Amanda Fisher
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British biologist
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Amanda Fisherbiology Degrees
Biology
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#7146
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Evolutionary Biology
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#379
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Genetics
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#1390
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Biology
Amanda Fisher's Degrees
- PhD Evolutionary Biology University of Oxford
Why Is Amanda Fisher Influential?
(Suggest an Edit or Addition)According to Wikipedia, Dame Amanda Gay Fisher is a British cell biologist and Director of the Medical Research Council London Institute of Medical Sciences at the Hammersmith Hospital campus of Imperial College London, where she is also a Professor leading the Institute of Clinical Sciences. She has made contributions to multiple areas of cell biology, including determining the function of several genes in HIV and describing the importance of a gene's location within the cell nucleus.
Amanda Fisher's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Chromatin signatures of pluripotent cell lines (2006) (1372)
- Cohesins Functionally Associate with CTCF on Mammalian Chromosome Arms (2008) (909)
- T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR (2008) (838)
- Association of Transcriptionally Silent Genes with Ikaros Complexes at Centromeric Heterochromatin (1997) (820)
- Subnuclear Compartmentalization of Immunoglobulin Loci During Lymphocyte Development (2002) (757)
- Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells (2007) (697)
- The trans-activator gene of HTLV-III is essential for virus replication (1986) (594)
- A role for Dicer in immune regulation (2006) (560)
- Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus (2009) (542)
- T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer (2005) (538)
- Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division. (1999) (431)
- Epigenetic signatures of stem-cell identity (2007) (400)
- Epigenetic programming and reprogramming during development (2013) (390)
- Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2. (2010) (388)
- The sor gene of HIV-1 is required for efficient virus transmission in vitro. (1987) (382)
- Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators (2010) (315)
- Neural induction promotes large-scale chromatin reorganisation of the Mash1 locus (2006) (308)
- Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments (2013) (300)
- A molecular clone of HTLV-III with biological activity (1985) (299)
- Biologically diverse molecular variants within a single HIV-1 isolate (1988) (282)
- Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding. (2000) (265)
- Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin. (1998) (263)
- A role for cohesin in T cell receptor rearrangement and thymocyte differentiation (2011) (241)
- How Many Thymocytes Audition for Selection? (1997) (240)
- CHD7 Targets Active Gene Enhancer Elements to Modulate ES Cell-Specific Gene Expression (2010) (239)
- Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes (2001) (226)
- Infectious mutants of HTLV-III with changes in the 3' region and markedly reduced cytopathic effects. (1986) (213)
- Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits. (2007) (192)
- Distinct Promoters Mediate the Regulation of Ebf1 Gene Expression by Interleukin-7 and Pax5 (2006) (186)
- Sensory Adaptation in Naive Peripheral CD4 T Cells (2001) (181)
- Epigenetic aspects of differentiation (2004) (174)
- ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency. (2010) (173)
- Chromatin structure and gene regulation in the immune system. (2002) (167)
- Chromatin states in pluripotent, differentiated, and reprogrammed cells. (2011) (160)
- Z-nucleic acid sensing triggers ZBP1-dependent necroptosis and inflammation (2020) (158)
- Role of DNA Methylation in Stable Gene Repression* (2007) (151)
- Spatial enhancer clustering and regulation of enhancer-proximal genes by cohesin (2015) (147)
- Heterokaryon-Based Reprogramming of Human B Lymphocytes for Pluripotency Requires Oct4 but Not Sox2 (2008) (139)
- LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis (2018) (138)
- Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation (2018) (137)
- Nuclear repositioning marks the selective exclusion of lineage‐inappropriate transcription factor loci during T helper cell differentiation (2004) (135)
- Dynamic assembly of silent chromatin during thymocyte maturation (2004) (135)
- Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression. (2009) (133)
- Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program. (2009) (126)
- Histone hypomethylation is an indicator of epigenetic plasticity in quiescent lymphocytes (2004) (117)
- Gene silencing, cell fate and nuclear organisation. (2002) (114)
- A Dynamic Switch in the Replication Timing of Key Regulator Genes in Embryonic Stem Cells upon Neural Induction (2004) (112)
- Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B-cell differentiation. (2013) (108)
- Heritable gene silencing in lymphocytes delays chromatid resolution without affecting the timing of DNA replication (2003) (103)
- Different Roles for Tet1 and Tet2 Proteins in Reprogramming-Mediated Erasure of Imprints Induced by EGC Fusion (2013) (102)
- Epidermal Stem Cells Are Defined by Global Histone Modifications that Are Altered by Myc-Induced Differentiation (2007) (100)
- Runx proteins regulate Foxp3 expression (2009) (97)
- Expression of alpha- and beta-globin genes occurs within different nuclear domains in haemopoietic cells. (2001) (91)
- Epigenetic priming of a pre-B cell-specific enhancer through binding of Sox2 and Foxd3 at the ESC stage. (2010) (91)
- Expression of α- and β-globin genes occurs within different nuclear domains in haemopoietic cells (2001) (90)
- Inactive yet indispensable: the tale of Jarid2 (2011) (88)
- The reorganisation of constitutive heterochromatin in differentiating muscle requires HDAC activity. (2005) (88)
- The Developmentally Regulated Expression of Twisted Gastrulation Reveals a Role for Bone Morphogenetic Proteins in the Control of T Cell Development (2002) (85)
- The impact of chromatin modifiers on the timing of locus replication in mouse embryonic stem cells (2007) (78)
- REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells (2009) (76)
- DNA Synthesis Is Required for Reprogramming Mediated by Stem Cell Fusion (2013) (75)
- Lymphoproliferative disorders in IL-7 transgenic mice: expansion of immature B cells which retain macrophage potential. (1995) (73)
- Getting rid of DNA methylation. (2014) (73)
- Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1 (2018) (72)
- DNA demethylation in pluripotency and reprogramming: the role of tet proteins and cell division. (2013) (69)
- Is REST required for ESC pluripotency? (2009) (68)
- Role of the carboxy-terminal portion of the HIV-1 transmembrane protein in viral transmission and cytopathogenicity. (1989) (64)
- Polycomb Repressive Complexes Restrain the Expression of Lineage-Specific Regulators in Embryonic Stem Cells (2006) (62)
- TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation (2018) (60)
- Acquisition and extinction of gene expression programs are separable events in heterokaryon reprogramming (2006) (58)
- Nuclear organisation and gene expression. (2002) (57)
- microRNA-mediated regulation of mTOR complex components facilitates discrimination between activation and anergy in CD4 T cells (2014) (54)
- Centromeric Repositioning of Coreceptor Loci Predicts Their Stable Silencing and the CD4/CD8 Lineage Choice (2004) (52)
- Human thymocyte development in mouse organ cultures. (1990) (50)
- ZBP1/DAI Drives RIPK3-Mediated Cell Death Induced by IFNs in the Absence of RIPK1 (2019) (47)
- Opinion-decision making in the immune system: Cellular identity and lineage choice (2002) (44)
- A high-resolution map of transcriptional repression (2017) (43)
- Lymphoproliferative disorders in an IL-7 transgenic mouse line. (1993) (43)
- CHD 7 Targets Active Gene Enhancer Elements to Modulate ES Cell-Specific Gene Expression (2010) (42)
- Differences in the epigenetic and reprogramming properties of pluripotent and extra-embryonic stem cells implicate chromatin remodelling as an important early event in the developing mouse embryo (2010) (42)
- Epigenetic mechanisms that regulate antigen receptor gene expression. (2003) (42)
- An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers (2017) (41)
- Rational primer design greatly improves differential display-PCR (DD-PCR). (1997) (40)
- miRNA-431 Prevents Amyloid-β-Induced Synapse Loss in Neuronal Cell Culture Model of Alzheimer's Disease by Silencing Kremen1 (2018) (40)
- Jarid2 Coordinates Nanog Expression and PCP/Wnt Signaling Required for Efficient ESC Differentiation and Early Embryo Development (2015) (39)
- G Protein Coupled Receptors in Embryonic Stem Cells: A Role for Gs-Alpha Signaling (2010) (39)
- CD45 isoform switching precedes the activation-driven death of human thymocytes by apoptosis. (1991) (37)
- Chromatin organization and differentiation in embryonic stem cell models. (2007) (37)
- Widespread distribution in human tissues of an antigenic determinant of granulocytes. (1984) (36)
- Erratum: Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaos at centromeric heterochromatin (Genes and Development (1998) 12 (782-796)) (1998) (34)
- Human X chromosome inactivation and reactivation: implications for cell reprogramming and disease (2017) (34)
- Evolutionary conservation, developmental expression, and genomic mapping of mammalian Twisted gastrulation (2001) (32)
- Visualizing Changes in Cdkn1c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults (2017) (32)
- Gamma delta T cells expressing CD8 or CD4low appear early in murine foetal thymus development. (1991) (31)
- IL4 blockade of inducible regulatory T cell differentiation: the role of Th2 cells, Gata3 and PU.1. (2009) (30)
- Intrathymic deletion of MHC class I‐restricted cytotoxic T cell precursors by constitutive cross‐presentation of exogenous antigen (1999) (30)
- Chromosomes, positions please! (2003) (29)
- Reprogramming somatic cells towards pluripotency by cellular fusion. (2012) (29)
- Initiation and maintenance of pluripotency gene expression in the absence of cohesin (2015) (29)
- Using heterokaryons to understand pluripotency and reprogramming (2011) (28)
- A rapid method for determining whether monoclonal antibodies react with the same or different antigens on the cell surface. (1980) (27)
- Allorecognition of HLA‐DR and ‐DQ transfectants by human CD45RA and CD45R0 CD4 T cells: Repertoire analysis and activation requirements (1991) (24)
- microRNAs Regulate Cell-to-Cell Variability of Endogenous Target Gene Expression in Developing Mouse Thymocytes (2015) (22)
- Studies of human myeloid antigens using monoclonal antibodies and variant lines from the promyeloid cell line HL60. (1982) (21)
- Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming (2016) (21)
- Embryonic stem cell-derived hemangioblasts remain epigenetically plastic and require PRC1 to prevent neural gene expression. (2011) (21)
- MicroRNAs of the miR-290–295 Family Maintain Bivalency in Mouse Embryonic Stem Cells (2016) (20)
- The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus (2021) (18)
- Expression of high molecular weight isoforms of CD45 by mouse thymic progenitor cells (1990) (18)
- Identifying proteins bound to native mitotic ESC chromosomes reveals chromatin repressors are important for compaction (2020) (18)
- Neuronatin deletion causes postnatal growth restriction and adult obesity in 129S2/Sv mice (2018) (17)
- Human postnatal thymocytes generate phenotypically immature CD3dim, CD5dim, CD1abright progeny in organ culture. (1992) (17)
- Necroptosis-based CRISPR knockout screen reveals Neuropilin-1 as a critical host factor for early stages of murine cytomegalovirus infection (2020) (17)
- Reprogramming and the pluripotent stem cell cycle. (2013) (16)
- Cohesin-dependence of neuronal gene expression relates to chromatin loop length (2022) (16)
- Can controversies be put to REST? (2010) (15)
- Heterokaryon-based reprogramming for pluripotency. (2009) (15)
- Isolation and characterisation of dimethylsulphoxide resistant variants from the human promyeloid cell line HL60. (1983) (15)
- The regulated long-term delivery of therapeutic proteins by using antigen-specific B lymphocytes. (2004) (14)
- Selective deployment of transcription factor paralogs with submaximal strength facilitates gene regulation in the immune system (2019) (14)
- Allele-specific analysis of cell fusion-mediated pluripotent reprograming reveals distinct and predictive susceptibilities of human X-linked genes to reactivation (2017) (13)
- Problems in the physiology of class I and class II MHC molecules, and of CD45. (1989) (13)
- Different doses of agonistic ligand drive the maturation of functional CD4 and CD8 T cells from immature precursors (2000) (13)
- In vitro construction of graded thymus chimeras. (1994) (13)
- Rapamycin Inhibits Growth Factor-Induced Cell Cycle Regulation in Pancreatic β Cells (2008) (13)
- Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin (2021) (12)
- Epigenetic memory and parliamentary privilege combine to evoke discussions on inheritance (2012) (12)
- Selective manipulation of the human T-cell receptor repertoire expressed by thymocytes in organ culture. (1992) (11)
- A reappraisal of evidence for probabilistic models of allelic exclusion (2009) (11)
- A microfluidic toolbox for cell fusion (2016) (11)
- Characterization of Murine Thymic Stromal-Cell Lines Immortalized by Temperature-Sensitive Simian Virus 40 Large T or Adenovirus 5 E1a (1991) (9)
- Type 1 human T-cell leukemia virus small envelope protein expressed in mouse cells by using a bovine papilloma virus-derived shuttle vector (1985) (9)
- Mechanisms of transcriptional regulation in lymphocyte progenitors: insight from an analysis of the terminal transferase promoter. (1999) (8)
- Illuminating Epigenetics and Inheritance in the Immune System with Bioluminescence. (2020) (7)
- Atypical heterochromatin organization and replication are rapidly acquired by somatic cells following fusion-mediated reprogramming by mouse ESCs (2013) (7)
- Expression of Functional MHC Class II Molecules By a Mouse Pro-B Cell Clone (1995) (7)
- T cell receptor repertoire of gamma delta cells generated from the 14-day embryonic mouse thymus. (1992) (7)
- A monoclonal antibody identifies a 215 000-dalton nuclear envelope protein restricted to certain cell types. (1985) (7)
- Chromatin jets define the properties of cohesin-driven in vivo loop extrusion. (2022) (7)
- Activity-induced gene expression and long-range enhancer-promoter contacts in cohesin-deficient neurons (2021) (6)
- Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation (2019) (6)
- Molecular characterization of biologically diverse envelope variants of human immunodeficiency virus type 1 derived from an individual (1991) (6)
- A recombinant clone of HIV-1 preferentially transmitted in normal peripheral blood mononuclear cells. (1989) (6)
- Replication Timing Profile Reflects the Distinct Functional and Genomic Features of the MHC Class II Region (2007) (6)
- Reprogramming of Somatic Cells Towards Pluripotency by Cell Fusion. (2016) (5)
- Reprogramming lineage identity through cell-cell fusion. (2021) (5)
- Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice (2022) (5)
- Cohesin's role in pluripotency and reprogramming (2016) (5)
- Cohesin couples transcriptional bursting probabilities of inducible enhancers and promoters (2022) (5)
- Fresh powder on Waddington's slopes (2010) (4)
- Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1 (2018) (4)
- Analysis of Human Haemopoietic Precursor Cell Antigens Using Astatine Labelled Monoclonal Antibodies (1982) (4)
- Selection of murine T cell receptor αβ and γδ cells in organ cultures established from 14‐day embryos (1992) (4)
- Publisher Correction: Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation (2020) (3)
- Maintaining Transcriptional States Through DNA Replication (2003) (3)
- LOCKing in Cellular Potential. (2009) (2)
- Unraveling epigenetic landscapes: the enigma of enhancers. (2011) (2)
- Epigenetic change induced by in utero dietary challenge provokes phenotypic variability across multiple generations of mice (2020) (2)
- Different Roles for Tet1 and Tet2 Proteins in Reprogramming-Mediated Erasure of Imprints Induced by EGC Fusion (2013) (2)
- Jarid 2 Coordinates Nanog Expression and PCP / Wnt Signaling Required for Efficient ESC Differentiation and Early Embryo Development Graphical (2)
- Correction of severe anaemia using immuno‐regulated gene therapy is achieved by restoring the early erythroblast compartment (2006) (2)
- Reliance of neuronal gene expression on cohesin scales with chromatin loop length (2022) (2)
- Antigen shared by human hemopoietic precursor cells and T and B lineage cells. (1983) (2)
- Selection of murine T cell receptor alpha beta and gamma delta cells in organ cultures established from 14-day embryos. (1992) (2)
- T cell development: new approaches. (1993) (1)
- Culture conditions dictate whether mouse fetal thymus lobes generate predominantly gamma/delta or alpha/beta T cells. (1991) (1)
- Monoclonal Antibodies to Human Myeloid Associated Antigens (1983) (1)
- Epigenetic Modulation of Class-Switch DNA Recombination to IgA by miR-146a Through Downregulation of Smad2, Smad3 and Smad4 (2021) (1)
- Chromosomes and expression mechanisms: life on the edge. (2009) (1)
- Loss of H3K9 tri-methylation alters chromosome compaction and transcription factor retention during mitosis (2022) (1)
- Systematic identification of factors bound to isolated metaphase ESC chromosomes reveals a role for chromatin repressors in compaction (2019) (1)
- Partial rescue of neuronal genes deregulated in Cornelia de Lange Syndrome by cohesin (2020) (1)
- Selection-induced gene expression in thymocytes (1997) (1)
- The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus (2021) (0)
- Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation (2018) (0)
- Intrinsic B cell TLR-BCR linked coengagement induces mature and protective antibody responses in the absence of T cells (2021) (0)
- Gene silencing in lymphocyte development (2005) (0)
- Physiological role of linear ubiquitination: more to it than meets the eye (2019) (0)
- Prevention of synaptic loss in cortico-hippocampal culture by silencing Kremen1 with siRNA (2017) (0)
- A Haemopoietic Precursor Cell Antigen Shared by Both T and B Cells (1984) (0)
- S05-01. Polycomb repressive complexes are required to maintain compact chromatin structure at Hox loci (2009) (0)
- Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells (2023) (0)
- LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis (2018) (0)
- Publisher Correction: Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation (2020) (0)
- Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation (2020) (0)
- Nuclear Organisation of Immunoglobulin Genes (2002) (0)
- Selective deployment of transcription factor paralogs with submaximal strength facilitates gene regulation in the immune system (2019) (0)
- Reconciling Epigenetic Memory and Transcriptional Responsiveness. (2017) (0)
- Widespread distribution inhumantissues ofan antigenic determinant ofgranulocytes (1984) (0)
- Evolutionary conservation, developmental expression, and genomic mapping of mammalian (2001) (0)
- Avrion Mitchison (1928–2022) (2023) (0)
- Author response: A high-resolution map of transcriptional repression (2017) (0)
- Nuclear Organisation and Gene Silencing in Lymphocytes (2001) (0)
- An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers (2017) (0)
- Endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon EZH2 and ERK1/2 inhibition (2023) (0)
- Studies of myelopoiesis using monoclonal antibodies and variant lines from the promyeloid cell line HL60. (1983) (0)
- Drug-induced loss of imprinting revealed using bioluminescent reporters of Cdkn1c (2023) (0)
- Abstracts of the First Biennial Symposium on Regulatory T Cells and T Helper Cells. March 30, 2012. London, United Kingdom. (2012) (0)
- Identification of murine thymocyte populations capable of extensive proliferation in serially passaged thymic organ cultures. (1992) (0)
- Heterokaryon-Based Reprogramming for (2009) (0)
- Visualizing Changes in Cd kn 1 c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults Graphical (0)
- Cohesins Contribute to Long-Range Chromosomal cis-Interactions (2010) (0)
- Document S1. Supplemental Experimental Procedures and Figures S1 and S2 (2013) (0)
- Allele-specific analysis of cell fusion-mediated pluripotent reprograming reveals distinct and predictive susceptibilities of human X-linked genes to reactivation (2017) (0)
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