) (10)
- Kinetic Isotope Effects and Transition State Structure for Human Phenylethanolamine N-Methyltransferase. (2017) (10)
- A complex of methylthioadenosine/S-adenosylhomocysteine nucleosidase, transition state analogue, and nucleophilic water identified by mass spectrometry. (2012) (10)
- Intracellular rebinding of transition-state analogues provides extended in vivo inhibition lifetimes on human purine nucleoside phosphorylase (2017) (10)
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- A preparative method for the enzymatic 5'-monophosphorylation of nucleosides. (1987) (9)
- Tight binding enantiomers of pre-clinical drug candidates. (2015) (9)
- Catalytic Site Cooperativity in Dimeric Methylthioadenosine Nucleosidase (2014) (9)
- Conformational freedom in tight binding enzymatic transition-state analogues. (2013) (9)
- Antibacterial Strategy against H. pylori: Inhibition of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis. (2019) (9)
- Phosphate activation in the ground state of purine nucleoside phosphorylase. (2006) (9)
- Assignment of downfield proton resonances in purine nucleoside phosphorylase immucillin-H complex by saturation-transferred NOEs. (2004) (9)
- Binding Isotope Effects for para-Aminobenzoic Acid with Dihydropteroate Synthase from Staphylococcus aureus and Plasmodium falciparum. (2015) (9)
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- Molecular cloning and expression of a purine specific N-ribohydrolase from trypanosoma bruce1 brvcel (1997) (8)
- Electrostatic potential surfaces of the transition state for AMP deaminase and for (R)-coformycin, a transition state inhibitor. (1994) (8)
- Syntheses of 5-Chlorouracils/Thymines with 1-[Phosphono(Methyl/Difluoromethyl)]-1,2-Unsaturated-Moiety-Substituted Methyl Groups at N(1) and Human Thymidine Phosphorylase Inhibitory Activity (2009) (8)
- Chemoenzymatic Synthesis of (36)S Isotopologues of Methionine and S-Adenosyl-L-methionine. (2015) (8)
- Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase. (2019) (7)
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- Constrained bonding environment in the Michaelis complex of Trypanosoma cruzi uridine phosphorylase. (2012) (7)
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- Transition-State Analogues of Phenylethanolamine N-methyltransferase. (2020) (7)
- [33] Adenosine monophosphate nucleosidase from Azotobacter vinelandii and Escherichia coli (1978) (7)
- Transition-State Analogues of Campylobacter jejuni 5'-Methylthioadenosine Nucleosidase. (2018) (6)
- Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues (2021) (6)
- A mutant AMP nucleosidase. Purification, properties, and in vivo turnover of the protein. (1981) (6)
- Stabilization of allosteric adenosine monophosphate nucleosidase by inorganic salts, substrate, and essential activator. (1971) (6)
- Structural Insights into Intermediate Steps in the Sir 2 Deacetylation Reaction (6)
- A New Class of C‐Nucleoside Analogues. 1‐(S)‐Aryl‐1,4‐dideoxy‐1,4‐ imino‐D‐ribitols, Transition State Analogue Inhibitors of Nucleoside Hydrolase. (1994) (6)
- Kinetics of adenosine monophosphate nucleosidase inactivation by phosphate and protection by substrate and allosteric activator. (1978) (6)
- Ribosyl geometry in the transition state of Streptococcus pneumoniae methylthioadenosine nucleosidase from the 3'-(2)H kinetic isotope effect. (2008) (6)
- Design and Synthesis of D-Ribofuranoamidrazones as Inhibitors of Nucleoside Processing Enzymes (1995) (6)
- Yeast AMP deaminase. Catalytic activity in Schizosaccharomyces pombe and chromosomal location in Saccharomyces cerevisiae. (1993) (6)
- PURINE NUCLEOSIDE HYDROLASE (1996) (6)
- Studies on the allosteric modification of nucleoside diphosphatase activity by magnesium nucleoside triphosphates and inosine diphosphate. (1971) (5)
- Transition State Structure of RNA Depurination by Saporin L3. (2016) (5)
- Mechanism and Inhibition of Human Methionine Adenosyltransferase 2A. (2021) (5)
- MALARIAL PURINE PHOSPHORIBOSYLTRANSFERASE (1999) (5)
- Evidence of substantial separation of the catalytic and allosteric sites of AMP nucleosidase. (1980) (5)
- Stereochemistry of the ADP-Ribosylation Catalyzed by Pertussis Toxin (1995) (5)
- Transition State Analogue Inhibitors of N‐Ribosyltransferases (2008) (4)
- Interaction of Mn2+ and MnATP2- with the allosteric sites of AMP nucleosidase. (1980) (4)
- Distortional binding of transition state analogs to human purine nucleoside phosphorylase probed by magic angle spinning solid-state NMR (2013) (4)
- Inverse heavy enzyme isotope effects in methylthioadenosine nucleosidases (2021) (4)
- Small molecule inhibitors targeting the interaction of ricin toxin A subunit with ribosomes. (2020) (4)
- Binding Isotope Effects for Interrogating Enzyme-Substrate Interactions. (2017) (4)
- Purine nucleoside phosphorylases as targets for transition-state analog design (2010) (4)
- Vinyldeoxyadenosine in a sarcin-ricin RNA loop and its binding to ricin toxin a-chain. (2007) (4)
- Crystallographic quaternary structural analysis of AMP nucleosidases from Escherichia coli and Azotobacter vinelandii. (1989) (3)
- Transition state analogs enhanced by fragment-based structural analysis: Bacterial methylthioadenosine nucleosidases. (2020) (3)
- A hypothesis to explain the substrate reactivity of ribosomal and stem-loop RNA with ricin A-chain. (1996) (3)
- Transition state analogue of MTAP extends lifespan of APCMin/+ mice (2020) (3)
- Mn 2 +-binding properties of a recombinant protein-tyrosine kinase derived from the human insulin receptor ( conformational change / secondary structure / electron a ge resonance / drcular dichroism ) (3)
- Crystallization and preliminary X-ray study of AMP nucleosidase. (1986) (3)
- Transition state analogue inhibitors of N-ribosyltransferases: new drugs by targeting nucleoside processing enzymes. (2007) (3)
- Studies on an aged preparation of nucleoside diphosphatase. Kinetics and reaction mechanism. (1970) (3)
- Quantum catalysis: The modeling of catalytic transition states (1999) (3)
- Enzymatic transition state structures constrained by experimental kinetic isotope effects: Experimental measurement of transition state variability (1999) (2)
- Kinetic Characterization and Inhibition of Trypanosoma cruzi Hypoxanthine–Guanine Phosphoribosyltransferases (2022) (2)
- Genetic resistance to purine nucleoside phosphorylase inhibition in (2018) (2)
- Adenosine monophosphate nucleosidase from Azotobacter vinelandii and Escherichia coli. (1978) (2)
- Adenylate Degradation in Escherichia coli (2001) (2)
- Mechanism of Triphosphate Hydrolysis by Human MAT2A at 1.07 Å Resolution. (2021) (2)
- Synthesis of bis-Phosphate Iminoaltritol Enantiomers and Structural Characterization with Adenine Phosphoribosyltransferase. (2017) (2)
- 5.05 – Deamination of Nucleosides and Nucleotides and Related Reactions (1999) (2)
- Mutagenic analysis of AMP nucleosidase from Escherichia coli. Deletion of a region similar to AMP deaminase and peptide characterization by mass spectrometry. (1993) (2)
- CRYSTAL STRUCTURE OF NUCLEOSIDE HYDROLASE FROM LEISHMANIA MAJOR (2000) (1)
- Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an SNi Mechanism and Ion Pair Transition State (2022) (1)
- Crystal Structure of Plasmodium falciparum purine nucleoside phosphorylase in complex with DADMe-ImmG (2011) (1)
- Transport, Subcellular Distribution and Export of Mn(II) in Rat Liver and Hepatocytes (1988) (1)
- Kinetic isotope effect studies of the S-adenosylmethionine synthetase reaction (1986) (1)
- A resistant mutant of Plasmodium falciparum purine nucleoside phosphorylase uses wild-type neighbors to maintain parasite survival (2021) (1)
- Enzymatic transition states and inhibitor design from principles of classical and quantum chemistry (1996) (1)
- A β -Fluoroamine Inhibitor of Purine Nucleoside Phosphorylase (2015) (1)
- Oligonucleotide transition state analogues of saporin L3. (2017) (1)
- Imino Sugar Based Nucleosides (2003) (1)
- Aminofutalosine Deaminase in the Menaquinone Pathway of Helicobacter pylori. (2021) (1)
- Synthesis and Characterization of Transition-State Analogue Inhibitors against Human DNA Methyltransferase 1. (2022) (1)
- Immucillin-H, a purine nucleoside phosphorylase transition state analog, causes non-lethal attenuation of growth in Staphylococcus aureus (2013) (1)
- Crystal structure of Plasmodium falciparum purine nucleoside phosphorylase (V181D) mutant complexed with DADMe-ImmG and phosphate (2018) (0)
- Alternate substrates and spectroscopic studies of P-enolpyruvate carboxykinase (1986) (0)
- Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with methylthio-DADMe-Immucillin-A (2017) (0)
- Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with 5'-methylthiotubercidin at 1.75 angstrom (2017) (0)
- Accelerated Publications One-Third-the-Sites Transition-State Inhibitors for Purine Nucleoside Phosphorylase † (1998) (0)
- PURINE NUCLEOSIDE HYDROLASE WITH A TRANSITION STATE INHIBITOR (1997) (0)
- Structure of Purine Nucleoside Phosphorylase from Anopheles gambiae in complex with DADMe-ImmH (2008) (0)
- A process for the preparation of inhibitors of the nucleoside metabolism (2000) (0)
- Addition of Lithiated 9‐Deazapurine Derivatives to a Carbohydrate Cyclic Imine: Convergent Synthesis of the Aza‐C‐nucleoside Immucillins. (2001) (0)
- Inhibitors of nukleosidphosphorylaser and nucleosidases (2006) (0)
- Crystal Structure of human 5'-deoxy-5'-methyladenosine phosphorylase (2011) (0)
- Transition‐State Analogs as Effective Inhibitors Against Helicobacter pylori 5′‐Methylthioadenosine Nucleosidase (2016) (0)
- Trypanosomes, transition states and design of transition state inhibitors (1997) (0)
- 1.75 A resolution structure of CT263-D161N (MTAN) from Chlamydia trachomatis bound to MTA (2014) (0)
- The transition state for RNA depurination by ricin a-chain (1997) (0)
- Nucleoside n-ribohydrolase inhibitor design applied to ricin a-chain (1996) (0)
- Sir2-S-alkylamidate complex crystal structure (2008) (0)
- The Sixth Annual Julius Marmur (2003) (0)
- Crystal structure of lactate dehydrogenase mutant (A85R) from staphylococcus aureus complexed with NAD and pyruvate (2010) (0)
- Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(((3-(1-benzyl-1H-1,2,3-triazol-4-yl)propyl)thio)methyl)pyrrolidin-3-ol (2019) (0)
- Structure of 5'-methylthionadenosine/S-Adenosylhomocysteine nucleosidase from S. pneumoniae with a transition-state inhibitor MT-ImmA (2006) (0)
- Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with DADMe-ImmG and phosphate (2013) (0)
- Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-((prop-2-yn-1-ylthio)methyl)pyrrolidin-3-ol (2019) (0)
- Kinetic isotope effect studies on the transition state of pertussis toxin (1996) (0)
- Substrate trapping experiments with P-enolpyruvate carboxykinase from rat and chickel liver (1987) (0)
- 1.45 A resolution structure of CT263 (MTAN) from Chlamydia trachomatis bound to Adenine (2014) (0)
- CRYSTAL STRUCTURE OF GIARDIA GUANINE PHOSPHORIBOSYLTRANSFERASE COMPLEXED WITH IMMUCILLING (2000) (0)
- Crystal structure of a putative 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Francisella philomiragia ATCC 25017 (Target NYSGRC-029335) (2013) (0)
- Over-The-Barrier Transition State Analogues Provide New Chemistries for Inhibitor Design: The Case of Purine Nucleoside Phosphorylase (2003) (0)
- Human Methionine Adenosyltransferase 2A bound to Methylthioadenosine, Malonate (MLA) and MgF3 (2021) (0)
- Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(((3-(1-benzyl-1H-1,2,3-triazol-4-yl)propyl)thio)methyl)pyrrolidin-3-ol (2019) (0)
- Enhanced Antibiotic Discovery by PROSPECTing. (2019) (0)
- Crystal structure of human NAMPT complexed with nicotinamide mononucleotide and pyrophosphate (2009) (0)
- Crystal structure of human CD38: cyclic-ADP-ribosyl synthetase/NAD+ glycohydrolase (2006) (0)
- Crystal Structure of APRTase from Giardia lamblia Complexed with 9-deazaadenine (2002) (0)
- Crystal Structure of Plasmodium falciparum purine nucleoside phosphorylase: The M183L mutant (2018) (0)
- Crystal structure of Saporin-L1 mutant (Y73A) from Saponaria officinalis (2009) (0)
- Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with methyl-thio-DADMe-Immucillin-A (2013) (0)
- Crystal structure of ricin A chain in complex with inhibitor 4-(2-thienylmethyl)benzoic acid (2020) (0)
- Enzymatic transition states and drug design (2014) (0)
- Structure of human purine nucleoside phosphorylase in complex with DADMe-Immucillin-H and sulfate (2005) (0)
- Crystal structure of Sir2Tm in complex with Acetyl p53 peptide and DADMe-NAD+ (2008) (0)
- Inhibitors of nukleosidmetabolisme (1998) (0)
- Inosine-Guanosine Nucleoside Hydrolase (IG-NH) (2010) (0)
- Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG (2011) (0)
- Crystal structure of phosphorylated mimic form of human NAMPT complexed with benzamide and phosphoribosyl pyrophosphate (2009) (0)
- Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with (((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)(hexyl)amino)methanol (2015) (0)
- Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with phosphate (2013) (0)
- Protein Mass-Modulated Effects in Alkaline Phosphatase. (2021) (0)
- Acrylic amininhibotorer of nukleosidphosphorylaser and hydrolases (2007) (0)
- Crystal structure of human NAMPT complexed with ADP analogue (2009) (0)
- Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-((prop-2-yn-1-ylthio)methyl)pyrrolidin-3-ol (2019) (0)
- Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with 2-amino-MTA and sulfate (2016) (0)
- Crystal structure of Purine Nucleoside Phosphorylase from Trichomonas vaginalis with DADMe-Imm-A (2007) (0)
- Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from neisseria meningitidis in complex with methylthio-immucillin-A (2009) (0)
- Crystal structure of phosphorylated mimic form of human NAMPT complexed with nicotinamide mononucleotide and pyrophosphate (2009) (0)
- The impact of methylthioadenosine phosphorylase (MTAP) mediated purine salvage on pemetrexed activity (2006) (0)
- Crystal structure of purine nucleoside phosphorylase from toxoplasma gondii in complex with immucillin-H (2011) (0)
- Crystal Structure of 5'-methylthioinosine phosphorylase from Psedomonas aeruginosa in complex with hypoxanthine (2011) (0)
- Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(((3-(1-butyl-1H-1,2,3-triazol-4-yl)propyl)thio)methyl)pyrrolidin-3-ol (2019) (0)
- CRYSTAL STRUCTURE OF PURINE NUCLEOSIDE PHOSPHORYLASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH A TRANSITION-STATE INHIBITOR (2001) (0)
- Crystal Structure Of a purine nucleoside phosphorylase (PSI-NYSGRC-029736) from Agrobacterium vitis (2014) (0)
- Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-((pent-4-yn-1-ylthio)methyl)pyrrolidin-3-ol (2019) (0)
- Human Methionine Adenosyltransferase 2A bound to Methylthioadenosine and two sulfate in the active site (2021) (0)
- Crystal structure of Escherichia coli 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with (3S,4R)-methylthio-DADMe-Immucillin-A (2015) (0)
- Crystal structure of Lactate Dehydrogenase from Staphylococcus Aureus (2009) (0)
- Cyrstal structure of MTA/AdoHcy nucleosidase complexed with MT-DADMe-ImmA (2005) (0)
- 1.27 A resolution structure of CT263-D161N (MTAN) from Chlamydia trachomatis (2014) (0)
- Crystal structure of purine nucleoside phosphorylase (E258D, L261A) mutant from human complexed with DADMe-ImmG and phosphate (2016) (0)
- Crystal structure of Saporin-L1 from Saponaria officinalis (2009) (0)
- HUMAN HGPRTASE WITH TRANSITION STATE INHIBITOR (1999) (0)
- CRYSTAL STRUCTURE OF M. TUBERCULOSIS PNP IN COMPLEX WITH IMINORIBITOL, 9-DEAZAHYPOXANTHINE AND PHOSPHATE ION (2001) (0)
- Kinetic properties and kinetic isotope effects for AMP deaminase from yeast (1986) (0)
- 1.58 A resolution structure of CT263 (MTAN) from Chlamydia trachomatis (2014) (0)
- Crystal structure of MTA/AdoHcy nucleosidase complexed with MT-ImmA. (2005) (0)
- Studies on the kinetic and chemical mechanism of yeast AMP deaminase (1987) (0)
- Crystal structure of Anopheles gambiae adenosine kinase in complex with P1,P4-di(adenosine-5) tetraphosphate (2011) (0)
- Inhibition of adenosine deaminse by R- and S-deoxycoformycin (1984) (0)
- Process for preparing nucleoside metabolic inhibitors. (2000) (0)
- MT-DADMe-ImmA: A novel MTAP inhibitor with potential for the treatment of human head and neck and prostate carcinoma (2005) (0)
- Protein dynamics by hydrogen/deuterium exchange coupled to mass spectrometry: Purine nucleoside phosphorylase (2002) (0)
- Nucleoside inhibitors metabolism. (1998) (0)
- Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-((pent-4-yn-1-ylthio)methyl)pyrrolidin-3-ol (2019) (0)
- Pathway Menaquinone Synthesis Occurs through the Hypothetical Protein CT 263 Supports that Chlamydia trachomatis (2014) (0)
- Kinetic isotope effects on acid and AMP nucleosidase catalyzed hydrolysis of dAMP (1984) (0)
- Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Helicobacter pylori with butyl-thio-DADMe-Immucillin-A (2012) (0)
- Crystal structure of Campylobacter jejuni 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with pyrazinylthio-DADMe-Immucillin-A (2015) (0)
- Crystal structure of Plasmodium falciparum PNP with 5'-methylthio-immucillin-H (2004) (0)
- Covalent modification of the f 8-1 , 4N-acetylmuramoylhydrolase of Streptococcus faecium with 5-mercaptouridine monophosphate ( nucleotidylation / exoceiular enzyme / autolysin / muramidase ) (0)
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- Chemistry & Biology Article Catalytic Site Conformations in Human PNP by 19 F-NMR and Crystallography (2013) (0)
- Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with Adenine (2013) (0)
- Crystal structure of Ricin A-chain in complex with the cyclic tetranucleotide inhibitor, a transition state analogue (2009) (0)
- Crystal Structure Of Adenosine Deaminase From Pseudomonas Aeruginosa Pao1 with bound Zn and methylthio-coformycin (2013) (0)
- A process for the preparation of inhibitors of nukleosidmetabolisme (2000) (0)
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- Transition state studies on the adp-ribosylation of g-proteins catalyzed by pertussis toxin (1997) (0)
- N-RIBOSYLTRANSFERASE TRANSITION STATES; INHIBITORS AND APPLICATIONS (2002) (0)
- Crystal structure of ricin A chain in complex with inhibitor 9-oxo-4-fluorenecarboxamide (2020) (0)
- Purine and Pyrimidine Pathways (2014) (0)
- Crystal structure of Saporin-L1 in complex with the trinucleotide inhibitor, a transition state analogue (2009) (0)
- Structure of human purine nucleoside phosphorylase with L-DADMe-ImmH and phosphate (2008) (0)
- MAT Gain of Activity Mutation in Helicobacter pylori Is Associated with Resistance to MTAN Transition State Analogues. (2023) (0)
- Crystal structure of Vibrio cholerae 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with methylthio-DADMe-Immucillin-A (2015) (0)
- Structure of human purine nucleoside phosphorylase in complex with Immucillin-H and phosphate (2005) (0)
- Supplemental Data Ribocation Transition State Capture and Rebound in Human Purine Nucleoside Phosphorylase (2009) (0)
- Crystal Structure of human 5'-deoxy-5'-methyladenosine phosphorylase in complex with pCl-phenylthioDADMeImmA (2011) (0)
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- CRYSTAL STRUCTURE OF ADENINE PHOSPHORIBOSYLTRANSFERASE (2001) (0)
- Synthesis of Transition State Analogue Inhibitors for Purine Nucleoside Phosphorylase and N‐Riboside Hydrolases. (2000) (0)
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- Crystal structure of ricin A chain in complex with inhibitor 5-phenyl-2-thiophenecarboxylic acid (2020) (0)
- Inhibition and Mechanism of Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase. (2022) (0)
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- Crystal Structure of Adenine Phosphoribosyltransferase from Saccharomyces cerevisiae Complexed with D-2,5-Dideoxy-2,5-Imino-Altritol 1,6-Bisphosphate (D-DIAB) and Adenine (2017) (0)
- Crystal structure of human phenylethanolamine N-methyltransferase (PNMT) in complex with (2S)-2-amino-4-((((2R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(3-(7,8-dichloro-1,2,3,4-tetrahydroisoquinolin-4-yl)propyl)amino)butanoic acid and AdoHcy (SAH) (2020) (0)
- Crystal Structure of Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase in complex with S-SerMe-ImmH phosphonate (2011) (0)
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- Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with 2-(2-hydroxyethoxy)ethylthiomethyl-DADMe-Immucillin-A (2015) (0)
- Structure of human purine nucleoside phosphorylase H257D mutant (2006) (0)
- The design of protozoan phosphoribosyltransferase inhibitors containing non-charged phosphate mimic residues. (2022) (0)
- Heavy atom /sup 15/N kinetic isotope effects on N-glycoside hydrolysis of AMP (1986) (0)
- Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with hydroxybutylthio-DADMe-Immucillin-A (2015) (0)
- Synthesis of a new 8-spin-labeled analog of adenosine 5'-phosphate and its interaction with AMP nucleosidase. (1979) (0)
- Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with diEtglycol-thio-DADMe-Immucillin-A (2013) (0)
- An enzyme-coupled microplate assay for activity and inhibition of hmdUMP hydrolysis by DNPH1. (2023) (0)
- Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(((3-(1-butyl-1H-1,2,3-triazol-4-yl)propyl)thio)methyl)pyrrolidin-3-ol (2019) (0)
- Heavy atom kinetic isotope effects on phosphorolysis and arsenolysis of inosine by purine nucleoside phosphorylase from calf spleen (1987) (0)
- Crystal Structure of Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase in complex with hypoxanthine (2011) (0)
- Abstract 18: Doubled lifespan in APCMin/+ mice by targeting MTAP (2019) (0)
- Crystal structure of Clostridium difficile Toxin B (TcdB) glucosyltransferase in complex with UDP and isofagomine (2021) (0)
- Crystal structure of human purine nucleoside phosphorylase (F159Y) mutant complexed with DADMe-ImmG and phosphate (2017) (0)
- A Small Molecule Inhibitor of Methylthioadenosine Phosphorylase (MTAP) for the Treatment of Human Head and Neck Carcinoma (2005) (0)
- Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with butylthio-DADMe-Immucillin-A and chloride (2017) (0)
- Abstract LB-89: Discovery and characterization of novel MTAP splice variants resulting in a hereditary form of osteosarcoma and demonstration of their dysregulation in sporadic forms of this cancer (2012) (0)
- Structure of human purine nucleoside phosphorylase in complex with L-Immucillin-H (2008) (0)
- Design of inhibitors for ricin A-chain☆ (1996) (0)
- Salmonella enterica MTAN at 1.36 Å resolution. Structure-based design of new transition state analogues (2013) (0)
- Crystal structure of Helicobacter pylori aminofutalosine deaminase (AFLDA) in complex with Methylthio-coformycin (2021) (0)
- Crystal structure of human purine nucleoside phosphorylase mutant H257D with Imm-H (2007) (0)
- Crystal structure of Escherichia coli 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with butylthio-DADMe-Immucillin-A (2009) (0)
- Crystal Structure of adenosine deaminase from Plasmodial vivax in complex with MT-coformycin (2009) (0)
- Crystal Structure of APRTase from Giardia lamblia Complexed with 9-deazaadenine, Mg2+ and PRPP (2002) (0)
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