Hilal Lashuel
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Researcher ORCID ID = 0000-0002-3737-1054
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Hilal Lashuelbiology Degrees
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Biochemistry
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Biology
Hilal Lashuel's Degrees
- PhD Biochemistry University of California, San Francisco
- Bachelors Biochemistry University of California, Berkeley
Why Is Hilal Lashuel Influential?
(Suggest an Edit or Addition)According to Wikipedia, Hilal Lashuel is an American-Yemeni neuroscientist and chemist, currently an associate professor at the EPFL . His research focuses on protein misfolding and aggregation in the pathogenesis of Alzheimer's and Parkinson's diseases.
Hilal Lashuel's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Neurodegenerative disease: Amyloid pores from pathogenic mutations (2002) (1266)
- The many faces of α-synuclein: from structure and toxicity to therapeutic target (2012) (1233)
- The UCH-L1 Gene Encodes Two Opposing Enzymatic Activities that Affect α-Synuclein Degradation and Parkinson's Disease Susceptibility (2002) (816)
- Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils. (2002) (796)
- A century-old debate on protein aggregation and neurodegeneration enters the clinic (2006) (656)
- α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, and Escherichia coli Exists Predominantly as Disordered Monomer* (2012) (480)
- Amyloidogenic protein-membrane interactions: mechanistic insight from model systems. (2010) (451)
- Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins? (2006) (400)
- Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein* (2008) (313)
- Inhibiting transthyretin amyloid fibril formation via protein stabilization. (1996) (309)
- The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration (2020) (302)
- Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies. (2010) (271)
- Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits α-Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions (2010) (261)
- Quaternary Structure, Protein Dynamics, and Synaptic Function of SAP97 Controlled by L27 Domain Interactions (2004) (254)
- Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. (2003) (246)
- Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores. (2003) (241)
- The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states. (2007) (232)
- Amyloid-β Aggregates Cause Alterations of Astrocytic Metabolic Phenotype: Impact on Neuronal Viability (2010) (232)
- The Ratio of Monomeric to Aggregated Forms of Aβ40 and Aβ42 Is an Important Determinant of Amyloid-β Aggregation, Fibrillogenesis, and Toxicity* (2008) (219)
- Highly efficient and chemoselective peptide ubiquitylation. (2009) (212)
- Protofilaments, filaments, ribbons, and fibrils from peptidomimetic self-assembly: implications for amyloid fibril formation and materials science. (2000) (212)
- Phosphorylation of Synucleins by Members of the Polo-like Kinase Family* (2009) (210)
- Preparation and characterization of toxic Aβ aggregates for structural and functional studies in Alzheimer's disease research (2010) (204)
- Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation. (1998) (195)
- The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells. (2014) (192)
- Inhibiting transthyretin conformational changes that lead to amyloid fibril formation. (1998) (184)
- Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease. (2008) (179)
- Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease. (2004) (177)
- Structural properties of pore-forming oligomers of alpha-synuclein. (2009) (172)
- Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method. (2012) (165)
- Transthyretin quaternary and tertiary structural changes facilitate misassembly into amyloid. (1997) (165)
- A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization. (2003) (163)
- Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo (2013) (160)
- Dissociation of amyloid fibrils of α-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities (2003) (160)
- Half a century of amyloids: past, present and future. (2020) (159)
- The most pathogenic transthyretin variant, L55P, forms amyloid fibrils under acidic conditions and protofilaments under physiological conditions. (1999) (158)
- Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site for oligomerization. (1998) (147)
- c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease. (2014) (146)
- The H50Q Mutation Enhances α-Synuclein Aggregation, Secretion, and Toxicity* (2014) (145)
- The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation. (2012) (143)
- Aβ42 Neurotoxicity Is Mediated by Ongoing Nucleated Polymerization Process Rather than by Discrete Aβ42 Species* (2010) (141)
- New class of inhibitors of amyloid-beta fibril formation. Implications for the mechanism of pathogenesis in Alzheimer's disease. (2002) (139)
- The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease (2017) (137)
- A glimpse of a possible amyloidogenic intermediate of transthyretin (2000) (136)
- Glycation potentiates &agr;-synuclein-associated neurodegeneration in synucleinopathies (2017) (136)
- Characterization of Semisynthetic and Naturally Nα-Acetylated α-Synuclein in Vitro and in Intact Cells (2012) (135)
- Alpha-synuclein Post-translational Modifications as Potential Biomarkers for Parkinson Disease and Other Synucleinopathies (2013) (133)
- Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces (2018) (133)
- Novel mechanistic insight into the molecular basis of amyloid polymorphism and secondary nucleation during amyloid formation. (2013) (133)
- Complete inhibition of Cdk/cyclin by one molecule of p21(Cip1). (1998) (132)
- Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization. (2015) (130)
- Abeta protofibrils possess a stable core structure resistant to hydrogen exchange. (2003) (128)
- Branched KLVFF Tetramers Strongly Potentiate Inhibition of β‐Amyloid Aggregation (2007) (123)
- Entacapone and Tolcapone, Two Catechol O-Methyltransferase Inhibitors, Block Fibril Formation of α-Synuclein and β-Amyloid and Protect against Amyloid-induced Toxicity* (2010) (122)
- Oxidative and nitrative alpha‐synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies (2013) (121)
- Parkinson’s Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein (2015) (117)
- Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology (2013) (115)
- Inhibition of α-Synuclein Fibrillization by Dopamine Is Mediated by Interactions with Five C-Terminal Residues and with E83 in the NAC Region (2008) (112)
- Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors. (2002) (111)
- α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson’s disease (2019) (110)
- Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis. (2015) (110)
- Nanoscale studies link amyloid maturity with polyglutamine diseases onset (2016) (106)
- Towards elucidation of the role of ubiquitination in the pathogenesis of Parkinson's disease with semisynthetic ubiquitinated α-synuclein. (2011) (105)
- Guanidine hydrochloride-induced denaturation and refolding of transthyretin exhibits a marked hysteresis: equilibria with high kinetic barriers. (1997) (101)
- Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation (2017) (99)
- Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125. (2012) (98)
- Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death (2015) (95)
- Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes (2017) (93)
- Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors (2011) (93)
- E46K Parkinson's-linked mutation enhances C-terminal-to-N-terminal contacts in alpha-synuclein. (2009) (91)
- Phosphorylation of α-Synuclein at Y125 and S129 alters its metal binding properties: implications for understanding the role of α-Synuclein in the pathogenesis of Parkinson's Disease and related disorders. (2011) (86)
- Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson’s disease (2016) (86)
- Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-β (2005) (86)
- Lead (Pb) exposure and its effect on APP proteolysis and Aβ aggregation (2005) (85)
- Identification and Characterization of Novel Classes of Macrophage Migration Inhibitory Factor (MIF) Inhibitors with Distinct Mechanisms of Action* (2010) (84)
- Health hazards of methylammonium lead iodide based perovskites: cytotoxicity studies. (2016) (84)
- Reverse engineering Lewy bodies: how far have we come and how far can we go? (2021) (80)
- Combined multi-plane phase retrieval and super-resolution optical fluctuation imaging for 4D cell microscopy (2017) (80)
- Stable α-Synuclein Oligomers Strongly Inhibit Chaperone Activity of the Hsp70 System by Weak Interactions with J-domain Co-chaperones* (2010) (79)
- Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection (2017) (79)
- The anti-Parkinsonian drug selegiline delays the nucleation phase of α-synuclein aggregation leading to the formation of nontoxic species. (2011) (78)
- Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model (2010) (77)
- Role of post-translational modifications in modulating the structure, function and toxicity of α-synuclein (2010) (75)
- Parkinson’s Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein (2015) (75)
- Mimicking Phosphorylation at Serine 87 Inhibits the Aggregation of Human α-Synuclein and Protects against Its Toxicity in a Rat Model of Parkinson's Disease (2012) (74)
- Murine apolipoprotein serum amyloid A in solution forms a hexamer containing a central channel (2002) (72)
- Amyloidogenic Protein—Membrane Interactions: Mechanistic Insight from Model Systems (2010) (69)
- C-abl Phosphorylates Alpha-synuclein And Regulates Its Degradation, Implication For Alpha-synuclein Clearance And Contribution To The Pathogenesis Of Parkinson's Disease (2014) (68)
- Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths (2017) (68)
- Hsp104 targets multiple intermediates on the amyloid pathway and suppresses the seeding capacity of Abeta fibrils and protofibrils. (2008) (67)
- How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology (2020) (65)
- Hydration and packing are crucial to amyloidogenesis as revealed by pressure studies on transthyretin variants that either protect or worsen amyloid disease. (2003) (65)
- Do Lewy bodies contain alpha-synuclein fibrils? and Does it matter? A brief history and critical analysis of recent reports (2020) (64)
- Chemical Synthesis and Expression of the HIV‐1 Rev Protein (2011) (63)
- Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils (2018) (62)
- Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States. (2018) (61)
- Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity (2020) (61)
- Parkinson Disease Mutant E46K Enhances α-Synuclein Phosphorylation in Mammalian Cell Lines, in Yeast, and in Vivo* (2015) (57)
- A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor. (2009) (57)
- Disruption of Amyloid‐Derived Peptide Assemblies through the Controlled Induction of a β‐Sheet to α‐Helix Transformation: Application of the Switch Concept (2007) (57)
- Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6. (2017) (51)
- Structure and function of the molecular chaperone Hsp104 from yeast. (2010) (51)
- Discovery and Structure Activity Relationship of Small Molecule Inhibitors of Toxic β-Amyloid-42 Fibril Formation* (2012) (50)
- Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta. (2005) (49)
- Membrane scission driven by the PROPPIN Atg18 (2017) (49)
- The nucleation of monomeric parallel beta-sheet-like structures and their self-assembly in aqueous solution. (1999) (49)
- N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting (2018) (48)
- Nuclear import factors importin α and importin β undergo mutually induced conformational changes upon association (2000) (48)
- Dopamine affects the stability, hydration, and packing of protofibrils and fibrils of the wild type and variants of alpha-synuclein. (2007) (48)
- Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations. (2016) (47)
- Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson’s Disease (2015) (46)
- Membrane permeabilization: a common mechanism in protein-misfolding diseases. (2005) (45)
- The conformational flexibility of the carboxy terminal residues 105-114 is a key modulator of the catalytic activity and stability of macrophage migration inhibitory factor. (2008) (44)
- One-pot semisynthesis of exon 1 of the Huntingtin protein: new tools for elucidating the role of posttranslational modifications in the pathogenesis of Huntington's disease. (2014) (43)
- Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation (2017) (42)
- A user's guide for α‐synuclein biomarker studies in biological fluids: Perianalytical considerations (2017) (42)
- Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease (2021) (40)
- Structural Properties of Pore-Forming Oligomers of r-Synuclein (2009) (39)
- Dissecting the mechanisms of tissue transglutaminase-induced cross-linking of alpha-synuclein: implications for the pathogenesis of Parkinson disease. (2009) (39)
- Parkin Deficiency Delays Motor Decline and Disease Manifestation in a Mouse Model of Synucleinopathy (2009) (39)
- Real-Time In Situ Secondary Structure Analysis of Protein Monolayer with Mid-Infrared Plasmonic Nanoantennas (2018) (37)
- Microtubule-Binding R3 Fragment from Tau Self-Assembles into Giant Multistranded Amyloid Ribbons. (2016) (36)
- Switch peptide via Staudinger reaction. (2008) (36)
- Antibody‐based methods for the measurement of α‐synuclein concentration in human cerebrospinal fluid – method comparison and round robin study (2018) (35)
- Site‐Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding† (2019) (33)
- Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM (2019) (32)
- Rescuing defective vesicular trafficking protects against alpha-synuclein toxicity in cellular and animal models of Parkinson's disease. (2006) (32)
- One-pot total chemical synthesis of human α-synuclein. (2013) (31)
- Switch-peptides as folding precursors in self-assembling peptides and amyloid fibrillogenesis. (2009) (31)
- Recombinant human retinol-binding protein refolding, native disulfide formation, and characterization. (1998) (31)
- An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation* (2016) (31)
- Interactions among α-synuclein, dopamine, and biomembranes (2007) (29)
- Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease (2015) (29)
- Real-time amyloid aggregation monitoring with a photonic crystal-based approach. (2013) (28)
- Chemical strategies for controlling protein folding and elucidating the molecular mechanisms of amyloid formation and toxicity. (2012) (27)
- A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of α-synuclein monomers, oligomers and fibrils: towards improving experimental reproducibility in α-synuclein research (2019) (26)
- Exploring the role of post‐translational modifications in regulating α‐synuclein interactions by studying the effects of phosphorylation on nanobody binding (2018) (26)
- Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin Binding (2019) (26)
- Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models (2017) (25)
- The materials science of protein aggregation (2005) (25)
- Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay (2019) (24)
- Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity? (2021) (24)
- In vitro preparation of prefibrillar intermediates of amyloid-beta and alpha-synuclein. (2005) (23)
- Nuclear import factors importin alpha and importin beta undergo mutually induced conformational changes upon association. (2000) (23)
- New Class of Inhibitors of Amyloid-β Fibril Formation (2002) (23)
- TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models (2020) (23)
- A simple, versatile and robust centrifugation‐based filtration protocol for the isolation and quantification of α‐synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in α‐synuclein research (2020) (23)
- From hexamer to amyloid: Marginal stability of apolipoprotein SAA2.2 leads to in vitro fibril formation at physiological temperature (2005) (22)
- Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties (2020) (21)
- Switch‐Peptides: Design and Characterization of Controllable Super‐Amyloid‐Forming Host–Guest Peptides as Tools for Identifying Anti‐Amyloid Agents (2008) (21)
- A42 Neurotoxicity Is Mediated by Ongoing Nucleated Polymerization Process Rather than by Discrete (2011) (21)
- Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies. (2021) (21)
- Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology (2019) (21)
- Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein. (2016) (20)
- E 46 K Parkinson ’ sLinked Mutation Enhances C-Terminal-toN-Terminal Contacts in α-Synuclein (2009) (19)
- Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on threonine 3 and regulation by IKKβ. (2015) (19)
- Switch-peptides: from conformational studies to Alzheimer's disease (2006) (18)
- Parkinson mice show functional and molecular changes in the gut long before motoric disease onset (2020) (17)
- Amyloid single-cell cytotoxicity assays by nanomotion detection (2017) (17)
- Amyloid fibril formation by macrophage migration inhibitory factor. (2005) (17)
- Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration. (2021) (17)
- The process of Lewy body formation, rather than simply alpha-synuclein fibrillization, is the major driver of neurodegeneration in synucleinopathies (2019) (16)
- Hypoxia Conditioning as a Promising Therapeutic Target in Parkinson's Disease? (2021) (16)
- An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity. (2010) (16)
- Molecular electron microscopy approaches to elucidating the mechanisms of protein fibrillogenesis. (2005) (16)
- Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau (2020) (15)
- Molecular mechanisms for neurodegeneration (2013) (15)
- Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson’s disease and other synucleinopathies (2022) (15)
- Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy (2018) (14)
- Disentangling the sequence, cellular and ultrastructural determinants of Huntingtin nuclear and cytoplasmic inclusion formation (2020) (13)
- The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus (2019) (13)
- Structural differences of amyloid-β fibrils revealed by antibodies from phage display (2015) (12)
- Structure and Function of the Molecular Chaperone Hsp 104 from Yeast (2009) (12)
- Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket (2012) (11)
- Kinetic-Based High-Throughput Screening Assay to Discover Novel Classes of Macrophage Migration Inhibitory Factor Inhibitors (2010) (11)
- Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13. (2020) (11)
- Monitoring alpha‐synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get (2020) (11)
- Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction. (2012) (10)
- Switch-peptides as folding precursors in self-assembling peptides and amyloid fibrillogenesis. (2007) (10)
- The busy lives of academics have hidden costs — and universities must take better care of their faculty members (2020) (9)
- Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates (2021) (9)
- Discovery of a novel aggregation domain in the huntingtin protein: implications for the mechanisms of Htt aggregation and toxicity. (2013) (9)
- Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: what you see is not always what you get (2020) (8)
- The Nt17 domain and its helical conformation regulate the aggregation, cellular properties and neurotoxicity of mutant huntingtin exon 1. (2021) (8)
- A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity (2022) (8)
- Pronounced α-Synuclein Pathology in a Seeding-Based Mouse Model Is Not Sufficient to Induce Mitochondrial Respiration Deficits in the Striatum and Amygdala (2020) (8)
- A New Caged‐Glutamine Derivative as a Tool To Control the Assembly of Glutamine‐Containing Amyloidogenic Peptides (2016) (8)
- Mental Health in Academia: What about faculty? (2020) (8)
- Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease (2017) (7)
- What about faculty? (2020) (7)
- Site‐Specific Phosphorylation of Huntingtin Exon 1 Recombinant Proteins Enabled by the Discovery of Novel Kinases (2020) (7)
- A New Chemoenzymatic Semisynthetic Approach Provides Insight into the Role of Phosphorylation beyond Exon1 of Huntingtin and Reveals N-Terminal Fragment Length-Dependent Distinct Mechanisms of Aggregation. (2021) (7)
- Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice (2013) (7)
- Site-specific phosphorylation of Huntingtin exon 1 recombinant proteins enabled by the discovery of novel kinases (2020) (7)
- Amyloids Go Genomic: Insights Regarding the Sequence Determinants of Prion Formation from Genome‐Wide Studies (2009) (6)
- To target Tau pathologies, we must embrace and reconstruct their complexities (2021) (6)
- Alpha‐Synuclein oligomerization and aggregation: All models are useful but only if we know what they model (2020) (6)
- Reactive oxidative species enhance amyloid toxicity in APP/PS1 mouse neurons (2012) (6)
- Phosphorylation of α-Synuclein at Y 125 and S 129 Alters Its Metal Binding Properties : Implications for Understanding the Role of α-Synuclein in the Pathogenesis of Parkinson ’ s Disease and Related Disorders (2011) (6)
- Dissecting the Mechanisms of Tissue Transglutaminase-induced Cross-linking of α-Synuclein (2009) (6)
- Structural Basis of Huntingtin Fibril Polymorphism Revealed by Cryogenic Electron Microscopy of Exon 1 HTT Fibrils. (2022) (5)
- Pathological substrate of memory impairment in multiple system atrophy (2022) (5)
- The Nt17 domain and its helical conformation regulate the aggregation, cellular properties and neurotoxicity of mutant huntingtin exon 1 (2021) (5)
- Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease (2021) (5)
- Site‐Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding (2020) (5)
- Disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation: application of the switch concept. (2007) (5)
- Establishing the links between Aβ aggregation and cytotoxicity in vitro using biophysical approaches. (2012) (4)
- Towards deciphering the Nt17 code: How the sequence and conformation of the first 17 amino acids in Huntingtin regulate the aggregation, cellular properties and neurotoxicity of mutant Httex1 (2021) (4)
- Pathological Relevance of Post-Translationally Modified Alpha-Synuclein (pSer87, pSer129, nTyr39) in Idiopathic Parkinson’s Disease and Multiple System Atrophy (2022) (4)
- Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology: How specific are the conformation-specific α-synuclein antibodies? (2020) (4)
- Arab world needs its science diaspora (2011) (3)
- Comparative Analysis of Total Alpha-Synuclein (αSYN) Immunoassays Reveals That They Do Not Capture the Diversity of Modified αSYN Proteoforms (2022) (3)
- Investigating Crosstalk Among PTMs Provides Novel Insight Into the Structural Basis Underlying the Differential Effects of Nt17 PTMs on Mutant Httex1 Aggregation (2021) (3)
- Neighbouring modifications interfere with the detection of phosphorylated alpha-synuclein at Serine 129: Revisiting the specificity of pS129 antibodies (2022) (3)
- Cover Picture: Real‐time Amyloid Aggregation Monitoring with a Photonic Crystal‐based Approach (ChemPhysChem 15/2013) (2013) (3)
- A novel mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein fibrils and recapitulates its pathological diversity (2021) (3)
- Looking at the recent advances in understanding α-synuclein and its aggregation through the proteoform prism (2018) (3)
- Extent of N-terminus exposure by altered long-range interactions of monomeric alpha-synuclein determines its aggregation propensity (2019) (3)
- Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity (2022) (3)
- Fatal attraction – The role of hypoxia when alpha-synuclein gets intimate with mitochondria (2021) (3)
- Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-B $ (2005) (3)
- The structural basis of huntingtin (Htt) fibril polymorphism, revealed by cryo-EM of exon 1 Htt fibrils (2021) (3)
- Combined multi-plane phase retrieval and super-resolution optical fluctuation imaging for 4D cell microscopy (2018) (2)
- Lewy body-associated proteins: victims, instigators, or innocent bystanders? The case of AIMP2 and alpha-synuclein (2021) (2)
- TBK1 regulates autophagic clearance of soluble mutant huntingtin and inhibits aggregation/toxicity in different models of Huntington’s disease (2019) (2)
- Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases (2022) (2)
- Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein (2023) (2)
- Education and research are essential for lasting peace in Yemen (2020) (2)
- Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson’s disease and other synucleinopathies (2022) (2)
- Functional and molecular early enteric biomarkers for Parkinson’s disease in mice and men (2020) (2)
- Non-monotonic fibril surface occlusion by GFP tags from coarse-grained molecular simulations (2021) (2)
- Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders (2022) (2)
- Publisher Correction: Reverse engineering Lewy bodies: how far have we come and how far can we go? (2021) (2)
- Semaphorin 3E and Plexin-D1 Control Vascular Pattern Independently of Neuropilins (2005) (1)
- Islam: governments need to reform education and build a scientific culture (2006) (1)
- Novel chemical tools to facilitate the synthesis and control the folding and Self-assembly of amyloid-forming polypeptides (2011) (1)
- PERFORMANCE EVALUATION OF NEW ABSORBANCE-BASED ELISAS FOR MEASURING DIFFERENT ALPHA-SYNUCLEIN (A-SYN) SPECIES IN CSF AND PLASMA (2016) (1)
- Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease (2020) (1)
- Chronic corticosterone enhancement aggravates alpha-synuclein brain spreading pathology and substantia nigra neurodegeneration in mice (2018) (1)
- Remembering John Q Trojanowski, in his own words: A life dedicated to discovering building blocks and using them to build bridges of knowledge, collaboration, and discovery (2022) (1)
- Neuronal growth on high-aspect-ratio diamond nanopillar arrays for biosensing applications (2022) (1)
- Erratum to: Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies. (2021) (1)
- Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the unfolded protein response (UPR) in models of neurodegeneration (2020) (1)
- N-terminal mutant huntingtin deposition correlates with CAG repeat length and symptom onset, but not neuronal loss in Huntington's disease (2022) (1)
- Author Correction: Combined multi-plane phase retrieval and super-resolution optical fluctuation imaging for 4D cell microscopy (2018) (1)
- Protein kinase R dependent phosphorylation of α-synuclein regulates its membrane binding and aggregation (2022) (1)
- Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice (2013) (1)
- Semisynthesis and Total Chemical Synthesis of alpha-synuclein to study Post-Translational Modifications in Health and Disease (2011) (0)
- The America I believe in. (2017) (0)
- Label-free Identification of Protein Aggregates Using Deep Learning (2023) (0)
- Transthyretin conformational changes facilitate misassembly into amyloid: a new therapeutic strategy based on preventing the amyloidogenic conformational changes (1997) (0)
- Novel Mechanism-Based Inhibitors of Aβ Aggregation and Toxicity (2014) (0)
- O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology (2023) (0)
- Identification Of Post-translationally Modified Α-synuclein Protein In Biofluids Of Parkinson's Disease Patients Using A Targeted And Quantitative Mass Spectrometry Approach. (2014) (0)
- The Role of post-translational modification (phosphorylation) in modulating alpha-synuclein, structure, aggregation and toxicity (2009) (0)
- Crystal Structure of MIF L46A mutant (2012) (0)
- Remembering John Q Trojanowski, in his own words: A life dedicated to discovering building blocks and using them to build bridges of knowledge, collaboration, and discovery (2022) (0)
- Parkinson’s Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein (2023) (0)
- Reactive oxidative species enhance amyloid toxicity in APP/PS1 mouse neurons (2012) (0)
- Pre-proof Lewy body-associated proteins : Victims , instigators , or innocent bystanders ? The case of AIMP 2 and alpha-synuclein (2021) (0)
- Parkinson mice show functional and molecular changes in the gut long before motoric disease onset (2021) (0)
- Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease (2021) (0)
- One-pot Semisynthesis Of Exon1 Of The Mutant Huntingtin Protein: An Important Advance Towards Elucidating The Molecular And Structural Determinants Of Huntingtin's Aggregation And Toxicity (2014) (0)
- Author Correction: Combined multi-plane phase retrieval and super-resolution optical fluctuation imaging for 4D cell microscopy (2018) (0)
- A new perspective on the role of phosphorylation in Alzheimer’s and other tau pathologies (2020) (0)
- Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease (2021) (0)
- Synthesis of beta-sheet peptides and proteins incorporating templates (2002) (0)
- DissectingtheMechanismsofTissueTransglutaminase-induced Cross-linking of -Synuclein IMPLICATIONSFORTHEPATHOGENESISOFPARKINSONDISEASE * (2009) (0)
- Identification and Characterization of Novel Classes of Macrophage Migration Inhibitory Factor (MIF) Inhibitors (2010) (0)
- Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces (2018) (0)
- Mid-infrared plasmonic nanoantennas for protein structure detection (2017) (0)
- HARMONIZATION OF IMMUNOCHEMICAL METHODS FOR MEASUREMENT OF α-SYNUCLEIN IN HUMAN CEREBROSPINAL FLUID: A ROUND ROBIN STUDY APPROACH (2018) (0)
- Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes (2017) (0)
- Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models (2017) (0)
- Publisher Correction: Reverse engineering Lewy bodies: how far have we come and how far can we go? (2021) (0)
- Combined MultiPlane Tomographic Phase Retrieval and Stochastic Optical Fluctuation Imaging for 4 D Cell Microscopy (2017) (0)
- New Insights into Individual Amyloid Aggregates Structure by Infrared Nanospectroscopy (2015) (0)
- Chemical Biology of alpha-synuclein: The role post-translational modification in the pathogenesis of Parkinson's disease & related disorders (2011) (0)
- Post-fibrillization nitration of alpha-synuclein abolishes its seeding activity and pathology formation in primary neurons and in vivo (2023) (0)
- The role of PTM crosstalks in Httex1 structure, aggregation and membrane interaction (2022) (0)
- Microsoft Word-Fauvet and Lashuel et al JBC main text corrected abstract 07Feb12.docx (2012) (0)
- Correlative light and electron microscopy reveals that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease (2021) (0)
- N-terminal phosphorylation of Huntingtin: A molecular switch for regulating Htt aggregation, helical conformation, internalization and nuclear targeting (2018) (0)
- THE ANTI-PARKINSONIAN DRUG SELEGILINE (R(-)-DEPRENYL) INHIBITS THE NUCLEATION PHASE OF a-SYNUCLEIN AGGREGATION. (2008) (0)
- On demand nanoliter sampling probe for collection of brain fluid (2022) (0)
- Reverse engineering Lewy bodies: how far have we come and how far can we go? (2021) (0)
- 1A03 Mechanistic Studies Suggest A New Small Molecule Therapeutic Strategy For Intervention In Human Amyloid Disease (1997) (0)
- A new chemoenzymatic semisynthetic approach provides novel insight into the role of phosphorylation beyond exon1 of Huntingtin and reveals N-terminal fragment length-dependent distinct mechanisms of aggregation (2021) (0)
- Polyglutamine Length Dependent Structural Properties and Phase Behavior of Huntingtin Exon 1 (2017) (0)
- The E46K Parkinson’s-linked mutation enhances C- to N-terminal contacts in α -synuclein (2009) (0)
- Amyloid-Beta Modifies Astrocytic Metabolic Phenotype (2009) (0)
- Resolving heterogeneous biological processes with chemically specific infrared biosensors based on multi-resonant metasurfaces (2018) (0)
- Small molecule approaches to dissecting the role of quaternary structure and tautomerase activity in regulating the biological functions of Macrophage Migration Inhibitory Factor (MIF) (2010) (0)
- Agents anti-amyloidogenes (1997) (0)
- 1H and 15N Chemical Shift Assignments for wild-type alpha-synuclein (2018) (0)
- The 8th International Conference on Alzheimer's Disease and Related Disorders, July 20–25, 2002, Stockholm, Sweden (2003) (0)
- Amyloid Diseases : A Truly Emergent Phenomenon (2006) (0)
- Site-specific hyperphosphorylation of tau inhibits its fibrillization in vitro, blocks its seeding capacity in cells, and disrupts its microtubule binding; Implications for the native state stabilization of tau (2019) (0)
- Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity (2020) (0)
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Other Resources About Hilal Lashuel
What Schools Are Affiliated With Hilal Lashuel?
Hilal Lashuel is affiliated with the following schools:
- University of California, Berkeley
- Central South University
- National University of Rosario
- École Polytechnique Fédérale de Lausanne
- Federal University of Rio de Janeiro
- Stanford University
- Ben-Gurion University of the Negev
- Texas A&M University
- University of California, San Francisco
- Hamad Bin Khalifa University
- Harvard University
