Janet Rossant
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Biology
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Developmental Biology
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Biology
Janet Rossant's Degrees
- Bachelors Zoology University of Oxford
Why Is Janet Rossant Influential?
(Suggest an Edit or Addition)Janet Rossant is president and Science Director at Gairdner Foundation, a senior scientist in the developmental & stem cell biology program, chief of research at the Hospital for Sick Children Research Institute, university professor at the University of Toronto teaching molecular genetics, pediatrics, and obstetrics/gynecology. He is deputy scientific director for the Canadian Stem Cell Network and senior editor of the journal eLife. She earned a B.A. in zoology from the University of Oxford and a Ph.D. in mammalian development from the University of Cambridge.
Rossant uses live imaging, proteomics, genetic manipulation, and single-cell expression analysis to study human cell biology and development. Her work has advanced our understanding of the human genome, how stem cells and human embryos develop, how we treat congenital abnormalities, and how we use cancer drugs.
Her work on genes in embryo development is world-renowned. She contributed to the discovery of the trophoblast stem cell – a discovery that has helped doctors and scientists to better understand congenital abnormalities in the placenta, blood vessels, and heart. Much of her work has built on the use of gene manipulation in mouse embryos, which has yielded a better understanding of the human genome.
In 2015, she won the 2015 Gairdner Wightman Award. Most recently, she was among five honorees for the L’Oreal-UNESCO for Women in Science Award.
Featured in Top Influential Biologists Today
According to Wikipedia, Janet Rossant, is a developmental biologist well known for her contributions to the understanding of the role of genes in embryo development. She is a world renowned leader in developmental biology. Her current research interests focus on stem cells, molecular genetics, and developmental biology. Specifically, she uses cellular and genetic manipulation techniques to study how genes control both normal and abnormal development of early mouse embryos. Rossant has discovered information on embryo development, how multiple types of stem cells are established, and the mechanisms by which genes control development. In 1998, her work helped lead to the discovery of the trophoblast stem cell, which has assisted in showing how congenital anomalies in the heart, blood vessels, and placenta can occur.
Janet Rossant's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice (1995) (4133)
- Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium (1995) (2766)
- Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. (1993) (2446)
- Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis (2007) (1652)
- Promotion of trophoblast stem cell proliferation by FGF4. (1998) (1299)
- Cardiac malformation in neonatal mice lacking connexin43. (1995) (1294)
- Placental development: Lessons from mouse mutants (2001) (1241)
- Interaction between Oct3/4 and Cdx2 Determines Trophectoderm Differentiation (2005) (1189)
- Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst (2005) (1102)
- Characterization of human embryonic stem cell lines by the International Stem Cell Initiative (2007) (1041)
- Control of Effector CD8+ T Cell Function by the Transcription Factor Eomesodermin (2003) (1037)
- A Requirement for Flk1 in Primitive and Definitive Hematopoiesis and Vasculogenesis (1997) (973)
- HNF-3β is essential for node and notochord formation in mouse development (1994) (957)
- Endothelial cells and VEGF in vascular development (2005) (955)
- Retinoid Signaling Determines Germ Cell Fate in Mice (2006) (942)
- Notch1 is required for the coordinate segmentation of somites. (1995) (922)
- The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. (2009) (905)
- Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway. (2006) (852)
- Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon. (1999) (839)
- Liver Organogenesis Promoted by Endothelial Cells Prior to Vascular Function (2001) (814)
- Direct Neural Fate Specification from Embryonic Stem Cells A Primitive Mammalian Neural Stem Cell Stage Acquired through a Default Mechanism (2001) (794)
- fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation. (1994) (788)
- Embryonic stem cells alone are able to support fetal development in the mouse. (1990) (786)
- flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors. (1993) (758)
- Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis. (1991) (719)
- The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. (2010) (686)
- FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. (2001) (684)
- The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse (1996) (657)
- Conservation of the Notch signalling pathway in mammalian neurogenesis. (1997) (646)
- The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins. (1993) (629)
- Essential role of Mash-2 in extraembryonic development (1994) (621)
- Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse (2009) (583)
- Dosage-sensitive requirement for mouse Dll4 in artery development. (2004) (566)
- The organizer factors Chordin and Noggin are required for mouse forebrain development (2000) (561)
- The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. (1998) (533)
- The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells. (1995) (531)
- FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst (2010) (529)
- A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain. (1996) (521)
- Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo. (1992) (511)
- Baf60c is essential for function of BAF chromatin remodelling complexes in heart development (2004) (500)
- Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes. (1989) (496)
- Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage (2011) (489)
- Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. (1998) (487)
- Global Survey of Organ and Organelle Protein Expression in Mouse: Combined Proteomic and Transcriptomic Profiling (2006) (470)
- tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors. (1992) (441)
- A Mouse for All Reasons (2007) (420)
- Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2 (2010) (418)
- Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox. (1991) (414)
- High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene (1989) (412)
- Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-β (1997) (408)
- Spatial and temporal patterns of ERK signaling during mouse embryogenesis (2003) (403)
- Degree of methylation of transgenes is dependent on gamete of origin (1987) (403)
- HNF-3 beta is essential for node and notochord formation in mouse development. (1994) (402)
- The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo. (2001) (401)
- The role of FGF/Erk signaling in pluripotent cells (2010) (394)
- Genomic imprinting of Mash2, a mouse gene required for trophoblast development (1995) (388)
- Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts (2005) (371)
- Investigation of the fate of 4-5 day post-coitum mouse inner cell mass cells by blastocyst injection. (1979) (371)
- The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis. (1998) (362)
- The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis. (1999) (351)
- Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein (2012) (349)
- Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants. (1994) (349)
- The functional landscape of mouse gene expression (2004) (341)
- Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: a role for FGFR1 in morphogenetic movement through the primitive streak. (1997) (341)
- Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo. (2008) (340)
- Making the blastocyst: lessons from the mouse. (2010) (339)
- Inducible expression of an hsp68-lacZ hybrid gene in transgenic mice. (1989) (338)
- Stem Cells and Early Lineage Development (2008) (335)
- Cdx2 is essential for axial elongation in mouse development. (2004) (333)
- Regulation of a transcription factor network required for differentiation and metabolism. (1998) (330)
- Hallmarks of pluripotency (2015) (322)
- Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium (2001) (315)
- Setting Standards for Human Embryonic Stem Cells (2003) (311)
- Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency (2009) (307)
- Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts (2014) (301)
- Multiple developmental roles of VEGF suggested by a LacZ-tagged allele. (1999) (297)
- Contiguous patterns of c-kit and steel expression: analysis of mutations at the W and Sl loci. (1991) (294)
- Cell and molecular regulation of the mouse blastocyst (2006) (292)
- A mouse cerberus/Dan-related gene family. (1999) (291)
- Transgenic RNA interference in ES cell–derived embryos recapitulates a genetic null phenotype (2003) (291)
- Non-injection methods for the production of embryonic stem cell-embryo chimaeras (1993) (287)
- Molecular profiling of non-small cell lung cancer and correlation with disease-free survival. (2002) (285)
- Deletion of the selection cassette, but not cis-acting elements, in targeted Flk1-lacZ allele reveals Flk1 expression in multipotent mesodermal progenitors. (2006) (284)
- The mammalian gene function resource: the international knockout mouse consortium (2012) (277)
- Differences in DNA methylation during oogenesis and spermatogenesis and their persistence during early embryogenesis in the mouse. (1987) (274)
- Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse. (2003) (269)
- The mouse dystonia musculorum gene is a neural isoform of bullous pemphigoid antigen 1 (1995) (262)
- Global Chromatin Architecture Reflects Pluripotency and Lineage Commitment in the Early Mouse Embryo (2010) (261)
- Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR beta. (2001) (259)
- Bone sialoprotein plays a functional role in bone formation and osteoclastogenesis (2008) (255)
- Stem Cells from the Mammalian Blastocyst (2001) (250)
- Annual review of cell and developmental biology. (2007) (248)
- Genetic ablation: targeted expression of a toxin gene causes microphthalmia in transgenic mice. (1987) (246)
- Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse (1999) (246)
- Gene expression profiling of embryo-derived stem cells reveals candidate genes associated with pluripotency and lineage specificity. (2002) (245)
- Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. (1998) (236)
- A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia (2005) (233)
- Expression analysis of a Notch homologue in the mouse embryo. (1992) (229)
- Experimental approaches to mammalian embryonic development: Molecular and biochemical aspects (1987) (227)
- Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles (1998) (227)
- Vascular endothelial growth factor a signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival. (2006) (226)
- Evidence for novel fate of Flk1+ progenitor: Contribution to muscle lineage (2003) (225)
- Cell lineage-specific undermethylation of mouse repetitive DNA (1984) (224)
- FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse. (2001) (219)
- Mash2 acts cell autonomously in mouse spongiotrophoblast development. (1997) (217)
- Expression of the homeo box-containing gene En-2 delineates a specific region of the developing mouse brain. (1988) (216)
- FGF signaling through FGFR1 is required for olfactory bulb morphogenesis (2003) (215)
- Distinct histone modifications in stem cell lines and tissue lineages from the early mouse embryo (2010) (211)
- A transgene containing lacZ inserted into the dystonia locus is expressed in neural tube (1988) (208)
- Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells. (2008) (205)
- Comparison of defined culture systems for feeder cell free propagation of human embryonic stem cells (2010) (204)
- Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs. (2008) (203)
- A public gene trap resource for mouse functional genomics (2004) (203)
- Mouse Development: Patterning, Morphogenesis, and Organogenesis (2002) (201)
- Mouse embryonic chimeras: tools for studying mammalian development (2003) (201)
- Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus. (1993) (201)
- Signaling pathways in vascular development. (2002) (199)
- FGFR1 is independently required in both developing mid‐ and hindbrain for sustained response to isthmic signals (2003) (197)
- Foxh1 is essential for development of the anterior heart field. (2004) (194)
- Isolation and characterization of a novel trophoblast-specific cDNA in the mouse. (1988) (194)
- Cell-autonomous action of the testis-determining gene: Sertoli cells are exclusively XY in XX----XY chimaeric mouse testes. (1988) (192)
- Postimplantation development of blastomeres isolated from 4- and 8-cell mouse eggs. (1976) (191)
- Three-Dimensional Analysis of Vascular Development in the Mouse Embryo (2008) (190)
- The Hippo Pathway Member Nf2 Is Required for Inner Cell Mass Specification (2013) (188)
- Fibroblast growth factors in mammalian development. (1995) (187)
- A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung. (1992) (186)
- Efficient generation of targeted large insertions by microinjection into two-cell-stage mouse embryos (2018) (184)
- Transcriptome Analysis of Mouse Stem Cells and Early Embryos (2003) (183)
- Notch and hippo converge on Cdx2 to specify the trophectoderm lineage in the mouse blastocyst. (2014) (181)
- Anterior mesendoderm induces mouse Engrailed genes in explant cultures. (1993) (181)
- New Insights into Early Human Development: Lessons for Stem Cell Derivation and Differentiation. (2017) (180)
- Disorganized epithelial polarity and excess trophectoderm cell fate in preimplantation embryos lacking E-cadherin (2010) (180)
- Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells (1989) (176)
- Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development (2011) (173)
- Live imaging and genetic analysis of mouse notochord formation reveals regional morphogenetic mechanisms. (2007) (172)
- The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome (2003) (172)
- Genetic regulation of stem cell origins in the mouse embryo (2005) (172)
- What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast (2016) (168)
- Expression of the c-fms proto-oncogene and of the cytokine, CSF-1, during mouse embryogenesis. (1989) (168)
- Lineage allocation and asymmetries in the early mouse embryo. (2003) (167)
- Emerging asymmetry and embryonic patterning in early mouse development. (2004) (166)
- Rom-1 is required for rod photoreceptor viability and the regulation of disk morphogenesis (2000) (166)
- Expression of the T-box gene Eomesodermin during early mouse development (1999) (166)
- Expression of the fibroblast growth factor receptor FGFR-1/flg during gastrulation and segmentation in the mouse embryo. (1992) (162)
- Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryo (1990) (160)
- Potential of isolated mouse inner cell masses to form trophectoderm derivatives in vivo. (1979) (159)
- Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. (2007) (158)
- PRISM, a Generic Large Scale Proteomic Investigation Strategy for Mammals*S (2003) (158)
- Comparative systems biology of human and mouse as a tool to guide the modeling of human placental pathology (2009) (156)
- Cell autonomous functions of the receptor tyrosine kinase TIE in a late phase of angiogenic capillary growth and endothelial cell survival during murine development. (1996) (152)
- Interaction of the TEK and TIE receptor tyrosine kinases during cardiovascular development. (1999) (151)
- Production of completely ES cell-derived fetuses. (1993) (150)
- Mice lacking all isoforms of retinoic acid receptor β develop normally and are susceptible to the teratogenic effects of retinoic acid (1995) (148)
- Cell-Surface Proteomics Identifies Lineage-Specific Markers of Embryo-Derived Stem Cells (2012) (148)
- Heparan Sulfation–Dependent Fibroblast Growth Factor Signaling Maintains Embryonic Stem Cells Primed for Differentiation in a Heterogeneous State (2009) (143)
- Gata 3 regulates trophoblast development downstream of Tead 4 and in parallel to Cdx 2 (142)
- Polytene chromosomes in mouse trophoblast giant cells. (1988) (139)
- Functional Annotation of Mouse Genome Sequences (2001) (136)
- Analysis of mammalian gene function through broad based phenotypic screens across a consortium of mouse clinics (2015) (135)
- The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse (2005) (133)
- Regulation of flt‐1 expression during mouse embryogenesis suggests a role in the establishment of vascular endothelium (1996) (133)
- HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles (2014) (133)
- Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells. (2015) (132)
- "Cre"-ating mouse mutants-a meeting review on conditional mouse genetics. (1999) (131)
- Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos. (2011) (130)
- The mouse embryo autonomously acquires anterior-posterior polarity at implantation. (2006) (128)
- Stem cells and interspecies chimaeras (2016) (126)
- In situ detection of beta-galactosidase in lenses of transgenic mice with a gamma-crystallin/lacZ gene. (1987) (124)
- Progressive expression of trophoblast‐specific genes during formation of mouse trophoblast giant cells in vitro (1993) (123)
- The SH2 tyrosine phosphatase Shp2 is required for mammalian limb development (2000) (122)
- A large-scale gene-trap screen for insertional mutations in developmentally regulated genes in mice. (1995) (120)
- Lineage development and polar asymmetries in the peri-implantation mouse blastocyst. (2004) (120)
- Ability of outside cells from preimplantation mouse embryos to form inner cell mass derivatives. (1980) (120)
- Mouse mutants and cardiac development: new molecular insights into cardiogenesis. (1996) (119)
- Neural induction and patterning in the mouse in the absence of the node and its derivatives. (1999) (117)
- Stem cells and lineage development in the mammalian blastocyst. (2007) (116)
- Mouse and human blastocyst-derived stem cells: vive les differences (2015) (114)
- A repertoire of differentially expressed transcription factors that offers insight into mechanisms of human cytotrophoblast differentiation. (1999) (113)
- Chimeras and mosaics in mouse mutant analysis. (1998) (113)
- Baf60c is a nuclear Notch signaling component required for the establishment of left–right asymmetry (2007) (112)
- brg1: a putative murine homologue of the Drosophila brahma gene, a homeotic gene regulator. (1994) (111)
- Dynamic expression of Lrp2 pathway members reveals progressive epithelial differentiation of primitive endoderm in mouse blastocyst. (2008) (111)
- Distinct functions of BMP4 during different stages of mouse ES cell neural commitment (2010) (110)
- Characterization of murine decidual natural killer (NK) cells and their relevance to the success of pregnancy. (1985) (109)
- Position- and Hippo signaling-dependent plasticity during lineage segregation in the early mouse embryo (2017) (109)
- Genome engineering: the new mouse genetics (1995) (108)
- Efficient Generation of Germ Line Transmitting Chimeras from C57BL/6N ES Cells by Aggregation with Outbred Host Embryos (2010) (108)
- The developmental potential of a euploid male teratocarcinoma cell line after blastocyst injection. (1982) (106)
- Vascular Endothelial Growth Factor Directly Inhibits Primitive Neural Stem Cell Survival But Promotes Definitive Neural Stem Cell Survival (2006) (104)
- Identification of Two Regulatory Elements within the Promoter Region of the Mouse Connexin 43 Gene (*) (1995) (103)
- Genetic identification of tissue of origin of cellular populations within the mouse placenta. (1985) (101)
- Dissecting Wnt/β-catenin signaling during gastrulation using RNA interference in mouse embryos (2005) (100)
- The International Stem Cell Initiative: toward benchmarks for human embryonic stem cell research (2005) (99)
- The ISSCR Guidelines for Human Embryonic Stem Cell Research (2007) (99)
- Interspecific chimeras in mammals: successful production of live chimeras between Mus musculus and Mus caroli. (1980) (98)
- Undermethylation of structural gene sequences in extraembryonic lineages of the mouse. (1986) (98)
- A New Partner for the International Knockout Mouse Consortium (2007) (97)
- Local Active Suppression by Suppressor Cells in the Decidua: A Review (1984) (96)
- Cdx 2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo (2008) (96)
- Mechanism of size regulation in mouse embryo aggregates. (1982) (94)
- Investigation of the determinative state of the mouse inner cell mass. II. The fate of isolated inner cell masses transferred to the oviduct. (1975) (94)
- Early trophoblast determination and stem cell maintenance in the mouse--a review. (2004) (94)
- Parental origin-specific expression of Mash2 is established at the time of implantation with its imprinting mechanism highly resistant to genome-wide demethylation (1999) (92)
- Properties of extra-embryonic ectoderm isolated from postimplantation mouse embryos. (1977) (92)
- Disruption of early proximodistal patterning and AVE formation in Apc mutants (2006) (91)
- Phenotypic annotation of the mouse X chromosome. (2010) (91)
- Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives (2008) (91)
- The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation. (2004) (90)
- Cell fate decisions in early blood vessel formation. (2003) (89)
- Acellular Lung Scaffolds Direct Differentiation of Endoderm to Functional Airway Epithelial Cells: Requirement of Matrix-Bound HS Proteoglycans (2015) (88)
- Of fin and fur: mutational analysis of vertebrate embryonic development. (1992) (85)
- Immunoregulation of host-versus-graft responses in the uterus. (1984) (83)
- Implementing Large-Scale ENU Mutagenesis Screens in North America (2004) (82)
- ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update (2021) (82)
- Developmental differences in the expression of FGF receptors between human and mouse embryos. (2014) (81)
- Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis. (2010) (80)
- Intercellular interactions, position, and polarity in establishing blastocyst cell lineages and embryonic axes. (2012) (80)
- Ets2 is necessary in trophoblast for normal embryonic anteroposterior axis development (2006) (79)
- Towards a molecular-genetic analysis of mammalian development. (1989) (79)
- Identification of embryonic cell lineages in histological sections of M. musculus↔M. caroli chimaeras (1983) (77)
- Characterization of immune effector cells present in early murine decidua. (1985) (76)
- Myeloid expression of the human c-fps/fes proto-oncogene in transgenic mice (1990) (76)
- Molecular determinants of lung development. (2013) (76)
- The development potential of parthenogenetically derived cells in chimeric mouse embryos: implications for action of imprinted genes. (1988) (76)
- Trophoblast expression of fms-like tyrosine kinase 1 is not required for the establishment of the maternal–fetal interface in the mouse placenta (2003) (74)
- Magnetic resonance imaging for detection and analysis of mouse phenotypes (2005) (73)
- Characterization of a gene trap insertion into a novel gene, cordon-bleu, expressed in axial structures of the gastrulating mouse embryo. (1995) (73)
- Postaxial polydactyly in forelimbs of CRABP-II mutant mice. (1995) (72)
- Haploid mouse blastocysts developed from bisected zygotes (1976) (72)
- Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli (2008) (72)
- Alternative induced pluripotent stem cell characterization criteria for in vitro applications. (2009) (72)
- The Sweet Pee model for Sglt2 mutation. (2011) (70)
- Investigation of the potency of cells from the postimplantation mouse embryo by blastocyst injection: a preliminary report. (1978) (69)
- Evaluating totipotency using criteria of increasing stringency (2021) (69)
- A novel regulatory region is required for trophoblast-specific transcription in transgenic mice. (1995) (69)
- Development of the extraembryonic lineages (1995) (69)
- Investigation of the determinative state of the mouse inner cell mass. I. Aggregation of isolated inner cell masses with morulae. (1975) (69)
- Interspecific hybrids and chimeras in mice. (1983) (69)
- Debate ethics of embryo models from stem cells (2018) (68)
- BMP signaling induces visceral endoderm differentiation of XEN cells and parietal endoderm. (2012) (68)
- Histological and immunological studies of post implantation death of Mus caroli embryos in the Mus musculus uterus. (1982) (68)
- Integrated proteomic and transcriptomic profiling of mouse lung development and Nmyc target genes (2007) (68)
- Mash2 is expressed in oogenesis and preimplantation development but is not required for blastocyst formation (1998) (68)
- Genetic Control of Early Cell Lineages in the Mammalian Embryo. (2018) (67)
- The relationship between embryonic, embryonal carcinoma and embryo-derived stem cells. (1984) (67)
- Experimental approaches to mammalian embryonic development: Development of extraembryonic cell lineages in the mouse embryo (1987) (66)
- iPS Cells: Mapping the Policy Issues (2009) (66)
- Elements both 5′ and 3′ to the murine Hoxd4 gene establish anterior borders of expression in mesoderm and neurectoderm (1997) (65)
- Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening (2013) (65)
- Effect of culture conditions on diploid to giant-cell transformation in postimplantation mouse trophoblast. (1981) (63)
- A Novel In Vitro Model of Trophoblast-Mediated Decidual Blood Vessel Remodeling (2003) (62)
- Porcn-dependent Wnt signaling is not required prior to mouse gastrulation (2013) (62)
- Trophoblast-specific gene manipulation using lentivirus-based vectors. (2007) (61)
- Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells (2015) (60)
- Importance of trophoblast genotype for survival of interspecific murine chimaeras. (1982) (59)
- Suppressor cell activity in uterine decidua correlates with success or failure of murine pregnancies. (1983) (59)
- Characterization of Mouse Rsk4 as an Inhibitor of Fibroblast Growth Factor-RAS-Extracellular Signal-Regulated Kinase Signaling (2004) (59)
- Vascular development and patterning: making the right choices. (2003) (58)
- First Mouse Model for Combined Osteogenesis Imperfecta and Ehlers‐Danlos Syndrome (2014) (58)
- Interaction Domains of Sos1/Grb2 Are Finely Tuned for Cooperative Control of Embryonic Stem Cell Fate (2013) (58)
- Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos. (2008) (57)
- Mouse-based phenogenomics for modelling human disease. (2001) (57)
- Location of transient ectodermal progenitor potential in mouse development (2013) (56)
- Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia (2017) (56)
- The genetics of induced pluripotency. (2010) (54)
- Tead4 is constitutively nuclear, while nuclear vs. cytoplasmic Yap distribution is regulated in preimplantation mouse embryos (2012) (53)
- Crucial roles of Foxa2 in mouse anterior–posterior axis polarization via regulation of anterior visceral endoderm-specific genes (2007) (52)
- Long-term reconstitution of the mouse hematopoietic system by embryonic stem cell-derived fetal liver. (1991) (52)
- Zfp206 regulates ES cell gene expression and differentiation (2006) (52)
- Genome-wide analysis of mouse transcripts using exon microarrays and factor graphs (2005) (51)
- Effect of delaying DNA replication on blastocyst formation in the mouse. (1984) (51)
- The mouse Enhancer trap locus 1 (Etl-1): a novel mammalian gene related to Drosophila and yeast transcriptional regulator genes (1992) (51)
- Toward Guidelines for Research on Human Embryo Models Formed from Stem Cells (2020) (51)
- Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells (2018) (50)
- Retinoic acid signaling regulates murine bronchial tubule formation (2003) (50)
- The mammalian blastocyst (2016) (50)
- Connexin31-deficient trophoblast stem cells: a model to analyze the role of gap junction communication in mouse placental development. (2004) (50)
- Mouse trophoblast stem cells. (2006) (49)
- Translational Analysis of Mouse and Human Placental Protein and mRNA Reveals Distinct Molecular Pathologies in Human Preeclampsia* (2011) (48)
- Stem cells: The magic brew (2007) (48)
- Gap junctions are required for trophoblast proliferation in early human placental development. (2004) (48)
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- FGFR1 Is Not Essential For Lens Fiber Cell Differentiation in Mice (2002) (2)
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- DNA and General PCR Methods: Restriction Digests (2009) (1)
- Mammalian development : networks, switches, and morphogenetic processes (2013) (1)
- Impaired Fetal Lung Development can be Rescued by Administration of Extracellular Vesicles Derived from Amniotic Fluid Stem Cells (2020) (1)
- qPCR: avoiding signals in the no-template control (2011) (1)
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- Myh9 Q1443L Is a Novel Mouse Model of MYH9-Related Disorders (2010) (0)
- Revealing the mystery (2013) (0)
- Abstract 21487: A Translational Proteomics Analysis of the Blood-Tissue Interface in the Vascular Bed of the Mouse Placenta Identifies Markers of Human Vascular Diseases (2010) (0)
- Profile of Jeff Lichtman: Professor of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA (2010) (0)
- Genes for regeneration FoxA, an evolutionarily conserved gene involved in the development of the digestive system in many animals, has an important role in regeneration in flatworms. (2014) (0)
- S, POETHIG IS IN THE PLANT SCIENCE INSTITUTE, OEPARTMENT (1989) (0)
- Profile of Hugo Bellen (2013) (0)
- Profile of Marisa S. Bartolomei (2010) (0)
- DNA and General PCR Methods: Amplified Fragment Length Polymorphism (AFLP) (2010) (0)
- Profile of Mary E. Hatten (2010) (0)
- Profile of Carol Greider. (2011) (0)
- Profile of Thomas Sakmar: Senior Physician and Richard M. and Isabel P. Furlaud Professor, Laboratory of Molecular Biology and Biochemistry, The Rockefeller University, New York, NY, USA (2010) (0)
- DNA and general PCR methods: allele-specific PCR. (2010) (0)
- Profile of Janet Rossant (2012) (0)
- Determination in the mouse inner cell mass . II 993 (2008) (0)
- 5' RACE. (2012) (0)
- Profile of Angelika Amon (2013) (0)
- Protein Methods: Selecting the Best Epitope Tag (2009) (0)
- 転写因子EsrrbとCdx2による栄養膜幹（TS）細胞特異的遺伝子発現制御 (2015) (0)
- Macromolecular Crystallography; Cytokinesis Probes (2009) (0)
- The NIH and Economic Recovery (2009) (0)
- Drosophila Proteome; Exome Re-sequencing; Sequencing in Nanopores (2009) (0)
- Profile of David Botstein (2009) (0)
- Profile of Jeff Doyle (2018) (0)
- Interdisciplinary Success: Profile of Scott Diamond (2009) (0)
- Molecular biology techniques Q&A. Native PAGE: polymerization. (2011) (0)
- Scientists. Passion breeds opportunities. Crislyn D'Souza-Schorey. (2009) (0)
- Profile of Douglas Cyr (2018) (0)
- Profile of Eric Lander (2014) (0)
- Profile of David Reich (2013) (0)
- Abstracts of papers presented at the 1998 Workshop on Conditional Genetic Technologies in the Mouse, August 31-September 2, 1998 (1998) (0)
- Investigating the role of the Hippo pathway member Nf2 in trophectoderm/inner cell mass specification (2011) (0)
- Pattern formation and developmental mechanisms. (1992) (0)
- Profile of Sir Richard Roberts (2013) (0)
- Profile of Bruce Beutler (2013) (0)
- Corrigendum: Hallmarks of pluripotency (2015) (0)
- Climbing the Hill (2018) (0)
- Profile of Robert Clarke (2011) (0)
- of Flk1-deficient vascular progenitor cells Activated Fps/Fes partially rescues the in vivo developmental potential (2013) (0)
- Laser capture microdissection. (2014) (0)
- Insight Rossant p7-15 (2007) (0)
- Profile of James J. Collins (2012) (0)
- Troubleshooting forum. SDS-page. What is the best way to separate proteins of similar molecular weight? (Thread 33111). (2014) (0)
- C. elegans Interactome; Human Binary Interactome; Rat Genome (2008) (0)
- Clone selection in weakly adherent cells. (2011) (0)
- High fidelity qPCR (2013) (0)
- Anne McLaren (1927-2007) (2007) (0)
- Profile of Rudolf Jaenisch (2009) (0)
- Profile of Eric Green (2018) (0)
- 11-P015 A role for apical membrane polarization in the divergence of trophectoderm and inner cell mass lineages (2009) (0)
- In the service of humankind. Interview by Kristie Nybo. (2011) (0)
- Symposia Abstracts (2005) (0)
- Cell Migration Analysis Software: Starting from Scratch (2009) (0)
- RNA Methods: RNA Extraction from Plasma (2009) (0)
- Rapid and specific degradation of endogenous proteins in mouse models 1 using auxin-inducible degrons 2 3 (0)
- Retroviral transfection. (2012) (0)
- The 4311 spongiotrophoblasts-specific enhancer iscontrolled by placental factors other than mash-2 (1996) (0)
- Scientists. Excitement for a new era. (2014) (0)
- Retrospective. Anne McLaren (1927-2007). (2007) (0)
- RNA Methods: Northern blot (2010) (0)
- Drosophila Genomics; Telomerases (2009) (0)
- Stem Cells from the Mammalian Blastocyst-Not All Stem Cells Are Alike. (2008) (0)
- WITHDRAWN: Stem cells and lineage decisions in the early mammalian embryo (2007) (0)
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