Aaron Ciechanover | Academic Influence

Aaron Ciechanover's AcademicInfluence.com Rankings

Aaron Ciechanover

Biology

#248

World Rank

#448

Historical Rank

Biochemistry

#66

World Rank

#86

Historical Rank

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Biology

Aaron Ciechanover's Degrees

PhD Biochemistry Technion – Israel Institute of Technology

Why Is Aaron Ciechanover Influential?

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According to Wikipedia, Aaron Ciechanover is an Israeli biologist who won the Nobel Prize in Chemistry for characterizing the method that cells use to degrade and recycle proteins using ubiquitin. Biography Early life Ciechanover was born in Haifa, British Mandate of Palestine on 1 October 1947 into a Jewish family. He is the son of Bluma , a teacher of English, and Yitzhak Ciechanover, an office worker. His mother and father supported the Zionist movement and immigrated to Israel from Poland in the 1920s.

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Aaron Ciechanover's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Papers

The ubiquitin system (2000) (4544)
The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. (2002) (4028)
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018) (3106)
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes (2009) (2078)
The ubiquitin-proteasome proteolytic pathway (1994) (1750)
The ubiquitin–proteasome pathway: on protein death and cell life (1998) (1398)
The ubiquitin system for protein degradation. (1992) (1342)
pH and the recycling of transferrin during receptor-mediated endocytosis. (1983) (1070)
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. (1999) (1027)
Proteolysis: from the lysosome to ubiquitin and the proteasome (2005) (1026)
Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown. (1983) (1011)
The Ubiquitin Proteasome System in Neurodegenerative Diseases Sometimes the Chicken, Sometimes the Egg (2003) (956)
Ubiquitin‐mediated proteolysis: biological regulation via destruction (2000) (847)
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 (2014) (799)
Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination (1997) (696)
Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis. (1980) (651)
Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies (2015) (635)
Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1. (1997) (571)
Mechanisms of intracellular protein breakdown. (1982) (515)
Mutation of the E6-AP Ubiquitin Ligase Reduces Nuclear Inclusion Frequency While Accelerating Polyglutamine-Induced Pathology in SCA1 Mice (1999) (514)
The HECT family of E3 ubiquitin ligases: multiple players in cancer development. (2008) (501)
Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents. (1983) (482)
The ubiquitin-proteasome pathway and pathogenesis of human diseases. (1999) (477)
Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85 (1984) (470)
ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation. (1980) (468)
Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85 (1984) (454)
Targeting proteins for destruction by the ubiquitin system: implications for human pathobiology. (2009) (450)
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway. (1995) (446)
The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy. (2017) (431)
Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin–proteasome system and onto human diseases and drug targeting* (2005) (394)
The ubiquitin-proteasome pathway: the complexity and myriad functions of proteins death. (1998) (387)
N-terminal ubiquitination: more protein substrates join in. (2004) (377)
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53 (2003) (366)
Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. (2011) (356)
Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor* (2001) (338)
Degradation of nuclear oncoproteins by the ubiquitin system in vitro. (1991) (335)
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018) (323)
The ubiquitin conjugation system is required for ligand‐induced endocytosis and degradation of the growth hormone receptor. (1996) (322)
Ubiquitin-dependent Degradation of Certain Protein Substrates in Vitro Requires the Molecular Chaperone Hsc70* (1997) (310)
A novel site for ubiquitination: the N‐terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein (1998) (302)
Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1 (2002) (285)
Modes of regulation of ubiquitin‐mediated protein degradation (2000) (283)
The ubiquitin‐mediated proteolytic pathway: Mode of action and clinical implications (2000) (283)
"Covalent affinity" purification of ubiquitin-activating enzyme. (1982) (268)
Components of Ubiquitin-Protein Ligase System (1983) (259)
Immunochemical analysis of the turnover of ubiquitin-protein conjugates in intact cells. Relationship to the breakdown of abnormal proteins. (1982) (257)
Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms (2011) (246)
Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway. (1998) (244)
The polycomb protein Ring1B generates self atypical mixed ubiquitin chains required for its in vitro histone H2A ligase activity. (2006) (242)
Inhibition of NF‐κB cellular function via specific targeting of the IκB‐ubiquitin ligase (1997) (235)
The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death (2016) (231)
Basic Medical Research Award. The ubiquitin system. (2000) (228)
Protein Quality Control by Molecular Chaperones in Neurodegeneration (2017) (216)
Non-canonical ubiquitin-based signals for proteasomal degradation (2012) (216)
Narrative Review: Protein Degradation and Human Diseases: The Ubiquitin Connection (2006) (212)
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells. (2001) (212)
Characterization of the heat-stable polypeptide of the ATP-dependent proteolytic system from reticulocytes. (1980) (212)
Activation of the heat-stable polypeptide of the ATP-dependent proteolytic system. (1981) (206)
The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation (2011) (198)
Degradation of the Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) by the Ubiquitin-Proteasome Pathway (2000) (196)
The unravelling of the ubiquitin system (2015) (195)
Caspase activation inhibits proteasome function during apoptosis. (2004) (194)
The ubiquitin‐mediated proteolytic pathway: mechanisms of recognition of the proteolytic substrate and involvement in the degradation of native cellular proteins (1994) (194)
Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP. (1979) (192)
The 26 S Proteasome: From Basic Mechanisms to Drug Targeting* (2009) (190)
Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: targeting via ubiquitination of the N-terminal residue (2000) (188)
Intracellular protein degradation: from a vague idea, through the lysosome and the ubiquitin-proteasome system, and onto human diseases and drug targeting (Nobel lecture). (2005) (187)
The ubiquitin‐mediated proteolytic pathway and mechanisms of energy‐dependent intracellular protein degradation (1984) (187)
p62- and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome (2016) (181)
Degradation of the proto-oncogene product c-Fos by the ubiquitin proteolytic system in vivo and in vitro: identification and characterization of the conjugating enzymes (1995) (178)
Protein synthesis elongation factor EF-1 alpha is essential for ubiquitin-dependent degradation of certain N alpha-acetylated proteins and may be substituted for by the bacterial elongation factor EF-Tu. (1994) (170)
The ubiquitin pathway for the degradation of intracellular proteins. (1986) (168)
The ubiquitin-proteasome system in cardiovascular diseases-a hypothesis extended. (2004) (166)
A Chinese hamster cell cycle mutant arrested at G2 phase has a temperature-sensitive ubiquitin-activating enzyme, E1. (1988) (164)
Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105. Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation. (1995) (163)
N-terminal Arginylation Targets Endoplasmic Reticulum Chaperone BiP to Autophagy Through p62 Binding (2015) (162)
Itch: a HECT-type E3 ligase regulating immunity, skin and cancer (2008) (160)
The ubiquitin system: pathogenesis of human diseases and drug targeting. (2004) (159)
The complexity of recognition of ubiquitinated substrates by the 26S proteasome. (2014) (150)
SCFβ‐TrCP ubiquitin ligase‐mediated processing of NF‐κB p 105 requires phosphorylation of its C‐terminus by IκB kinase (2000) (147)
Intracellular protein degradation: from a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. (2013) (146)
p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis (2017) (145)
The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation. (2012) (143)
The asialoglycoprotein receptor internalizes and recycles independently of the transferrin and insulin receptors (1983) (138)
Role of UEV-1, an Inactive Variant of the E2 UbiquitinConjugating Enzymes, in In Vitro Differentiation and Cell Cycle Behavior of HT-29-M6 Intestinal Mucosecretory Cells (1998) (138)
Sorting and recycling of cell surface receptors and endocytosed ligands: The asialoglycoprotein and transferrin receptors (1983) (137)
Climate change and the integrity of science. (2010) (137)
The ubiquitin proteolytic system (2006) (133)
The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation (2011) (132)
Structural Motifs Involved in Ubiquitin-Mediated Processing of the NF-κB Precursor p105: Roles of the Glycine-Rich Region and a Downstream Ubiquitination Domain (1999) (131)
Identification of the Ubiquitin Carrier Proteins, E2s, Involved in Signal-induced Conjugation and Subsequent Degradation of IκBα* (1999) (130)
Ubiquitin as a central cellular regulator (2004) (129)
Numerous proteins with unique characteristics are degraded by the 26S proteasome following monoubiquitination (2016) (129)
The ubiquitin-proteasome system and autophagy: Coordinated and independent activities. (2016) (125)
Mechanism of processing of the NF-κB2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCFβ-TrCP ubiquitin ligase (2004) (124)
Role of arginine-tRNA in protein degradation by the ubiquitin pathway (1987) (122)
A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1. (2003) (121)
Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1. (1991) (121)
Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. (2006) (120)
Degradation of Myogenic Transcription Factor MyoD by the Ubiquitin Pathway In Vivo and In Vitro: Regulation by Specific DNA Binding (1998) (119)
Functional Interaction between SEL-10 , an F-box Protein , and the Nuclear Form of Activated Notch 1 Receptor * (2001) (118)
Degradation of ornithine decarboxylase in reticulocyte lysate is ATP-dependent but ubiquitin-independent. (1989) (117)
Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. (2012) (116)
Mammalian reticulocytes lose adhesion to fibronectin during maturation to erythrocytes. (1985) (116)
Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology (2013) (115)
The Ubiquitin System: From Basic Mechanisms to the Patient Bed (2004) (113)
Identification of the active amino acid residue of the polypeptide of ATP-dependent protein breakdown. (1981) (113)
The ubiquitin proteolytic system and pathogenesis of human diseases: a novel platform for mechanism-based drug targeting. (2003) (111)
Hypoxia-Mediated Degradation of Na,K-ATPase via Mitochondrial Reactive Oxygen Species and the Ubiquitin-Conjugating System (2006) (105)
High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy (2014) (104)
The Tumor Suppressor Protein p16INK4a and the Human Papillomavirus Oncoprotein-58 E7 Are Naturally Occurring Lysine-less Proteins That Are Degraded by the Ubiquitin System (2004) (103)
c-Abl Regulates p53 Levels under Normal and Stress Conditions by Preventing Its Nuclear Export and Ubiquitination (2001) (99)
The ubiquitin-activating enzyme, E1, is required for stress-induced lysosomal degradation of cellular proteins. (1991) (99)
How are substrates recognized by the ubiquitin-mediated proteolytic system? (1989) (99)
Degradation of proteins with acetylated amino termini by the ubiquitin system (1989) (96)
Degradation of the tumor suppressor protein p53 by the ubiquitin-mediated proteolytic system requires a novel species of ubiquitin-carrier protein, E2. (1994) (95)
Modification by single ubiquitin moieties rather than polyubiquitination is sufficient for proteasomal processing of the p105 NF-kappaB precursor. (2009) (93)
KPC1-Mediated Ubiquitination and Proteasomal Processing of NF-κB1 p105 to p50 Restricts Tumor Growth (2015) (89)
The eye lens has an active ubiquitin-protein conjugation system. (1986) (88)
Degradation of ornithine decarboxylase in mammalian cells is ATP dependent but ubiquitin independent. (1989) (86)
On the involvement of calpains in the degradation of the tumor suppressor protein p53 (1997) (83)
Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome (2010) (83)
Degradation of ubiquitin: The fate of the cellular reaper (2010) (83)
Differential interaction of plakoglobin and β-catenin with the ubiquitin-proteasome system (2000) (82)
Intracellular transport of transferrin- and asialoorosomucoid-colloidal gold conjugates to lysosomes after receptor-mediated endocytosis. (1985) (81)
Inverse relationship between Skp2 ubiquitin ligase and the cyclin dependent kinase inhibitor p27Kip1 in prostate cancer. (2003) (81)
Nonenzymatic polyubiquitination of expressed proteins. (2014) (81)
Degradation of the Id2 developmental regulator: targeting via N-terminal ubiquitination. (2004) (81)
The Nuclear Ubiquitin-Proteasome System Degrades MyoD* (2001) (78)
Ubiquitin‐mediated degradation of cellular proteins in health and disease (2002) (78)
Ubiquitin degradation with its substrate, or as a monomer in a ubiquitination-independent mode, provides clues to proteasome regulation (2009) (76)
SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase. (2000) (75)
Immunoelectron microscopic localization of ubiquitin in hepatoma cells. (1988) (71)
Human ubiquitin-activating enzyme, E1. Indication of potential nuclear and cytoplasmic subpopulations using epitope-tagged cDNA constructs. (1994) (70)
Ubiquitin binding by a CUE domain regulates ubiquitin chain formation by ERAD E3 ligases. (2013) (69)
Regulation of the Polycomb protein RING1B ubiquitination by USP7. (2010) (69)
The N-Degron Pathway Mediates ER-phagy. (2019) (66)
The NEDD8 Pathway Is Essential for SCFβ-TrCP-mediated Ubiquitination and Processing of the NF-κB Precursor p105* (2002) (66)
Dual Effects of IκB Kinase β-Mediated Phosphorylation on p105 Fate: SCFβ-TrCP-Dependent Degradation and SCFβ-TrCP-Independent Processing (2004) (64)
Ubiquitin-Proteasome-mediated Degradation of Id1 Is Modulated by MyoD* (2004) (63)
Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase. (1997) (63)
Cellular proteolytic systems (1994) (62)
Ubiquitin-activating enzyme, E1, is associated with maturation of autophagic vacuoles (1992) (62)
Physical and Functional Interaction of the HECT Ubiquitin-protein Ligases E6AP and HERC2* (2011) (62)
Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways (2007) (61)
NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1 (2012) (59)
Purification and characterization of a novel species of ubiquitin-carrier protein, E2, that is involved in degradation of non-"N-end rule" protein substrates. (1994) (59)
E12 and E47 modulate cellular localization and proteasome-mediated degradation of MyoD and Id1 (2005) (58)
The Ubiquitin-activating Enzyme E1 Is Phosphorylated and Localized to the Nucleus in a Cell Cycle-dependent Manner* (1996) (58)
Stress-induced alterations in autophagic pathway: relationship to ubiquitin system. (1992) (58)
Ubiquitin-Proteasome-mediated Degradation, Intracellular Localization, and Protein Synthesis of MyoD and Id1 during Muscle Differentiation* (2005) (57)
Increased ubiquitin immunoreactivity in unstable atherosclerotic plaques associated with acute coronary syndromes. (2002) (57)
Oxidative stress‐related increase in ubiquitination in early coronary atherogenesis (2003) (57)
Mechanisms of ubiquitin-mediated, limited processingof the NF-κB1 precursor protein p105 (2001) (56)
Regulation of Drosophila IAP 1 degradation and apoptosis by reaper and ubcD 1 (2002) (56)
Ubiquitin-Proteasome-mediated Degradation of Keratin Intermediate Filaments in Mechanically Stimulated A549 Cells* (2008) (55)
Purification and characterization of arginyl-tRNA-protein transferase from rabbit reticulocytes. Its involvement in post-translational modification and degradation of acidic NH2 termini substrates of the ubiquitin pathway. (1988) (54)
Determinants of Nuclear and Cytoplasmic Ubiquitin-mediated Degradation of MyoD* (2003) (53)
Transfer RNA is required for conjugation of ubiquitin to selective substrates of the ubiquitin- and ATP-dependent proteolytic system. (1986) (53)
PRAJA1 is a ubiquitin ligase for the polycomb repressive complex 2 proteins. (2011) (52)
The Ubiquitin‐Mediated Proteolytic Pathway (1993) (50)
The ubiquitin-mediated proteolytic pathway: mechanisms of action and cellular physiology. (1994) (49)
The lysine48-based polyubiquitin chain proteasomal signal: not a single child anymore. (2013) (49)
The Tumor Suppressor Protein p 16 INK 4 a and the Human Papillomavirus Oncoprotein-58 E 7 Are Naturally Occurring Lysine-less Proteins (2004) (48)
Phosphorylation and ubiquitination are necessary for Na,K-ATPase endocytosis during hypoxia. (2007) (48)
Intracellular protein degradation: From a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. (2017) (46)
Immunoelectron microscopic localization of the ubiquitin-activating enzyme E1 in HepG2 cells. (1992) (46)
Transfer RNA is an essential component of the ubiquitin- and ATP-dependent proteolytic system. (1985) (45)
Nuclear localization of the ubiquitin-activating enzyme, E1, is cell-cycle-dependent. (1994) (45)
Intracellular Protein Degradation From a Vague Idea through the Lysosome and the Ubiquitin‐Proteasome System and on to Human Diseases and Drug Targeting (2007) (44)
FAT10 is a proteasomal degradation signal that is itself regulated by ubiquitination (2012) (42)
De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains (2019) (42)
The 26S proteasome of the yeast Saccharomyces cerevisiae (1994) (41)
p62 at the crossroad of the ubiquitin-proteasome system and autophagy (2016) (41)
Protein synthesis elongation factor EF-1 alpha is an isopeptidase essential for ubiquitin-dependent degradation of certain proteolytic substrates. (1996) (41)
N-terminal arginylation generates a bimodal degron that modulates autophagic proteolysis (2018) (40)
The NEDD8 pathway is essential for SCF(beta -TrCP)-mediated ubiquitination and processing of the NF-kappa B precursor p105. (2002) (40)
Degradation of ornithine decarboxylase by the mammalian and yeast 26S proteasome complexes requires all the components of the protease. (1995) (39)
Intracellular Protein Degradation: From a Vague Idea Thru the Lysosome and the Ubiquitin-Proteasome System and onto Human Diseases and Drug Targeting* * (2006) (39)
Complete reconstitution of conjugation and subsequent degradation of the tumor suppressor protein p53 by purified components of the ubiquitin proteolytic system (1994) (38)
Tracing the history of the ubiquitin proteolytic system: the pioneering article. (2009) (38)
Hypoxia‐mediated Na‐K‐ATPase degradation requires von Hippel Lindau protein (2008) (37)
Identification of a Region within the Ubiquitin-activating Enzyme Required for Nuclear Targeting and Phosphorylation* (1997) (37)
Switches, Excitable Responses and Oscillations in the Ring1B/Bmi1 Ubiquitination System (2011) (37)
HUWE1 ubiquitinates MyoD and targets it for proteasomal degradation. (2012) (37)
Monoubiquitination joins polyubiquitination as an esteemed proteasomal targeting signal (2017) (36)
Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbations (2016) (36)
Diverse fate of ubiquitin chain moieties: The proximal is degraded with the target, and the distal protects the proximal from removal and recycles (2019) (35)
HIF and HOIL-1L–mediated PKCζ degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury (2017) (35)
The ubiquitin proteasome system and its involvement in cell death pathways (2010) (35)
Processing of p105 Is Inhibited by Docking of p50 Active Subunits to the Ankyrin Repeat Domain, and Inhibition Is Alleviated by Signaling via the Carboxyl-terminal Phosphorylation/ Ubiquitin-Ligase Binding Domain* (2001) (34)
N-terminal ubiquitination. (2005) (34)
The endoplasmic reticulum–residing chaperone BiP is short-lived and metabolized through N-terminal arginylation (2018) (34)
Regulation of the Proapoptotic ARTS Protein by Ubiquitin-mediated Degradation* (2005) (34)
On the linkage between the ubiquitin-proteasome system and the mitochondria. (2016) (34)
Isolation, Characterization, and Partial Purification of a Novel Ubiquitin-Protein Ligase, E3 (1996) (33)
The ubiquitin proteolytic system: from an idea to the patient bed. (2006) (33)
Post-translational addition of an arginine moiety to acidic NH2 termini of proteins is required for their recognition by ubiquitin-protein ligase. (1990) (32)
Decreased level of the cell cycle regulator p27 and increased level of its ubiquitin ligase Skp2 in endometrial carcinoma but not in normal secretory or in hyperstimulated endometrium. (2004) (32)
Immunofluorescent localization of the ubiquitin-activating enzyme, E1, to the nucleus and cytoskeleton. (1993) (32)
ABIN-1 negatively regulates NF-kappaB by inhibiting processing of the p105 precursor. (2009) (31)
Purification and characterization of a novel protein that is required for degradation of N-alpha-acetylated proteins by the ubiquitin system. (1991) (30)
Mechanisms of ubiquitin-mediated, limited processing of the NF-kappaB1 precursor protein p105. (2001) (30)
The ubiquitin-mediated proteolytic system: involvement of molecular chaperones, degradation of oncoproteins, and activation of transcriptional regulators. (1995) (30)
Regulation of autophagic proteolysis by the N-recognin SQSTM1/p62 of the N-end rule pathway (2017) (30)
HOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growth. (2014) (30)
Linking ubiquitin, parkin and synphilin-1 (2001) (30)
Multiple Sclerosis Autoantigen Myelin Basic Protein Escapes Control by Ubiquitination during Proteasomal Degradation* (2014) (30)
Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 Fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing. (2004) (30)
Ubiquitination of specific mitochondrial matrix proteins. (2016) (29)
Degradation of tyrosine aminotransferase (TAT) via the ubiquitin–proteasome pathway (1997) (29)
The ubiquitin-proteasome system: A potential therapeutic target for heart failure. (2017) (29)
Two distinct ubiquitin-dependent mechanisms are involved in NF-kappaB p105 proteolysis. (2006) (28)
Rescue of the complex temperature-sensitive phenotype of Chinese hamster ovary E36ts20 cells by expression of the human ubiquitin-activating enzyme cDNA. (1994) (27)
Ubiquitination participates in the lysosomal degradation of Na,K-ATPase in steady-state conditions. (2009) (27)
Modification by single ubiquitin moieties rather than polyubiquitination is sufficient for proteasomal processing of the p105 NF-κB precursor. (2011) (27)
Epstein‐Barr virus‐encoded EBNA‐5 forms trimolecular protein complexes with MDM2 and p53 and inhibits the transactivating function of p53 (2011) (26)
Glioma‐derived cancer stem cells are hypersensitive to proteasomal inhibition (2017) (26)
Antibody-induced receptor loss. Different fates for asialoglycoproteins and the asialoglycoprotein receptor in HepG2 cells. (1986) (26)
p62-containing, proteolytically active nuclear condensates, increase the efficiency of the ubiquitin–proteasome system (2021) (26)
Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-κB Pathway in Melanoma (2017) (25)
Modifying the vicinity of the isopeptide bond to reveal differential behavior of ubiquitin chains with interacting proteins: organic chemistry applied to synthetic proteins. (2013) (23)
Degradation of MyoD by the ubiquitin pathway: regulation by specific DNA-binding and identification of a novel site for ubiquitination (1999) (23)
The N-terminal domain of MyoD is necessary and sufficient for its nuclear localization-dependent degradation by the ubiquitin system (2008) (22)
Intracellular Protein Degradation: From a Vague Idea through the Lysosome and the Ubiquitin-Proteasome System and onto Human Diseases and Drug Targeting (2012) (21)
Stress-induced polyubiquitination of proteasomal ubiquitin receptors targets the proteolytic complex for autophagic degradation (2017) (21)
Generation of free ubiquitin chains is up-regulated in stress and facilitated by the HECT domain ubiquitin ligases UFD4 and HUL5. (2012) (21)
Ubiquitin is degraded by the ubiquitin system as a monomer and as part of its conjugated target. (2007) (21)
E2A protein degradation by the ubiquitin-proteasome system is stage-dependent during muscle differentiation (2007) (20)
Modulation of SQSTM1/p62 activity by N-terminal arginylation of the endoplasmic reticulum chaperone HSPA5/GRP78/BiP (2016) (20)
Post-translational modification profiling – A novel tool for mapping the protein modification landscape in cancer (2016) (20)
Intracellular protein degradation from a vague idea through the lysosome and the ubiquitin-proteasome system and on to human diseases and drug targeting: Nobel Lecture, December 8, 2004. (2007) (20)
The ubiquitin-proteasome system and activation of NF-κB: involvement of the ubiquitin ligase KPC1 in p105 processing and tumor suppression (2015) (19)
Early work on the ubiquitin proteasome system, an interview with Aaron Ciechanover (2005) (18)
Ubiquitin-mediated protein modification and degradation. (1992) (18)
Degradation of MYCN oncoprotein by the ubiquitin system. (1991) (17)
Modification of the inflammatory mediator LRRFIP2 by the ubiquitin-like protein FAT10 inhibits its activity during cellular response to LPS. (2012) (17)
Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-κB1 Target SerpinE1 in Aggressive Glioblastoma Tumors (2020) (17)
Early effects of serum on phospholipid metabolism in untransformed and oncogenic virus-transformed cultured fibroblasts. (1976) (16)
Purification, characterization, and rapid inactivation of thermolabile ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85. (1989) (16)
A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes. 1978. (2012) (16)
Characterization of ubiquitin genes and -transcripts and demonstration of a ubiquitin-conjugating system in Entamoeba histolytica. (1996) (16)
Ubiquitin-mediated Processing of NF-κB Transcriptional Activator Precursor p105 (1995) (16)
Regulation of the ubiquitin‐mediated proteolytic pathway: Role of the substrate α‐NH2 group and of transfer RNA (1987) (16)
The testis-specific USP26 is a deubiquitinating enzyme of the ubiquitin ligase Mdm2. (2017) (15)
Ubiquitin-mediated degradation of cellular proteins: why destruction is essential for construction, and how it got from the test tube to the patient's bed. (2001) (15)
Immune defects caused by mutations in the ubiquitin system. (2017) (14)
ATP-stimulated degradation of endogenous proteins in cell-free extracts of BHK 21/C13 fibroblasts. A key role for the proteinase, macropain, in the ubiquitin-dependent degradation of short-lived proteins. (1991) (14)
Ubiquitin–mediated proteolysis and male sterility (1996) (13)
Protein Degradation: Ubiquitin and the Chemistry of Life (2005) (13)
In vivo interactions of MyoD, Id1, and E2A proteins determined by acceptor photobleaching fluorescence resonance energy transfer (2008) (13)
Mammalian cell cycle mutant defective in intracellular protein degradation and ubiquitin-protein conjugation. (1985) (13)
Identification of UBact, a ubiquitin-like protein, along with other homologous components of a conjugation system and the proteasome in different gram-negative bacteria. (2017) (13)
Degradation of proteins by the ubiquitin-mediated proteolytic pathway. (1990) (12)
Ubiquitination and degradation of proteins. (2011) (12)
KRAS/NRAS/BRAF Mutations as Potential Targets in Multiple Myeloma (2019) (12)
Excess of the NF-ĸB p50 subunit generated by the ubiquitin ligase KPC1 suppresses tumors via PD-L1– and chemokines-mediated mechanisms (2020) (11)
The N-terminal cysteine is a dual sensor of oxygen and oxidative stress (2021) (10)
Protein Degradation: Cell Biology of the Ubiquitin-Proteasome System, Volume 3 (2007) (10)
Trafficking of the transferrin receptor. (1991) (10)
Corrigendum to: “The ubiquitin–proteasome system in cardiovascular diseases—a hypothesis extended” [Cardiovasc. Res. 61 (2004) 11–21] (2004) (10)
Site-specific ubiquitination of pathogenic huntingtin attenuates its deleterious effects (2020) (10)
In vivo modulation of ubiquitin chains by N-methylated non-proteinogenic cyclic peptides (2020) (10)
The ubiquitin-activating enzyme is required for lysosomal degradation of cellular proteins under stress. (1991) (9)
A path toward understanding neurodegeneration (2016) (9)
The ubiquitin‐proteasome system—micro target for macro intervention? (2005) (9)
The ubiquitin-mediated proteolytic pathway: enzymology and mechanisms of recognition of the proteolytic substrates. (1990) (9)
[The ubiquitin-proteasome system: the relationship between protein degradation and human diseases]. (2001) (8)
Affinity Maturation of Macrocyclic Peptide Modulators of Lys48-linked Diubiquitin by a Twofold Strategy. (2020) (8)
The Lysine48‐Based Polyubiquitin Chain Proteasomal Signal: Not a Single Child Anymore (2013) (8)
Ubiquitin and the chemistry of life (2005) (8)
Identification of proteins regulated by the proteasome following induction of endoplasmic reticulum stress. (2019) (8)
The ubiquitin-proteasome proteolytic system : from classical biochemistry to human diseases (2002) (7)
Inhibition of ubiquitin-proteasome dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus (EBV) nuclear antigen (EBNA)-1 (1997) (7)
Comprar Protein Degradation: Vol. 4: The Ubiquitin Proteasome System and Disease | R. John Mayer | 9783527314362 | Wiley (2007) (7)
Intracellular Protein Degradation: From a Vague Idea through the Lysosome and the Ubiquitin-Proteasome System and onto Human Diseases and Drug Targeting (2005) (6)
Ubiquitin Proteasome Pathway (2008) (6)
Personalized medicine: the road ahead. (2012) (6)
The ubiquitin system: historical perspective. (2010) (6)
Isolation, Characterization, and Partial Purification of a Novel Ubiquitin-Protein Ligase, E 3 TARGETING OF PROTEIN SUBSTRATES VIA MULTIPLE AND DISTINCT RECOGNITION SIGNALS AND CONJUGATING ENZYMES* (1995) (6)
Corrigendum to “PRAJA1 is a ubiquitin ligase for the polycomb repressive complex 2 proteins” [Biochem. Biophys. Res. Commun. 408 (2011) 393–398] (2011) (6)
Sorting and Recycling of Cell Surface Receptors and Endocytosed Ligands (1985) (5)
N-terminal Ubiquitination (2008) (5)
A new class of α-ketoamide derivatives with potent anticancer and anti-SARS-CoV-2 activities (2021) (5)
A novel small molecule CXCR4 antagonist potently mobilizes hematopoietic stem cells in mice and monkeys (2020) (4)
Ubiquitin-mediated degradation of tyrosine aminotransferase (TAT) in vitro and in vivo (1997) (4)
Monitoring stress-induced autophagic engulfment and degradation of the 26S proteasome in mammalian cells. (2019) (4)
The ubiquitin-dependent proteolytic pathway: specificity of recognition of the proteolytic substrates. (1989) (4)
Response to health in the Occupied Palestinian Territory (2011) (4)
p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis (2017) (4)
The Ubiquitin-Mediated System for Intracellular Protein Degradation (1991) (4)
Innate and adaptive immunity: the 2011 Nobel Prize in Physiology or Medicine. (2011) (4)
A short binding site in the KPC1 ubiquitin ligase mediates processing of NF-κB1 p105 to p50: A potential for a tumor-suppressive PROTAC (2021) (3)
Loss of adhesion of erythrocyte precursors to fibronectin during erythroid differentiation. (1985) (3)
Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors. (2022) (3)
Glioma‐derived cancer stem cells are hypersensitive to proteasomal inhibition (2017) (3)
The ubiquitin-proteasome system and disease (2008) (3)
Israel–Gaza conflict (2014) (3)
Corrigendum to: Glioma-derived cancer stem cells are hypersensitive to proteasomal inhibition (EMBO reports, (2017), 18, 1, (150-168), 10.15252/embr.201642360) (2017) (3)
Complete switch from Mdm 2 to human papillomavirus E 6-mediated degradation of p 53 in cervical cancer cells (2017) (3)
Excitable Responses and Oscillations in the Ring 1 B / Bmi 1 Ubiquitination System (3)
Exploiting the ubiquitin system in myeloid malignancies. From basic research to drug discovery in MDS and AML. (2022) (3)
A possible non-proteolytic role of ubiquitin conjugation in alleviating the pathology of Huntingtin’s aggregation (2020) (2)
Modulation of the cell cycle regulating transcription factor E2F1 pathway by the proteasome following amino acid starvation. (2019) (2)
Interview with Aaron Ciechanover. (2009) (2)
The Ubiquitin-Proteasome System : Death of Proteins is Required for Life of Cells (2003) (2)
Protein Degradation Series (2007) (2)
The p105 NF-ĸB precursor is a pseudo substrate of the ubiquitin ligase FBXO7, and its binding to the ligase stabilizes it and results in stimulated cell proliferation. (2020) (2)
In-depth characterization of ubiquitin turnover in mammalian cells by fluorescence tracking. (2021) (2)
Proteasome phase separation: a novel layer of quality control (2020) (2)
Transferrin and Apotransferrin: pH‐dependent Conformational Changes Associated with Receptor‐mediated Uptake a (1986) (2)
A conversation with Aaron Ciechanover. Interview by Ushma S. Neill. (2013) (1)
Molecular cloning, sequence, and tissue distribution of the human (2016) (1)
A synthetic bivalent peptide ligand of EphB4 with potent agonistic activity. (2022) (1)
Nucleoporin-93 overexpression overcomes multiple nucleocytoplsamic trafficking bottlenecks to permit robust metastasis (2020) (1)
Glioma‐derived cancer stem cells are hypersensitive to proteasomal inhibition (2018) (1)
Abstract 3541: Epigenetic regulation of KPC1 ubiquitin ligase has a regulatory role on the NF-κB pathway in metastatic melanoma (2018) (1)
Role of the ubiquitin ligase KPC1 in NF-κB activation and tumor suppression (2016) (1)
Correction: In vivo modulation of ubiquitin chains by N-methylated non-proteinogenic cyclic peptides (2021) (1)
Erratum: The predator becomes the prey: Regulating the ubiquitin system by ubiquitylation and degradation (Nature Reviews Molecular Cell Biology (2011) 12 605-620)) (2011) (1)
The unraavelling of the ubiquitin system (2016) (1)
A fragment integrational approach to GPCR inhibition: Identification of a high affinity small molecule CXCR4 antagonist. (2022) (1)
RING1B ubiquitination and stability are regulated by ARF. (2012) (1)
Organic Chemistry Applied to Synthetic Proteins: Modifying the Vicinity of the Isopeptide Bond Revealed Differential Behavior of Ubiquitin Chains with Interacting Proteins (2014) (1)
Comprar Protein Degradation Series: 4 Volume Set | R. John Mayer | 9783527318780 | Wiley (2007) (1)
Nobel Round-Table Discussion #1: The Future of Interdisciplinary Research and Training (2006) (1)
Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1. (1991) (1)
Ubiquitin-mediated protein degradation: The early days The ubiquitin system (2000) (0)
pH and the recycling of transferrin mediated endocytosis (endocytic vesicle/apotransferrin/transferrin receptor) (2016) (0)
Why Our Proteins Have to Die so We shall Live or The Ubiquitin Proteolytic System – From Basic Mechanisms and onto Disease Mechanisms and Drug Development (2010) (0)
N‐terminal Ubiquitination: No Longer Such a Rare Modification (2005) (0)
Chapter 2. N-terminal Ubiquitination: No Longer Such a Rare Modification (2007) (0)
Inhibitors of the Ubiquitin-Proteasome System as Potential Therapeutic Agents for Cardiovascular Diseases (2008) (0)
Award for the ubiquitin pathway (2000) (0)
An interview with Aaron Ciechanover. (2013) (0)
Methods in Protein Ubiquitination (2006) (0)
Targeted Degradation of Proteins — The Ubiquitin System (2021) (0)
Celebrating the death of proteins (2004) (0)
Simultaneous Detection and Classification of Partially and Weakly Supervised Cells (2022) (0)
The tumor suppressor functions of ubiquitin ligase KPC1: from cell cycle control to NF-κB regulator. (2023) (0)
ATP-dependent conjugation of retic polypeptide required for protein de! (protein/breakdown/energy requirement/covalent linkage of poly (2016) (0)
The bedside-bench-bedside cycle: Robert Lefkowitz and GPCRs. (2021) (0)
Table of Contents (1988) (0)
(1178) - The Ubiquitin Proteasome System as Potential Therapeutic Target in Dilated and Ischemic Cardiomyopathy (2017) (0)
Nucleoporin-93 Overcomes Multiple Nucleocytoplasmic Trafficking Bottlenecks and Permits Robust Metastasis (2021) (0)
Breaking Down the Molecular Mechanisms of Pathogenesis in SCA1 : A Role for the Ubiquitin-Proteasome Pathway in Neurodegenerative Disease (1999) (0)
Nobel Round-Table Discussion #2: Conflicts of Interest, Scientific Misconduct, Fair Sharing, and Intellectual Property in an Interdisciplinary/Inter-Institutional Consortium (2006) (0)
A possible non-proteolytic role of ubiquitin conjugation in alleviating the pathology of Huntingtin’s aggregation (2020) (0)
CHAPTER 290 – Proteasome/Ubiquitination (2003) (0)
Re ections under a jacaranda tree 1 CRS 4 talks to Aaron Ciechanover , 2004 Nobel Prize winner for chemistry , about personalized medicine and innovative cancer therapies (2015) (0)
Ubiquitin-Proteasome System for Controlling Cellular Protein Levels (2006) (0)
The ubiquitin – proteolytic pathway : From obscurity to the patient bed (2000) (0)
Mechanisms and Regulation of Ubiquitin-Mediated, Limited Processing of the NF-κBα Precursor Protein p105 (2002) (0)
DL The ubiquitin-proteolytic system: from bench to bedside (2008) (0)
How multi-component cascades operate in cells: lessons from the ubiquitin system-containing liquid-separated condensates (2021) (0)
A novel small molecule CXCR4 antagonist potently mobilizes hematopoietic stem cells in mice and monkeys (2021) (0)
Role of Transfer RNA in the Degradation of Selective Substrates of the Ubiquitin- and ATP-Dependent Proteolytic System (1988) (0)
Erratum: Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1 (Proc. Natl. Acad. Sci. USA (January 1991) 88 (258-262)) (1991) (0)
On the wings of imagination (2011) (0)
The NF-ĸB p50 subunit generated by KPC1-mediated ubiquitination and limited proteasomal processing, suppresses tumor growth (2023) (0)
26 S Proteasome Following Monoubiquitination (2017) (0)
COMPOSITIONS AND METHODS FOR MODULATION OF CELLULAR ACTIVITY OF NF-kappaB (1998) (0)
Special Issue: Introductory Note (Adv. Funct. Mater. 18/2020) (2020) (0)
Bortezomib Abrogates TGF-β1 Signaling by a Non-Smad Pathway and Upregulates PPAR-γ. (2009) (0)
Cell biology of the ubiquitin-proteasome syatem (2006) (0)
The Ubiquitin Proteolytic System - From Basic Mechanisms thru Human Diseases and onto Drug Development (2016) (0)
The bedside-bench-bedside cycle: Robert Lefkowitz and GPCRs (2021) (0)
DECREASED LEVEL OF THE CELL CYCLE INHIBITOR P-27 IN ENDOMETRIAL CARCINOMA BUT NOT IN NORMAL OR IN ESTROGEN HYPERSTIMULATED ENDOMETRIAL CELLS (2004) (0)
Proteasome phase separation: a novel layer of quality control (2020) (0)
PL-1 The ubiquitin proteolytic system : from basic mechanisms through human diseases and onto drug targeting (2006) (0)
Chapter 255 – Ubiquitination/Proteasome (2010) (0)
Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme El (protein degradation) (2018) (0)
Ubiquitin-mediated proteolysis The Nobel Prize in Chemistry for 2004 is shared between three scientists who have made fundamental discoveries concerning how cells regulate the breakdown of intracellular proteins with extreme specificity as to target, time and space (2004) (0)
The 2008 Lindau Nobel Laureate Meeting: Aaron Ciechanover, Chemistry 2004. (2009) (0)
Apoptotic cell death in disease—Current understanding of the NCCD 2023 (2023) (0)

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