Leroy Hood | Academic Influence

Leroy Hood's AcademicInfluence.com Rankings

Leroy Hood

Biology

#183

World Rank

#333

Historical Rank

#107

USA Rank

Systems Biology

#1

World Rank

#1

Historical Rank

#1

USA Rank

Computational Biology

#8

World Rank

#8

Historical Rank

#4

USA Rank

Molecular Biology

#79

World Rank

#82

Historical Rank

#50

USA Rank

biology Degrees

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Biology

Leroy Hood's Degrees

PhD Biochemistry California Institute of Technology
Doctorate Medicine Johns Hopkins University

Why Is Leroy Hood Influential?

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According to Wikipedia, Leroy "Lee" Edward Hood is an American biologist who has served on the faculties at the California Institute of Technology and the University of Washington. Hood has developed ground-breaking scientific instruments which made possible major advances in the biological sciences and the medical sciences. These include the first gas phase protein sequencer , for determining the sequence of amino acids in a given protein; a DNA synthesizer , to synthesize short sections of DNA; a peptide synthesizer , to combine amino acids into longer peptides and short proteins; the first automated DNA sequencer , to identify the order of nucleotides in DNA; ink-jet oligonucleotide technology for synthesizing DNA and nanostring technology for analyzing single molecules of DNA and RNA.

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Leroy Hood's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Initial sequencing and analysis of the human genome. (2001) (15222)
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 (2005) (4461)
Integration of biological networks and gene expression data using Cytoscape (2007) (2342)
Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. (2001) (2037)
Direct multiplexed measurement of gene expression with color-coded probe pairs (2008) (1902)
A gas-liquid solid phase peptide and protein sequenator. (1981) (1678)
Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripes (2002) (1549)
A Genomic Regulatory Network for Development (2002) (1518)
A cellular gene encodes scrapie PrP 27-30 protein (1985) (1496)
Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. (1983) (1366)
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1 (1997) (1194)
The evolution of vertebrate Toll-like receptors. (2005) (1142)
Circulating microRNAs, potential biomarkers for drug-induced liver injury (2009) (1124)
Analysis of Genetic Inheritance in a Family Quartet by Whole-Genome Sequencing (2010) (1072)
Systems Biology and New Technologies Enable Predictive and Preventative Medicine (2004) (1060)
A ligase-mediated gene detection technique. (1988) (832)
A common language for physical mapping of the human genome. (1989) (817)
Isolation of microgram quantities of proteins from polyacrylamide gels for amino acid sequence analysis. (1983) (812)
Complete sequence and gene map of a human major histocompatibility complex (1999) (805)
Dynorphin-(1-13), an extraordinarily potent opioid peptide. (1979) (793)
Integrated Genomic and Proteomic Analyses of Gene Expression in Mammalian Cells*S (2004) (777)
A physical map of the human genome (2001) (753)
Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. (1997) (749)
The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition. (1986) (729)
Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity (1993) (726)
Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways (1980) (714)
Genome sequence of Halobacterium species NRC-1. (2000) (706)
An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH (1980) (703)
Systems biology, proteomics, and the future of health care: toward predictive, preventative, and personalized medicine. (2004) (683)
Complementary Profiling of Gene Expression at the Transcriptome and Proteome Levels in Saccharomyces cerevisiae*S (2002) (657)
Predictive, personalized, preventive, participatory (P4) cancer medicine (2011) (637)
Rat transforming growth factor type 1: structure and relation to epidermal growth factor. (1984) (634)
Internal amino acid sequence analysis of proteins separated by one- or two-dimensional gel electrophoresis after in situ protease digestion on nitrocellulose. (1987) (609)
Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy (1988) (576)
Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing. (1993) (574)
Two mRNAs with different 3′ ends encode membrane-bound and secreted forms of immunoglobulin μ chain (1980) (555)
Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel. (1999) (536)
The Inferelator: an algorithm for learning parsimonious regulatory networks from systems-biology data sets de novo (2006) (533)
Acetylcholine receptor: complex of homologous subunits. (1980) (519)
High-sensitivity sequencing with a gas-phase sequenator. (1983) (515)
Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2. (1999) (514)
Reverse Engineering of Biological Complexity (2007) (496)
Extracellular microRNA: a new source of biomarkers. (2011) (483)
IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts (1981) (479)
The terminology and methodology associated with basic starch phenomena (1988) (469)
Purification and structural studies of a major scrapie prion protein (1984) (467)
Integrated barcode chips for rapid, multiplexed analysis of proteins in microliter quantities of blood (2008) (462)
The program of androgen-responsive genes in neoplastic prostate epithelium (2002) (460)
A personal view on systems medicine and the emergence of proactive P4 medicine: predictive, preventive, personalized and participatory. (2012) (455)
PTEN-deficient intestinal stem cells initiate intestinal polyposis (2007) (429)
A single VH gene segment encodes the immune response to phosphorylcholine: Somatic mutation is correlated with the class of the antibody (1981) (427)
A molecular map of the immune response region from the major histocompatibility complex of the mouse (1982) (426)
Structure, Organization and Polymorphism of Murine and Human T‐Cell Receptor a and β Chain Gene Families (1988) (425)
Hematopoietic stem cells contribute to the regeneration of renal tubules after renal ischemia-reperfusion injury in mice. (2003) (415)
Introduced T cell receptor variable region gene segments recombine in pre-B cells: Evidence that B and T cells use a common recombinase (1986) (409)
T cell antigen receptors and the immunoglobulin supergene family (1985) (407)
The Complete 685-Kilobase DNA Sequence of the Human β T Cell Receptor Locus (1996) (404)
Comparative hybridization of an array of 21,500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas. (1999) (398)
P4 medicine: how systems medicine will transform the healthcare sector and society. (2013) (396)
The organization, expression, and evolution of antibody genes and other multigene families. (1975) (391)
Gene families: the taxonomy of protein paralogs and chimeras. (1997) (390)
Mouse T cell antigen receptor: Structure and organization of constant and joining gene segments encoding the β polypeptide (1984) (378)
Systems medicine: the future of medical genomics and healthcare (2009) (375)
Expression of a myelin basic protein gene in transgenic shiverer mice: Correction of the dysmyelinating phenotype (1987) (374)
Clusters of genes encoding mouse transplantation antigens (1982) (374)
Electroblotting onto activated glass. High efficiency preparation of proteins from analytical sodium dodecyl sulfate-polyacrylamide gels for direct sequence analysis. (1986) (367)
Characterization of cloned cDNA representing rat myelin basic protein: Absence of expression in brain of shiverer mutant mice (1983) (365)
Transforming growth factors produced by retrovirus-transformed rodent fibroblasts and human melanoma cells: amino acid sequence homology with epidermal growth factor. (1983) (355)
Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19 (2020) (351)
Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide. (1981) (344)
A provisional regulatory gene network for specification of endomesoderm in the sea urchin embryo. (2002) (341)
Testing for Differentially-Expressed Genes by Maximum-Likelihood Analysis of Microarray Data (2000) (340)
Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36. (1999) (336)
A data integration methodology for systems biology. (2005) (336)
A new strategy for genome sequencing (1996) (333)
Developmentally controlled expression of immunoglobulin VH genes. (1985) (331)
Purification and properties of the cellular and scrapie hamster prion proteins. (1988) (326)
Large-scale and automated DNA sequence determination. (1991) (323)
Understanding the adaptation of Halobacterium species NRC-1 to its extreme environment through computational analysis of its genome sequence. (2001) (322)
Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray. (1999) (321)
Chromosomal mapping of mouse myelin basic protein gene and structure and transcription of the partially deleted gene in shiverer mutant mice (1985) (318)
Genes of the major histocompatibility complex of the mouse. (1983) (317)
Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry (2004) (314)
Multiple early factors anticipate post-acute COVID-19 sequelae (2022) (313)
Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea. (2004) (310)
OPG/FDCR-1, a TNF receptor family member, is expressed in lymphoid cells and is up-regulated by ligating CD40. (1998) (309)
Antibody diversity: Somatic hypermutation of rearranged VH genes (1981) (308)
A Predictive Model for Transcriptional Control of Physiology in a Free Living Cell (2007) (300)
Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells (2011) (299)
A wellness study of 108 individuals using personal, dense, dynamic data clouds (2017) (296)
The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1. (1998) (295)
Dysregulated gene expression networks in human acute myelogenous leukemia stem cells (2009) (294)
A molecular correlate to the Gleason grading system for prostate adenocarcinoma. (2006) (289)
High-density oligonucleotide arrays (1996) (289)
Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. (1996) (288)
Automated DNA diagnostics using an ELISA-based oligonucleotide ligation assay. (1990) (286)
The synthesis of oligonucleotides containing an aliphatic amino group at the 5' terminus: synthesis of fluorescent DNA primers for use in DNA sequence analysis. (1985) (284)
Diversity of the immunoglobulin gene superfamily. (1989) (281)
Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry (2005) (281)
The human t cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene (1984) (281)
Direct microsequence analysis of polypeptides using an improved sequenator, a nonprotein carrier (polybrene), and high pressure liquid chromatography. (1978) (279)
Systems biology: integrating technology, biology, and computation (2003) (276)
Asparagine-linked glycosylation of the scrapie and cellular prion proteins. (1989) (270)
The murine T-cell receptor uses a limited repertoire of expressed Vβ gene segments (1985) (268)
MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death. (1997) (266)
Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans. (1998) (265)
Human SRMAtlas: A Resource of Targeted Assays to Quantify the Complete Human Proteome (2016) (264)
Zinc-dependent structure of a single-finger domain of yeast ADR1. (1988) (262)
The digital code of DNA (2003) (260)
The structure, rearrangement and expression of Dβ gene segments of the murine T-cell antigen receptor (1984) (259)
DNA diagnostics--molecular techniques and automation. (1988) (258)
Conserved organization of the human and murine T-cell receptor β-gene families (1988) (258)
Light Chain Evolution (1967) (258)
A systems approach to prion disease (2009) (250)
Amino acid sequence of homogeneous antibodies to dextran and DNA rearrangments in heavy chain V-region gene segments (1980) (244)
An immunoglobulin heavy-chain gene is formed by at least two recombinational events (1980) (240)
A pseudogene homologous to mouse transplantation antigens: Transplantation antigens are encoded by eight exons that correlate with protein domains (1981) (240)
Regulatory gene networks and the properties of the developmental process (2003) (240)
Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression. (1999) (239)
Proteomic analysis of human prostasomes (2003) (235)
Systems medicine and integrated care to combat chronic noncommunicable diseases (2011) (230)
Three cDNA clones encoding mouse transplantation antigens: Homology to immunoglobulin genes (1981) (229)
The impact of systems approaches on biological problems in drug discovery (2004) (228)
Revolutionizing medicine in the 21st century through systems approaches. (2012) (227)
Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes. (2002) (225)
Diversity and structure of human T-cell receptor alpha-chain variable region genes. (1986) (221)
Analysis of phenylthiohydantoins by ultrasensitive gradient high-performance liquid chromatography. (1983) (219)
Systems cancer medicine: towards realization of predictive, preventive, personalized and participatory (P4) medicine (2012) (218)
Human Gut Microbiota and Gastrointestinal Cancer (2018) (215)
Activation of the NF-κB pathway by Caspase 8 and its homologs (2000) (215)
Gene expression dynamics in the macrophage exhibit criticality (2008) (212)
DNA sequence determination by hybridization: a strategy for efficient large-scale sequencing. (1993) (212)
Cell-cell interaction in prostate gene regulation and cytodifferentiation. (1997) (210)
Genes of the major histocompatibility complex in mouse and man. (1983) (210)
Cloning and characterization of the myelin basic protein gene from mouse: one gene can encode both 14 kd and 18.5 kd MBPs by alternate use of exons (1985) (210)
Specific-primer-directed DNA sequencing. (1986) (210)
Modulation of the NF-κB pathway by virally encoded Death Effector Domains-containing proteins (1999) (205)
Systems Biology and P4 Medicine: Past, Present, and Future (2013) (203)
Rearrangement of genetic information may produce immunoglobulin diversity (1978) (201)
Diversity and structure of genes of the α family of mouse T-cell antigen receptor (1985) (201)
Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate. (1990) (201)
Complete genomic sequence and analysis of the prion protein gene region from three mammalian species. (1998) (201)
Mouse epidermal Ia molecules have a bone marrow origin (1979) (199)
Predominant use of a Vα gene segment in mouse T-cell receptors for cytochrome c (1986) (199)
Label-Free Quantitative Detection of Tumor-Derived Exosomes through Surface Plasmon Resonance Imaging (2014) (198)
The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. (1996) (197)
Mechanism of antibody diversity: germ line basis for variability. (1970) (192)
Kaviar: an accessible system for testing SNV novelty (2011) (188)
The Code of Codes Scientific and Social Issues in the Human Genome Project (1992) (187)
A T cell clone expresses two T cell receptor α genes but uses one αβ heterodimer for allorecognition and self MHC-restricted antigen recognition (1988) (187)
Messenger RNA translation state: the second dimension of high-throughput expression screening. (1999) (186)
Automated chemical synthesis of a protein growth factor for hemopoietic cells, interleukin-3. (1986) (185)
MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia (2011) (184)
Myelin deficient mice: Expression of myelin basic protein and generation of mice with varying levels of myelin (1987) (182)
The T cell receptor β chain genes are located on chromosome 6 in mice and chromosome 7 in humans (1984) (181)
Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity. (2002) (180)
Boosting Signal-to-Noise in Complex Biology: Prior Knowledge Is Power (2011) (179)
DNA sequences mediating class switching in alpha-immunoglobulins. (1980) (177)
Differential gene expression profiling of adult murine hematopoietic stem cells. (2002) (176)
The Human Genome Project: big science transforms biology and medicine (2013) (176)
Location and chemical synthesis of a binding site for HIV-1 on the CD4 protein. (1988) (175)
Conservation of Toll-Like Receptor Signaling Pathways in Teleost Fish. (2006) (173)
Comparative genomics of the human and mouse T cell receptor loci. (2001) (171)
A Blood-Based Proteomic Classifier for the Molecular Characterization of Pulmonary Nodules (2013) (171)
Purification and primary structure of the neuropeptide egg-laying hormone of Aplysia californica. (1979) (170)
Gut microbiome pattern reflects healthy aging and predicts survival in humans (2021) (170)
Mutations in STX1B, encoding a presynaptic protein, cause fever-associated epilepsy syndromes (2014) (170)
Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins. (1999) (170)
The P4 Health Spectrum – A Predictive, Preventive, Personalized and Participatory Continuum for Promoting Healthspan (2017) (170)
The SOX2 response program in glioblastoma multiforme: an integrated ChIP-seq, expression microarray, and microRNA analysis (2011) (169)
The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (1994) (166)
Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas. (1982) (165)
Striking sequence similarity over almost 100 kilobases of human and mouse T–cell receptor DNA (1994) (164)
Genomic organization of the genes encoding mouse T-cell receptor α-chain (1985) (164)
Genomic structure of the human prion protein gene. (1991) (161)
A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics. (2005) (161)
Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus. (1980) (158)
DNA sequence of a gene encoding a BALB/c mouse Ld transplantation antigen. (1982) (158)
Human fibroblast interferon: amino acid analysis and amino terminal amino acid sequence. (1980) (157)
Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas (2007) (155)
Predictive, preventive, personalized and participatory medicine: back to the future (2010) (153)
Doppel-induced cerebellar degeneration in transgenic mice (2001) (152)
The generation of diversity in phosphorylcholine-binding antibodies. (1984) (152)
Activated Notch4 Inhibits Angiogenesis: Role of β1-Integrin Activation (2002) (152)
Blood metabolome predicts gut microbiome α-diversity in humans (2019) (151)
Rearrangement and transcription of the β-chain genes of the T-cell antigen receptor in different types of murine lymphocytes (1985) (150)
Rearrangement and expression of T cell antigen receptor and gamma genes during thymic development (1986) (149)
Molecular analysis of the hotspot of recombination in the murine major histocompatibility complex. (1986) (149)
Unusual gene order and organization of the sea urchin hox cluster. (2006) (149)
Shotgun Glycopeptide Capture Approach Coupled with Mass Spectrometry for Comprehensive Glycoproteomics *S (2007) (148)
Prevention and treatment of murine experimental allergic encephalomyelitis with T cell receptor V beta-specific antibodies (1990) (145)
The germline repertoire of T cell receptor β-chain genes in patients with chronic progressive multiple sclerosis (1989) (145)
Systems level insights into the stress response to UV radiation in the halophilic archaeon Halobacterium NRC-1. (2004) (145)
Peptide-specific prevention of experimental allergic encephalomyelitis. Neonatal tolerance induced to the dominant T cell determinant of myelin basic protein (1989) (144)
The joining of V and J gene segments creates antibody diversity (1980) (144)
Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma. (2006) (143)
Rare variants in neuronal excitability genes influence risk for bipolar disorder (2015) (143)
Elevated expression of DKK1 is associated with cytoplasmic/nuclear beta-catenin accumulation and poor prognosis in hepatocellular carcinomas. (2009) (140)
Two minor determinants of myelin basic protein induce experimental allergic encephalomyelitis in SJL/J mice (1988) (140)
Silencing SOX2 Induced Mesenchymal-Epithelial Transition and Its Expression Predicts Liver and Lymph Node Metastasis of CRC Patients (2012) (139)
Proteins Associated with Cisplatin Resistance in Ovarian Cancer Cells Identified by Quantitative Proteomic Technology and Integrated with mRNA Expression Levels*S (2006) (138)
Direct evidence for chromosomal inversion during T-cell receptor β-gene rearrangements (1986) (138)
RNA transcripts for I-J polypeptides are apparently not encoded between the I-A and I-E subregions of the murine major histocompatibility complex. (1983) (137)
GrpL, a Grb2-related Adaptor Protein, Interacts with SLP-76 to Regulate Nuclear Factor of Activated T Cell Activation (1999) (136)
Organization, structure, and function of 95 kb of DNA spanning the murine T-cell receptor CαCδ region (1992) (135)
Participatory medicine: a driving force for revolutionizing healthcare (2013) (134)
A data integration methodology for systems biology: experimental verification. (2005) (132)
Amino terminal sequence of the major component of human lymphoblastoid interferon. (1980) (131)
Identification of the class I genes of the mouse major histocompatibility complex by DNA-mediated gene transfer (1982) (130)
Pairwise end sequencing: a unified approach to genomic mapping and sequencing. (1995) (130)
Cancer as robust intrinsic state of endogenous molecular-cellular network shaped by evolution. (2008) (129)
Coordinate regulation of energy transduction modules in Halobacterium sp. analyzed by a global systems approach (2002) (128)
Protein sequence analysis: automated microsequencing. (1983) (127)
Parallel microfluidic surface plasmon resonance imaging arrays. (2010) (126)
Expression of IgD may use both DNA rearrangement and RNA splicing mechanisms. (1981) (125)
Proteomic analysis identifies that 14-3-3ζ interacts with β-catenin and facilitates its activation by Akt (2004) (125)
Gene transfer of H-2 class II genes: Antigen presentation by mouse fibroblast and hamster B-cell lines (1984) (124)
The nucleotide sequence of a human immunoglobulin C gamma1 gene (1982) (123)
Detailed transcriptome atlas of the pancreatic beta cell (2009) (123)
New protein sequenator with increased sensitivity. (1980) (123)
Cell-type-specific cDNA probes and the murine I region: the localization and orientation of Ad alpha. (1984) (123)
The T-cell receptor repertoire and autoimmune diseases. (1989) (123)
The immunoglobulin μ chains of membrane-bound and secreted IgM molecules differ in their C-terminal segments (1980) (122)
Linkage analysis of 49 high-risk families does not support a common familial prostate cancer-susceptibility gene at 1q24-25. (1997) (122)
Detection of c-sis transcripts and synthesis of PDGF-like proteins by human osteosarcoma cells. (1984) (121)
From functional genomics to systems biology: concepts and practices. (2003) (121)
Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (2003) (121)
Characterization of the T cell receptor repertoire causing collagen arthritis in mice (1993) (121)
A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51 (2015) (120)
A CD133-related gene expression signature identifies an aggressive glioblastoma subtype with excessive mutations (2011) (119)
Systems genomics evaluation of the SH-SY5Y neuroblastoma cell line as a model for Parkinson’s disease (2014) (119)
Snapshot of a large dynamic replicon in a halophilic archaeon: megaplasmid or minichromosome? (1998) (119)
A sea urchin genome project: sequence scan, virtual map, and additional resources. (2000) (119)
Optimized conditions for pulsed field gel electrophoretic separations of DNA. (1988) (117)
One heavy chain variable region gene segment subfamily in the BALB c mouse contains 500–1000 or more members (1986) (116)
Pulsed field gel electrophoresis. (1989) (116)
General transcription factor specified global gene regulation in archaea (2007) (114)
Genetic mapping in the major histocompatibility complex by restriction enzyme site polymorphisms: most mouse class I genes map to the Tla complex. (1983) (113)
Identification of an embryonic isoform of myelin basic protein that is expressed widely in the mouse embryo. (1993) (113)
A speculative view of the multicomponent nature of T cell antigen recognition (1986) (111)
Analysis of phenylthiohydantoin amino acids by high-performance liquid chromatography on DuPont Zobax cyanopropylsilane columns. (1979) (111)
Diversity and structure of human T-cell receptor beta-chain variable region genes. (1986) (111)
Activation of the NF-kappaB pathway by caspase 8 and its homologs. (2000) (109)
Regulation of gene expression by interferons: control of H-2 promoter responses. (1988) (109)
Detergent-solubilised H-2 alloantigen is associated with a small molecular weight polypeptide (1974) (108)
Isolation and amino acid sequence analysis of a 4,000-dalton dynorphin from porcine pituitary. (1982) (107)
Erratum: Initial sequencing and analysis of the human genome: International Human Genome Sequencing Consortium (Nature (2001) 409 (860-921)) (2001) (106)
The Genetic, Molecular, and Cellular Basis of Antibody Formation: Some Facts and a Unifying Hypothesis (1967) (106)
Evidence for the presence of disease-perturbed networks in prostate cancer cells by genomic and proteomic analyses: a systems approach to disease. (2005) (106)
Calculating biological behaviors of epigenetic states in the phage λ life cycle (2004) (106)
Organization and evolution of D region class I genes in the mouse major histocompatibility complex (1986) (105)
Structure of a gene encoding a murine thymus leukemia antigen, and organization of Tla genes in the BALB/c mouse (1985) (105)
Structural correlates of cross-reactive and individual idiotypic determinants on murine antibodies to alpha-(1 leads to 3) dextran (1980) (104)
A single gene encodes soluble and membrane-bound forms of the major histocompatibility Qa-2 antigen: Anchoring of the product by a phospholipid tail (1987) (103)
Identification of a diversity segment of human T-cell receptor β-chain, and comparison with the analogous murine element (1984) (103)
Mechanism of Antibody Synthesis: Size Differences between Mouse Kappa Chains (1967) (102)
A Review of Computational Tools in microRNA Discovery (2013) (101)
Rearranged β t cell receptor genes in a helper t cell clone specific for lysozyme: No correlation between Vβ and MHC restriction (1985) (101)
Chimeric immunoglobulin-T cell receptor proteins form functional receptors: Implications for T cell receptor complex formation and activation (1990) (101)
Attachment of carbohydrate to the variable region of myeloma immunoglobulin light chains. (1970) (100)
Sequencing the human genome. (1997) (100)
Isolation and characterization of a corticotropin-releasing hormone-like peptide from human placenta. (1988) (100)
Nucleotide sequence of a light chain gene of the mouse I-A subregion: A beta d. (1983) (100)
A genomic scan of families with prostate cancer identifies multiple regions of interest. (2000) (99)
Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes. (1982) (99)
Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation. (2002) (99)
Predictive Big Data Analytics: A Study of Parkinson’s Disease Using Large, Complex, Heterogeneous, Incongruent, Multi-Source and Incomplete Observations (2016) (98)
Identification of cellular proteins binding to the scrapie prion protein. (1990) (98)
PART-1: a novel human prostate-specific, androgen-regulated gene that maps to chromosome 5q12. (2000) (97)
Purification and primary structure of two neuroactive peptides that cause bag cell afterdischarge and egg-laying in Aplysia. (1980) (97)
Electrochemically programmed, spatially selective biofunctionalization of silicon wires. (2004) (97)
A unified test of linkage analysis and rare-variant association for analysis of pedigree sequence data (2014) (96)
The Molecular Evolution of the Vertebrate Trypsinogens (1997) (96)
Susceptibility for multiple sclerosis is determined, in part, by inheritance of a 175-kb region of the TcR Vβ chain locus and HLA class II genes (1993) (95)
Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer (2017) (94)
A novel instrument for separating large DNA molecules with pulsed homogeneous electric fields. (1988) (94)
Proteomics Analysis of the Interactome of N-myc Downstream Regulated Gene 1 and Its Interactions with the Androgen Response Program in Prostate Cancer Cells*S (2007) (94)
Proteomic analysis identifies that 14-3-3zeta interacts with beta-catenin and facilitates its activation by Akt. (2004) (93)
A microchemical facility for the analysis and synthesis of genes and proteins (1984) (91)
Expression and function of transplantation antigens with altered or deleted cytoplasmic domains (1983) (90)
Mouse interferons: amino terminal amino acid sequences of various species. (1980) (90)
Immunoglobulin heavy chain gene organization in mice: analysis of a myeloma genomic clone containing variable and alpha constant regions. (1979) (89)
Massively Parallel Signature Sequencing and Bioinformatics Analysis Identifies Up-Regulation of TGFBI and SOX4 in Human Glioblastoma (2010) (89)
Rabbit Antibody Light Chains and Gene Evolution (1970) (89)
Differences between liver gap junction protein and lens MIP 26 from rat: Implications for tissue specificity of gap junctions (1983) (87)
Identification of a BALB/c H-2Ld gene by DNA-mediated gene transfer. (1982) (86)
Identifying Tightly Regulated and Variably Expressed Networks by Differential Rank Conservation (DIRAC) (2010) (86)
Rat liver gap junction protein: properties and partial sequence. (1981) (86)
Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBA/1j mice. (1999) (86)
On the role of the transmembrane anchor sequence of influenza hemagglutinin in target cell recognition by class I MHC-restricted, hemagglutinin-specific cytolytic T lymphocytes (1987) (85)
Human T cell receptor V beta gene polymorphism (1987) (85)
POSaM: a fast, flexible, open-source, inkjet oligonucleotide synthesizer and microarrayer (2004) (85)
Integrated Expression Profiling and ChIP-seq Analyses of the Growth Inhibition Response Program of the Androgen Receptor (2009) (83)
Chromosomal proteins of Drosophila embryos. (1973) (82)
Amino acid sequence of a mouse immunoglobulin mu chain. (1979) (82)
Negative and positive selection of antigen-specific cytotoxic T lymphocytes affected by the α3 domain of MHC I molecules (1991) (81)
Demystifying Disease, Democratizing Health Care (2014) (81)
Autoimmune T cells: Immune recognition of normal and variant peptide epitopes and peptide-based therapy (1989) (81)
The area-code hypothesis: the immune system provides clues to understanding the genetic and molecular basis of cell recognition during development. (1977) (81)
Testing the Hypothesis of a Recombinant Origin of Human Immunodeficiency Virus Type 1 Subtype E (2000) (80)
Physical maps of the mouse and human immunoglobulin-like loci. (1989) (80)
Systems Approaches to Biology and Disease Enable Translational Systems Medicine (2012) (79)
Bayesian Classification of DNA Array Expression Data (2000) (79)
Structural analysis of proteins by capillary HPLC electrospray tandem mass spectrometry (1991) (78)
Big biomedical data as the key resource for discovery science (2015) (78)
DNA sequence of the mouse H-2Dd transplantation antigen gene. (1985) (77)
Robustness, Stability and Efficiency of Phage lambda Genetic Switch: Dynamical Structure Analysis (2004) (77)
Bridging the BMP and Wnt Pathways by PI3 Kinase/Akt and 14-3-3? (2005) (77)
The DNA sequence and analysis of human chromosome 14 (2003) (76)
EST analysis of gene expression in early cleavage-stage sea urchin embryos. (1999) (76)
Equipping scientists for the new biology (2000) (76)
Immunology: The growing immunoglobulin gene superfamily (1986) (76)
Gene rearrangement in cells with natural killer activity and expression of the β-chain of the T-cell antigen receptor (1985) (76)
Quantitative proteomics analysis integrated with microarray data reveals that extracellular matrix proteins, catenins, and p53 binding protein 1 are important for chemotherapy response in ovarian cancers. (2009) (75)
The Mr 28,000 gap junction proteins from rat heart and liver are different but related. (1985) (75)
Integrating big data and actionable health coaching to optimize wellness (2015) (75)
Quantitative Serum Proteomics from Surface Plasmon Resonance Imaging* (2008) (74)
A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types (1987) (73)
Solid-phase sequencing of 32P-labeled phosphopeptides at picomole and subpicomole levels. (1991) (73)
Analysis of the DNA sequence and duplication history of human chromosome 15 (2006) (73)
Imunoglobulin Structure: Amino Terminal Sequences of Mouse Myeloma Proteins That Bind Phosphorylcholine (1974) (73)
Systems biology at the Institute for Systems Biology. (2008) (72)
Nucleotide Sequence of a Human Immunoglobulin Cγ4 Gene (1981) (72)
Cell type-specific genes show striking and distinct patterns of spatial expression in the mouse brain (2013) (72)
Novel submicroscopic extrachromosomal elements containing amplified genes in human cells (1987) (72)
Sequence-tagged connectors: a sequence approach to mapping and scanning the human genome. (1999) (72)
Helper and killer T cells do not express B cell immunoglobulin joining and constant region gene segments (1980) (71)
Analysis of chemotherapy response programs in ovarian cancers by the next-generation sequencing technologies. (2010) (71)
Cell population structure prior to bifurcation predicts efficiency of directed differentiation in human induced pluripotent cells (2017) (70)
Regulation of murine class I genes by interferons is controlled by regions located both 5' and 3' to the transcription initiation site. (1987) (70)
Genetic evaluation of suspected cases of transient HIV-1 infection of infants. (1998) (70)
Analysis of chromosome 1q42.2-43 in 152 families with high risk of prostate cancer. (1999) (70)
Scrapie and cellular prion proteins share polypeptide epitopes. (1986) (70)
Relationship Estimation from Whole-Genome Sequence Data (2014) (70)
Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden. (2006) (69)
Tracts of high or low sequence divergence in the mouse major histocompatibility complex. (1984) (69)
Identification of a novel retroviral gene unique to human immunodeficiency virus type 2 and simian immunodeficiency virus SIVMAC (1988) (69)
Expression of a murine polyclonal T cell receptor marker correlates with the use of specific members of the V beta 8 gene segment subfamily (1987) (68)
Initial Proteome Analysis of Model Microorganism Haemophilus influenzae Strain Rd KW20 (2003) (68)
Integrated Blood Barcode Chips (2008) (68)
The ht beta gene encodes a novel CACCC box-binding protein that regulates T-cell receptor gene expression (1993) (68)
Random mutagenesis of Thermus aquaticus DNA polymerase I: concordance of immutable sites in vivo with the crystal structure. (1996) (68)
Hevin, an antiadhesive extracellular matrix protein, is down-regulated in metastatic prostate adenocarcinoma. (1998) (67)
Sequence analysis of mouse vomeronasal receptor gene clusters reveals common promoter motifs and a history of recent expansion (2001) (67)
DNA sequence of the gene encoding the E alpha Ia polypeptide of the BALB/c mouse. (1982) (67)
Mouse immunoglobulin chains. A survey of the amino-terminal sequences of kappa chains. (1973) (66)
Molecular cloning of translocations involving chromosome 15 and the immunoglobulin C alpha gene from chromosome 12 in two murine plasmacytomas. (1982) (66)
Landscape of the SOX2 protein–protein interactome (2011) (66)
Genomic scan of 254 hereditary prostate cancer families (2003) (65)
An expressed-sequence-tag database of the human prostate: sequence analysis of 1168 cDNA clones. (1998) (64)
Structure of murine Ia antigens. Two dimensional electrophoretic analyses and high pressure liquid chromatography tryptic peptide maps of products of the I-A and I-E subregions and of an associated invariant polypeptide (1981) (63)
Structural changes of tumor necrosis factor alpha associated with membrane insertion and channel formation. (1996) (63)
Structure and evolution of transplantation antigens: partial amino-acid sequences of H-2K and H-2D alloantigens. (1976) (63)
Gene expression profiles in prostate cancer: association with patient subgroups and tumour differentiation. (2005) (63)
Product of a transferred H–2Ld gene acts as restriction element for LCMV-specific killer T cells (1982) (63)
Evolutionary history of Tibetans inferred from whole-genome sequencing (2017) (63)
Differential Transcriptional Regulation of Individual TCR Vβ Segments Before Gene Rearrangement1 (2001) (63)
Molecular cloning and chromosomal localization of one of the human glutamate receptor genes. (1991) (63)
Identification and physical mapping of a polymorphic human T cell receptor V beta gene with a frequent null allele (1993) (62)
Global analysis of H3K4me3 and H3K27me3 profiles in glioblastoma stem cells and identification of SLC17A7 as a bivalent tumor suppressor gene (2015) (62)
Transcription factor expression in lipopolysaccharide-activated peripheral-blood-derived mononuclear cells (2007) (62)
A personal journey of discovery: developing technology and changing biology. (2008) (62)
PEDB: the Prostate Expression Database (1999) (61)
Molecular Cloning and Characterization of a Novel Regulator of G-protein Signaling from Mouse Hematopoietic Stem Cells* (2001) (61)
Activation of the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway by Overexpression of Caspase-8 and Its Homologs* (1999) (61)
New and improved proteomics technologies for understanding complex biological systems: Addressing a grand challenge in the life sciences (2012) (61)
Structure of murine Ia antigens: partial NH2-terminal amino acid sequences of products of the I-E or I-C subregion. (1977) (60)
Proteomic Analysis of an Extreme Halophilic Archaeon, Halobacterium sp. NRC-1* (2003) (60)
Glycosaparaginase from human leukocytes. Inactivation and covalent modification with diazo-oxonorvaline. (1991) (60)
Immunoglobulin Lambda Chain Structure: Two Genes, One Polypeptide Chain (1968) (60)
Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new member of the short-chain steroid dehydrogenase/reductase family highly expressed in normal and neoplastic prostate epithelium. (2001) (59)
Human cerebrospinal fluid protein database: Edition 1992 (1992) (59)
Purification and characterization of canine intestinal motilin (1983) (59)
Whole-Genome Sequencing of the World’s Oldest People (2014) (58)
A personal view of molecular technology and how it has changed biology. (2002) (58)
Allelic exclusion and nonproductive immunoglobulin gene rearrangements (1981) (58)
Diversity in the germline antibody repertoire. Molecular evolution of the T15 VN gene family (1985) (58)
Expression of complete transplantation antigens by mammalian cells transformed with truncated class I genes (1983) (58)
Deep depletion of abundant serum proteins reveals low‐abundant proteins as potential biomarkers for human ovarian cancer (2009) (57)
Chromosomal haplotypes by genetic phasing of human families. (2011) (57)
Repetitive DNA (TGGA)n 5' to the human myelin basic protein gene: a new form of oligonucleotide repetitive sequence showing length polymorphism. (1990) (57)
Identification of clusters of biallelic polymorphic sequence-tagged sites (pSTSs) that generate highly informative and automatable markers for genetic linkage mapping. (1992) (57)
Sequence to array: Probing the genome's secrets (1996) (57)
Genomic perspective on the photobiology of Halobacterium species NRC-1, a phototrophic, phototactic, and UV-tolerant haloarchaeon (2004) (57)
Gene expression relationship between prostate cancer cells of Gleason 3, 4 and normal epithelial cells as revealed by cell type-specific transcriptomes (2009) (56)
H-2Kb antigen expression has no effect on natural killer susceptibility and tumorigenicity of a murine hepatoma. (1988) (56)
Molecular basis of the dm1 mutation in the major histocompatibility complex of the mouse: a D/L hybrid gene (1985) (56)
Sequence length and error analysis of Sequenase and automated Taq cycle sequencing methods. (1993) (56)
Oligonucleotide arrays for high-throughput SNPs detection in the MHC class I genes: HLA-B as a model system. (2002) (56)
Multi-omic biomarker identification and validation for diagnosing warzone-related post-traumatic stress disorder (2019) (55)
Principal network analysis: identification of subnetworks representing major dynamics using gene expression data (2011) (55)
Complete nucleotide sequence of two generations of a bacterial artificial chromosome cloning vector. (1997) (55)
Identification of T-cell receptor alpha-chain genes in the chicken. (1994) (54)
Mouse Cμ heavy chain immunoglobulin gene segment contains three intervening sequences separating domains (1980) (54)
Nonhistone chromosomal proteins of rat tissues. A comparative study by gel electrophoresis. (1973) (54)
Systems Biology and the Discovery of Diagnostic Biomarkers (2010) (54)
Genes of the major histocompatibility complex (1982) (54)
The germline repertoire of T-cell receptor beta-chain genes in patients with multiple sclerosis. (1989) (54)
Molecular characterization of the recombination region of six murine major histocompatibility complex (MHC) I-region recombinants. (1984) (54)
Expression of I–Ak class II genes in mouse L cells after DNA-mediated gene transfer (1983) (53)
Prostate cancer and genetic susceptibility: A genome scan incorporating disease aggressiveness (2006) (53)
Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19 (2021) (53)
gamma Heavy chain disease in man: cDNA sequence supports partial gene deletion model. (1982) (53)
Structure-function studies of human granulocyte-macrophage colony-stimulating factor. Identification of residues required for activity. (1988) (53)
Targeting stem cells-clinical implications for cancer therapy. (2009) (53)
Partial amino acid sequences of chicken and turkey immunoglobulin light chains. Homology with mammalian lambda chains. (1971) (52)
Purification and partial amino acid sequence of asialo murine granulocyte-macrophage colony stimulating factor. (1985) (52)
The cardiac gap junction protein (Mr 47,000) has a tissue-specific cytoplasmic domain of Mr 17,000 at its carboxy-terminus. (1987) (52)
Clonal variation in cell surface display of an H-2 protein lacking a cytoplasmic tail (1986) (52)
Systems Biology and Emerging Technologies Will Catalyze the Transition from Reactive Medicine to Predictive, Personalized, Preventive and Participatory (P4) Medicine (2009) (51)
Three T cell hybridomas do not contain detectable heavy chain variable gene transcripts (1983) (51)
Antibodies to proteins dissolved in sodium dodecyl sulfate. (1974) (51)
Chemical characterization of products of the H-2 complex. (1977) (51)
Increased Expression of SIM2-s Protein Is a Novel Marker of Aggressive Prostate Cancer (2007) (51)
Low-pass sequencing for microbial comparative genomics (2004) (50)
Ia-transfected L-cell fibroblasts present a lysozyme peptide but not the native protein to lysozyme-specific T cells. (1985) (50)
Preliminary amino acid sequences of transplantation antigens: genetic and evolutionary implications. (1976) (50)
Haplotyping the human T-cell receptor beta-chain gene complex by use of restriction fragment length polymorphisms. (1990) (50)
Extracellular vesicle RNAs reflect placenta dysfunction and are a biomarker source for preterm labour (2018) (50)
Immunoglobulin class switching: Developmentally regulated DNA rearrangements during differentiation (1980) (50)
Analysis of a human V beta gene subfamily (1986) (49)
Further localization of a multiple sclerosis susceptibility gene on chromosome 7q using a new T cell receptor beta-chain DNA polymorphism (1991) (49)
Temporal profiling of cytokine-induced genes in pancreatic β-cells by meta-analysis and network inference. (2014) (49)
Comprehensive de novo structure prediction in a systems-biology context for the archaea Halobacterium sp. NRC-1 (2004) (49)
Localization of the human myelin basic protein gene (MBP) to region 18q22----qter by in situ hybridization. (1985) (49)
Linkage analysis of 150 high‐risk prostate cancer families at 1q24‐25 (2000) (49)
Immunoglobulins with hapten‐binding activity: structure‐function correlations and genetic implications (1978) (49)
Synthesis of a site-specific DNA-binding peptide. (1987) (49)
Systems approach to neurodegenerative disease biomarker discovery. (2014) (49)
Human immunodeficiency virus type 1 infection despite prior immunization with a recombinant envelope vaccine regimen. (1996) (49)
T and B cells that recognize the same antigen do not transcribe similar heavy chain variable region gene segments (1983) (49)
Quantitative Liver-Specific Protein Fingerprint in Blood: A Signature for Hepatotoxicity (2014) (48)
ERG upregulation and related ETS transcription factors in prostate cancer. (2007) (47)
Development of an automated procedure for fluorescent DNA sequencing. (1990) (47)
Peptide map analyses of murine Ia antigens of the I–E subregion using HPLC (1979) (47)
Cloning, characterization, and the complete 56.8-kilobase DNA sequence of the human NOTCH4 gene. (1998) (47)
Cloning of the shark Po promoter using a genomic walking technique based on the polymerase chain reaction. (1990) (47)
Analysis of the 1.1-Mb Human α/δ T-Cell Receptor Locus with Bacterial Artificial Chromosome Clones (1997) (47)
Spectroscopic studies of wild-type and mutant "zinc finger" peptides: determinants of domain folding and structure. (1990) (47)
Mouse immunoglobulin chains. Pattern of sequence variation among kappa chains with limited sequence differences. (1973) (47)
The structure and genetics of mouse immunoglobulins: an analysis of NZB myeloma proteins and sets of BALB/c myeloma proteins binding particular haptens. (1977) (46)
Genomic organization of the mouse T-cell receptor beta-chain gene family. (1987) (45)
DNA methyltransferase-mediated transcriptional silencing in malignant glioma: a combined whole-genome microarray and promoter array analysis (2009) (45)
Multiple VH gene segments encode murine antistreptococcal antibodies (1984) (45)
Transcriptional regulatory networks underlying gene expression changes in Huntington's disease (2018) (45)
Amino-acid sequence of the variable region of the heavy (alpha) chain of a mouse myeloma protein with anti-hapten activity. (1974) (45)
Nucleotide sequence analysis of 77.7 kb of the human V beta T-cell receptor gene locus: direct primer-walking using cosmid template DNAs. (1994) (44)
Tackling the Microbiome (2012) (44)
Epigenetic regulation of wnt pathway antagonists in human glioblastoma multiforme. (2010) (44)
Calculating biological behaviors of epigenetic states in the phage lambda life cycle. (2004) (44)
Nucleotide sequence analysis of 95 kb near the 3′ end of the murine T-cell receptor αδ chain locus: Strategy and methodology (1992) (44)
Mouse immunoglobulin heavy chains are coded by multiple germ line variable region genes. (1974) (44)
The synthesis and use of fluorescent oligonucleotides in DNA sequence analysis. (1987) (44)
Isolation and characterization of starch from breadfruit [Artocarpus communis]. (1981) (44)
Immunoglobulin allotypes of rabbit kappa chains: polymorphism of a control mechanism regulating closely linked duplicated genes? (1976) (43)
A Third Approach to Gene Prediction Suggests Thousands of Additional Human Transcribed Regions (2006) (43)
Genetic Linkage Analysis of Prostate Cancer Families to Xq27–28 (2000) (43)
Analysis of acute myelogenous leukemia: preparation of samples for genomic and proteomic analyses. (2002) (43)
Genomic and molecular characterization of preterm birth (2019) (43)
Structure and regulation of immunoglobulins: kappa allotypes in the rat have multiple amino-acid differences in the constant region. (1975) (42)
Partial N-terminal amino acid sequence of rat transplantation antigens (1978) (42)
Expression of a type II collagen-specific TCR transgene accelerates the onset of arthritis in mice. (1998) (42)
Whole-genome DNA methylation status associated with clinical PTSD measures of OIF/OEF veterans (2017) (42)
Characterization of prion proteins with monospecific antisera to synthetic peptides. (1988) (42)
A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD (2020) (42)
Cotransfer of the Ed alpha and Ad beta genes into L cells results in the surface expression of a functional mixed-isotype Ia molecule. (1986) (42)
Aspartylglycosaminuria in the Finnish population: identification of two point mutations in the heavy chain of glycoasparaginase. (1991) (41)
Characterization of C14orf4, a novel intronless human gene containing a polyglutamine repeat, mapped to the ARVD1 critical region. (2000) (41)
Origin of the PSEN1 E280A mutation causing early-onset Alzheimer's disease (2014) (41)
Evolution of a Simian Immunodeficiency Virus Pathogen (1998) (41)
REARRANGEMENT AND EXPRESSION OF T CELL ANTIGEN RECEPTOR AND ~' GENES DURING THYMIC DEVELOPMENT (1986) (41)
Long-range multilocus haplotype phasing of the MHC. (2006) (41)
Differences in T cell receptor restriction fragment length polymorphisms in patients with rheumatoid arthritis. (1992) (40)
On the mechanism of antibody synthesis: a species comparison of L-chains. (1966) (40)
Organization of the V gene segments in mouse T-cell antigen receptor alpha/delta locus. (1994) (40)
Organization of the murine T-cell receptor γ locus (1993) (40)
Isolation and characterization of the chicken trypsinogen gene family. (1995) (40)
The effect of maternal SARS-CoV-2 infection timing on birth outcomes: a retrospective multicentre cohort study (2022) (40)
Rapid preimplantation detection of mutant (shiverer) and normal alleles of the mouse myelin basic protein gene allowing selective implantation and birth of live young. (1990) (40)
Down-Regulation of Shadoo in Prion Infections Traces a Pre-Clinical Event Inversely Related to PrPSc Accumulation (2011) (39)
Antibody differentiation: apparent sequence identity between variable regions shared by IgA and IgG immunoglobulins. (1976) (39)
SPR imaging for high throughput, label-free interaction analysis. (2009) (39)
Covalent immobilization of proteins for high-sensitivity sequence analysis: electroblotting onto chemically activated glass from sodium dodecyl sulfate-polyacrylamide gels. (1988) (39)
Microarray based screening of peptide nano probes for HER2 positive tumor. (2015) (39)
Cleavage at tryptophanyl residues with dimethyl sulfoxide-hydrochloric acid and cyanogen bromide. (1983) (39)
TGFβ‐Responsive HMOX1 Expression Is Associated with Stemness and Invasion in Glioblastoma Multiforme (2016) (39)
Conservation and diversity in the class I genes of the major histocompatibility complex: sequence analysis of a Tlab gene and comparison with a Tlac gene. (1986) (39)
Optimization of asymmetric polymerase chain reaction for rapid fluorescent DNA sequencing. (1990) (39)
Self–organized living systems: conjunction of a stable organization with chaotic fluctuations in biological space–time (2003) (39)
EVIDENCE FOR AMINO ACID SEQUENCE DIFFERENCES AMONG PROTEINS RESEMBLING THE L-CHAIN SUBUNITS OF IMMUNOGLOBULINS. (1965) (39)
Molecular evidence of stress-induced acute heart injury in a mouse model simulating posttraumatic stress disorder (2014) (38)
Clinical characteristics of prostate cancer in an analysis of linkage to four putative susceptibility loci. (2001) (38)
Opening a SWATH Window on Posttranslational Modifications: Automated Pursuit of Modified Peptides* (2015) (38)
Quod erat faciendum: sequence analysis of the H2-D and H2-Q regions of 129/SvJ mice (2002) (38)
Antibody structure: amino terminal sequences of nurse shark light and heavy chains. (1974) (38)
Evolutionary etiology of high-grade astrocytomas (2013) (38)
Rapid screening of peptide probes through in situ single-bead sequencing microarray. (2014) (38)
A Cell-Surface Membrane Protein Signature for Glioblastoma. (2017) (37)
Interchromosomal segmental duplications explain the unusual structure of PRSS3, the gene for an inhibitor-resistant trypsinogen. (2005) (37)
Oligogenic segregation analysis of hereditary prostate cancer pedigrees: Evidence for multiple loci affecting age at onset (2003) (37)
Qa-region class I gene expression: identification of a second class I gene, Q9, encoding a Qa-2 polypeptide. (1988) (37)
Silkmoth chorion proteins: sequence analysis of the products of a multigene family. (1978) (37)
Automation of dideoxynucleotide DNA sequencing reactions using a robotic workstation. (1988) (37)
Organization of kappa light chain genes in germ-line and somatic tissue. (1980) (37)
A novel mutation in myelin-deficient mice results in unstable myelin basic protein gene transcripts (1988) (37)
Population-specific genetic modification of Huntington's disease in Venezuela (2018) (37)
Prostate cancer expression profiling by cDNA sequencing analysis. (1999) (37)
Human fibroblastoid interferon: immunosorbent column chromatography and N-terminal amino acid sequence. (1980) (36)
KLK31P is a novel androgen regulated and transcribed pseudogene of kallikreins that is expressed at lower levels in prostate cancer cells than in normal prostate cells (2006) (36)
Specific-primer-directed DNA sequencing using automated fluorescence detection. (1989) (36)
Role of disulfide bridges in determining the biological activity of interleukin 3. (1988) (36)
Genetic Predisposition Impacts Clinical Changes in a Lifestyle Coaching Program (2019) (35)
Comparison of exon 5 sequences from 35 class I genes of the BALB/c mouse (1989) (35)
P4 medicine needs P4 education. (2014) (35)
New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections (2016) (35)
Pulsed field gel electrophoresis techniques for separating 1- to 50-kilobase DNA fragments. (1989) (35)
Editorial: Systems biology and personalized medicine – the future is now (2012) (35)
Major histocompatibility complex-restricted antigen receptor on T cells. VIII. Role of the LFA-1 molecule (1985) (34)
Epitope clusters of Qa-2 antigens defined by a panel of new monoclonal antibodies. (1989) (34)
Organization, structure, and function of 95 kb of DNA spanning the murine T-cell receptor C alpha/C delta region. (1992) (34)
An lmmunoglobulin Heavy Chain Variable Region Gene Is Generated from Three Segments of DNA : VH (2004) (34)
A T cell clone expresses two T cell receptor alpha genes but uses one alpha beta heterodimer for allorecognition and self MHC-restricted antigen recognition. (1988) (33)
Expression and T cell recognition of hybrid antigens with amino- terminal domains encoded by Qa-2 region of major histocompatibility complex and carboxyl termini of transplantation antigens (1985) (33)
Nanomedicine targets cancer. (2009) (33)
SRM targeted proteomics in search for biomarkers of HCV‐induced progression of fibrosis to cirrhosis in HALT‐C patients (2012) (33)
Specific recognition of the product of a transferred major histocompatibility complex gene by cytotoxic T lymphocytes. (1982) (33)
Identification of a brain-specific human cerebrospinal fluid glycoprotein, beta-trace protein. (1993) (33)
A gain-of-function mutation in TRPV3 causes focal palmoplantar keratoderma in a Chinese family. (2015) (33)
The class II genes of the rat MHC. (1989) (32)
Structure of the T15 VH gene subfamily: identification of immunoglobulin gene promotor homologies. (1987) (32)
Characterization of multiple immunoglobulin mu-chains synthesized by two clones of a B cell lymphoma. (1980) (32)
A Systems Approach to Rheumatoid Arthritis (2012) (32)
Genome-Scale Transcriptional Regulatory Network Models of Psychiatric and Neurodegenerative Disorders. (2019) (31)
RNASEQR—a streamlined and accurate RNA-seq sequence analysis program (2011) (31)
FVB/N (H2q) mouse is resistant to arthritis induction and exhibits a genomic deletion of T-cell receptor V beta gene segments (1999) (31)
Analytical and micropreparative two-dimensional electrophoresis of proteins (1991) (31)
The myelin proteins of the shark brain are similar to the myelin proteins of the mammalian peripheral nervous system (1989) (31)
Human prostate epithelial cell‐type cDNA libraries and prostate expression patterns (2002) (30)
Leroy Hood expounds the principles, practice and future of systems biology. (2003) (30)
Human and Mouse T‐Cell Receptor Loci: Genomics, Evolution, Diversity, and Serendipity a (1995) (30)
On the evolution of antibody light chains (1966) (30)
Automated Validation of Results and Removal of Fragment Ion Interferences in Targeted Analysis of Data-independent Acquisition Mass Spectrometry (MS) using SWATHProphet* (2015) (30)
Immunologic memory to phosphocholine. IV. Hybridomas representative of Group I (T15-like) and Group II (non-T15-like) antibodies utilize distinct VH genes. (1984) (30)
Human and mouse T-cell-receptor loci: the importance of comparative large-scale DNA sequence analyses. (1993) (29)
Towards predictive stochastic dynamical modeling of cancer genesis and progression (2010) (29)
Mouse immunoglobulin chains. Partial amino acid sequence of a kappa chain. (1973) (29)
An automated DNA synthesizer employing deoxynucleoside 3'-phosphoramidites. (1987) (29)
Characterization of the Japanese pufferfish (Takifugu rubripes) T-cell receptor α locus reveals a unique genomic organization (2001) (29)
Rabbit immunoglobulin light chains: correlation of variable region sequences with allotypic markers. (1973) (29)
Biotechnology and medicine of the future. (1988) (29)
High-throughput plasmid mini preparations facilitated by micro-mixing. (1996) (29)
Dense genome-wide SNP linkage scan in 301 hereditary prostate cancer families identifies multiple regions with suggestive evidence for linkage. (2009) (29)
High resolution time‐course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock‐in mice across multiple genetic backgrounds (2017) (29)
Implications of the diversity of the immunoglobulin gene superfamily. (1989) (28)
Revised nomenclature of mouse H-2 genes. (1990) (28)
A highly conserved apoptotic suppressor gene is located near the chicken T-cell receptor alpha chain constant region (1997) (28)
Automated DNA sequencing and analysis of the human genome. (1987) (28)
Multi-Omic Biological Age Estimation and Its Correlation With Wellness and Disease Phenotypes: A Longitudinal Study of 3,558 Individuals. (2019) (28)
Transgenic mouse model for neurocristopathy: Schwannomas and facial bone tumors. (1993) (28)
From Phage lambda to human cancer: endogenous molecular-cellular network hypothesis (2013) (28)
The Interdisciplinary Challenge (1993) (28)
Amino-terminal sequence analysis of the structural proteins of Sindbis virus. (1978) (28)
Optimal Scaling of Digital Transcriptomes (2013) (28)
Rapid cloning of any rearranged mouse immunoglobulin variable genes (1996) (28)
Analysis of sequence-tagged-connector strategies for DNA sequencing. (1999) (27)
A systems approach to clinical oncology uses deep phenotyping to deliver personalized care (2019) (27)
T cell receptor DJ but not VDJ rearrangement within a recombination substrate introduced into a pre-B cell line. (1989) (27)
Complete amino acid sequences of the major early embryonic alpha-like globins of the chicken. (1980) (27)
The complete V domain amino acid sequences of two myeloma inulin-binding proteins. (1982) (27)
Bridging Systems Medicine and Patient Needs (2015) (27)
Longitudinal analysis reveals transition barriers between dominant ecological states in the gut microbiome (2020) (27)
Immunology in the post-genomic era (2001) (27)
The Prion Disease Database: a comprehensive transcriptome resource for systems biology research in prion diseases (2009) (26)
An experimentally derived data set constructed for testing large-scale DNA sequence assembly algorithms. (1993) (26)
Identification and characterization of novel SNPs in CHEK2 in Ashkenazi Jewish men with prostate cancer. (2008) (26)
N‐terminal and internal sequence determination of microgram amounts of proteins separated by isoelectric focusing in immobilized pH gradients (1988) (26)
The Prostate Expression Database (PEDB): status and enhancements in 2000 (2000) (26)
The building blocks of successful translation of proteomics to the clinic (2018) (26)
Expression of hybrid class I genes of the major histocompatibility complex in mouse L cells. (1985) (25)
Covalent attachment of peptides for high sensitivity solid-phase sequence analysis. (1990) (25)
Use of DNA-mediated gene transfer to analyze the role of H-2Ld in controlling the specificity of anti-vesicular stomatitis virus cytotoxic T cells (1983) (25)
Inexpensive handheld device for the construction of high-density nucleic acid arrays. (1997) (25)
A novel 6:10 chromosomal translocation in the murine plasmacytoma NS-1 (1984) (25)
Genomic organization of the genes encoding mouse T-cell receptor alpha-chain. (1985) (25)
Mapping and Sequencing the Human Genome: How to Proceed (1987) (25)
Interaction of alpha 1 with alpha 2 region in class I MHC proteins contributes determinants recognized by antibodies and cytotoxic T cells. (1985) (25)
Large-scale DNA sequencing. (1991) (25)
A simple method using T4 DNA polymerase to clone polymerase chain reaction products. (1994) (24)
Endogenous molecular-cellular hierarchical modeling of prostate carcinogenesis uncovers robust structure. (2015) (24)
Human T-cell receptor Vα gene polymorphism (1991) (24)
Genome-wide linkage scan of prostate cancer Gleason score and confirmation of chromosome 19q (2007) (24)
Identification of a prostate cancer susceptibility locus on chromosome 7q11–21 in Jewish families (2004) (24)
Genomic Analysis of the Olfactory Receptor Region of the Mouse and Human T-Cell Receptor α/δ Loci (2002) (24)
Taking Systems Medicine to Heart. (2018) (24)
Conserved organization of the human and murine T-cell receptor beta-gene families. (1988) (24)
Identification of copy number variants in whole-genome data using Reference Coverage Profiles (2015) (24)
Cyclic AMP has a differentiative effect on an immortalized oligodendrocyte cell line (1993) (24)
Amino terminal amino acid sequence of the major polypeptide subunit of Torpedo californica acetylcholine receptor. (1979) (24)
Modeling the feasibility of whole genome shotgun sequencing using a pairwise end strategy. (2000) (24)
The Q7 α3 domain alters T cell recognition of class I antigens (1991) (23)
Proteomics cataloging analysis of human expressed prostatic secretions reveals rich source of biomarker candidates (2008) (23)
Microscale structure analysis of a high-molecular-weight, hydrophobic membrane glycoprotein fraction with platelet-derived growth factor-dependent kinase activity. (1986) (23)
Realistic artificial DNA sequences as negative controls for computational genomics (2014) (23)
The nucleotide sequence of a human immnnoglobulin C-gamma-1 gene (1982) (23)
An epigenetic biomarker panel for glioblastoma multiforme personalized medicine through DNA methylation analysis of human embryonic stem cell-like signature. (2014) (23)
The growing immunoglobulin gene superfamily. (1986) (23)
Protein-Centric N-Glycoproteomics Analysis of Membrane and Plasma Membrane Proteins (2014) (22)
An extension of the nomenclature for immunoglobulins. (1970) (22)
Pulsed field gel electrophoresis: Studies of DNA migration made with the programmable, autonomously‐controlled electrode electrophoresis system (1989) (22)
Gaps in the Human Genome Project (1999) (22)
Atlas of Transcription Factor Binding Sites from ENCODE DNase Hypersensitivity Data Across 27 Tissue Types (2018) (22)
Partial N‐terminal amino acid sequence analyses and comparative tryptic peptide maps of murine Ia molecules encoded by the I‐A subregion (1979) (22)
A physical map of human chromosome 14 (2001) (22)
Sequence-Level Analysis of the Major European Huntington Disease Haplotype. (2015) (22)
Mapping genomic organization by field inversion and two-dimensional gel electrophoresis: application to the murine T-cell receptor gamma gene family. (1988) (22)
Systems biology and cancer stem cells (2007) (22)
Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients. (2016) (22)
Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene. (2000) (22)
An approach to amino acid sequence analysis of transplantation antigens (1975) (22)
Complexity of sea urchin embryo nuclear proteins that contain basic domains. (1992) (22)
Antipeptide antibodies of predetermined specificity recognize and neutralize the bioactivity of the pan-specific hemopoietin interleukin 3. (1987) (21)
Two types of DNA rearrangements in immunoglobulin genes. (1981) (21)
NanoSystems biology. (2003) (21)
Cytotoxic T lymphocytes from mice with soluble class I Q10 molecules in their serum are not tolerant to membrane-bound Q10. (1987) (21)
Fluorescence-based sequencing directly from bacterial and P1-derived artificial chromosomes. (1997) (21)
Predominant use of a V alpha gene segment in mouse T-cell receptors for cytochrome c. (1986) (21)
Restriction fragment length polymorphisms of the mouse T-cell receptor gene families (2006) (20)
The Human Genome Project: creating an infrastructure for biology and medicine. (1991) (20)
Genetics of immunoglobulin kappa-chains: chemical analysis of normal human light chains of differing Inv types. (1969) (20)
Systems Biology Experimental Design - Considerations for Building Predictive Gene Regulatory Network Models for Prokaryotic Systems (2004) (20)
Amino acid variations at a single residue in an autoimmune peptide profoundly affect its properties: T-cell activation, major histocompatibility complex binding, and ability to block experimental allergic encephalomyelitis. (1990) (20)
WaveletQuant, an improved quantification software based on wavelet signal threshold de-noising for labeled quantitative proteomic analysis (2010) (20)
Polygenic risk associated with post-traumatic stress disorder onset and severity (2019) (20)
Multi-study Integration of Brain Cancer Transcriptomes Reveals Organ-Level Molecular Signatures (2013) (20)
A microtiter plate-based high-throughput DNA purification method. (1995) (20)
Restricted structural heterogeneity in antibodies: might different heavy chains have a common light chain? (1972) (20)
Automated microsequence analysis by use of radioactive phenylisothiocyanate. (1975) (19)
Myeloma proteins from NZB and BALB/c mice: structural and functional differences. (1979) (19)
Separation of peptides by reverse-phase high-performance liquid chromatography using propyl- and cyanopropylsilyl supports. (1984) (19)
Mechanistic inferences on metabolic dysfunction in posttraumatic stress disorder from an integrated model and multiomic analysis: role of glucocorticoid receptor sensitivity (2019) (19)
Substitution Model of Sequence Evolution for the Human Immunodeficiency Virus Type 1 Subtype B gp120 Gene over the C2-V5 Region (2001) (19)
An automated Teflon microfluidic peptide synthesizer. (2013) (19)
Negative selection: a method for obtaining low-abundance cDNAs using high-density cDNA clone arrays. (1999) (19)
Sequence of histone 2B of Drosophila melanogaster. (1979) (19)
Molecular profiling of stem cells. (2007) (19)
Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories (2020) (19)
Promoting Wellness & Demystifying Disease: The 100K Project (2014) (19)
P 4 Medicine needs P 4 Education (2014) (19)
Combining site specificities of mouse hybridoma antibodies to dextran B1355S (1983) (18)
Hopper: software for automating data tracking and flow in DNA sequencing (1997) (18)
Antipeptide antibodies define the NH2-terminal structure of the pan-specific hemopoietin interleukin 3. (1987) (18)
Amino acid sequence restriction in rabbit antibody light chains. (1969) (18)
Effect of electric field switching on the electrophoretic mobility of single‐stranded DNA molecules in polyacrylamide gels (1989) (18)
Finding the T-cell antigen receptor: Past attempts and future promise (1983) (18)
Two "big" dynorphins from porcine pituitary. (1982) (18)
Diversity and structure of genes of the alpha family of mouse T-cell antigen receptor. (1985) (18)
Studies on IgA and IgA monoclonal proteins derived from a single patient. Evidence for identical light chains and variable regions of the heavy chain. (1975) (18)
Amino terminal sequences of human immunoglobulin heavy chains. (1971) (18)
iNetModels 2.0: an interactive visualization and database of multi-omics data (2019) (18)
An enigmatic fourth runt domain gene in the fugu genome: ancestral gene loss versus accelerated evolution (2004) (18)
Meta-analysis of gene expression in human pancreatic islets after in vitro expansion. (2009) (17)
WDR19 Expression is Increased in Prostate Cancer Compared with Normal Cells, but Low-Intensity Expression in Cancers is Associated with Shorter Time to Biochemical Failures and Local Recurrence (2008) (17)
Isolation of unknown genes from human bone marrow by differential screening and single-pass cDNA sequence determination. (1994) (17)
Efficiency, Robustness, and Stochasticity of Gene Regulatory Networks in Systems Biology: λ Switch as a Working Example (2005) (17)
A Systems Approach to Medicine Will Transform Healthcare (2008) (17)
Reverse Engineering Galactose Regulation in Yeast through Model Selection (2005) (17)
Structure-function relationship among T-cell receptors specific for lysozyme peptides bound to Ab or Abm-12 molecules. (1992) (17)
Glycocapture-assisted global quantitative proteomics (gagQP) reveals multiorgan responses in serum toxicoproteome. (2013) (16)
T-cell receptor Vbeta deletion and Valpha polymorphism are responsible for the resistance of SWR mouse to arthritis induction (1999) (16)
Advances in Brief Prostate-localized and Androgen-regulated Expression of the Membrane-bound Serine Protease TMPRSS 2 1 (1999) (16)
An immunoglobulin VH pseudogene. (1981) (16)
A prologue to the study of the nonhistone chromosomal proteins. (1974) (16)
Automated sequential affinity chromatography of sea urchin embryo DNA binding proteins. (1992) (16)
Prequips - an extensible software platform for integration, visualization and analysis of LC-MS/MS proteomics data (2009) (16)
Molecular Imaging and Biology (2003) (16)
Distinct hypomyelinated phenotypes in MBP‐SV40 large T transgenic mice (1993) (16)
Complete amino acid sequence of the major early embryonic beta-like globin in chickens. (1981) (16)
Immunoglobulin gene rearrangements in normal mouse B cells (1982) (16)
N-Glycoproteome of E14.Tg2a Mouse Embryonic Stem Cells (2013) (16)
Immunologic memory to phosphocholine. V. Hybridomas representative of group II antibodies utilize V kappa 1-3 gene(s). (1984) (15)
Genomic architecture of inflammatory bowel disease in five families with multiple affected individuals (2016) (15)
Ultrafast Comparison of Personal Genomes via Precomputed Genome Fingerprints (2017) (15)
N-Terminal sequence of human big gastrin: sequence, synthetic and immunochemical studies. (1980) (15)
Automated microsequence analysis in the presence of a synthetic "carrier". (1974) (15)
Immunoglobulin heavy chain gene organization in mice : Analysis of a myeloma genomic clone containing variable and a constant regions (15)
Deep phenotyping during pregnancy for predictive and preventive medicine (2020) (15)
Measurement of organ-specific and acute-phase blood protein levels in early Lyme disease (2019) (15)
N-terminal analysis of normal immunoglobulin light chains. I. A study of thirteen individual humans. (1971) (15)
CHAPTER 6 – Systems Biology and the Emergence of Systems Medicine (2009) (15)
Multiplex genotype determination at a DNA sequence polymorphism cluster in the human immunoglobulin heavy-chain region. (1995) (15)
Frequency and polymorphism of simple sequence repeats in a contiguous 685-kb DNA sequence containing the human T-cell receptor beta-chain gene complex. (1995) (15)
Analysis of the 1.1-Mb human alpha/delta T-cell receptor locus with bacterial artificial chromosome clones. (1997) (14)
A conserved sequence block in murine and human T cell receptor (TCR) Jalpha region is a composite element that enhances TCR alpha enhancer activity and binds multiple nuclear factors. (1998) (14)
Complete amino acid sequence of a mouse mu chain: homology among heavy chain constant region domains. (1982) (14)
Genomic scan of 12 hereditary prostate cancer families having an occurrence of pancreas cancer (2007) (14)
Isolation and characterization of human and mouse WDR19,a novel WD-repeat protein exhibiting androgen-regulated expression in prostate epithelium. (2003) (14)
Molecular Biology of Eucaryotic Cells (1976) (14)
Analysis of a new class I gene mapping to theHmt region of the mouse (2006) (14)
Mouse Immunoglobulin Genes (1981) (14)
Organization of the murine T-cell receptor gamma locus. (1993) (14)
Bioprocessing of human glioblastoma brain cancer tissue. (2010) (14)
ACGT - A Comparative Genomics Tool (2003) (14)
Minor early embryonic chick hemoglobin M. Amino acid sequences of the epsilon and alpha D chains. (1982) (14)
PARTIAL AMINO ACID SEQUENCE ANALYSES OF Ia MOLECULES (1978) (14)
SWR: an inbred strain suitable for generating transgenic mice. (1997) (14)
Functional Genomics, Proteomics, Metabolomics and Bioinformatics for Systems Biology (2013) (13)
Monoclonal antipeptide antibodies recognize IL-3 and neutralize its bioactivity in vivo. (1988) (13)
Quantitative proteomic approaches for biomarker discovery (2007) (13)
Genes of the major histocompatibility complex. (1982) (13)
A strategy to study gene polymorphism by direct sequence analysis of cosmid clones and amplified genomic DNA. (1989) (13)
Automatable screening of yeast artificial-chromosome libraries based on the oligonucleotide-ligation assay. (1992) (13)
Antigen/major histocompatibility complex-specific activation of murine T cells transfected with functionally rearranged T-cell receptor genes. (1987) (13)
Multiomic blood correlates of genetic risk identify presymptomatic disease alterations (2020) (13)
A high-throughput plasmid DNA preparation method. (1994) (13)
Systems approaches applied to the study of Saccharomyces cerevisiae and Halobacterium sp. (2003) (12)
N-terminal amino acid sequences of the alpha and beta chains of HLA-DR1 and HLA-DR2 antigens. (1983) (12)
Rearranged beta T cell receptor genes in a helper T cell clone specific for lysozyme: no correlation between V beta and MHC restriction. (1985) (12)
Localization of diphtheria toxin nuclease activity to fragment A (1992) (12)
Antibody genes and other multigene families. (1976) (12)
Autoimmune disease and T-cell immunologic recognition. (1989) (12)
Model genomes: the benefits of analysing homologous human and mouse sequences. (1992) (12)
Sponge‐like electrophoresis media: Mechanically strong materials compatible with organic solvents, polymer solutions and two‐dimensional electrophoresis (1994) (12)
Modulation of Immune Checkpoints by Chemotherapy in Human Colorectal Liver Metastases (2020) (12)
Use of cloned H-2 genes for study of H-2-restricted cytotoxicity: Ld is the LCMV restriction element for H-2d. (1983) (12)
Oligonucleotide arrays for high resolution HLA typing. (1999) (11)
Epigenetic biotypes of post-traumatic stress disorder in war-zone exposed veteran and active duty males (2020) (11)
Automated fluorescent DNA sequencing of polymerase chain reaction products. (1993) (11)
Baseline Gut Metagenomic Functional Gene Signature Associated with Variable Weight Loss Responses following a Healthy Lifestyle Intervention in Humans (2021) (11)
Expression of mouse Tla region class I genes in tissues enriched for γδ cells (1992) (11)
Heavy chain genes of rabbit IgG: isolation of a cDNA encoding gamma heavy chain and identification of two genomic C gamma genes. (1982) (11)
Suggestive genetic linkage to chromosome 11p11.2‐q12.2 in hereditary prostate cancer families with primary kidney cancer (2007) (11)
A new approach to understanding T cell development: the isolation and characterization of immature CD4-, CD8-, CD3- T cell cDNAs by subtraction cloning. (1992) (11)
MS-BID: a Java package for label-free LC-MS-based comparative proteomic analysis (2008) (11)
Confirmation of prostate cancer susceptibility genes using high-risk families. (1999) (11)
A sequence restriction in the variable region of immunoglobulin light chains from sharks, birds, and mammals. (1974) (11)
Rapid restriction map constructions using a modified pWE15 cosmid vector and a robotic workstation. (1991) (11)
Analysis of the diversity of murine antibodies to dextran B1355: N-terminal amino acid sequences of heavy chains from serum antibody. (1976) (11)
7 – Deciphering Genomes Through Automated Large-scale Sequencing (1999) (11)
Simultaneous analysis of phosphoproteins and total cellular proteins from PC12 cells (1991) (11)
The Role of Chemistry (1988) (10)
Lims and the Human Genome Project (1991) (10)
THE ORGANIZATION AND REARRANGEMENT OF HEAVY CHAIN IMMUNOGLOBULIN GENES IN MICE (1979) (10)
Embryonal carcinoma cells express Qa and Tla class I genes of the major histocompatibility complex. (1989) (10)
Amino-terminal sequence of the Tn3 transposase protein (1982) (10)
Sequence and expression of a novel human T-cell receptor β-chain variable gene segment subfamily (2004) (10)
Biochemical identification of the Qa-1 alloantigen (2005) (10)
Organization, Sequence, and Function of 34.5 kb of Genomic DNA Encompassing Several Murine T-Cell Receptor α/δ Variable Gene Segments (1994) (10)
Control of VDJ recombinase activity. (1989) (10)
Expression of mouse Tla region class I genes in tissues enriched for gamma delta cells. (1992) (10)
DNA length polymorphism located 5' to the human myelin basic protein gene. (1987) (10)
The human genome project (1994) (10)
Predicting demographic group structures based on DNA sequence data. (2003) (10)
Antibody Diversity Patterns and Structure of Idiotypic Determinants on Murine Anti- α(1 → 3) Dextran Antibodies (1980) (10)
Systems Biology and Systems Medicine (2013) (10)
Viva Europa, a Land of Excellence in Research and Innovation for Health and Wellbeing (2017) (10)
Systems Biology and Emerging Technologies Will Catalyze the Transition from Reactive Medicine to Predictive , Personalized , Preventive and Participatory ( P 4 ) Medicine (2009) (10)
Beyond cancer genes: colorectal cancer as robust intrinsic states formed by molecular interactions (2017) (10)
Distinct Profiles of Cell-Free MicroRNAs in Plasma of Veterans with Post-Traumatic Stress Disorder (2019) (10)
Genome–microbiome interplay provides insight into the determinants of the human blood metabolome (2022) (10)
Mechanical precision in two-dimensional electrophoresis can improve protein spot positional reproducibility. (1993) (10)
Utilization of machine learning for identifying symptom severity military-related PTSD subtypes and their biological correlates (2021) (10)
ANTIBODY DIVERSITY: AN ASSESSMENT (1974) (9)
Comparisons of myeloma proteins from NZB and BALB/c mice: structural and functional differences of heavy chains. (1979) (9)
Gene regulatory networks and embryonic specification (2008) (9)
Molecular signals for phosphatidylinositol modification of the Qa-2 antigen. (1990) (9)
Blood Is a Window into Health and Disease. (2019) (9)
An H-2Ld hybrid molecule with a Qa-2 alpha-3 domain and phosphatidyl-inositol anchor is not recognized by H-2Ld-specific cytotoxic T lymphocytes. (1989) (9)
Whole genome sequence and comparative analysis of Borrelia burgdorferi MM1 (2017) (9)
Analysis of MHC class I gene expression in adult bone marrow and fetal liver of the BALB/c mouse. (1991) (9)
Nucleotide sequence analysis of 95 kb near the 3' end of the murine T-cell receptor alpha/delta chain locus: strategy and methodology. (1992) (9)
Multiple C4/Slp genes distinguished by expression after transfection (1986) (9)
NH2-terminal dodecapeptide of porcine big gastrin: Revised sequence and confirmation of structure by immunochemical analysis (1979) (8)
Evolution and selection of primate T cell antigen receptor BV8 gene subfamily. (1997) (8)
Effect of Combat Exposure and Posttraumatic Stress Disorder on Telomere Length and Amygdala Volume. (2020) (8)
Untargeted longitudinal analysis of a wellness cohort identifies markers of metastatic cancer years prior to diagnosis (2020) (8)
Detailed transcriptome atlas of the pancreatic β cell (2008) (8)
Human T-cell receptor genes: organization, diversity, and polymorphism. (1986) (8)
Amino acid sequences of the epsilon and alpha E globins of HbE, a minor early embryonic hemoglobin of the chicken. (1982) (8)
Systems Medicine and the Emergence of Proactive P4 Medicine: Predictive, Preventive, Personalized and Participatory (2013) (8)
Partial amino acid sequences of marine Ia antigens of the I-ECd subregion (1978) (8)
Heterogeneity in statin responses explained by variation in the human gut microbiome (2021) (8)
Biological Complexity Under Attack (2011) (8)
la-transfected L-cell fibroblasts present a lysozyme peptide but not the native protein to lysozyme-specific T cells ( antigen presentation / antigen processing / T-cell activation ) (8)
Expression of theQ8/9d gene by T cells of the mouse (1989) (8)
Human Antibody Genes (1983) (8)
Sequencing reactions in microtiter plates. (1990) (8)
Science Over Politics (1999) (8)
Foreword: from the TRANSCRIPTOME conferences to the SYSTEMOSCOPE international consortium. (2003) (8)
Essential Concepts in Immunology (1978) (8)
Molecular characterization of meiotic recombination within the major histocompatibility complex of the mouse: Mapping of crossover sites within theI region (1987) (8)
Thiobenzoylation Method of Protein Sequencing: Gas Chromatography/Mass Spectrometric Detection of 5-Acetoxy-2-Phenylthiazoles (1993) (7)
“Systems biology and systems medicine: From reactive to predictive, personalized, preventive and participatory (P4) medicine” (2008) (7)
Ideker Perturbed Metabolic Network Integrated Genomic and Proteomic Analyses of a Systematically (2013) (7)
Relaxation intervals alter the mobility of large DNA molecules in pulsed field gel electrophoresis. (1988) (7)
Transcripts of Tla genes (1987) (7)
Identifying DNA polymorphisms in human TCRA/D variable genes by direct sequencing of PCR products (1996) (7)
In individual T cells one productive alpha rearrangement does not appear to block rearrangement at the second allele [retracted by Hood L, Urban JL. In: J Exp Med 1990 Sep 1;172(3):1005] (1989) (7)
Structural analysis of the mouse T-cell receptor Tcra V2 subfamily (2004) (7)
Systems Biology (2013) (7)
Oral tolerance in experimental autoimmune encephalomyelitis (eae) (1996) (7)
Genome-scale transcriptional regulatory network models of psychiatric and neurodegenerative disorders (2017) (7)
Genomic organization of the mouse T-cell receptor 8-chain gene family ( deletion mapping / fleld-inversion gel electrophoresis ) (7)
A systems‐biology clinical trial of a personalized multimodal lifestyle intervention for early Alzheimer's disease (2021) (7)
C-terminal peptides from human γ-chains of differing subclass and allotype (1970) (7)
Corrigendum: Direct multiplexed measurement of gene expression with color-coded probe pairs (2008) (7)
Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer’s disease (2021) (7)
High-throughput cDNA screening utilizing a low order neural network filter. (1996) (7)
Restriction fragment length polymorphisms of the mouse T-cell receptor gene families (2004) (7)
Myelin basic protein and myelinogenesis: morphometric analysis of normal, mutant and transgenic central nervous system. (1990) (7)
Label-free detection with surface plasmon resonance imaging. (2011) (6)
GENES OF THE MAJOR HISTOCOMPATIBILI TY COMPLEX OF THE MOUSE (1983) (6)
Genomic analysis of the olfactory receptor region of the mouse and human T-cell receptor alpha/delta loci. (2002) (6)
Serological and biochemical characterization of rat (RT1) class II molecules with restricted mouse anti-Ia sera (2004) (6)
Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBA y 1 j mice ( rheumatoid y genome scan y collagen-induced arthritis ) (1999) (6)
General Discussion on Theories of Antibody Variability (1967) (6)
Partial amino acid sequences of mouse transplantation antigens (1978) (6)
Robustness, Stability and Efficiency of Phage lambda Gene Regulatory Network: Dynamical Structure Analysis (2004) (6)
Nucleotide sequence of a human immunoglobulin C gamma 4 gene. (1981) (6)
The evolution of multigene families. (1977) (6)
Efficient region-based test strategy uncovers genetic risk factors for functional outcome in bipolar disorder (2019) (6)
Core transcriptional regulatory circuits in prion diseases (2020) (6)
High-throughput genotyping (1996) (6)
N-terminal sequence heterogeneity of guinea pig anti-DNP kappa chains. (1967) (6)
Gut microbiome pattern reflects healthy ageing and predicts survival in humans (2021) (6)
BDQC: a general-purpose analytics tool for domain-blind validation of Big Data (2018) (6)
Antibody and MHC genes. (1982) (6)
Retraction. In individual T cells one productive alpha rearrangement does not appear to block rearrangement at the second allele [retraction of Kumar V, Urban JL, Hood L. In: J Exp Med 1989 Dec 1;170(6):2183-8] (1990) (6)
DNA sequence of the mouse H-2 Dd transplantation antigen gene ( class I genes / H-2 Dd protein sequence ) (5)
Retraction-autoimmune T cells: Immune recognition of normal and variant peptide epitopes and peptide-based therapy (1991) (5)
Author Correction: Gut microbiome pattern reflects healthy ageing and predicts survival in humans (2021) (5)
Lessons Learned as President of the Institute for Systems Biology (2000–2018) (2018) (5)
Report on the Human Genome Initiative (1987) (5)
Immunoglobulin genetics. (1972) (5)
Germalin repertoire of T-cell receptor β-chain genes in patients with insulin-dependent diabetes mellitus (1991) (5)
The genetics, evolution and expression of antibody molecules (1973) (5)
Gut Microbiome Pattern Reflects Healthy Aging and Predicts Extended Survival in Humans (2020) (5)
Wu and Kabat 1970: A Transforming View of Antibody Diversity (2008) (5)
The nucleotide sequence of a human immunoglobulin C , , gene (5)
Biological Regulation and Development (1984) (5)
On different aspects of network analysis in systems biology (2013) (5)
Increased Expression of SIM 2s Protein Is a Novel Marker of Aggressive Prostate Cancer (2007) (5)
Structural Correlates of Cross-reactive and Individual Idiotypic Determinants on Murine Antibodies to A-(1 ~ 3) Dextran* (2003) (5)
Personalized, Precision, and N-of-One Medicine: A Clarification of Terminology and Concepts (2019) (5)
Human T-cell receptor V alpha gene polymorphism. (1991) (5)
Peptide map analysis of mutant transplantation antigens (1979) (4)
COVID-19 and beyond: a call for action and audacious solidarity to all the citizens and nations, it is humanity’s fight (2020) (4)
Predictive parameters of joint disease in DBA/1 transgenic mice. (1999) (4)
My life and adventures integrating biology and technology (2002) (4)
Erratum: Genome sequence of Haloarcula marismortui: A halophilic archaeon from the dead sea (Genome Research (2004) vol. 14 (2221-2234)) (2004) (4)
Transgenic Mice in Neurobiological Research (1990) (4)
Betaine homocysteine methyltransferase (BHMT) as a specific and sensitive blood marker for acute liver injury (2014) (4)
A Blueprint for Systems Biology. (2019) (4)
Sequence Analysis of Proteins from Whole-Cell Lysates After Separation in Analytical Two-Dimensional Gels (1987) (4)
UW Team Reaches Out to Grade- and High-School Students. (1994) (4)
Molecular genetics of anti-carbohydrate antibodies. (1984) (4)
Cytotoxic T lymphocytes recognize determinants on the BALB/c-H-2Ld molecule controlled by α1 and α2 but not α3 external domains (2004) (4)
Molecular biology of eucaryotic cells: A problems approach (1975) (4)
Computational Infrastructures for Data and Knowledge Management in Systems Biology (2013) (4)
Every Life Has Equal Value (2013) (4)
The geometry of clinical labs and wellness states from deeply phenotyped humans (2021) (4)
Genomic constitution of an H-2:Tla variant leukemia. (1984) (4)
eview xtracellular microRNA : A new source of biomarkers (2011) (4)
Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90 (2022) (4)
Light on molecular recognition (1991) (4)
A computer simulation of evolutionary forces controlling the size of a multigene family (1980) (4)
Disrupted SOX10 function causes spongiform neurodegeneration in gray tremor mice (2015) (4)
Polymorphism detection and sequence analysis of human T-cell receptor Vα-chain-encoding gene segments (2004) (4)
ANALYSIS OF A HUMAN V,B GENE SUBFAMILY (2003) (4)
The effect of COVID-19 vaccination and booster on maternal-fetal outcomes: a retrospective multicenter cohort study (2022) (4)
39 – Cloned T Cells as a Tool for Molecular Geneticists: Approaches to Cloning Genes Which Encode T Cell Antigen Receptors (1982) (4)
Health Care of the 21st Century: Predictive, Preventive, Personalized and Participatory (P4) Medicine (2006) (4)
The impact of maternal SARS-CoV-2 infection and COVID-19 vaccination on maternal-fetal outcomes (2022) (4)
Partial N-terminal amino acid sequences of guinea pig classic histocompatibility antigens. (1980) (4)
Specific primer-directed DNA sequence analysis using automated fluorescence detection and labeled primers. (1993) (3)
Thioacetylation method of protein sequencing: Gas chromatography/Ion trap mass spectrometric detection of 5-acetoxy-2-methylthiazoles (1992) (3)
Analysis of D2d: a D-region class I gene (1989) (3)
Mechanistic insights on metabolic dysfunction in PTSD: Role of glucocorticoid receptor sensitivity and energy deficit (2018) (3)
Sequence similarities of myelin basic protein promoters from mouse and shark: implications for the control of gene expression in myelinating cells. (1993) (3)
Large-Scale Production of Human Glioblastoma-Derived Cancer Stem Cell Tissue in Suspension Bioreactors to Facilitate the Development of Novel Oncolytic Therapeutics (2011) (3)
The expression of mouse T-cell receptor TCRDV genes in BALB/c spleen (2004) (3)
Chapter 11 – Systems Biology and Systems Medicine (2010) (3)
Tryptic peptide map analyses of mouse transplantation antigens (2005) (3)
Accelerated High Sensitivity Sequence Analysis of Proteins and Peptides Immobilized on Chemically-modified Glass Fiber Discs (1989) (3)
The Coaching for Cognition in Alzheimer's (COCOA) trial: Study design (2022) (3)
A Novel Approach to Isolation of Proteins for Microsequence Analysis: Electroblotting Onto Activated Glass (1987) (3)
Cloning and identification of the H-2Dp gene (2004) (3)
A Common Phenotype Polymorphism in Mammalian Brains Defined by Concomitant Production of Prolactin and Growth Hormone (2016) (3)
Diversification of antibody genes through DNA rearrangements. (1981) (3)
Human antibody genes. Evolutionary and molecular genetic perspectives. (1983) (3)
A New Protein Microsequenator Using Gas Phase Edman Reagents (1982) (3)
Diversity of T-Cell Receptor Structures Specific for Minimal Peptide/Ia Determinants: Implications for Immune Response Gene Defects (1986) (3)
Nucleotide sequence of the BALB/c H-2T region gene, T3d (2004) (3)
Correction: A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD (2020) (3)
Scientific and Social Issues in the Human Genome Project, London: Harvard University Press, 1992. Price (US) $29.95 (1993) (3)
Single Syringe-Pump Solid-Phase Protein Sequencer (1993) (3)
Identification of T-cell receptor a-chain genes in the chicken (2004) (3)
Amino acid variations at a single residue in an autoimmune peptide profoundly affect its properties: T-cell activation, major histocompatibility complex binding, and ability to block experimental allergic encephalomyelitis. (1991) (3)
Issues in Computational Methods for Functional Genomics and Systems Biology (2003) (3)
Genome maps 8. Building gene families. Wall chart. (1997) (3)
The Hallmarks of Cancer Revisited Through Systems Biology and Network Modelling (2011) (3)
Epidermal Ia molecules from theI-A andI-EC subregions of the mouseH-2 complex (1978) (3)
Genome-scale transcriptional regulatory network models for the mouse and human striatum predict roles for SMAD3 and other transcription factors in Huntington’s disease (2016) (3)
Structure-Function Studies of Lymphokines by Total Chemical Synthesis (1987) (3)
Regulatory Elements in the Promoter of the H-2Dd Class I Gene (1987) (3)
Pillars article: Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell. 1993. 72: 551-560. (2013) (2)
Stochasticity of Gene Regulatory Networks in Systems Biology: l Switch as a Working Example (2007) (2)
The rs16906252:C>T SNP is not associated with increased overall survival or temozolomide response in a Han-Chinese glioma cohort (2017) (2)
Chemical Characterization of Murine Ia Antigens (1978) (2)
Analysis ofD2d: AD-region class I gene (1989) (2)
Nanomedicine Targets CANCER: Viewing each human body as a system of interacting molecular networks and targeting disruptions in the system with nanoscale technologies can transform how disease is understood, attacked and possibly prevented (2009) (2)
DNA sequence of a class I pseudogene from theTla region of the murine MHC: Recombination at a B2 Alu repetitive sequence (1989) (2)
12 – OLIGONUCLEOTIDE LIGATION ASSAY (1990) (2)
TCRV and TCRJ gene usage in MBP responding T cells from (B10.PL×PL/J)F1 mice is biased towards that of B10.PL mice (1997) (2)
High-throughput genotyping: practical considerations concerning the day-to-day application (1996) (2)
Blood metabolome signature predicts gut microbiome α-diversity in health and disease (2019) (2)
Investigating the importance of acylcarnitines in Alzheimer’s disease (2021) (2)
Reply to "Precision medicine in the clouds" (2018) (2)
Case Study: A Precision Medicine Approach to Multifactorial Dementia and Alzheimer's Disease. (2021) (2)
ANALYSIS OF PROTEINS BY MASS SPECTROMETRY (1992) (2)
The nonhistone chromosomal proteins of vertebrate liver and kidney: A comparative study by gel electrophoresis (1975) (2)
Serum brain-derived neurotrophic factor remains elevated after long term follow-up of combat veterans with chronic post-traumatic stress disorder (2021) (2)
Epigenetic Biotypes of PTSD in War-Zone Exposed Veteran and Active Duty Males (2020) (2)
P4 medicine could transform healthcare, but payers and physicians are not yet convinced. (2010) (2)
MOBN: an interactive database of multi-omics biological networks (2019) (2)
Altered Huntingtin-Chromatin Interactions Predict Transcriptional and Epigenetic Changes in Huntington’s Disease (2020) (2)
L3T4 but not LFA-1 participates in antigen presentation by Ak-positive L-Cell transformants (2004) (2)
Antibody diversity. (1971) (2)
Mouse Organ-Specific Proteins and Functions (2021) (1)
The Q7 alpha 3 domain alters T cell recognition of class I antigens. (1991) (1)
Synaptopathies Heat Up: Mutations in STX1B in Fever-Associated Epilepsies (2015) (1)
Signal Sequencing for Gene Expression Profiling (2010) (1)
Leroy Hood: Reflections on a Legendary Career (2021) (1)
Foreword (1997) (1)
Immunoglobulins: Structure, Genetics and Evolution (1968) (1)
L1 - How technology, big data and systems approaches are transforming 21st century healthcare (2020) (1)
Amino acid diversity in the mouse heavy chain family and its correla- tion with hapten binding specificities. Abstr. (1975) (1)
Mechanistic inferences on metabolic dysfunction in PTSD from an integrated model and multi-omic analysis: Role of glucocorticoid receptor sensitivity. (2019) (1)
Scale-invariant geometric data analysis (SIGDA) provides robust, detailed visualizations of human ancestry specific to individuals and populations (2018) (1)
PI3K/APC pathway and cyclin-dependent kinase pathway to predict complete responders in CRC patients treated with ADAPT therapy. (2015) (1)
Abstract 2441: NanoString 3D Biology™ technology: simultaneous digital counting of DNA, RNA and protein (2017) (1)
, Systematically Perturbed Metabolic Network Integrated Genomic and Proteomic Analyses of a (2010) (1)
Structural and serological studies of six iga myeloma proteins from balb/c mice that bind phosphoryl-choline. Abstr. (1970) (1)
Cytotoxic T lymphocytes recognize determinants on the BALB/c-H-2Ld molecule controlled by alpha 1 and alpha 2 but not alpha 3 external domains. (1984) (1)
COACHING FOR COGNITION IN ALZHEIMER'S (COCOA) TRIAL (2019) (1)
Germline repertoire of T-cell receptor beta-chain genes in patients with insulin-dependent diabetes mellitus. (1991) (1)
A RARE PROSTATE CANCER SUSCEPTIBILITY LOCUS MAPPED TO THE SHORT ARM OF CHROMOSOME 1 (1p36) (1999) (1)
Cell Antigen Receptors and the lmmunoglobulin Supergene Family Review (2004) (1)
Organization, sequence, and function of 34.5 kb of genomic DNA encompassing several murine T-cell receptor alpha/delta variable gene segments. (1994) (1)
Microchemical instrumentation. (1981) (1)
Expression ofIgDmayusebothDNA rearrangement andRNA splicing mechanisms (1981) (1)
Peptide map comparisons of epidermal and spleen H-2 molecules (1981) (1)
Manifestations of genetic risk for Alzheimer’s Disease in the blood: a cross-sectional multi-omic analysis in healthy adults aged 18-90+ (2021) (1)
Purification andprimary structure oftwoneuroactive peptides that causebagcell afterdischarge andegg-laying inAplysia (1980) (1)
Expression of mouse Tla region class I genes in tissue enriched for γδ cells (2004) (1)
Optimizing antibody microarrays for high resolution SPR microscopy (2006) (1)
Pillars Article: An Immunoglobulin Heavy Chain Variable Region Gene Is Generated from Three Segments of DNA: VH, D and JH. Cell, 1980, 19: 981–992. (2004) (1)
Structure of murine Ia antigens : Partial NH 2-terminal amino acid sequences of products of the I-E or IC subregion ( H-2 complex gene products / immunoprecipitation / microsequence analysis / sequence ! homology ) (1)
The role of cysteine residues in interleukin-3 function established by total chemical synthesis of analogs (1988) (1)
Current Awareness on Comparative and Functional Genomics (2004) (1)
Multiomic signatures of body mass index identify heterogeneous health phenotypes and responses to a lifestyle intervention (2023) (1)
Rapid detection of bovine type II collagen-specific T-cell hybridomas. (1997) (1)
Cancer Genesis and Progression as Dynamics in Functional Landscape of Endogenous Molecular-Cellular Network (2007) (1)
So many genes; So little time A short cut to mapping genes (1994) (1)
Generally-healthy individuals with aberrant bowel movement frequencies show enrichment for microbially-derived blood metabolites associated with impaired kidney function (2023) (1)
Transcriptomics, metabolomics, lipidomics, metabolic flux and mGWAS analyses of sphingolipid pathway highlights novel drugs for Alzheimer’s disease (2021) (1)
Tools of genetic manipulation. (1984) (1)
Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19 (2021) (1)
Complete Genomic Sequence and Analysis of 117 kb of Human DNA Containing the Gene BRCAI (2007) (1)
Advances in Brief PART-1 : A Novel Human Prostate-specific , Androgen-regulated Gene that Maps to Chromosome 5 q 121 (2000) (1)
Complete nucleotide sequence of the cosmid vector pWE15A. (1992) (1)
Practical High Performance Liquid Chromatography of Proteins and Peptides (1987) (1)
Pillars Article: Evidence for Amino Acid Sequence Differences among Proteins Resembling the L-chain Subunits of Immunoglobulins. J. Mol. Biol. 1965. 12: 81-87. (2018) (1)
The Structure and Evolution of Transplantation Antigens (1976) (1)
Integrated blood barcode chips for rapid multiplexed protein analysis of microliter quantities of blood (2008) (1)
Antibodies and T-Cell Receptors: Jumping Genes and Supergene Families and New Instruments for Studying Them (1987) (1)
Participatory medicine: a driving force for revolutionizing healthcare (2013) (1)
Correction: Optimal Scaling of Digital Transcriptomes (2014) (0)
Home Genomics News & Information Research Cores Resources People Workspaces My Account About Us (2015) (0)
6 Doppel, a New PrP-like Mammalian Protein (2004) (0)
Blood Biomarkers for Assessing the Exposure and Response of Mammals to Chemical and Biological Agents (2012) (0)
Protein Structure and Biology (2013) (0)
Fugu rubripes Whole-Genome Shotgun Assembly and Analysis of the Genome of (2013) (0)
Developmental biologist Eric H. Davidson, 1937–2015 (2015) (0)
725 Identification and Characterization of Pescadillo, a Novel BRCT-domain Containing Gene with Increased Expression in Glioblastoma (2000) (0)
Viewing each human body as a system of interacting molecular networks and targeting disruptions in the system with nanoscale technologies can transform how disease is understood , attacked and possibly prevented By (2009) (0)
A Vision for Twenty‐First Century Healthcare (2017) (0)
Abstract 1809: Analysis of molecular networks that drive astrocytoma initiation and progression. (2013) (0)
MECHANISTIC AND DIRECTIONAL TRANSCRIPTIONAL REGULATORY NETWORKS IN ALZHEIMER’S DISEASE (2018) (0)
COVID-19 and beyond: a call for action and audacious solidarity to all the citizens and nations, it is humanity’s fight [version 1; peer review: 3 approved with reservations] (2021) (0)
Current Awareness on Comparative and Functional Genomics (2005) (0)
A systematic approach to exosome-based translational (2012) (0)
Gaps in the Human Genome Project: If the Multinational Human Genome Project Is to Continue Its Successful Start, Sequencing Strategies Must Be Changed. (1999) (0)
One stone, two birds: how a WGS-enabled diagnostic journey transforms into a precision population health service for the 21st century (2021) (0)
Parallel microfluidic arrays for SPRi detection (2010) (0)
COVID-19 and Beyond: A Call for Action and Audacious Solidarity to All the Citizens and Nations, It Is Humanity’s Fight (2020) (0)
The uman enome roject: big science (2013) (0)
COVID-19 and beyond: a call for action and audacious solidarity to all the citizens and nations, it is humanity’s fight [version 1; peer review: awaiting peer review] (2020) (0)
Publisher Correction: Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer (2019) (0)
LineageRelationship BetweenLNCaPand LNCaP-Derived ProstateCancerCell Lines (2004) (0)
Welcome to Progress in Preventive Medicine from the Editorial Board (2016) (0)
Weight loss response following lifestyle intervention associated with baseline gut metagenomic signature in humans (2021) (0)
What did the human genome project entail ? (2013) (0)
Systems Approach to Studying Disease (2008) (0)
Gene expression profiling in prostate cancer (2003) (0)
Organ-Specific Blood Signatures for Host Response to Infections (2012) (0)
Membrane Expression and Function of MHC Class I Antigens with Truncated or Altered Cytoplasmic Tails (1985) (0)
Author Correction: New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections (2020) (0)
SIM2 overexpression in prostate cancer (2005) (0)
Classifying Veterans With Post-Traumatic Stress Disorder Based on Blood Protein and Circulating MicroRNA Patterns (2020) (0)
Ultrafast comparison of personal genomes (2017) (0)
Example of peptides confirming a case of alternative splicing of the lamin A/C gene (LMNA) (2011) (0)
Cell-type-specific cDNA probes and the murine I region : The localization and orientation of Al ( Ia gene / cell-type-specific probe / selected cDNA cloning ) (0)
Studies on the primary structure of the heavy chain from the myeloma protein produced by mouse plasmacytoma mopc-315. Abstr. (1972) (0)
C-terminal peptides from human gamma-chains of differing subclass and allotype. (1970) (0)
Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer (2017) (0)
Structure function relationship of MHC class I molecules (1984) (0)
Resource Human SRMAtlas : A Resource of Targeted Assays to Quantify the Complete Human Proteome Graphical Abstract Highlights (2016) (0)
Title Sequence-Level Analysis of the Major European Huntington Disease Haplotype Permalink (0)
Prion and Prion-like Diseases in Humans (2013) (0)
Biological Networks : A Systems Approach to Medicine (2008) (0)
Structure and evolution of transplantation antigens: Partial amino-acid sequences of H-2K and H-2D alloantigens (indirect immunoprecipitation/microsequence analysis/sequence homology/evolutionary models) (2016) (0)
1329: Identification of Candidate Stromal Mesenchyme Cell Genes Associated With the Organ-Specific Differentiation of Epithelial (2004) (0)
Purification andprimary structure oftheneuropeptide egg-laying hormoneofAplysia californica (1979) (0)
Antibody Genes: Organization, Rearrangement and Diversification (1984) (0)
Diversity and structure of human T-cell receptor a 8-chain variable region genes ( nucleotide sequence / repertoire size / gene subfamilies / somatic mutation ) (0)
Molecular biology and genetics From functional genomics to systems biology: concepts and practices (2003) (0)
Early Host Responses to Prion Infection: Development of In Vivo and In Vitro Assays (2005) (0)
Examination of circulating DNA by using next generation sequence technology in colorectal cancer. (2015) (0)
Molecular biology and genetics Foreword: from the TRANSCRIPTOMEconferences to the SYSTEMOSCOPEInternational Consortium (2003) (0)
Microsoft Word-Final Souvenir Science and Scientist-2016.docx (2016) (0)
Current Awareness on Comparative and Functional Genomics (2005) (0)
1602 HUMAN Vs GENE SUBFAMILY (2003) (0)
Myelomaproteins fromNZBandBALB/cmice: Structural and functional differences (1979) (0)
Genome-Scale Transcriptional Regulatory Network Models of Psychiatric Disorders (2017) (0)
Protein Chemistry and the Biotechnology of the Future (1989) (0)
An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH. 1980. (2004) (0)
Variable Region Sequence Differences Associated with Rabbit Light Chain Allotypes (1971) (0)
Abstract #1185: Loss of N-myc downstream-regulated gene 1 (NDRG1) increases prostate cancer cell invasion by upregulating CCL5 (2009) (0)
A system of DNA Amplification for detection of genetic diseases by a thermostable ligase (1991) (0)
Results Recognition of H-2 L a in Transformed H-2 L Cells (2003) (0)
Publication rights for sequence data producers (Multiple letters) [3] (2000) (0)
BIOLOGICAL PROPERTIES OF CLASS I MHC MOLECULES EXPRESSED AFTER DNA-MEDIATED GENE TRANSFER (1982) (0)
A mathematical approach to the analysis of diversity in antibody gene families (1976) (0)
Early Host Responses to Prion Infection and Development of an In Vitro Bioassay (2007) (0)
Is Up-Regulated by Ligating CD40 Member, Is Expressed in Lymphoid Cells and OPG/FDCR-1, a TNF Receptor Family (1998) (0)
Large-Scale Sequencing of Human, Mouse, and Sheep Prion Protein Genes (1998) (0)
Differential transcriptional regulation of individual T-cell receptor Vbeta segments before gene rearrangement (2001) (0)
Disrupted SOX10 function causes spongiform neurodegeneration in gray tremor mice (2014) (0)
Method and system for electrophoresis analysis of DNA fragments obtained by sequencing (1985) (0)
Activation of Notch1 by its ligand, Jagged1, inhibits granulocytic differentiation and permits expansion of immature myeloid progenitors (1997) (0)
A Chromosomal Inversion Generates a Functional T Cell Receptor β Chain Gene (1986) (0)
Prostate Specific or Enriched Genes as Composite Biomarkers for Prostate Cancer (2009) (0)
Brain Region and Cell Type Transcripts for Informative Diagnostics (2010) (0)
Altered spectra of hypermutatio deficient for the DNA mismatch (1998) (0)
The complete nucleotide sequence of cosmid vector pTL5: location and origin of its genetic components. (1994) (0)
Protein Mice After Oral Administration of Myelin Antigen-Specific T Cells in TCR-Transgenic Rapid Depletion of Peripheral Hood and (2001) (0)
Sugar chemistry: By R. S. Shallenberger and G. G. Birch. Westport, Connecticut, AVI, 1975 (1977) (0)
Gene transfer of balb/c transplantation antigen genes into l-cells and the identification of foreign mhc gene products. Abstr. (1982) (0)
Single molecule flips between dim and bright states (2005) (0)
Parallel microfluidic arrays for SPRi detection (2010) (0)
Nomenclature Revised nomenclature of mouse B-2 genes (1993) (0)
Current Awareness on Comparative and Functional Genomics (2002) (0)
Publication rights for sequence data producers. (2000) (0)
Parallel microfluidic arrays for SPRi detection (2008) (0)
Proteomic analysis of an extreme halophilic archaeon Halobacterium species NRC-1 (2002) (0)
CELL-TYPE SPECIFIC MECHANISTIC AND DIRECTIONAL TRANSCRIPTIONAL REGULATORY NETWORKS IN ALZHEIMER’S DISEASE (2019) (0)
ISOLATION AND CHARACTERIZATION OF cDNA CLONES ENCODING MOUSE TRANSPLANTATION ANTIGENS1 (1981) (0)
Apparatus and method for progressive implementation of chemical processes (1981) (0)
Chemical Characterization of Rat Ia Antigens (1978) (0)
ORGANIZATION OF IMMUNOGLOBULIN KAPPA LIGHT CHAIN GENES IN GERM LINE AND SOMATIC CELLS (1979) (0)
Candidate mutations for early-onset lung cancer by family genome sequencing (2011) (0)
Isolation and Characterization of I Region Genes from the Major Histocompatibility Complex of the Mouse (1983) (0)
Publisher Correction: Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer (2019) (0)
Erratum to: On Different Aspects of Network Analysis in Systems Biology (2013) (0)
Interview with Leroy Hood. (2013) (0)
P3-356 Use of expression arrays to prioritize and RNAI to test prion incubation time modifier gene candidates (2004) (0)
Localization of Diphtheria Toxin Nuclease Activity (0)
Diversification of Immunoglobulins and T Cell Receptors (1986) (0)
8th Key Symposium: Translational and systems medicine (2012) (0)
The Codes of Codes (1995) (0)
High-throughput fluorescent DNA sequence analysis: Methods and automation (1991) (0)
Contents: proteomics - clinical applications 4/2008. (2008) (0)
Adventures Leading to a Paradigm Shift in Healthcare (2021) (0)
MULTI-OMIC BIOLOGICAL AGE ESTIMATION, CORRELATION WITH WELLNESS, DISEASE PHENOTYPES: LONGITUDINAL SAMPLE OF 3558 (2019) (0)
Immunit ) l , Disease , and Cancer (2007) (0)
A systematic future? Interview by Katherine Vickers. (2007) (0)
Genes of the Major Histocompatibility Complex in Mouse and Man (2019) (0)
The InTouch interview with biotech man Leroy Hood, MD, PhD. Interview by Peter Tarr. (2002) (0)
The Age of Scientific Wellness (2023) (0)
A systematic future? Interview by Katherine Vickers. (2007) (0)
Protein Sequence Analysis: Automated Microsequencing (2019) (0)
Systems approaches to biology and disease: integrating discovery and hypothesis‐driven paradigms (2010) (0)
QnAs with Leroy E. Hood. Interview by Prashant Nair. (2011) (0)
Human Genome Project Interview with Leroy Hood with Tim Hunkapiller (1991) (0)
Cancer, Disease, and Immunity (1979) (0)
On unique sequences within the variable territory of the T cell receptor-based diagnostic agents and their use (1986) (0)
Midwinter conference of immunologists. (1981) (0)
The human genome project : implications for biology, medicineandsociety (2001) (0)
Computing life and global technologies (abstract only) (2000) (0)
The ontogenetic and evolutionary origins of antibody diversity : (antibody diversity, ontogeny, evolution, transposable elements) (1982) (0)
A systematic future? Interview by Katherine Vickers. (2007) (0)
The human project: A technological challenge of striking dimension (1994) (0)
A systematic future? Interview by Katherine Vickers. (2007) (0)
The ABC's of Cancer (1973) (0)
Diagnostic and therapeutic tools of the 21st century (1992) (0)
CLASS II GENES OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN MICE1 (1983) (0)
The Actionable Possibilities of Scientific Wellness (2017) (0)
The wellness revolution (2015) (0)
A conversation with Dr. Leroy Hood: visionary biologist and biotechnologist. Interview by Paul S. Weiss. (2007) (0)
Computational Problems and the Human Genome Project (1991) (0)
The Impact of Genetic Engineering on Society (1972) (0)
Strain-specific variation in the t15 gene family at the dna level. Abstr. (1982) (0)
Annotation: Immunoglobulin genetics (1972) (0)
Medical Genetics and the Engineering of Man (1974) (0)
Antibody Diversity Wu and Kabat 1970: A Transforming View of (2008) (0)
Neel Distinguished Research Lectureship (1995) (0)
The Human Genome Project: big science transforms biology and medicine (2013) (0)
What’s the Business Case for Promoting Wellness? (2017) (0)
Chemistry and Biology in the Braun Laboratories (1983) (0)
Method for the electrophoretic analysis of dna - fragments (1985) (0)
Blood metabolome predicts gut microbiome α-diversity in humans (2019) (0)
Dense data enables 21st century clinical trials (2022) (0)
Multiomic investigations of Body Mass Index reveal heterogeneous trajectories in response to a lifestyle intervention (2022) (0)
In Vitro Mutagenesis of the H-2 L d Gene Subgene Fragments Used to Reconstruct Mutant Genes (2002) (0)
Manifestations of Alzheimer’s Disease Genetic Risk in the Blood: A Cross-Sectional Multi-Omic Analysis in Healthy Adults Aged 18-90+ (2021) (0)
Systems-level patterns in biological processes are changed under prolongevity interventions and across biological age (2022) (0)
Genetic Predisposition Impacts Clinical Changes in a Lifestyle Coaching Program (2019) (0)
The Effect of COVID-19 Vaccination and Booster on Maternal-Fetal Outcomes (2022) (0)
Core transcriptional regulatory circuits in prion diseases (2020) (0)
Personal Dense Dynamic Data Clouds Connect Systems Biomedicine to Scientific Wellness. (2022) (0)
Author Correction: Gut microbiome pattern reflects healthy ageing and predicts survival in humans (2021) (0)
Author Correction: New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections (2020) (0)
A multimodal intervention for Alzheimer's disease results in multifaceted systemic effects reflected in blood and ameliorates functional and cognitive outcomes (2022) (0)
Amino acid sequence comparison of three new balb/c mouse kappa chains. Abstr. (1972) (0)
Amino acid sequence of a mouse immunoglobulin ji chain ( automated sequencer / immunoglobulin domain / myeloma tumor (0)
Characterization of the mouseTcra-V22 gene subfamily (1996) (0)
Polymerases thermostables presentant une fidelite modifiee (1997) (0)
Genome-wide scan for high-risk prostate cancer families with breast cancer reveals new loci for prostate cancer and breast cancer (2001) (0)
Biopolymers. Light on molecular recognition. (1991) (0)
nssystem for determination of genetic diseases (1991) (0)
A PHENOME-WIDE ASSOCIATION STUDY (PHEWAS) OF BLOOD-BASED BIOLOGICAL MARKERS AND APOLIPOPROTEIN E GENOTYPE ACROSS THE ADULT LIFESPAN (2018) (0)
ThehtI3 GeneEncodes a NovelCACCC Box-Binding Protein ThatRegulates T-Cell Receptor GeneExpression (1993) (0)
THE MANIFESTATION OF GENETIC RISK FOR ALZHEIMER’S DISEASE IN BLOOD ACROSS ADULTHOOD: A MULTI-OMIC PHENOME-WIDE ASSOCIATION STUDY (PHEWAS) APPROACH (2019) (0)
Detecting Mitochondrial Genotypes by Temperature Gradient Gel Electrophoresis and Heteroduplex Analysis (1999) (0)
Biopolymers: protein and nucleic acids. Annual report, 15 September 1987-14 September 1988 (1988) (0)
Isolation of multiple ir-associated cell-surface molecules from mice. (1975) (0)
GENETIC AND EVOLUTIONARY IMPLICATIONS OF THE PARTIAL AMINO ACID SEQUENCES OF H-2K AND H-2D ALLOANTIGENS (1976) (0)
The nncleotide sequence of a human immunoglobulin C^ j gene (1982) (0)
Identifylng DNA polymorphisms in humanTCRA/D variable genes by direct sequencing of PCR products (2007) (0)
Characterization of the T Cell Receptor Repertoire Causing Collagen Arthritis in Mice By Gamal E. Osman, Masaaki Toda, Osami Kanagawa,* (1993) (0)
Biopolymers: Proteins and Nucleic Acids. (1990) (0)
STRUCTURAL STUDIES OF MOUSE TRANSPLANTATION ANTIGEN GENES (1981) (0)
activity to fragment A. Localization of diphtheria toxin nuclease (2013) (0)
Biopolymers: Protein and Nucleic Acids (1987) (0)
Bipolymers: Proteins and Nucleic Acids. (1995) (0)
Subject Index Vol. 39, 1985 (1985) (0)
A NEW PROTEIN MICROSEQUENATOR USING GAS PHASE (1982) (0)
Biochemical and Molecular Characterization of Q-Region Class I Gene Products (1987) (0)
DNA amplification system mediated thermostable ligase for the detection of genetic diseases. (1991) (0)
DNA amplification for the detection of genetic diseases using thermostable ligase (1991) (0)
Systems genomics evaluation of the SH-SY5Y neuroblastoma cell line as a model for Parkinson’s disease (2014) (0)
Molecular Signatures of Post-Traumatic Stress Disorder in War-Zone Exposed Veteran and Active Duty Soldiers (2022) (0)
230. Distinct Profiles of Extracellular Vesicles-Encapsulated RNA in Veterans With Post-Traumatic Stress Disorder (2019) (0)
THE PROSTATE EXPRESSION DATABASE: A TOOL FOR NOVEL GENE DISCOVERY AND THE VIRTUAL ANALYSIS OF PROSTATE GENE EXPRESSION (1999) (0)
the Halophilic Archaeon Systems Level Insights Into the Stress Response to UV Radiation in (2006) (0)

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