Li-Huei Tsai

Q: What Schools Are Affiliated With Li-Huei Tsai

Li-Huei Tsai is affiliated with the following schools: National Chung Hsing University, University of Texas at Austin, University of Wisconsin–Madison, Massachusetts Institute of Technology, Baylor College of Medicine, National Taiwan University, University of Texas Southwestern Medical Center, Harvard University

Li-Huei Tsai's AcademicInfluence.com Rankings

Li-Huei Tsai

Biology

#2288

World Rank

#3652

Historical Rank

Neuroscience

#288

World Rank

#303

Historical Rank

biology Degrees

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Biology

Li-Huei Tsai's Degrees

PhD Biochemistry University of Texas Southwestern Medical Center
Bachelors Chemistry National Taiwan University

Why Is Li-Huei Tsai Influential?

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According to Wikipedia, Li-Huei Tsai is an American neuroscientist and the director of the Picower Institute for Learning and Memory in the Department of Brain and Cognitive Sciences at the Massachusetts Institute of Technology.

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Li-Huei Tsai's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Integrative analysis of 111 reference human epigenomes (2015) (4979)
Driving fast-spiking cells induces gamma rhythm and controls sensory responses (2009) (2326)
A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27 Kip1 -Deficient Mice (1996) (1610)
Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration (1999) (1508)
HDAC2 negatively regulates memory formation and synaptic plasticity (2009) (1429)
Recovery of learning and memory is associated with chromatin remodelling (2007) (1136)
Single-cell transcriptomic analysis of Alzheimer’s disease (2019) (1099)
A decade of CDK5 (2001) (1089)
Inhibition of cyclin-dependent kinases by p21. (1995) (1063)
Neurotoxicity induces cleavage of p35 to p25 by calpain (2000) (1058)
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis (2007) (1001)
p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5 (1994) (927)
A novel pathway regulates memory and plasticity via SIRT1 and miR-134 (2010) (877)
Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling (2009) (781)
Mice Lacking p35, a Neuronal Specific Activator of Cdk5, Display Cortical Lamination Defects, Seizures, and Adult Lethality (1997) (752)
An epigenetic blockade of cognitive functions in the neurodegenerating brain (2012) (711)
The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation. (1996) (622)
Trekking across the Brain: The Journey of Neuronal Migration (2007) (590)
Aberrant Cdk5 Activation by p25 Triggers Pathological Events Leading to Neurodegeneration and Neurofibrillary Tangles (2003) (581)
Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons (1999) (562)
A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1 (1996) (560)
A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior (2011) (559)
Author Correction: Gamma frequency entrainment attenuates amyloid load and modifies microglia (2016) (533)
APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types (2018) (529)
NUDEL Is a Novel Cdk5 Substrate that Associates with LIS1 and Cytoplasmic Dynein (2000) (513)
Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes (2015) (499)
Histone acetylation: molecular mnemonics on the chromatin (2013) (494)
Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2 (2010) (488)
Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease (2015) (486)
Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. (1993) (480)
Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields (2017) (449)
Efficient derivation of microglia-like cells from human pluripotent stem cells (2016) (448)
Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution (2017) (442)
DNA Damage and Its Links to Neurodegeneration (2014) (440)
The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity (1998) (432)
APP processing is regulated by cytoplasmic phosphorylation (2003) (430)
Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase (1991) (419)
Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient–Derived Neurons (2013) (410)
Regulation of cytoplasmic dynein behaviour and microtubule organization by mammalian Lis1 (2000) (404)
Tet1 Is Critical for Neuronal Activity-Regulated Gene Expression and Memory Extinction (2013) (397)
p35 and p39 Are Essential for Cyclin-Dependent Kinase 5 Function during Neurodevelopment (2001) (394)
Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth (2000) (392)
The road to restoring neural circuits for the treatment of Alzheimer's disease (2016) (388)
Guiding neuronal cell migrations. (2010) (382)
Cyclin-dependent kinases: a family portrait (2009) (378)
Ndel1 Operates in a Common Pathway with LIS1 and Cytoplasmic Dynein to Regulate Cortical Neuronal Positioning (2004) (372)
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent. (2000) (371)
Life is a journey: a genetic look at neocortical development (2002) (368)
Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F (1992) (367)
Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation. (1995) (357)
Nucleokinesis in Neuronal Migration (2005) (350)
Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes (2016) (348)
The cdk2 kinase is required for the G1-to-S transition in mammalian cells. (1993) (345)
Targeting the correct HDAC(s) to treat cognitive disorders. (2010) (344)
Epigenetic regulation of gene expression in physiological and pathological brain processes. (2011) (336)
Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons (2013) (330)
Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected]. (2013) (327)
p35, the Neuronal-specific Activator of Cyclin-dependent Kinase 5 (Cdk5) Is Degraded by the Ubiquitin-Proteasome Pathway* (1998) (320)
Serine 732 Phosphorylation of FAK by Cdk5 Is Important for Microtubule Organization, Nuclear Movement, and Neuronal Migration (2003) (317)
Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition (2019) (317)
Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories (2014) (298)
Gamma frequency entrainment attenuates amyloid load and modifies microglia (2016) (296)
Cyclin-dependent kinases in brain development and disease. (2011) (293)
Opposing Roles of Transient and Prolonged Expression of p25 in Synaptic Plasticity and Hippocampus-Dependent Memory (2005) (288)
14-3-3ε is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller–Dieker syndrome (2003) (272)
Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity (2008) (272)
Amyloid-Independent Mechanisms in Alzheimer's Disease Pathogenesis (2010) (269)
What is memory? The present state of the engram (2016) (268)
APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types (2018) (267)
Functional integration of dopaminergic neurons directly converted from mouse fibroblasts. (2011) (259)
Cdk5 deregulation in the pathogenesis of Alzheimer's disease. (2004) (259)
The potential of HDAC inhibitors as cognitive enhancers. (2013) (252)
Cdk5 Phosphorylation of Doublecortin Ser297 Regulates Its Effect on Neuronal Migration (2004) (250)
G Protein βγ Subunits and AGS3 Control Spindle Orientation and Asymmetric Cell Fate of Cerebral Cortical Progenitors (2005) (238)
Cyclin-Dependent Kinase 5 Phosphorylates the N-Terminal Domain of the Postsynaptic Density Protein PSD-95 in Neurons (2004) (227)
Structure and Regulation of the CDK5-p25nck5a Complex (2001) (225)
Interaction between human cyclin A and adenovirus E1A-associated p107 protein. (1992) (214)
p25/Cyclin-Dependent Kinase 5 Induces Production and Intraneuronal Accumulation of Amyloid β In Vivo (2006) (212)
SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons (2013) (208)
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects. (2014) (205)
Modeling Alzheimer’s disease with iPSC-derived brain cells (2019) (202)
p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton. (2000) (187)
Regulation of N-cadherin-mediated adhesion by the p35–Cdk5 kinase (2000) (186)
Validation of schizophrenia-associated genes CSMD1, C10orf26, CACNA1C and TCF4 as miR-137 targets (2013) (184)
MicroRNAs in learning, memory, and neurological diseases. (2012) (182)
Cep120 and TACCs Control Interkinetic Nuclear Migration and the Neural Progenitor Pool (2007) (180)
HDAC 2 Negatively Regulates Memory Formation and Synaptic Plasticity (2012) (179)
A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease (2004) (175)
Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection (2019) (174)
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity (2010) (174)
A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains (2002) (173)
Mechanism of CDK5/p25 binding by CDK inhibitors. (2005) (171)
Cdk5rap2 Interacts with Pericentrin to Maintain the Neural Progenitor Pool in the Developing Neocortex (2010) (170)
A novel disruption of cortical development in p35−/− mice distinct from reeler (1998) (169)
Cdk5 behind the wheel: a role in trafficking and transport? (2002) (168)
Disabled-1-Regulated Adhesion of Migrating Neurons to Radial Glial Fiber Contributes to Neuronal Positioning during Early Corticogenesis (2004) (168)
The schizophrenia risk gene product miR-137 alters presynaptic plasticity (2015) (168)
Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling (2016) (167)
G protein betagamma subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitors. (2005) (160)
Negative regulation of Vps34 by Cdk mediated phosphorylation. (2010) (157)
Dixdc1 Is a Critical Regulator of DISC1 and Embryonic Cortical Development (2010) (152)
Histone deacetylases in memory and cognition (2014) (151)
BACE1 Suppression by RNA Interference in Primary Cortical Neurons* (2004) (148)
Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex (2012) (147)
Calpain-mediated Cleavage of the Cyclin-dependent Kinase-5 Activator p39 to p29* (2002) (143)
A hippocampal Cdk5 pathway regulates extinction of contextual fear (2007) (142)
Par-4 Links Dopamine Signaling and Depression (2005) (141)
Meta-Analysis of the Alzheimer’s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models (2020) (140)
Doublecortin-like Kinase Controls Neurogenesis by Regulating Mitotic Spindles and M Phase Progression (2006) (135)
The role of Cdk5 in neuroendocrine thyroid cancer. (2013) (135)
Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in the aging and Alzheimer human brain (2018) (134)
Differential Cellular Phosphorylation of Neurofilament Heavy Side‐Arms by Glycogen Synthase Kinase‐3 and Cyclin‐Dependent Kinase‐5 (1996) (133)
Amphiphysin 1 Binds the Cyclin-dependent Kinase (cdk) 5 Regulatory Subunit p35 and Is Phosphorylated by cdk5 and cdc2* (2001) (133)
The brain-specific activator p35 allows Cdk5 to escape inhibition by p27Kip1 in neurons. (1996) (131)
Coupling PAF Signaling to Dynein Regulation Structure of LIS1 in Complex with PAF-Acetylhydrolase (2004) (127)
The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning. (1997) (127)
Centrosome Motility Is Essential for Initial Axon Formation in the Neocortex (2010) (127)
Common DISC1 Polymorphisms Disrupt Wnt/GSK3β Signaling and Brain Development (2011) (125)
Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons (2014) (125)
Structure and regulation of the CDK5-p25(nck5a) complex. (2001) (123)
REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease (2019) (122)
Cdk5, a therapeutic target for Alzheimer's disease? (2004) (121)
Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes (2020) (120)
Reelin and Cyclin-Dependent Kinase 5-Dependent Signals Cooperate in Regulating Neuronal Migration and Synaptic Transmission (2004) (119)
Hook3 Interacts with PCM1 to Regulate Pericentriolar Material Assembly and the Timing of Neurogenesis (2010) (118)
Alternative Functions of Core Cell Cycle Regulators in Neuronal Migration, Neuronal Maturation, and Synaptic Plasticity (2009) (116)
Cdk5 on the brain. (2001) (116)
Layering defect in p35 deficiency is linked to improper neuronal-glial interaction in radial migration (2003) (115)
The Cyclin-Dependent Kinase 5 Activators p35 and p39 Interact with the α-Subunit of Ca2+/Calmodulin-Dependent Protein Kinase II and α-Actinin-1 in a Calcium-Dependent Manner (2002) (113)
A Dietary Regimen of Caloric Restriction or Pharmacological Activation of SIRT1 to Delay the Onset of Neurodegeneration (2013) (112)
Cdk5 Promotes Synaptogenesis by Regulating the Subcellular Distribution of the MAGUK Family Member CASK (2007) (111)
Cdk5: one of the links between senile plaques and neurofibrillary tangles? (2003) (106)
The Role of Epigenetic Mechanisms in the Regulation of Gene Expression in the Nervous System (2016) (105)
A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons (2004) (105)
Abnormal Morphological and Functional Organization of the Hippocampus in a p35 Mutant Model of Cortical Dysplasia Associated with Spontaneous Seizures (2001) (105)
Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia (2017) (104)
Cyclin-dependent kinase 5 permits efficient cytoskeletal remodeling--a hypothesis on neuronal migration. (2006) (103)
Microglia states and nomenclature: A field at its crossroads (2022) (99)
Epigenetic modifications in the nervous system and their impact upon cognitive impairments (2014) (97)
SIRT 1 deacetylase protects against neurodegeneration in models for Alzheimer ’ s disease and amyotrophic lateral sclerosis (2013) (97)
Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells (2015) (94)
Pyramidal neuron polarity axis is defined at the bipolar stage (2008) (90)
Temporal and spatial patterns of expression of p35, a regulatory subunit of cyclin-dependent kinase 5, in the nervous system of the mouse (1997) (87)
Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity (2011) (87)
Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity (2012) (84)
Early remodeling of the neocortex upon episodic memory encoding (2014) (84)
Callosal axon guidance defects in p35−/− mice (1999) (83)
Gamma Entrainment: Impact on Neurocircuits, Glia, and Therapeutic Opportunities (2019) (81)
Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior (2016) (81)
ASPM regulates Wnt signaling pathway activity in the developing brain. (2011) (80)
Activity-Dependent p25 Generation Regulates Synaptic Plasticity and Aβ-Induced Cognitive Impairment (2014) (79)
Cyclin-dependent Kinase 5 Phosphorylates Serine 31 of Tyrosine Hydroxylase and Regulates Its Stability* (2004) (78)
Neuronal Morphogenesis Is Regulated by the Interplay between Cyclin-Dependent Kinase 5 and the Ubiquitin Ligase Mind Bomb 1 (2007) (75)
Colocalization and Fluorescence Resonance Energy Transfer between cdk5 and AT8 Suggests a Close Association in Pre‐Neurofibrillary Tangles and Neurofibrillary Tangles (2002) (74)
Regulation of N-type Voltage-Gated Calcium Channels and Presynaptic Function by Cyclin-Dependent Kinase 5 (2012) (73)
Cdk5 Is Required for Memory Function and Hippocampal Plasticity via the cAMP Signaling Pathway (2011) (73)
HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease (2020) (72)
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia (2021) (72)
Mammalian Cdk5 is a functional homologue of the budding yeast Pho85 cyclin-dependent protein kinase. (1999) (71)
Bridging Physiology and Pathology in AD (2009) (70)
Synaptic localization of p39, a neuronal activator of cdk5 (2000) (69)
S-nitrosation of proteins relevant to Alzheimer’s disease during early stages of neurodegeneration (2016) (65)
Spindle regulation in neural precursors of flies and mammals (2007) (65)
The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner. (2002) (65)
Control of Activating Transcription Factor 4 (ATF4) Persistence by Multisite Phosphorylation Impacts Cell Cycle Progression and Neurogenesis* (2010) (64)
A High-Throughput Screen for Wnt/β-Catenin Signaling Pathway Modulators in Human iPSC-Derived Neural Progenitors (2012) (64)
Mechanisms of age-related cognitive change and targets for intervention: epigenetics. (2012) (63)
The Transcription Factor Sp3 Cooperates with HDAC2 to Regulate Synaptic Function and Plasticity in Neurons. (2017) (63)
A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations (2017) (58)
Single-cell dissection of the human brain vasculature (2022) (55)
Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble (2020) (55)
Epigenetic regulation in memory and cognitive disorders (2014) (55)
Cables Links Cdk 5 and c-Abl and Facilitates Cdk 5 Tyrosine Phosphorylation , Kinase Upregulation , and Neurite Outgrowth (2000) (55)
Noninvasive 40-Hz light flicker to recruit microglia and reduce amyloid beta load (2018) (54)
Cdk5 sinks into ALS (2002) (53)
Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology (2008) (53)
Basolateral amygdala bidirectionally modulates stress-induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway (2015) (52)
Ankyrin-G Regulates Neurogenesis and Wnt Signaling by Altering the Subcellular Localization of β-catenin (2014) (52)
GC Box-binding Transcription Factors Control the Neuronal Specific Transcription of the Cyclin-dependent Kinase 5 Regulator p35* (2002) (52)
Ndel1 Controls the Dynein-mediated Transport of Vimentin during Neurite Outgrowth* (2008) (51)
DISC1–ATF4 transcriptional repression complex: dual regulation of the cAMP-PDE4 cascade by DISC1 (2013) (50)
Disc1 regulates both β‐catenin‐mediated and noncanonical Wnt signaling during vertebrate embryogenesis (2011) (49)
Cyclin E-p27 opposition and regulation of the G1 phase of the cell cycle in the murine neocortical PVE: a quantitative analysis of mRNA in situ hybridization. (1999) (47)
Cyclin-Dependent Kinase 5 and Neuronal Migration in the Neocortex (2003) (46)
Diaminothiazoles Modify Tau Phosphorylation and Improve the Tauopathy in Mouse Models*♦ (2013) (45)
Chromatin regulation of DNA damage repair and genome integrity in the central nervous system. (2014) (44)
Cdk5 Phosphorylation of FAK Regulates Centrosome-Associated Microtubules and Neuronal Migration (2004) (44)
Phosphorylation of the homer‐binding domain of group I metabotropic glutamate receptors by cyclin‐dependent kinase 5 (2009) (43)
p25 protein in neurodegeneration (2001) (42)
Partial Rescue of the p35−/− Brain Phenotype by Low Expression of a Neuronal-Specific Enolase p25 Transgene (2003) (39)
In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory (2017) (37)
Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons (2011) (35)
Phosphoproteomic analysis with a solid-phase capture-release-tag approach. (2005) (35)
Synaptic Deficits Are Rescued in the p25/Cdk5 Model of Neurodegeneration by the Reduction of β-Secretase (BACE1) (2011) (33)
APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes (2022) (31)
Capzb2 Interacts with β-Tubulin to Regulate Growth Cone Morphology and Neurite Outgrowth (2009) (30)
The role of the p35/cdk5 kinase in cortical development. (2000) (30)
PICALM Rescues Endocytic Defects Caused by the Alzheimer's Disease Risk Factor APOE4. (2020) (30)
S-nitrosylation of E3 ubiquitin-protein ligase RNF213 alters non-canonical Wnt/Ca+2 signaling in the P301S mouse model of tauopathy (2019) (30)
The cyclin-dependent kinase family. (1991) (29)
Alzheimer's disease: A protective factor for the ageing brain (2014) (29)
Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function (2021) (29)
Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt (2015) (29)
Author Correction: Single-cell transcriptomic analysis of Alzheimer’s disease (2019) (29)
HDAC2 expression in parvalbumin interneurons regulates synaptic plasticity in the mouse visual cortex (2015) (28)
APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation (2021) (26)
A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory (2016) (26)
Loss of Protein Arginine Methyltransferase 8 Alters Synapse Composition and Function, Resulting in Behavioral Defects (2017) (25)
Control of Cortical Neuron Migration and Layering: Cell and Non Cell-Autonomous Effects of p35 (2004) (25)
Neuronal differentiation and patterning in Xenopus: the role of cdk5 and a novel activator xp35.2. (1999) (25)
Cdk5 is a New Rapid Synaptic Homeostasis Regulator Capable of Initiating the Early Alzheimer-Like Pathology. (2016) (24)
Common DISC 1 Polymorphisms Disrupt Wnt / GSK 3 b Signaling and Brain Development (2011) (24)
TFP5, a Peptide Inhibitor of Aberrant and Hyperactive Cdk5/p25, Attenuates Pathological Phenotypes and Restores Synaptic Function in CK-p25Tg Mice. (2017) (24)
Lipid Accumulation Induced by APOE4 Impairs Microglial Surveillance of Neuronal-Network Activity (2022) (23)
Linking Cell Cycle Reentry and DNA Damage in Neurodegeneration (2009) (23)
3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice (2019) (22)
The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer’s amyloid pathology (2019) (22)
Activity and regulation of p35/Cdk5 kinase complex. (2000) (22)
Forebrain-specific deletion of Cdk5 in pyramidal neurons results in mania-like behavior and cognitive impairment (2013) (21)
Targeting p35/Cdk5 Signalling via CIP-Peptide Promotes Angiogenesis in Hypoxia (2013) (21)
Cortical neurons gradually attain a post-mitotic state (2016) (21)
Putting a Notch in Our Understanding of Nuclear Migration (2008) (20)
Three decades of Cdk5 (2021) (20)
Defining Microglial States and Nomenclature: A Roadmap to 2030 (2022) (20)
Loss of Cyclin-Dependent Kinase 5 from Parvalbumin Interneurons Leads to Hyperinhibition, Decreased Anxiety, and Memory Impairment (2015) (20)
reply: Neurobiology: p25 protein in neurodegeneration (2001) (19)
DNA methylation in cognition comes of age (2012) (19)
Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors. (2022) (18)
Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation. (2016) (18)
MicroTUB(B3)ules and Brain Development (2010) (17)
Profiling DNA break sites and transcriptional changes in response to contextual fear learning (2021) (17)
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects. (2021) (16)
Induction of specific brain oscillations may restore neural circuits and be used for the treatment of Alzheimer's disease (2021) (16)
Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory. (2018) (16)
Dissecting the complexities of Alzheimer disease with in vitro models of the human brain (2021) (16)
3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice (2017) (16)
Glutamate Receptors in Alzheimer's Disease: Mechanisms and Therapies (2016) (15)
Phosphoproteomics identifies microglial Siglec‐F inflammatory response during neurodegeneration (2020) (15)
On the resilience of remote traumatic memories against exposure therapy‐mediated attenuation (2014) (15)
A Kinase to Dampen the Effects of Cocaine? (2001) (15)
Chronically implanted hyperdrive for cortical recording and optogenetic control in behaving mice (2011) (15)
Cdk5 selectively affects the migration of different populations of neurons in the developing spinal cord (2007) (15)
MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration (2021) (13)
Expansion Revealing: Decrowding Proteins to Unmask Invisible Brain Nanostructures (2020) (13)
Gamma Frequency Sensory Stimulation in Probable Mild Alzheimer’s Dementia Patients: Results of a Preliminary Clinical Trial (2021) (13)
40Hz sensory stimulation induces gamma entrainment and affects brain structure, sleep and cognition in patients with Alzheimer's dementia (2021) (13)
Synaptic Deficits Are Rescued in the p 25 / Cdk 5 Model of Neurodegeneration by the Reduction of beta-Secretase ( BACE 1 ) (2011) (12)
Cognitive enhancement: A molecular memory booster (2011) (11)
Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease (2022) (11)
Cdk5 is a dynamo at the synapse (2003) (11)
Mammalian Cdk 5 is a functional homologue of the budding yeast Pho 85 cyclin-dependent protein kinase (1999) (11)
DISC 1 – ATF 4 transcriptional repression complex : dual regulation of the cAMP-PDE 4 cascade by DISC 1 (2013) (11)
Cognitive Function in Health and Disease: The Role of Epigenetic Mechanisms (2012) (10)
Revealing nanostructures in brain tissue via protein decrowding by iterative expansion microscopy (2022) (10)
Nucleokinesis illuminated (2004) (10)
Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration (2021) (10)
Harnessing cerebral organoids for Alzheimer's disease research (2022) (9)
Unraveling the Paradox of Statins with Human Neurons: New Leads in Alzheimer's Disease. (2019) (9)
Axon selection (2011) (9)
Cell type-specific histone acetylation profiling of Alzheimer’s disease subjects and integration with genetics (2020) (8)
Gamma frequency sensory stimulation in mild probable Alzheimer’s dementia patients: Results of feasibility and pilot studies (2022) (8)
Neuronal differentiation: 5-HT6R can do it alone. (2014) (8)
Single-cell deconvolution of 3,000 post-mortem brain samples for eQTL and GWAS dissection in mental disorders (2021) (8)
A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes (2022) (8)
Single-cell anatomical analysis of human hippocampus and entorhinal cortex uncovers early-stage molecular pathology in Alzheimer’s disease (2021) (8)
BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1 (2022) (8)
Erratum: Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog (Cell Stem Cell (2013) 12 426-439)) (2013) (7)
Histone Deacetylases 1 and 2 in Memory Function. (2022) (7)
Human induced pluripotent stem cells: now open to discovery. (2014) (7)
The Top3β way to untangle RNA (2013) (7)
A critical role for NMDA receptors in parvalbumin interneurons for gamma induction and behavior (2011) (7)
HDAC 2 expression in parvalbumin interneurons regulates synaptic plasticity in the mouse visual cortex (2015) (7)
Telomerase reverse transcriptase preserves neuron survival and cognition in Alzheimer’s disease models (2021) (7)
Cyclin Dependent Kinase 5 (Cdk5) (2008) (7)
Counteracting Molecular Pathways Regulating the Reduction of Fear: Implications for the Treatment of Anxiety Diseases (2009) (7)
Epigenome-wide study uncovers tau pathology-driven changes of chromatin organization in the aging human brain (2018) (6)
Reelin Improves Cognition and Extends the Lifespan of Mutant Ndel1 Mice with Postnatal CA1 Hippocampus Deterioration. (2020) (6)
Sensory gamma frequency stimulation in cognitively healthy and AD individuals safely induces highly coordinated 40 hz neural oscillation: A preliminary study of non‐invasive sensory stimulation for treating Alzheimer’s disease (2020) (6)
Exifone is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration (2020) (6)
Cdk5 at the junction (2001) (6)
Hedgehog patterns midbrain ARChitecture (2001) (6)
Proteomic profiling dataset of chemical perturbations in multiple biological backgrounds (2021) (5)
Label-free three-photon imaging of intact human cerebral organoids for tracking early events in brain development and deficits in Rett syndrome (2022) (5)
Cyclin Dependent Kinase 5 ( Cdk 5 ) (2012) (5)
MethyLock: DNA Demethylation Is the Epigenetic Key to Axon Regeneration (2017) (5)
Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions (2020) (5)
Three-dimensional chromatin organization in brain function and dysfunction (2021) (5)
reply: Neurobiologyp25 protein in neurodegeneration. (2001) (5)
A Developmental Switch in Microglial HDAC Function. (2018) (5)
HDAC Inhibitors as Novel Therapeutics in Aging and Alzheimer’s Disease (2013) (5)
Erratum: Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons (2015) (5)
The role of cyclin-dependent kinase 5 in brain development and degeneration (2003) (4)
Cyclin-Dependent Kinase 5 (2003) (4)
Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer’s human brains (2018) (4)
Transient enhancement of proliferation of neural progenitors and impairment of their long-term survival in p25 transgenic mice (2016) (4)
DISC1 regulates neural progenitor proliferation via modulation of GSK3β/β-catenin signaling (2009) (4)
Insights into Alzheimer’s disease from single-cell genomic approaches (2023) (3)
Capzb 2 Interacts with b-Tubulin to Regulate Growth Cone Morphology and Neurite Outgrowth (2009) (3)
SUMMARY p 39 activates cdk 5 in neurons , and is associated with the actin cytoskeleton (3)
JAKMIP1: Translating the Message for Social Behavior (2015) (3)
Addendum: The schizophrenia risk gene product miR-137 alters presynaptic plasticity (2016) (3)
Addressing the complex etiology of Alzheimer's disease: the role of p25/Cdk5 (2011) (3)
Molecular biology: Local metabolites linked to memory (2017) (3)
Author Correction: Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes (2021) (2)
Neuronal enhancers get a break (2021) (2)
Neurodegenerative Diseases and the Aging Brain (2018) (2)
Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3β) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein. (2020) (2)
Neutools: A collection of bioinformatics web tools for neurogenomic analysis (2018) (2)
Elimination of senescent cells prevents neurodegeneration in mice (2018) (2)
Single-cell multi-region dissection of brain vasculature in Alzheimer’s Disease (2022) (2)
Cdk 5 is a dynamo at the synapse (2003) (2)
From a polarized cytoplasm to a migrating neuron (2011) (2)
Calcineurin dephosphorylates topoisomerase IIβ and regulates the formation of neuronal-activity-induced DNA breaks. (2022) (2)
Integrative analysis of 111 reference human epigenomes Open (2015) (2)
A cyclin-dependent kinase 5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes (2020) (2)
Gamma frequency sensory stimulation prevents brain atrophy, improves sleep and memory in probable mild Alzheimer’s patients (2021) (2)
ApoE4-carrying Human Astrocytes Oversupply Cholesterol into Neurons and Promote Aβ Generation (2020) (1)
Single-cell mosaicism analysis reveals cell-type-specific somatic mutational burden in Alzheimer’s Dementia (2022) (1)
Alterations in a cross-hemispheric circuit associates with novelty discrimination deficits in mouse models of neurodegeneration (2022) (1)
Cyclin-Dependent Kinase 5 (Cdk5): Linking Synaptic Plasticity and Neurodegeneration (2008) (1)
Proteomic profiling dataset of chemical perturbations in multiple biological backgrounds (2021) (1)
Neuronal Motility and Structure: Cdk5 Pathways (2009) (1)
Cdk6: Cyclin-dependent kinase-6 (vertebrates) (PLSTIIRE) (1995) (1)
The hippocampus grows up (2016) (1)
Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience. (2023) (1)
Faculty Opinions recommendation of Temporally precise in vivo control of intracellular signalling. (2009) (1)
Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3β) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein (2020) (1)
Tissue-wide Effects Overrule Cell-intrinsic Gene Function in Cortical Projection Neuron Migration (2022) (1)
Microglial MorphOMICs unravel region- and sex-dependent morphological phenotypes from postnatal development to degeneration (2021) (1)
Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration. (2021) (1)
Examining the Role of HDACs in DNA Double-Strand Break Repair in Neurons. (2019) (1)
Tissue-Wide Effects Override Cell-Intrinsic Gene Function in Radial Neuron Migration (2022) (1)
How MicroRNAs Are Involved in Splitting the Mind. (2016) (1)
The complexity of neuroinflammation at single-cell resolution (2019) (1)
A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes. (2023) (0)
RNA Interference Technology: miRNAs in the brain and the application of RNAi to neurons (2005) (0)
Probing the functions of microglial cyclin-dependent kinase 5 under physiological and pathological conditions (2020) (0)
Over-Expression Of Cyclin-Dependent Kinase 5 Stimulates Cell Migration But Not Cell Differentiation In Human Brain Microvascular Endothelial Cells (2011) (0)
Editorial (2003) (0)
Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes (2020) (0)
Noninvasive brain stimulation to attenuate Alzheimer's pathology (2019) (0)
P1-416 APP processing and cell cycle reentry signaling pathways are involved in p25/cdk5-mediated neurodegeneration (2006) (0)
Yeun Chung Derived Neurons − Patient-Synuclein Toxicity in Parkinson α Identification and Rescue (2016) (0)
Editorial (2014) (0)
Colocalization of PDE4D9 and DISC1 in cultured hippocampal neurons (2013) (0)
P35/Cdk5: two critical players in cytoskeletal/cell junction stability in human brain endothelial cell angiogenesis (2010) (0)
P3-307 Glycogen synthase kinase-3beta and the p25 activator of cyclin-dependent kinase-5 decrease neuritogenesis and fast axoplasmic transport in differentiated PC12 cells (2006) (0)
Title Page / Table of Contents (2003) (0)
What is memory? The present state of the engram (2016) (0)
Epigenetic Mechanisms Regulating Memory Formation in Health and Disease (2012) (0)
Verwendung von ci-994 und dinalin zur behandlung von gedächtnis-/kognitiven und angststörungen (2010) (0)
HowMicroRNAs Are Involved in Splitting theMind (2016) (0)
Editorial. Molecular and Cellular Cognition Society (MCCS) meetings. (2014) (0)
MechanismsSynaptic Potentiation Mediated by Postsynaptic Attenuation of Paired-Pulse Facilitation Associated (2015) (0)
Micro(TUBB3)ules Rule in Brain Development (2010) (0)
A novel PU.1 inhibitor for the treatment of Alzheimer’s disease (2021) (0)
Lateral mammillary body neurons in mouse brain are disproportionately vulnerable in Alzheimer’s disease (2023) (0)
Regulation of synaptic calcium influx by Cdk5 phosphorylation (2006) (0)
PAF-AH Holoenzyme: Lis1/Alfa2 (2005) (0)
Building in vitro models of the brain to understand the role of APOE in Alzheimer’s disease (2022) (0)
Alzheimer research forum live discussion: meet new players, histone deacetylase and sirtuin--will they help the cell cycle, DNA repair, and gene expression break into Alzheimerology's major league? (2009) (0)
The SNARE-mediated vesicular transport pathway plays major roles in synaptic remodeling (2016) (0)
USING NON-INVASIVE SENSORY STIMULI TO ELICIT NEUROPROTECTION IN ALZHEIMER’S DISEASE MOUSE MODELS (2018) (0)
Temporal Tracking of Micr oglia Activation in Neurodegeneration at Single-Cell Resolution Graphical (2017) (0)
Single-cell transcriptomic analysis of Alzheimer’s disease (2019) (0)
Epigenetic Mechanisms Regulating Social Behaviors Relevant to The Autism Spectrum Disorders (2017) (0)
Cross-Hemispheric Circuit Dysfunction Impairs Novelty Discrimination in Alzheimer's Disease Mice (2021) (0)
Alzheimer’s Disease and the Sleep–Wake Cycle (2016) (0)
Li-Huei Tsai: I well remember. Interview by Caitlin Sedwick. (2012) (0)
Distinct effects of disease-associated TREM2 R47H/+ and T66M mutations on iPSC-derived microglia (2022) (0)
Three decades of Cdk5 (2021) (0)
Neurodevelopment and Schizophrenia (2013) (0)
S3-04-03: CDK5 and Aβ production (2008) (0)
Elimination of senescent cells prevents neurodegeneration in mice (2018) (0)
Alterations in Cyclin-dependent Kinase 5 Activator p35 Signaling Are Associated With Angiogenesis, in Brain Endothelial Cells (2010) (0)
TITLE: 40Hz sensory stimulation induces gamma entrainment and affects brain structure, sleep and cognition in patients with Alzheimer's dementia (2021) (0)
itor of Cdk 2 and Cdk 4 kinase complexes in vitro ( Gu (0)
- Cdk5: Cyclin-dependent kinase 5 (vertebrates) (PSSALRE) (1995) (0)
AD-Linked TREM2 Mutation Induces Unique Microglial States Associated with Toxic Function in Tauopathy (2019) (0)
Negative Regulation of Vps 34 by Cdk Mediated Phosphorylation Citation (2012) (0)
Author Correction: Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes (2021) (0)
Self-Organizing3D HumanNeural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’sDisease Phenotypes (2016) (0)
[Using reprogramming techniques of human somatic cells to understand genetic risk variations associated with psychiatric disorders]. (2013) (0)
Systems and methods for treating dementia (2016) (0)
Chung Derived Neurons − Patient-Synuclein Toxicity in Parkinson α Identification and Rescue of (2014) (0)
Cdk3: Cyclin-dependent kinase-3 (vertebrates) (1995) (0)
From Cdk5 to Alzheimer’s disease: future challenges (2012) (0)
P2-092 Aberrant activation of CDK5 triggers events leading to Alzheimer's pathology (2004) (0)
Neurobiology Select (2006) (0)
Correction: Building in vitro models of the brain to understand the role of APOE in Alzheimer’s disease (2022) (0)
Walking the high wire: How neurons maintain stability in the crossline of neurodegeneration. (2022) (0)
Comprar Cyclin Dependent Kinase 5 (Cdk5) | Ip, Nancy Y. | 9780387788869 | Springer (2008) (0)
Common DISC 1 Polymorphisms Disrupt Wnt / GSK 3 Signaling and Brain Development Citation (2011) (0)
The role of cyclin-dependent kinase 5 and a novel regulatory subunit in 1 g muscle differentiation regu atin . and patterning (2007) (0)
Abstract 2387: Modulation Of P35/cyclin-dependent Kinase 5 Signaling Rectifies Defective Human Brain Endothelial Cell Migration Produced By In Vitro Simulation Of Ischemic Stroke (2012) (0)
USING HUMAN IPSC MODELS TO PROBE TREM2 FUNCTION (2019) (0)
Author Correction: Single-cell transcriptomic analysis of Alzheimer’s disease (2019) (0)
Molecular Mechanisms Underlying Migration and Positioning of Neurons in the Developing Neocortex (2004) (0)
HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease (2020) (0)
Corrigendum: Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex (2014) (0)
Calpain-mediated P35 to P25 conversion is induced by neurotoxic processes and amyloid βtreatment (2000) (0)
Gamma frequency entrainment attenuates amyloid load and modifies microglia (2016) (0)
A Doublecortin-like Kinase on the Road to Mitosis (0)
Reprogramming brain immunosurveillance with engineered cytokines (2022) (0)
Noninvasive 40-Hz light flicker to recruit microglia and reduce amyloid beta load (2018) (0)
A Conversation with Li-Huei Tsai. (2019) (0)

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