Earl Wilbur Sutherland Jr.

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According to Wikipedia, Earl Wilbur Sutherland Jr. was an American pharmacologist and biochemist born in Burlingame, Kansas. Sutherland won a Nobel Prize in Physiology or Medicine in 1971 "for his discoveries concerning the mechanisms of the action of hormones", especially epinephrine, via second messengers, namely cyclic adenosine monophosphate, or cyclic AMP.

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Earl Wilbur Sutherland Jr.'s Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. (1962) (1835)
Some Aspects of the Biological Role of Adenosine 3′,5′‐monophosphate (Cyclic AMP) (1968) (977)
Fractionation and characterization of a cyclic adenine ribonucleotide formed by tissue particles. (1958) (929)
THE RELATION OF ADENOSINE-3', 5'-PHOSPHATE AND PHOSPHORYLASE TO THE ACTIONS OF CATECHOLAMINES AND OTHER HORMONES (1960) (794)
Adenyl Cyclase I. DISTRIBUTION, PREPARATION, AND PROPERTIES (1962) (657)
Studies on the mechanism of hormone action. (1972) (630)
ADENYL CYCLASE AS AN ADRENERGIC RECEPTOR * (1967) (626)
Formation of a cyclic adenine ribonucleotide by tissue particles. (1958) (621)
The role of cyclic-3',5'-AMP in responses to catecholamines and other hormones. (1966) (553)
Purification of the hyperglycemic-glycogenolytic factor from insulin and from gastric mucosa. (1949) (527)
Effects of lipolytic and antilipolytic substances on adenosine 3',5'-monophosphate levels in isolated fat cells. (1968) (481)
Adenyl cyclase. III. The effect of catecholamines and choline esters on the formation of adenosine 3',5'-phosphate by preparations from cardiac muscle and liver. (1962) (472)
Adenosine 3',5'-monophosphate in biological materials. II. The measurement of adenosine 3',5'-monophosphate in tissues and the role of the cyclic nucleotide in the lipolytic response of fat to epinephrine. (1965) (465)
Effects of xanthine derivatives on lipolysis and on adenosine 3',5'-monophosphate phosphodiesterase activity. (1970) (461)
ADENOSINE 3',5'-PHOSPHATE IN ESCHERICHIA COLI. (1965) (407)
THE ACTION OF EPINEPHRINE AND THE ROLE OF THE ADENYL CYCLASE SYSTEM IN HORMONE ACTION. (1965) (393)
The relationship of epinephrine and glucagon to liver phosphorylase. IV. Effect of epinephrine and glucagon on the reactivation of phosphorylase in liver homogenates. (1957) (388)
Guanyl cyclase, an enzyme catalyzing the formation of guanosine 3',5'-monophosphate from guanosine trihosphate. (1969) (324)
Adenosine 3',5'-monophosphate as the intracellular mediator of the action of adrenocorticotropic hormone on the adrenal cortex. (1967) (313)
Derivatives of cyclic 3',5'-adenosine monophosphate. (1962) (312)
Subcellular Distribution of Adenyl Cyclase and Cyclic Phosphodiesterase in Rat Brain Cortex (1967) (310)
Adenyl cyclase. IV. The effects of neurohormones on the formation of adenosine 3',5'-phosphate by preparations from brain and other tissues. (1962) (297)
The effect of epinephrine on adenosine 3', 5'-phosphate levels in the isolated perfused rat heart. (1965) (269)
Studies on the role of adenosine 3',5'-monophosphate in the hepatic actions of glucagon and catecholamines. (1971) (267)
Role of adenosine 3',5'-monophosphate in the effects of insulin and anti-insulin serum on liver metabolism. (1968) (266)
Hydrolysis of cyclic guanosine and adenosine 3',5'-monophosphates by rat and bovine tissues. (1970) (264)
Effects of parathyroid hormone on plasma and urinary adenosine 3',5'-monophosphate in man. (1970) (253)
Nutrition Classics: Science, Volume 179, 1973, pages 588-591: Selenium: biochemical role as a component of glutathione peroxidase. (1980) (248)
Kinetic parameters and renal clearances of plasma adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in man. (1970) (247)
Stimulation of adenosine 3',5'-monophosphate hydrolysis by guanosine 3',5'-monophosphate. (1971) (247)
Effect of insulin on adenosine 3',5'-monophosphate in the rat epididymal fat pad. (1966) (245)
The importance of calcium ions for the regulation of guanosine 3':5'-cyclic monophosphage levels. (1973) (237)
THE EFFECT OF L-EPINEPHRINE AND OTHER AGENTS ON THE SYNTHESIS AND RELEASE OF ADENOSINE 3',5'-PHOSPHATE BY WHOLE PIGEON ERYTHROCYTES. (1963) (222)
Determination of guanosine 3',5'-monophosphate in tissues and of guanyl cyclase in rat intestine. (1969) (219)
The relationship of epinephrine and glucagon to liver phosphorylase. II. Enzymatic inactivation of liver phosphorylase. (1956) (210)
The relationship of epinephrine and glucagon to liver phosphorylase. III. Reactivation of liver phosphorylase in slices and in extracts. (1956) (209)
The relationship of epinephrine and glucagon to liver phosphorylase. I. Liver phosphorylase; preparation and properties. (1956) (200)
Effect of hyperglycemic-glycogenolytic factor and epinephrine on liver phosphorylase. (1951) (198)
THE CELLULAR LOCATION OF ADENYL CYCLASE IN THE PIGEON ERYTHROCYTE. (1963) (193)
THE PROPERTIES OF AN ADENINE RIBONUCLEOTIDE PRODUCED WITH CELLULAR PARTICLES, ATP, Mg++, AND EPINEPHRINE OR GLUCAGON (1957) (192)
The Role of Cyclic AMP in the Control of Carbohydrate Metabolism (1969) (186)
Effects of derivatives of adenosine 3',5'-phosphate on liver slices and intact animals. (1967) (186)
Effects of glucagon on adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in human plasma and urine. (1970) (181)
The effect of vasopressin and of theophylline on the concentration of adenosine 3',5'-phosphate in the urinary bladder of the toad. (1965) (177)
The effect of epinephrine and other agents on adenyl cyclase in the cell membrane of avian erythrocytes. (1966) (158)
Effects of catecholamines and adrenergic-blocking agents on plasma and urinary cyclic nucleotides in man. (1972) (155)
The stimulatory effect of luteinizing hormone on adenosine 3',5'-monophosphate accumulation in corpus luteum slices. (1966) (155)
Adenyl cyclase. II. The enzymatically catalyzed formation of adenosine 3',5'-phosphate and inorganic pyrophosphate from adenosine triphosphate. (1962) (147)
Formation and release of a hormone antagonist by rat adipocytes. (1971) (145)
Inactivation and Activation of Liver Phosphorylase (1955) (142)
USE OF LIVER ADENYL CYCLASE FOR ASSAY OF GLUCAGON IN HUMAN GASTRO-INTESTINAL TRACT AND PANCREAS. (1964) (126)
The effect of serotonin (5-hydroxytryptamine) on the formation of adenosine 3',5'-phosphate by tissue particles from the liver fluke, Fasciola hepatica. (1960) (123)
THE EFFECTS OF THE CATECHOLAMINES, ADRENERGIC BLOCKING AGENTS, PROSTAGLANDIN E1, AND INSULIN ON CYCLIC AMP LEVELS IN THE RAT EPIDIDYMAL FAT PAD IN VITRO * (1967) (116)
[26] Polysaccharide phosphorylase, liver: Polysaccharide + P ⥂ G-1-P☆ (1955) (113)
Effects of some hormonal and other factors on the excretion of guanosine 3',5'-monophosphate and adenosine 3',5'-monophosphate in rat urine. (1969) (112)
Detergent-dispersed adenylate cyclase from rat brain. Effects of fluoride, cations, and chelators. (1973) (112)
Cyclic AMP. (1968) (109)
The role of cyclic AMP in hormone actions. (1968) (108)
EXTRACELLULAR CYCLIC NUCLEOTIDES * (1971) (105)
THE FORMATION AND METABOLISM OF CYCLIC GMP * (1971) (101)
Immunological differences of phosphorylases. (1957) (100)
Preparation of derivatives of adenosine 3′,5′-phosphate (1967) (91)
Influence of insulin preparations on glycogenolysis in liver slices. (1948) (91)
On the biological role of cyclic AMP. (1970) (90)
A new enzymatic assay for guanosine 3':5'-cyclic monophosphate and its application to the ductus deferens of the rat. (1973) (89)
Analysis of adenosine 3',5'-monophosphate with luciferase luminescence. (1970) (87)
Origin and distribution of the hyperglycemic-glycogenolytic factor of the pancreas. (1948) (83)
Measurement of guanosine 3',5'-monophosphate and other cyclic nucleotides. Variations in urinary excretion with hormonal state of the rat. (1966) (83)
Mechanism of the phosphoglyceric mutase reaction. (1949) (78)
The role of cyclic adenylic acid in hormone action. (1960) (74)
Enzymes of cyclic nucleotide metabolism in invertebrate and vertebrate sperm. (1976) (70)
Displacement of phenytoin from plasma binding sites by salicylate (1980) (64)
EFFECTS OF PHOSPHODIESTERASE INHIBITORS ON CYCLIC AMP LEVELS AND ON LIPOLYSIS * (1971) (64)
Adenosine 3':5'-monophosphate content and actions in the division cycle of synchronized HeLa cells (1976) (62)
POLYSACCHARIDE SYNTHESIS FROM GLUCOSE BY MEANS OF PURIFIED ENZYMES (1942) (59)
The regulatory role of adenosine-3', 5'-phosphate. (1961) (58)
Effect of epinephrine on cyclic adenosine 3',5'-phosphate and hexose phosphates in intestinal smooth muscle. (1966) (56)
THE EFFECT OF THE HYPERGLYCEMIC FACTOR AND EPINEPHRINE ON ENZYME SYSTEMS OF LIVER AND MUSCLE (1951) (55)
Effects of guanosine 3',5'-monophosphate on the perfused rat liver. (1971) (53)
The effect of the hyperglycemic factor and epinephrine on enzyme systems of liver and muscle. (1951) (53)
Effects of methylxanthines on adenosine 3',5'-monophosphate and corticosterone in the rat adrenal. (1973) (50)
CYCLIC AMP AND THE FUNCTION OF EUKARYOTIC CELLS: AN INTRODUCTION (1971) (47)
V. CATECHOLAMINES CYCLIC AMP‐ANGIOTENSIN RECEPTORS: Sympathin E, Sympathin I, and the Intracellular Level of Cyclic AMP (1970) (47)
CHAPTER 2 – Cyclic AMP and Hormone Action (1971) (46)
The mechanism of the phosphoglucomutase reaction. (1949) (44)
The assay of glucagon and epinephrine with use of liver homogenates. (1957) (43)
A cyclic 3',5'-nucleotide phosphodiesterase from heart with specificity for uridine 3',5'-phosphate. (1965) (43)
Activation of phosphoglucomutase by metal-binding agents. (1949) (38)
The interconversion of phosphorylase a and phosphorylase b from dog heart muscle. (1956) (33)
Observations on the action of certain sulfonylurea derivatives. (1956) (33)
The mechanism of action of phosphoglucomutase and phosphoglyceric acid mutase. (1949) (32)
On the development and properties of the brain adenyl cyclase system. (1970) (28)
Regulation of protein kinase and phosphoprotein phosphatase by cyclic AMP and cyclic AMP antagonist (1975) (27)
Hormonal effects on extracellular cyclic nucleotides in man. (1970) (26)
A comparison of cyclic nucleotide levels in plasma and cells of rat and human blood. (1974) (24)
Action of feedback regulator on adenylate cyclase. (1975) (24)
ADENYL CYCLASE AND HORMONE ACTION (1965) (21)
Adenyl cylase. I. Distribution, preparation, and properties. (1962) (21)
The Role of Adenosine 3′,5′-monophosphate in Hormone Action (1967) (20)
Increased release of amino acids from rat thymus after cortisol administration. (1967) (20)
THE ENZYMATIC CONVERSION OF GLUCOSE-6-PHOSPHATE TO GLYCOGEN (1941) (19)
[50] Enzymes concerned with interconversion of liver phosphorylases (1962) (19)
The effect of the hyperglycemic factor of the pancreas and of the epinephrine on glycogenolys. (1950) (19)
Apparent multiple forms of cyclic AMP phosphodiesterase from rat erythrocytes (1976) (16)
Cellular levels of feedback regulator of adenylate cyclase and the effect of epinephrine and insulin. (1975) (15)
Formation of adenosine-3,5-phosphate (cyclic adenylate) and its relation to the action of several neurohormones or hormones. (1960) (15)
Action of epinephrine and norepinephrine in broken cell preparations. (1959) (14)
Cyclic nucleotides. (1971) (14)
Altered metabolism of DNA in rat thymus, and early response to cortisol. (1967) (13)
Presence of a glucagon-like material in blood of man and dog. (1958) (12)
Phenytoin toxicity and blood levels after a large oral dose. (1980) (12)
cAMP-mediated feedback regulation in target cells. (1975) (11)
Synthesis and Secretion of Gammaglobulin by Lymph Node Cells: The Acquisition of Carbohydrate Residues of Immunoglobulin in Relation to Interchain Disulfide Bond Formation (1972) (11)
Concepts for the rational selection of assays to be used in monitoring therapeutic drugs. (1975) (9)
On the relation of cyclic AMP to adrenergic receptors and sympathin. (1971) (8)
Activation by "feedback regulator" and some properties of guanylate cyclase of plasma membrane of rat epididymal fat cells. (1976) (8)
Preparation of particulate and detergent-dispersed adenylate cyclase from brain. (1974) (7)
Synthesis and secretion of gamma-globulin by lymph node cells, VIII. Order of synthesis of the interchain disulfide linkages of immunoglobulins. (1970) (7)
Hydrolysis of guanosine and adenosine 3',5'-monophosphates by rat blood. (1975) (6)
CHAPTER 9 – Cyclic Nucleotides and Smooth Muscle Function* (1973) (6)
Cyclic GMP: Vestige or Another Intracellular Messenger? (1974) (6)
Medication problems handled by a consumer-oriented drug information center. (1982) (5)
Preparation and characterization of a hormone antagonist from adipocytes. (1975) (5)
The contribution of laboratory medicine to clinical pharmacology. (1975) (5)
A glycogenolytic factor from pancreas. (1948) (3)
Cyclic AMP and Steroidogenesis (1971) (2)
Influence of insulin on glycogen synthesis and breakdown in liver slices. (1947) (1)
CHAPTER 4 – The Catecholamines (1972) (1)
The formation of adenosine 3 ,5 -phosphate (1964) (0)
Action ofFeedback Regulator onAdenylate Cyclase (plasma membrane/adipocytes/inembrane phosphorylation/adenosine 5'-(8,-y-imino)triphosphate/ adenosine 5'-(a,#-methylene)triphosphate) (1975) (0)
FORMATION DE ADENOSINA-3', 5'-PHOSPHATO (ADENYLATO CYCLIC) E SU RELATION AL ACTION DE PLURE NEUROHORMONES O HORMONES (1960) (0)
Synthesis and secretion of gammaglobulin by lymph node cells: the acquisition of carbohydrate residues of immunoglobulin in relation to interchain disulfide bond formation (heavy and light chains-murine myeloma-mannose-glucosamine-galactose). (1972) (0)
Comparative Aspects of the Metabolism and Distribution of Cyclic AMP and Cyclic GMP (1972) (0)
THE FOURTH FEODOR LYNEN LECTURE: My Life and Cyclic AMP (1973) (0)
1966 Annual Meeting program and abstracts (1966) (0)
to Be Used in MonitoringTherapeuticDrugs (1975) (0)
The order of synthesis of the interchain disulfide linkages of immuno- globulins, in vitro, abstr. (1970) (0)
A NEW ENZYME OF RNA SYNTHESIS: RNA METHYLASE* (0)
DISCUSSION (1971) (0)
序 (Cyclic AMP(adenosine-3',5'-monophosphate)) (1970) (0)

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