Bruce Beutler | Academic Influence

Bruce Beutler's AcademicInfluence.com Rankings

Bruce Beutler

Biology

#369

World Rank

#662

Historical Rank

#216

USA Rank

Immunology

#42

World Rank

#46

Historical Rank

#15

USA Rank

Genetics

#91

World Rank

#126

Historical Rank

#59

USA Rank

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Biology

Bruce Beutler's Degrees

Bachelors Biology University of California, San Diego
Doctorate Medicine University of Chicago

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Why Is Bruce Beutler Influential?

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According to Wikipedia, Bruce Alan Beutler is an American immunologist and geneticist. Together with Jules A. Hoffmann, he received one-half of the 2011 Nobel Prize in Physiology or Medicine, for "discoveries concerning the activation of innate immunity." Beutler discovered the long-elusive receptor for lipopolysaccharide . He did so by identifying spontaneous mutations in the gene coding for mouse Toll-like receptor 4 in two unrelated strains of LPS-refractory mice and proving they were responsible for that phenotype. Subsequently, and chiefly through the work of Shizuo Akira, other TLRs were shown to detect signature molecules of most infectious microbes, in each case triggering an innate immune response.

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Bruce Beutler's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. (1998) (8255)
Shock and tissue injury induced by recombinant human cachectin. (1986) (2564)
Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. (1985) (2405)
The biology of cachectin/TNF--a primary mediator of the host response. (1989) (1729)
Cachectin and tumour necrosis factor as two sides of the same biological coin (1986) (1616)
Inferences, questions and possibilities in Toll-like receptor signalling (2004) (1506)
Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators. (1986) (1501)
Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1 (1986) (1474)
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling (2003) (1354)
The tumor necrosis factor ligand and receptor families. (1996) (1315)
Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance. (1986) (1302)
Innate immune sensing and its roots: the story of endotoxin (2003) (1300)
Cachectin: more than a tumor necrosis factor. (1987) (1231)
Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts (1985) (1227)
Innate immunity: an overview. (2004) (1200)
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. (2006) (1175)
Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections (2005) (1174)
Identity of tumour necrosis factor and the macrophage-secreted factor cachectin (1985) (1126)
Intracellular toll-like receptors. (2010) (1088)
TYPE I INTERFERONS (/) IN IMMUNITY AND AUTOIMMUNITY (2005) (1087)
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. (2004) (1021)
CD36 is a sensor of diacylglycerides (2005) (913)
The interface between innate and adaptive immunity (2004) (909)
Tumor necrosis, cachexia, shock, and inflammation: a common mediator. (1988) (821)
Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. (2006) (811)
Tlr4: central component of the sole mammalian LPS sensor. (2000) (805)
TLRs and innate immunity. (2009) (804)
Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells (1985) (791)
Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo. (1985) (777)
Type I interferons (alpha/beta) in immunity and autoimmunity. (2005) (756)
Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation (1988) (744)
Herpes Simplex Virus Encephalitis in Human UNC-93B Deficiency (2006) (700)
CD14 is required for MyD88-independent LPS signaling (2005) (687)
A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease (2003) (659)
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9 (2006) (651)
The evolution and genetics of innate immunity (2001) (644)
Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria (2006) (640)
How we detect microbes and respond to them: the Toll‐like receptors and their transducers (2003) (612)
Adjuvant-Enhanced Antibody Responses in the Absence of Toll-Like Receptor Signaling (2006) (608)
Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties (1988) (568)
Three novel mammalian toll-like receptors: gene structure, expression, and evolution. (2000) (544)
The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency (2008) (541)
Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway (1990) (523)
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways (2003) (514)
A macrophage factor inhibits adipocyte gene expression: an in vitro model of cachexia. (1985) (492)
TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity (2007) (492)
NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component (2015) (475)
Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism (2009) (468)
Unraveling function in the TNF ligand and receptor families. (1994) (467)
Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation. (2000) (464)
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling (2007) (439)
Cachectin/tumor necrosis factor induces lethal shock and stress hormone responses in the dog. (1987) (422)
Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region. (1998) (403)
Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level [published erratum appears in J Exp Med 1990 Mar 1;171(3):971-2] (1990) (382)
Recognition of Hyaluronan Released in Sterile Injury Involves a Unique Receptor Complex Dependent on Toll-like Receptor 4, CD44, and MD-2* (2007) (375)
Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression. (2007) (369)
The role of cachectin/TNF in endotoxic shock and cachexia. (1988) (348)
A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity (1991) (340)
Tumor Necrosis Factor: The molecules and Their Emerging Role in Medicine (1992) (333)
Cachectin/tumor necrosis factor-alpha formation in human decidua. Potential role of cytokines in infection-induced preterm labor. (1989) (315)
Cutting Edge: Priming of NK Cells by IL-181 (2008) (297)
The role of tumor necrosis factor in health and disease. (1999) (294)
K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria. (2016) (292)
Correlation of interleukin-1 beta and cachectin concentrations in cerebrospinal fluid and outcome from bacterial meningitis. (1989) (288)
TNF, immunity and inflammatory disease: lessons of the past decade. (1995) (285)
Toll-like receptors (2011) (283)
PU.1 and Interferon Consensus Sequence-binding Protein Regulate the Myeloid Expression of the Human Toll-like Receptor 4 Gene* (2000) (277)
Tumor necrosis factor in the pathogenesis of infectious diseases (1993) (265)
Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility (2003) (254)
The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia. (1992) (253)
Lipopolysaccharide Signals Activation of Tumor Necrosis Factor Biosynthesis Through the Ras/Raf-1/MEK/MAPK Pathway (1994) (252)
Cachectin (tumor necrosis factor): a macrophage hormone governing cellular metabolism and inflammatory response. (1988) (251)
Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases (2009) (251)
Plant and Animal Sensors of Conserved Microbial Signatures (2010) (249)
TLR4 as the mammalian endotoxin sensor. (2002) (242)
Endotoxin, toll-like receptor 4, and the afferent limb of innate immunity. (2000) (240)
Effect of gamma interferon on cachectin expression by mononuclear phagocytes. Reversal of the lpsd (endotoxin resistance) phenotype (1986) (238)
Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer. (1994) (234)
Recombinant interleukin 1 suppresses lipoprotein lipase activity in 3T3-L1 cells. (1985) (216)
CACHECTIN: MORE THAN A TUMOR NECROSIS FACTOR (1988) (208)
Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. (2007) (203)
Genetic analysis of resistance to viral infection (2007) (202)
Tuning of Natural Killer Cell Reactivity by NKp46 and Helios Calibrates T Cell Responses (2012) (201)
Weight loss associated with an endotoxin-induced mediator from peritoneal macrophages: the role of cachectin (tumor necrosis factor). (1985) (199)
Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress (2009) (198)
A Toll-Like Receptor 2-Responsive Lipid Effector Pathway Protects Mammals against Skin Infections with Gram-Positive Bacteria (2005) (191)
Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (TLR4) (2000) (186)
Modulation of inflammation and cachectin activity in relation to treatment of experimental Hemophilus influenzae type b meningitis. (1989) (185)
Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells (2010) (184)
R‐form LPS, the master key to the activation ofTLR4/MD‐2‐positive cells (2006) (180)
Sepsis and evolution of the innate immune response. (2001) (177)
Comparison of predicted and actual consequences of missense mutations (2015) (173)
Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease. (2005) (173)
Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing (2009) (172)
The common mediator of shock, cachexia, and tumor necrosis. (1988) (169)
Lipoproteins of Borrelia burgdorferi and Treponema pallidum activate cachectin/tumor necrosis factor synthesis. Analysis using a CAT reporter construct. (1991) (169)
The MyD88-Dependent, but Not the MyD88-Independent, Pathway of TLR4 Signaling Is Important in Clearing Nontypeable Haemophilus influenzae from the Mouse Lung1 (2005) (165)
TLR7: A new sensor of viral infection. (2004) (164)
Cachectin/tumor necrosis factor mediates changes of skeletal muscle plasma membrane potential (1986) (164)
Mechanism of pathogen‐specific TLR4 activation in the mucosa: Fimbriae, recognition receptors and adaptor protein selection (2006) (161)
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus (2009) (157)
Interactive effects of the tumor necrosis factor promoter and 3'-untranslated regions. (1991) (156)
Diphosphoryl lipid A from Rhodopseudomonas sphaeroides ATCC 17023 blocks induction of cachectin in macrophages by lipopolysaccharide (1989) (153)
Evolution of the TIR, tolls and TLRs: functional inferences from computational biology. (2002) (149)
Tumor necrosis factor in mediating experimental Haemophilus influenzae type B meningitis. (1989) (148)
Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors. (2007) (147)
Toll-like receptors: how they work and what they do (2002) (147)
Excess of rare amino acid polymorphisms in the Toll-like receptor 4 in humans. (2001) (145)
The history, properties, and biological effects of cachectin. (1988) (144)
NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responses. (2009) (144)
Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: benefits and hazards of LPS hypersensitivity. (2008) (141)
Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis. (2006) (139)
MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands (2010) (137)
The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans (2019) (136)
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response (2009) (133)
Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor. (1999) (132)
Identification of a TLR4‐ and TRIF‐dependent activation program of dendritic cells (2004) (131)
Antigen-Specific Cytotoxicity by Invariant NKT Cells In Vivo Is CD95/CD178-Dependent and Is Correlated with Antigenic Potency (2010) (126)
The Toll-like receptors: analysis by forward genetic methods (2005) (122)
A reporter transgene indicates renal-specific induction of tumor necrosis factor (TNF) by shiga-like toxin. Possible involvement of TNF in hemolytic uremic syndrome. (1993) (118)
TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS (2016) (117)
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger (2008) (116)
Autoimmunity and apoptosis: the Crohn's connection. (2001) (116)
Sensors of the innate immune system: their mode of action (2009) (114)
The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis. (2004) (113)
MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses (2014) (110)
Adenovirus-mediated blockade of tumor necrosis factor in mice protects against endotoxic shock yet impairs pulmonary host defense. (1995) (108)
Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus (2013) (107)
Murine cerebral malaria development is independent of toll-like receptor signaling. (2007) (107)
Commitment to the Regulatory T Cell Lineage Requires CARMA1 in the Thymus but Not in the Periphery (2009) (104)
Immunology: Toll-like receptors and antibody responses (2006) (104)
Cachectin/tumor necrosis factor: An endogenous mediator of shock and inflammation (1986) (104)
Lipopolysaccharide Signal Transduction, Regulation of Tumor Necrosis Factor Biosynthesis, and Signaling by Tumor Necrosis Factor Itself (1995) (104)
Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway. (2006) (103)
Soluble CD36 Ectodomain Binds Negatively Charged Diacylglycerol Ligands and Acts as a Co-Receptor for TLR2 (2009) (101)
Dendritic cells produce macrophage inflammatory protein-1 gamma, a new member of the CC chemokine family. (1996) (99)
The BTB-ZF transcription factors (2012) (98)
TNF, apoptosis and autoimmunity: a common thread? (1998) (97)
A model for familial exudative vitreoretinopathy caused by LPR5 mutations. (2008) (97)
Helsinki alert of biodiversity and health (2015) (96)
Constitutive synthesis of tumor necrosis factor in the thymus. (1992) (95)
Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models (2012) (95)
Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis (2007) (94)
Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis (2008) (94)
Limits of a deletion spanning Tlr4 in C57BL/10ScCr mice (2000) (92)
Tumor necrosis factor inhibitor ameliorates murine intestinal graft-versus-host disease. (1999) (91)
Innate immune responses to microbial poisons: discovery and function of the Toll-like receptors. (2003) (91)
iRhom2 is required for the secretion of mouse TNFα. (2012) (88)
Enhanced Antibacterial Potential in UBP43-Deficient Mice against Salmonella typhimurium Infection by Up-Regulating Type I IFN Signaling1 (2005) (87)
Identification of Toll-like receptor 4 (Tlr4) as the sole conduit for LPS signal transduction: genetic and evolutionary studies. (2001) (86)
A Novel Hypomorphic PDX1 Mutation Responsible for Permanent Neonatal Diabetes With Subclinical Exocrine Deficiency (2009) (86)
Sensors of the innate immune system: their link to rheumatic diseases (2010) (85)
The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow (2011) (85)
Identification of Toll-like receptor 4 (Tlr4) as the sole conduit for LPS signal transduction: genetic and evolutionary studies (2001) (85)
IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms. (2015) (84)
Constitutive activity of the tumor necrosis factor promoter is canceled by the 3' untranslated region in nonmacrophage cell lines; a trans-dominant factor overcomes this suppressive effect. (1992) (82)
Tumor necrosis factor α stimulates leukotriene production in vivo (1988) (81)
The Rab27a Effectors JFC1/Slp1 and Munc13‐4 Regulate Exocytosis of Neutrophil Granules (2008) (80)
Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice. (2010) (80)
Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes. (2007) (80)
A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity (2012) (78)
Sensitizing Anthrax Lethal Toxin-resistant Macrophages to Lethal Toxin-induced Killing by Tumor Necrosis Factor-α* (2003) (77)
A Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence (2010) (74)
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses (2011) (74)
The essential role of the UA-rich sequence in endotoxin-induced cachectin/TNF synthesis. (1990) (72)
Loss of T Cell and B Cell Quiescence Precedes the Onset of Microbial Flora-Dependent Wasting Disease and Intestinal Inflammation in Gimap5-Deficient Mice (2010) (71)
ATP-sensitive potassium channels mediate survival during infection in mammals and insects (2007) (70)
Velvet, a Dominant Egfr Mutation That Causes Wavy Hair and Defective Eyelid Development in Mice (2004) (70)
Alternative cleavage of the cachectin/tumor necrosis factor propeptide results in a larger, inactive form of secreted protein. (1989) (70)
Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti–PD-L1 to eliminate melanoma in mice (2018) (70)
Viral RNA induces type I interferon-dependent cytokine release and cell death in mesangial cells via melanoma-differentiation-associated gene-5: Implications for viral infection-associated glomerulonephritis. (2009) (70)
Positional cloning of Lps, and the general role of toll-like receptors in the innate immune response. (2000) (69)
Real-time resolution of point mutations that cause phenovariance in mice (2015) (68)
Complex regulation of tumor necrosis factor mRNA turnover in lipopolysaccharide-activated macrophages. (1991) (67)
A catechol-O-methyltransferase that is essential for auditory function in mice and humans (2008) (66)
UNC93B1 Mediates Host Resistance to Infection with Toxoplasma gondii (2010) (66)
The endogenous mediator of endotoxic shock. (1987) (66)
Neo‐ligands for innate immune receptors and the etiology of sterile inflammatory disease (2007) (65)
MIP-1 gamma: molecular cloning, expression, and biological activities of a novel CC chemokine that is constitutively secreted in vivo. (1995) (65)
Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity (2017) (64)
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis (2010) (64)
The sole gateway to endotoxin response: how LPS was identified as Tlr4, and its role in innate immunity. (2001) (64)
Intracellular nucleic acid sensors and autoimmunity. (2011) (62)
Lipopolysaccharide-treated RAW 264.7 cells produce a mediator that inhibits lipoprotein lipase in 3T3-L1 cells. (1985) (62)
Rapid Identification of a Disease Allele in Mouse Through Whole Genome Sequencing and Bulk Segregation Analysis (2011) (62)
Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet (2011) (62)
ATP-sensitive potassium channel (KATP)–dependent regulation of cardiotropic viral infections (2011) (61)
Suppression of the hepcidin‐encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase‐2/TMPRSS6 (2009) (61)
Tumour predisposition and cancer syndromes as models to study gene–environment interactions (2020) (61)
Consequences of the recurrent MYD88L265P somatic mutation for B cell tolerance (2014) (60)
Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening. (2003) (60)
How do tumor necrosis factor receptors work? (1995) (60)
Genetic dissection of innate immunity to infection: the mouse cytomegalovirus model. (2005) (59)
Science review: Key inflammatory and stress pathways in critical illness – the central role of the Toll-like receptors (2002) (59)
Analysis of the MCMV resistome by ENU mutagenesis (2006) (59)
TLR signaling pathways: opportunities for activation and blockade in pursuit of therapy. (2006) (58)
A CAT reporter construct allows ultrasensitive estimation of TNF synthesis, and suggests that the TNF gene has been silenced in non-macrophage cell lines. (1991) (58)
LPS, dsRNA and the interferon bridge to adaptive immune responses: Trif, Tram, and other TIR adaptor proteins. (2004) (57)
Going forward with genetics: recent technological advances and forward genetics in mice. (2013) (56)
X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C (2011) (56)
Application of transcriptional and posttranscriptional reporter constructs to the analysis of tumor necrosis factor gene regulation. (1992) (55)
ENU mutagenesis in mice. (2008) (55)
The HLA-dependent expression of testis-organizing H-Y antigen by human male cells (1978) (55)
Attenuated Activation of Macrophage TLR9 by DNA from Virulent Mycobacteria (2008) (54)
Detection of Interleukin 1β but Not Tumor Necrosis Factor—α in Cerebrospinal Fluid of Children With Aseptic Meningitis (1990) (54)
Effect of amrinone on tumor necrosis factor production in endotoxic shock. (1992) (53)
Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival (2017) (52)
Genetic analysis of innate immunity: identification and function of the TIR adapter proteins. (2005) (51)
Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis (2006) (51)
Multifunctional prenylated peptides for live cell analysis. (2009) (49)
Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells (2010) (48)
Translational control mediated by UA-rich sequences. (1990) (47)
Precis on forward genetics in mice (2007) (47)
Extinction of the tumor necrosis factor locus, and of genes encoding the lipopolysaccharide signaling pathway (1993) (47)
An essential role for Rxrα in the development of Th2 responses (2005) (47)
Adenoviral vectors given intravenously to immunocompromised mice yield stable transduction of the colonic epithelium. (1997) (46)
De Novo Lipogenesis Products and Endogenous Lipokines (2016) (46)
Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function (2009) (46)
Erratum: Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer (Proc. Natl. Acad. Sci. USA (January 4, 1994) 91:1 (215-219)) (1994) (46)
B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IκBNS (2014) (46)
Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice. (2011) (45)
Endotoxin, tumor necrosis factor, and related mediators: new approaches to shock. (1993) (45)
Unlocking the Bottleneck in Forward Genetics Using Whole-Genome Sequencing and Identity by Descent to Isolate Causative Mutations (2013) (45)
Crystallization of trimeric recombinant human tumor necrosis factor (cachectin). (1988) (44)
Porcine tumor necrosis factor alpha: cloning with the polymerase chain reaction and determination of the nucleotide sequence. (1989) (44)
Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors (2018) (44)
The presence of cachectin/tumor necrosis factor in human disease states. (1988) (43)
Genetic analysis of innate immunity. (2006) (43)
ENU-induced phenovariance in mice: inferences from 587 mutations (2012) (43)
Expression of the tumor necrosis factor gene by dermal fibroblasts in response to ultraviolet irradiation or lipopolysaccharide. (1995) (42)
An Evolutionary and Functional Approach to the TNF Receptor/Ligand Family (1994) (42)
RNA and Imidazoquinolines Are Sensed by Distinct TLR7/8 Ectodomain Sites Resulting in Functionally Disparate Signaling Events (2014) (42)
Chimeric tumor necrosis factor receptors with constitutive signaling activity. (1995) (41)
Creatine maintains intestinal homeostasis and protects against colitis (2017) (41)
The biosynthesis of tumor necrosis factor during pregnancy: studies with a CAT reporter transgene and TNF inhibitors. (1992) (41)
TRAF3: a new component of the TLR-signaling apparatus. (2006) (40)
Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim. (2019) (40)
Crystallin γB-I4F Mutant Protein Binds to α-Crystallin and Affects Lens Transparency* (2005) (39)
SHIP, TGF-β, and Endotoxin Tolerance (2004) (39)
Role of Nucleic Acid–Sensing TLRs in Diverse Autoantibody Specificities and Anti-Nuclear Antibody–Producing B Cells (2013) (39)
IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice (2017) (38)
Bulk Segregation Mapping of Mutations in Closely Related Strains of Mice (2010) (38)
Hypothalamic action of cachectin to alter pituitary hormone release (1989) (37)
Expansion and Function of CD8+ T Cells Expressing Ly49 Inhibitory Receptors Specific for MHC Class I Molecules1 (2004) (37)
Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype (2011) (36)
Sepsis begins at the interface of pathogen and host. (2001) (36)
Cachectin, cachexia, and shock. (1988) (36)
A gain-of-function voltage-gated sodium channel 1.8 mutation drives intense hyperexcitability of A- and C-fiber neurons (2014) (35)
Not "molecular patterns" but molecules. (2003) (34)
Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif. (2009) (34)
ZBTB1 is a determinant of lymphoid development (2012) (34)
LGP2: Positive about viral sensing (2010) (33)
Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity (2016) (33)
Increased Susceptibility to DNA Virus Infection in Mice with a GCN2 Mutation (2011) (33)
Toll-like receptors and their place in immunology (2004) (32)
A Point Mutation in the Amino Terminus of TLR7 Abolishes Signaling without Affecting Ligand Binding (2011) (32)
Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database (2018) (32)
An essential role for Rxr alpha in the development of Th2 responses. (2005) (32)
Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR (2019) (31)
Expression of a TNF inhibitor in transgenic mice. (1993) (31)
Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2–ADAM17-dependent proteolysis (2017) (31)
Forward genetic dissection of afferent immunity: the role of TIR adapter proteins in innate and adaptive immune responses. (2004) (31)
Forward genetic analysis of TLR-signaling pathways: an evaluation. (2008) (31)
The tumor necrosis factors: cachectin and lymphotoxin. (1990) (30)
LPS in microbial pathogenesis: promise and fulfilment. (2002) (30)
Intracellular lipid metabolism impairs &bgr; cell compensation during diet-induced obesity (2018) (30)
Genetic analysis of innate immunity: TIR adapter proteins in innate and adaptive immune responses. (2004) (29)
SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell–mediated immunity (2021) (29)
The Tpl2 Mutation Sluggish Impairs Type I IFN Production and Increases Susceptibility to Group B Streptococcal Disease1 (2009) (29)
Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease (2012) (29)
Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways (2006) (29)
Tumor Necrosis Factor α and Interleukin 1β in Synovial Fluid of Infants and Children With Suppurative Arthritis (1990) (29)
Metabolic Characterization of a Mouse Deficient in All Known Leptin Receptor Isoforms (2009) (29)
Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice (2012) (28)
Antagonism between MyD88‐ and TRIF‐dependent signals in B7RP‐1 up‐regulation (2005) (28)
Diprovocims: A New and Exceptionally Potent Class of Toll-like Receptor Agonists. (2018) (28)
Polymorphism of the mouse TNF-alpha locus: sequence studies of the 3'-untranslated region and first intron. (1993) (28)
Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling (2014) (28)
Inhibition of mitogen activated protein kinases increases the sensitivity of A549 lung cancer cells to the cytotoxicity induced by a kava chalcone analog. (2012) (27)
Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing (2015) (27)
Cachectin--Tumour necrosis factor: a cytokine that mediates injury initiated by invasive parasites. (1987) (27)
The forward genetic dissection of afferent innate immunity. (2008) (26)
Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function (2018) (26)
Lps2 and Signal Transduction in Sepsis: At the Intersection of Host Responses to Bacteria and Viruses (2003) (25)
Emerging roles of spliceosome in cancer and immunity (2021) (25)
Toll-Like Receptor Family Members and Their Ligands (2002) (25)
The Long Terminal Repeat-Containing Retrotransposon Tf1 Possesses Amino Acids in Gag That Regulate Nuclear Localization and Particle Formation (2005) (25)
Mutation of the gastric hydrogen-potassium ATPase alpha subunit causes iron-deficiency anemia in mice. (2011) (25)
LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling (2019) (24)
Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner. (2011) (24)
Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice (2016) (23)
Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids (2015) (23)
Cachexia: a fundamental mechanism. (2009) (23)
Discovery and Structure-Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists. (2016) (23)
Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes (2005) (23)
A mutation of Ikbkg causes immune deficiency without impairing degradation of IκBα (2010) (23)
TNF in pathophysiology: biosynthetic regulation. (1990) (23)
PanR1, a Dominant Negative Missense Allele of the Gene Encoding TNF-α (Tnf), Does Not Impair Lymphoid Development1 (2006) (22)
The complex regulation and biology of TNF (cachectin). (1990) (22)
Cachectin in tissue injury, shock, and related states. (1989) (22)
Cachectin: a pluripotent hormone released during the host response to invasion. (1987) (22)
Point mutations in the melanocortin-4 receptor cause variable obesity in mice (2006) (22)
Impact of β2 integrin deficiency on mouse natural killer cell development and function. (2011) (22)
Unraveling innate immunity using large scale N-ethyl-N-nitrosourea mutagenesis. (2005) (22)
Photochemical Modulation of Ras‐Mediated Signal Transduction Using Caged Farnesyltransferase Inhibitors: Activation by One‐ and Two‐Photon Excitation (2012) (22)
Tumor necrosis factor-α, and interleukin-1β production by human fetal Kupffer cells (1991) (22)
Cachectin/Tumor Necrosis Factor and Lymphotoxin (1990) (22)
Reciprocal regulation of extracellular signal regulated kinase 1/2 and mitogen activated protein kinase phosphatase-3. (2008) (21)
Erratum: Genetic and physical mapping of the Lps locus: Identification of the toll-4 receptor as a candidate gene in the critical region (Blood Cells, Molecules, and Diseases (1998) 24:3 (340-355)) (1999) (21)
Severe retinal degeneration caused by a novel rhodopsin mutation. (2010) (20)
Assessing the function of human UNC-93B in Toll-like receptor signaling and major histocompatibility complex II response. (2007) (20)
Prion-like behavior of MAVS in RIG-I signaling (2011) (20)
The search for Lps: 1993-1998. (2000) (20)
Tumor necrosis factor and the Jarisch-Herxheimer reaction. (1996) (20)
Toward a cell-based cure for diabetes: advances in production and transplant of beta cells. (2008) (20)
Reconstruction of the Mouse Inflammasome System in HEK293T Cells. (2016) (20)
LPS, dsRNA and the interferon bridge to adaptive immune responses: Trif, Tram, and other TIR adaptor proteins (2004) (20)
Comparative expression of TNF-α alleles from normal and autoimmune-prone MHC haplotypes (1995) (19)
HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections (2017) (19)
The ESRP1-GPR137 axis contributes to intestinal pathogenesis (2017) (19)
Innate immune sensing of microbial infection: the mechanism and the therapeutic challenge. (2002) (18)
Regulation of cachectin biosynthesis occurs at multiple levels. (1990) (18)
SHIP, TGF-beta, and endotoxin tolerance. (2004) (18)
Akirins versus infection (2008) (18)
Cachectin: A Monokine Implicated as a Mediator of Cachexia and Shock (1987) (18)
Endotoxin-mimetic effect of antibodies against Toll-like receptor 4 (2000) (18)
Toll we meet again . . . (2001) (17)
Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5 (2017) (17)
From phenomenon to phenotype and from phenotype to gene: forward genetics and the problem of sepsis. (2003) (17)
Orchestration of septic shock by cytokines: the role of cachectin (tumor necrosis factor). (1989) (17)
Sulfatides are endogenous ligands for the TLR4–MD-2 complex (2021) (16)
Tumor necrosis factor alpha stimulates leukotriene production in vivo. (1988) (16)
Cytokines and cancer cachexia. (1993) (16)
KDM5A mutations identified in autism spectrum disorder using forward genetics (2020) (15)
Extracellular signal-regulated kinase transmits palytoxin-stimulated signals leading to altered gene expression in mouse keratinocytes. (2002) (15)
Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV). (2005) (15)
Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science, 1985, 229(4716):869-871. Classical article. (2008) (15)
Investigation of the sequence and length dependence for cell-penetrating prenylated peptides. (2010) (15)
YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity (2019) (15)
University of California/Davis Interdepartmental Conference on gram-negative septicemia. (1991) (15)
Special delivery: granulin brings CpG DNA to Toll-like receptor 9. (2011) (15)
Sox17 Regulates Liver Lipid Metabolism and Adaptation to Fasting (2014) (14)
DEXAMETHASONE AND PENTOXIFYLLINE INHIBIT ENDOTOXIN-INDUCED CACHECTIN TNF SYNTHESIS AT SEPARATE POINTS IN THE SIGNALING PATHWAY (1990) (14)
Slc15a4 function is required for intact class switch recombination to IgG2c in response to TLR9 stimulation (2015) (14)
The search for Lps (2000) (14)
Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening (2003) (13)
Crystallin {gamma}B-I4F mutant protein binds to {alpha}-crystallin and affects lens transparency. (2005) (13)
Receptor-mediated label-transfer assay (RELAY): a novel method for the detection of plasma tumor necrosis factor at attomolar concentrations. (1994) (13)
The role of Vldlr in intraretinal angiogenesis in mice. (2011) (13)
I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development. (2010) (13)
Induction of Systemic Autoimmunity by a Xenobiotic Requires Endosomal TLR Trafficking and Signaling from the Late Endosome and Endolysosome but Not Type I IFN (2017) (13)
Mitogen activated protein kinases selectively regulate palytoxin-stimulated gene expression in mouse keratinocytes. (2003) (12)
Lymphoid Hyperplasia, CD45RBhigh to CD45RBlow T-cell imbalance, and suppression of Type I diabetes mellitus result from TNF blockade in NOD→NOD-scid adoptive T cell transfer (1998) (12)
How the mighty have fallen: fatal infectious diseases of divine composers. (2004) (12)
Detection of interleukin 1 beta but not tumor necrosis factor-alpha in cerebrospinal fluid of children with aseptic meningitis. (1990) (12)
Toll-like receptor 4 polymorphisms and atherogenesis. (2002) (11)
Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of MYD88L265P plasmablasts in vivo. (2016) (11)
Tumor necrosis factor alpha and interleukin 1 beta in synovial fluid of infants and children with suppurative arthritis. (1990) (11)
N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization (2021) (10)
Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation (2020) (10)
How host defense is encoded in the mammalian genome (2011) (10)
Hypopigmentation and Maternal-Zygotic Embryonic Lethality Caused by a Hypomorphic Mbtps1 Mutation in Mice (2012) (10)
Essential requirement for nicastrin in marginal zone and B-1 B cell development (2020) (10)
Use of transcriptome data to unravel the fine structure of genes involved in sepsis. (2003) (10)
Extracellular signal regulated kinase 5 mediates signals triggered by the novel tumor promoter palytoxin. (2009) (10)
Expression of an adenovirally encoded lymphotoxin-beta inhibitor prevents clearance of Listeria monocytogenes in mice. (1995) (10)
The class I myosin MYO1D binds to lipid and protects against colitis (2018) (10)
Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice (2019) (9)
The Mask Mutation Identifies TMPRSS6 as an Essential Suppressor of Hepcidin Gene Expression, Required for Normal Uptake of Dietary Iron. (2007) (9)
Big pharma shows signs of renewed interest in RNAi drugs (2014) (9)
Regulation of Tau Homeostasis and Toxicity by Acetylation. (2019) (9)
Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection (2015) (9)
Tumor promoter-induced MMP-13 gene expression in a model of initiated epidermis. (2004) (9)
Mutagenesis by retroviral insertion in chemical mutagen-generated quasi-haploid mammalian cells. (2007) (8)
Erratum: Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor (Blood Cells, Molecules, and Diseases (1999) 25:6 (328-338)) (2000) (8)
Rita Levi-Montalcini: NGF, the prototypical growth factor (2013) (8)
Dominant atopy risk mutations identified by mouse forward genetic analysis (2020) (8)
Altered Marginal Zone B Cell Selection in the Absence of IκBNS (2018) (8)
Calcium flux control by Pacs1‐Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases (2021) (8)
Cachectin: the dark side of tumor necrosis factor. (1986) (8)
Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation (2013) (8)
Resisting viral infection: the gene by gene approach. (2011) (8)
The solute carrier SLC15A4 is required for optimal trafficking of nucleic acid–sensing TLRs and ligands to endolysosomes (2022) (7)
Biallelic loss of function variant in the unfolded protein response gene PDIA6 is associated with asphyxiating thoracic dystrophy and neonatal‐onset diabetes (2021) (7)
Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development (2020) (7)
Innate immunity and the new forward genetics. (2016) (7)
Tumor Necrosis Factor and Other Cytokines in Septic Syndrome (1994) (7)
Forward genetic analysis using OCT screening identifies Sfxn3 mutations leading to progressive outer retinal degeneration in mice (2020) (7)
TLRs as bacterial sensors (2006) (7)
Creating diseases to understand what prevents them: genetic analysis of inflammation in the gastrointestinal tract. (2012) (7)
B-1a Cell Development in Splenectomized Neonatal Mice (2018) (7)
Comparative expression of TNF-alpha alleles from normal and autoimmune-prone MHC haplotypes. (1995) (7)
Update on the listeriosis outbreak (2011) (7)
An ENU-induced splice site mutation of mouse Col1a1 causing recessive osteogenesis imperfecta and revealing a novel splicing rescue (2017) (6)
Inflammatory bowel disease and ADAM17 deletion. (2012) (6)
Heterozygous Mutation in IκBNS Leads to Reduced Levels of Natural IgM Antibodies and Impaired Responses to T-Independent Type 2 Antigens (2016) (6)
Endotoxin antagonism: conceptual basis and therapeutic potential (2002) (6)
Tumor necrosis factor-alpha and interleukin-1 beta production by human fetal Kupffer cells. (1991) (6)
Recognition and Rejection of Self in Plant Reproduction (2002) (5)
A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis (2018) (5)
The Tpl 2 Mutation Sluggish Impairs Type I IFN Production and Increases Susceptibility to Group B Streptococcal Disease 1 (2009) (5)
Adenosine monophosphate deaminase 3 null mutation causes reduction of naive T cells in mouse peripheral blood. (2020) (5)
Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40 (2019) (5)
Pathogens, Commensals, and Immunity: From the Perspective of the Urinary Bladder (2016) (5)
Corrigendum: Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections (2006) (5)
Cachectin/tumor necrosis factor participates in reduction of skeletal muscle membrane potential: Evidence for bioactivity in plasma during critical illness (1986) (5)
Pillars Article: Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin. Science, 1985, 229(4716):869–871. (2008) (4)
Plasmacytoid Dendritic Cells are the Primary Source of IFN-α During the Immunopathogenesis of Desiccating Stress-Induced Dry Eye Disease (2013) (4)
Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function (2020) (4)
Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity (2022) (4)
Cachexia: a basic biochemical mechanism. (1989) (4)
A Proinflammatory Mediator with Potential Relevance in Aging (1990) (4)
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger (Proceedings of the National Academy of Sciences of the United States of America (2008) 105, 39, (15028-15033) DOI: 10.1073/pnas.0806619105) (2008) (4)
QnAs with Kirk R. Smith (2012) (4)
The explosion of septic shock (1990) (4)
Erratum: TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS (Proceedings of the National Academy of Sciences of the United States of America (2016) 113 (E884-E893)) (2016) (4)
An update on the African polio outbreak (2011) (3)
Straight talk with...Jamie Heywood (2014) (3)
What infections actually are. (2009) (3)
Immunology, Phenotype First: How Mutations Have Established New Principles and Pathways in Immunology - Preface (2008) (3)
Tissue-specific disruption of Kbtbd2 uncovers adipocyte-intrinsic and -extrinsic features of the teeny lipodystrophy syndrome (2020) (3)
Characterization of mouse mutants with abnormal RPE cells. (2006) (3)
Profile of Michael B. A. Oldstone (2013) (3)
Cryptographic methods enable analyses without privacy breaches (2014) (3)
The toll-like receptors as the primary sensors of the innate immune system (2000) (2)
New frontiers in immunology (2005) (2)
Profile of David Jablonski (2013) (2)
Immunology, phenotype first. Preface. (2008) (2)
Research Techniques Made Simple: Forward Genetic Screening to Uncover Genes Involved in Skin Biology. (2019) (2)
Review paper: LPS in microbial pathogenesis: promise and fulfilment (2002) (2)
Review: The search for Lps: 1993—1998 (2000) (2)
Signal Transduction During Innate and Adaptive Immunity (2001) (2)
De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes (2021) (2)
Curved-crease sculpture (2013) (2)
Genetic analysis of host responses in sepsis (2001) (2)
William G. Kaelin Jr. and Gregg L. Semenza receive the 2012 ASCI/Stanley J. Korsmeyer Award. (2012) (2)
Mina Bissell focuses on context (2011) (2)
A mystery unfolds: Franz-Ulrich Hartl and Arthur L. Horwich win the 2011 Albert Lasker Basic Medical Research Award. (2011) (2)
Restoration of the Lipopolysaccharide‐Responsive Phenotype in C3H/HeJ Peritoneal Macrophage‐P388D1 Cell Hybrids (1988) (2)
A research institute at a turning point (2012) (2)
Nobel Prize to immunology (2011) (2)
Forward Genetic Analysis of TLR Pathways (2005) (2)
Quantification of early learning and movement sub-structure predictive of motor performance (2021) (2)
Innate immune sensing and response (2009) (2)
IκBNS expression in B cells is dispensable for IgG responses to T cell-dependent antigens (2022) (2)
Tumor Necrosis Factor Biosynthesis: From Gene to Protein (1993) (2)
Chimeric TNF receptors with constitutive signalling activity. (1995) (2)
Erratum: Plant and animal sensors of conserved microbial signatures (Science (2015) 330:6007 (1061-1064)) (2015) (1)
Next-Generation Diprovocims with Potent Human and Murine TLR1/TLR2 Agonist Activity That Activate the Innate and Adaptive Immune Response. (2022) (1)
Federal funding for stem cell research: 15 years of indecision. (2011) (1)
Masters of metabolism: Matthias Tschöp and Richard DiMarchi (2011) (1)
Forward Genetic Screen Reveals Genetic Causes of Atopy: 621 (2019) (1)
Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice (2022) (1)
Obesity caused by an OVOL2 mutation reveals dual roles of OVOL2 in promoting thermogenesis and limiting white adipogenesis. (2022) (1)
Microbial Pathogenesis and the Discovery of Toll-Like Receptor Function (2006) (1)
Fighting malaria: mosquitoes know how. (2006) (1)
Weighing in on the future of gene patenting. (2011) (1)
Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice (2020) (1)
European-African clinical research scheme expands into phase 1 (2014) (1)
ENU-induced phenovariance in mice: inferences from 587 mutations (2012) (1)
Cytokines in Shock: 1992 (1992) (1)
Saturation mutagenesis defines novel mouse models of severe spine deformity (2021) (1)
Association of Hyperglycemia with the Development of Retinopathy of Prematurity (2003) (1)
QnAs with Ann M. Graybiel (2013) (1)
Clinical expert round table discussion (session 1) at the Margaux Conference on Critical Illness: innate immunity: host recognition of and sensitivity to bacterial components. (2001) (1)
Pinkie , the First Viable Germline Hypomorph Allele of Retinoid X Receptor Alpha, Reveals an Important Role for RXRa in Th2 Development. (2004) (1)
Forward genetic screen of allergy reveals genetic basis for allergic disease (2018) (1)
Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing (2015) (1)
Tumor Necrosis Factor (TNF) (2003) (1)
Bruce Beutler: the persistent prospector. Interview by Ruth Williams. (2013) (1)
Saturation mutagenesis defines novel mouse models of severe spine deformity. (2021) (1)
Summary of the 5TH International Congress on TNF and related cytokines: scientific advances and their medical applications1 (1995) (1)
Genetics of Innate Immunity (2008) (1)
Profile of Kevan M. Shokat (2012) (1)
Finding New Components of the Mammalian Immune System* (2016) (1)
Thrivin’ (not just survivin’) in Philadelphia (2010) (1)
The Molecular Basis of Shock: The Role of Cachectin (1988) (1)
Laurie Glimcher to take the helm of Weill Cornell Medical College (2011) (0)
Brian Druker and Charles Sawyers receive the 2011 ASCI/Stanley J. Korsmeyer Award. (2011) (0)
For Huda Zoghbi, collaboration is the key to unlocking the secrets of neurobiology (2011) (0)
Pier Paolo Pandolfi wins Pezcoller-AACR International Award for Cancer Research (2011) (0)
Abstract 001: Germline Mutagenesis Induces Blood Pressure And Heart Rate Variation In Mice Uncovering Novel Insights On The Genesis Of Cardiovascular Disease Risks (2022) (0)
Sean Morrison and the Texas brain gain. (2012) (0)
receptors and their transducers (2003) (0)
Bruce Beutler wins the 2013 ASCI/Stanley J. Korsmeyer Award (2013) (0)
How the innate immune system senses infection (2001) (0)
CHAPTER 33 – Toll-like receptors (2003) (0)
Gene pioneers: Donald Brown and Thomas Maniatis win the 2012 Lasker~Koshland Special Achievement Award in Medical Science. (2012) (0)
List of Contributors and Discussants (1981) (0)
The 2010 Paul Janssen Award recognizes achievement in AIDS research. (2010) (0)
The role of a ubiquitin ligase adaptor protein in glucose homeostasis and beta cell mass (2009) (0)
An ENU-induced splice site mutation of mouse Col1a1 causing recessive osteogenesis imperfecta and revealing a novel splicing rescue (2017) (0)
Ernest Beutler: his life and contribution to medical science (2011) (0)
Translational control of the biosynthesis: Studies using cat reporter constructs and CSAID™ inhibitors (1994) (0)
NZB;NZW chimeras develop strong autoimmunity earlier than NZB/NZW F1 (2018) (0)
Afferent ( sensing ) Efferent ( effector ) (2003) (0)
Pococurante (Poc): An ENU-Induced Missense Mutation of MyD88 with Selective Effects on TLR Signal Transduction. (2004) (0)
Workshop on The Road Ahead: Future Directions in Fundamental and Clinical Immunology (2005) (0)
The central answer. Interview by Kristie Nybo. (2013) (0)
Genetic analysis of host responses in sepsis (2001) (0)
Unc93 homolog B1 regulates the balance of toll-like receptor 7 and toll-like receptor 9 responses reciprocally in dendritic cells (2009) (0)
ENU–induced New Recessive Mutations for Retinal Neovascularization and Ischemia (2004) (0)
Celebrating remarkable vision (2010) (0)
Author Correction: Quantification of early learning and movement sub-structure predictive of motor performance (2021) (0)
Sphinx: A novel mutation that promotes liver tumor growth and impairs cytotoxic lymphocyte development (2007) (0)
Forward genetic and cellular studies of immune regulation: the roles of Carma1, Interleukin-10 and Gimap5 (2010) (0)
De novo germline mutation in the Dual Specificity Phosphatase 10 gene accelerates autoimmune diabetes in Non-Obese Diabetic (NOD) mice (2021) (0)
The nonsense allele oblivious reveals a sensor of di-acylglycerides acting in conjunction with TLR2 and TLR6 (2004) (0)
3D , a Novel Mutation That Confers Defective Sensing by Toll-Like Receptors 3, 7 and 9. (2004) (0)
Forward Genetic Studies of Mouse Mutants with Retinal Diseases (2003) (0)
TUMOR NECROSIS FACTOR AND THE JARISH-HERXHEIMER REACTION (1996) (0)
S1634 Inadequate Unfolded Protein Response As a Mechanism for Acute Colitis in Mbtps1 Mutant Mice (2009) (0)
Toll-like receptor 8 : augmentation of innate immunity in platinum resistant ovarian carcinoma (2013) (0)
Consensus and confusion among the Contradas (1990) (0)
1434 FEVER , TUMOR NECROSIS FACTOR (1986) (0)
Glycosylation regulates IgE production and stability in vivo (2023) (0)
Chapter 25. Programmed Cell Death Mediated by Members of the TNF Receptor Family (1995) (0)
A New Mouse Mutation Develops Nuclear Cataract in Heterozygote While Posteriorly Ruptured Lens in Homozygote (2005) (0)
SHORT THESIS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY (PhD) Migration of the monocyte derived dendritic cells for different activation signals (2015) (0)
Thousands of induced germline mutations affecting immune cells identified by automated meiotic mapping coupled with machine learning (2021) (0)
Macrophage-derived inflammatory mediators (MIP-1-alpha et MIP-1-beta) (1988) (0)
Random Germline Mutagenesis in the Analysis of Immunity (2013) (0)
Toll‐like receptors are critical for protection against West Nile virus infection (2008) (0)
Positive opening switches assure safety (1993) (0)
Bruce Beutler wins the 2013 ASCI/Stanley J. Korsmeyer Award. Interview by Kathryn Claiborn. (2013) (0)
in Functionally Disparate Signaling Events Distinct TLR7/8 Ectodomain Sites Resulting RNA and Imidazoquinolines Are Sensed by (2014) (0)
Adenoviral gene transfer of a lymphotoxin β inhibitor protein versus gene-targeted lymphotoxin-α knockout: Effect on delayed-type cutaneous hypersensitivity versus abnormal development of peripheral lymphoid tissues in lymphotoxin-α-deficient mice (1996) (0)
Interleukins Etc.: Guidebook to Cytokines and Their Receptors . Nicos A. Nicola, Ed. Oxford University Press, New York, 1995. xvi, 261 pp., illus., + plates. $75 or £45; paper, $39.50 or £22.50. A Sambrook and Tooze publication. (1995) (0)
Mechanism of negative regulation of NF-κB by N4BP1 (2020) (0)
The crystal structure of mouse TLR4/MD-2/neoseptin-3 complex (2016) (0)
QnAs with Bruce Beutler. Interview by Nicholette Zeliadt. (2012) (0)
Crystal structure of mouse xm RABL3 in complex with GTPgammsS (2020) (0)
928 Deficiency of Intestinal Mucin-2 Protects From Alcoholic Liver Disease in Mice (2012) (0)
with Antigenic Potency CD95/CD178-Dependent and Is Correlated NKT Cells In Vivo Is Antigen-Specific Cytotoxicity by Invariant (2010) (0)
Molecular basis for the cachexia of parasitic disease (1987) (0)
Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40 (2019) (0)
Abstract 16596: Dominant Mouse Mutagenesis Screen Unveils a Complex Genetic Architecture for Congenital Heart Disease (2018) (0)
Consensus and confusion among the Contradas. Molecular and Cellular Biology of IL-1, TNF, and Lipocortins in Inflammation and Differentiation, sponsored by Sclavo Research Center, Siena, Italy, October 22-25, 1989. (1990) (0)
Crystal structure of mouse RABL3 in complex with GDP (2020) (0)
AI-21 Defective ikappabns leads to loss of peritoneal B1 cells and a reduction in induced but not spontaneous autoimmune hemolytic anaemia (2016) (0)
186 RAFFINOSE AND STACH YOSE FREE DIET REDUCES GALACTOSE-1-PHOSPHATE IN ERYTHROCYTES FROM GALACTOSEMIC PATIENTS (1990) (0)
Novel Cataractous Mouse Mutants (2003) (0)
Tu1793 - Rapid and Automated Mapping of Genes Critical for Intestinal Homeostasis (2018) (0)
The ligand-free structure of the mouse TLR4/MD-2 complex (2016) (0)
New frontiers in immunology. Workshop on the road ahead: future directions in fundamental and clinical immunology. (2005) (0)
Brief report iRhom2 is required for the secretion of mouse TNF (cid:1) (2012) (0)
Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database (2018) (0)
Author response: KDM5A mutations identified in autism spectrum disorder using forward genetics (2020) (0)
TLR4 as a direct interface with the microbial world (2000) (0)
Estimation of Physical Distance in the Genome through Probabilistic Analysis of Marker Density and Yeast Artificial Chromosome (YAC) Size (1999) (0)
MiceIntestinal Inflammation in Gimap5-Deficient Flora-Dependent Wasting Disease and Precedes the Onset of Microbial Loss of T Cell and B Cell Quiescence (2010) (0)
Diphosphoryl Lipid A fromRhodopseudomonas sphaeroides ATCC 17023Blocks Induction ofCachectin in Macrophages byLipopolysaccharide (1989) (0)
RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice (2022) (0)
Tumour predisposition and cancer syndromes as models to study gene–environment interactions (2020) (0)
David Weatherall wins the 2010 Lasker~Koshland Special Achievement Award in Medical Research for advances in thalassemia (2010) (0)
Autosomal Dominant Retinal Degeneration in ENU Mutagnized Mice Caused By a Cys185Arg Mutation in Rhodopsin (2004) (0)
Modeling IBD in the mouse through random germline mutagenesis: P-173. (2011) (0)
AN ALPORT SYNDROME MUTATION IN MOUSE Col 4 a 4 IDENTIFIED BY WHOLE GENOME SEQUENCING AND BULK SEGREGATION ANALYSIS (2010) (0)
Goodwin and Rose Helen Breinin Lectureship in Basic Sciences (2013) (0)
Editorial (2008) (0)
Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors (2018) (0)
The crystal structure of mouse TLR4/MD-2/lipid A complex (2016) (0)
Ligand Binding TLR7 Abolishes Signaling without Affecting A Point Mutation in the Amino Terminus of (2011) (0)
Differential role of nucleic acid-sensing toll-like receptors in autoantibody production. (44.29) (2011) (0)
Immunology 2007 (2008) (0)
An inflammatory cytokine, method for measuring the binding sites, the test system, kit and use thereof. (1988) (0)
Forward genetics: searching for novel genes essential to retinal development and function (2017) (0)
Forward Genetic Analysis of Gut Homeostasis Using a Sensitized Screen in Mice (2011) (0)
Tumour necrosis factor and related cytokines (CIBA foundation symposium 131) edited by Gregory Bock and Joan Marsh, John Wiley & Sons, 1987. £28.95 (ix + 241 pages) ISBN 0 471 91097. (1988) (0)
Activated macrophages secrete a novel lipolytic polypeptide hormone (1985) (0)
Tnf gene expression is governed by the untranslated regions in non macrophage cell lines identification of a trans dominant activator (1992) (0)
Identification of novel and potent synthetic TLR agonists (2017) (0)
A forward genetics approach to discovering novel genes essential to retinal development and function (2016) (0)
Identification of a Novel Toll-Like Receptor-Independent Immunoadjuvant Pathway That Depends upon Programmed Cell Death. (2004) (0)
Structural characterization of TLRs with novel agonists (2017) (0)
Direct Detection of Microbial Infection Through Activation Coupling of the Toll-Like Receptors (2004) (0)
The development of autoimmunity in NZB/NZW embryonic chimeras. (2016) (0)
Primordial germ cell derivation from mouse iPS cells and associated epigenetic changes (2010) (0)
The ligand-free structure of mouse RABL3 (2020) (0)
Immunology, phenotype firs (2013) (0)
Autism genetics, explained (2021) (0)
Spotted around the web: Mapping histones; COVID-19 births; acetaminophen lawsuits (2022) (0)
Erratum for the Review “Plant and animal sensors of conserved microbial signatures” by P. C. Ronald and B. Beutler (2015) (0)
The relationship between Toll-like receptor (TLR)4, tumor necrosis factor (TNF), and IL-1 (2011) (0)
Drilling for microbes (2013) (0)
Candidate Explorer: a tool for discovery, evaluation, and display of mutations causing significant immune phenotypes (2020) (0)
Bumper scan of genomes pinpoints inherited risk factors for autism (2019) (0)
Negative regulation of oncogenic Ras signaling by mitogen-activated protein kinase phosphatase-3. (2010) (0)
QnAs with Porter W. Anderson, Jr. (2012) (0)
Autism in motion (2017) (0)
A conversation with Bruce Beutler. Interview by Ushma S. Neill. (2013) (0)
Autism’s sex ratio, explained (2018) (0)
Profile of Richard Eisenberg (2013) (0)
Four models of clinical trial data sharing offered in new report (2014) (0)
New diagnostic code for PTEN syndrome may spur research (2022) (0)
Toll-like receptor family members and their ligands: Preface (2002) (0)
Specific for MHC Class I Molecules Expressing Ly 49 Inhibitory Receptors T Cells + Expansion and Function of CD 8 Brossay and (2004) (0)
Profile of Scott J. Hultgren (2013) (0)
Cover Picture: Photochemical Modulation of Ras-Mediated Signal Transduction Using Caged Farnesyltransferase Inhibitors: Activation by One- and Two-Photon Excitation (ChemBioChem 7/2012) (2012) (0)
Respond to "No antigen-presentation defect in Unc93b13d/3d (3d) mice" (2013) (0)
New data protection rules could harm research, science groups say (2014) (0)
QnAs with Bruce Beutler (2012) (0)
What Lies Ahead? Scientists Look into Their Crystal Balls: Forward Genetics and Viral Pathogenesis (2016) (0)
Crystal structure of mouse RABL3 in complex with GTPgammaS (2020) (0)
QnAs with Ruth S. DeFries (2012) (0)
A Lifetime Without Memory (2013) (0)
Profile of Michael I. Jordan (2013) (0)
Profile of Robert B. Goldberg (2012) (0)
Profile of Marc R. Montminy (2012) (0)
Trash Is Her Treasure (2010) (0)
Cachectin - Tumour Necrosis Factor: A cytokine that mediates injury by invasive parasites (1987) (0)

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