Marc Kirschner | Academic Influence

Marc Kirschner's AcademicInfluence.com Rankings

Marc Kirschner

Biology

#263

World Rank

#474

Historical Rank

#152

USA Rank

Cell Biology

#8

World Rank

#8

Historical Rank

#4

USA Rank

Developmental Biology

#7

World Rank

#9

Historical Rank

#2

USA Rank

Molecular Biology

#80

World Rank

#83

Historical Rank

#51

USA Rank

biology Degrees

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Biology

Marc Kirschner's Degrees

PhD Biochemistry Stanford University
Bachelors Biochemistry University of California, Berkeley

Why Is Marc Kirschner Influential?

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According to Wikipedia, Marc Wallace Kirschner is an American cell biologist and biochemist and the founding chair of the Department of Systems Biology at Harvard Medical School. He is known for major discoveries in cell and developmental biology related to the dynamics and function of the cytoskeleton, the regulation of the cell cycle, and the process of signaling in embryos, as well as the evolution of the vertebrate body plan. He is a leader in applying mathematical approaches to biology. He is the John Franklin Enders University Professor at Harvard University. In 2021 he was elected to the American Philosophical Society.

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Marc Kirschner's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. (1977) (4468)
Dynamic instability of microtubule growth (1984) (3061)
A protein factor essential for microtubule assembly. (1975) (2588)
Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells (2015) (2457)
Cyclin is degraded by the ubiquitin pathway (1991) (2365)
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling (2009) (1793)
Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS (2003) (1712)
A major developmental transition in early xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage (1982) (1576)
The Interaction between N-WASP and the Arp2/3 Complex Links Cdc42-Dependent Signals to Actin Assembly (1999) (1379)
How Proteolysis Drives the Cell Cycle (1996) (1372)
Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probes (1980) (1345)
Beyond self-assembly: From microtubules to morphogenesis (1986) (1322)
Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. (1997) (1313)
Cyclin synthesis drives the early embryonic cell cycle (1989) (1194)
Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation (2012) (1169)
A major developmental transition in early xenopus embryos: II. control of the onset of transcription (1982) (1139)
Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos (1991) (1127)
The role of cyclin synthesis and degradation in the control of maturation promoting factor activity (1989) (1072)
A 20s complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B (1995) (1021)
Geminin, an Inhibitor of DNA Replication, Is Degraded during Mitosis (1998) (942)
Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau. (1992) (912)
Synergistic induction of mesoderm by FGF and TGF-β and the identification of an mRNA coding for FGF in the early xenopus embryo (1987) (873)
Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. (1996) (861)
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck (2002) (849)
Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. (1999) (845)
Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. (1977) (837)
cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2 (1991) (822)
Mitosis in transition (1994) (802)
Cytoskeletal dynamics and nerve growth (1988) (793)
Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. (1997) (788)
Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly. (1977) (788)
The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. (2000) (786)
Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins (1986) (770)
Microtubule assembly nucleated by isolated centrosomes (1984) (758)
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner (2012) (740)
Tau protein function in living cells (1986) (715)
The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway (2003) (698)
Dominoes and clocks: the union of two views of the cell cycle. (1989) (694)
The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. (1998) (649)
Mechanism of N-Wasp Activation by Cdc42 and Phosphatidylinositol 4,5-Bisphosphate (2000) (645)
Rescuing US biomedical research from its systemic flaws (2014) (640)
Filament organization revealed in platinum replicas of freeze-dried cytoskeletons (1980) (640)
mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2 (1991) (638)
Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA (1995) (617)
The primary structure and heterogeneity of tau protein from mouse brain. (1988) (614)
γ-Tubulin is a highly conserved component of the centrosome (1991) (613)
Pericentrin, a highly conserved centrosome protein involved in microtubule organization (1994) (588)
Cell cycle dynamics of an M-phase-specific cytoplasmic factor in Xenopus laevis oocytes and eggs (1984) (565)
A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity (2002) (544)
Cells, Embryos and Evolution (1997) (540)
Tau protein binds to microtubules through a flexible array of distributed weak sites (1991) (529)
Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1. (1998) (516)
Cyclin activation of p34 cdc2 (1990) (506)
Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains (1989) (503)
Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors (1985) (502)
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex (2004) (493)
Anteroposterior Patterning in Hemichordates and the Origins of the Chordate Nervous System (2003) (450)
Role of phosphorylation in p34cdc2 activation: identification of an activating kinase. (1992) (447)
In vitro reconstitution of centrosome assembly and function: The central role of γ-tubulin (1994) (438)
Toca-1 Mediates Cdc42-Dependent Actin Nucleation by Activating the N-WASP-WIP Complex (2004) (427)
Sites of microtubule assembly and disassembly in the mitotic spindle (1986) (424)
Nck and Phosphatidylinositol 4,5-Bisphosphate Synergistically Activate Actin Polymerization through the N-WASP-Arp2/3 Pathway* (2001) (424)
Microtubule dynamics (1986) (410)
The dynamics of gene expression in vertebrate embryogenesis at single-cell resolution (2018) (403)
Polewards chromosome movement driven by microtubule depolymerization in vitro (1988) (398)
The incoherent feedforward loop can provide fold-change detection in gene regulation. (2009) (388)
Dual Inhibition of Sister Chromatid Separation at Metaphase (2001) (381)
Cell Growth and Size Homeostasis in Proliferating Animal Cells (2009) (380)
Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C (1990) (377)
The theory of facilitated variation (2007) (373)
An Actin-Based Wave Generator Organizes Cell Motility (2007) (370)
The role of microtubule dynamics in growth cone motility and axonal growth (1995) (368)
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities (2007) (365)
Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins. (1993) (364)
Unpolymerized tubulin modulates the level of tubulin mRNAs (1981) (361)
The presence of fibroblast growth factor in the frog egg: its role as a natural mesoderm inducer. (1988) (360)
Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation (2007) (360)
Using buoyant mass to measure the growth of single cells (2010) (360)
Posttranslational modification and microtubule stability (1987) (358)
Regulation of the cell cycle during early Xenopus development (1984) (354)
FGF signalling in the early specification of mesoderm in Xenopus. (1993) (354)
A cytoplasmic clock with the same period as the division cycle in Xenopus eggs. (1980) (352)
The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. (1998) (352)
Microtubule behavior in the growth cones of living neurons during axon elongation (1991) (350)
A microtubule-associated protein from Xenopus eggs that specifically promotes assembly at the plus-end (1987) (350)
Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts. (2000) (341)
The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC–Cdc20 complex (2004) (333)
The events of the midblastula transition in Xenopus are regulated by changes in the cell cycle (1987) (329)
Dorsoventral Patterning in Hemichordates: Insights into Early Chordate Evolution (2006) (322)
Microtubule dynamics in interphase cells (1986) (321)
Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry (2004) (320)
Centrosome development in early mouse embryos as defined by an autoantibody against pericentriolar material (1983) (317)
Nucleotide and corresponding amino acid sequences encoded by α and β tubulin mRNAs (1981) (307)
Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates. (1996) (305)
The Meaning of Systems Biology (2005) (305)
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus (2014) (301)
Erk/Src Phosphorylation of Cortactin Acts as a Switch On-Switch Off Mechanism That Controls Its Ability To Activate N-WASP (2004) (300)
LIS1 Regulates CNS Lamination by Interacting with mNudE, a Central Component of the Centrosome (2000) (298)
Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling. (2009) (295)
An antisense mRNA directs the covalent modification of the transcript encoding fibroblast growth factor in Xenopus oocytes (1989) (289)
The Processivity of Multiubiquitination by the APC Determines the Order of Substrate Degradation (2006) (288)
Multiple Phases of Chondrocyte Enlargement Underlie Differences in Skeletal Proportions (2013) (286)
A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis (2014) (280)
Phosphorylation of microtubule‐associated protein tau: identification of the site for Ca2(+)‐calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles. (1990) (278)
On being the right (cell) size (2015) (272)
Mitotic inactivation of a human SWI/SNF chromatin remodeling complex. (1998) (271)
Dynamic and stable populations of microtubules in cells (1987) (264)
Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (1998) (261)
Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex. (2001) (258)
Spontaneous formation of nucleus-like structures around bacteriophage DNA microinjected into Xenopus eggs (1983) (253)
Cdc42 is required for PIP2-induced actin polymerization and early development but not for cell viability (2000) (250)
Activation of the WAVE complex by coincident signals controls actin assembly. (2009) (245)
Phosphorylation Analysis by Mass Spectrometry (2006) (242)
Influence of the centrosome on the structure of nucleated microtubules (1985) (242)
Properties of the kinetochore in vitro. II. Microtubule capture and ATP- dependent translocation (1985) (241)
Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. (1980) (241)
Induction of early mitotic events in a cell-free system (1985) (239)
Systematic identification of mitotic phosphoproteins (1997) (235)
Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation. (1998) (233)
Bioenergetics and kinetics of microtubule and actin filament assembly-disassembly. (1982) (233)
Purification and architecture of the ubiquitous Wave complex. (2004) (231)
A polymer-dependent increase in phosphorylation of beta-tubulin accompanies differentiation of a mouse neuroblastoma cell line (1985) (230)
Microtubule assembly and nucleation. (1978) (230)
Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. (2005) (227)
UBE2S drives elongation of K11-linked ubiquitin chains by the Anaphase-Promoting Complex (2010) (227)
Expression cloning of a Xenopus T-related gene (Xombi) involved in mesodermal patterning and blastopore lip formation. (1996) (227)
Ubiquitination of the G1 cyclin Cln2p by a Cdc34p‐dependent pathway. (1995) (225)
Temporal and spatial regulation of fibronectin in early Xenopus development (1984) (224)
Interconversion of metaphase and interphase microtubule arrays, as studied by the injection of centrosomes and nuclei into Xenopus eggs (1984) (223)
INH, a negative regulator of MPF, is a form of protein phosphatase 2A (1991) (221)
Microtubule behavior during guidance of pioneer neuron growth cones in situ (1991) (219)
The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. (2010) (218)
Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20 (2000) (218)
Early events in DNA replication require cyclin E and are blocked by p21CIP1 (1995) (218)
Identification of BIME as a Subunit of the Anaphase-Promoting Complex (1996) (216)
Implications of treadmilling for the stability and polarity of actin and tubulin polymers in vivo (1980) (215)
Deep Proteomics of the Xenopus laevis Egg using an mRNA-Derived Reference Database (2014) (211)
Stable isotope-free relative and absolute quantitation of protein phosphorylation stoichiometry by MS. (2005) (211)
Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors (1999) (207)
Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle (2013) (207)
Cells, embryos, and evolution: toward a cellular and developmental understanding of phenotypic variation and evolutionary adaptability (1997) (203)
Direct observation of mammalian cell growth and size regulation (2012) (201)
Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality. (2004) (200)
A reinvestigation of the role of the grey crescent in axis formation in Xenopus laevis (1981) (197)
Corequirement of Specific Phosphoinositides and Small GTP-binding Protein Cdc42 in Inducing Actin Assembly in Xenopus Egg Extracts (1998) (197)
WAVE2 deficiency reveals distinct roles in embryogenesis and Rac‐mediated actin‐based motility (2003) (195)
Regulation of MPF activity in vitro (1988) (194)
Mapping gene expression in two Xenopus species: evolutionary constraints and developmental flexibility. (2011) (193)
The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42. (1998) (193)
Tubulin requires tau for growth onto microtubule initiating sites. (1976) (192)
Tome-1, a Trigger of Mitotic Entry, Is Degraded during G1 via the APC (2003) (192)
Identification of a novel ubiquitin-conjugating enzyme involved in mitotic cyclin degradation (1996) (192)
New features of microtubule behaviour observed in vivo (1988) (186)
Substrate degradation by the proteasome: A single-molecule kinetic analysis (2015) (184)
Properties of the kinetochore in vitro. I. Microtubule nucleation and tubulin binding (1985) (181)
Microtubules from mammalian brain: some properties of their depolymerization products and a proposed mechanism of assembly and disassembly. (1974) (181)
The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction. (2001) (180)
Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation (2004) (180)
Sizzled: a secreted Xwnt8 antagonist expressed in the ventral marginal zone of Xenopus embryos. (1997) (177)
Pin1 acts catalytically to promote a conformational change in Cdc25. (2001) (177)
Mouse ribonucleotide reductase R2 protein: A new target for anaphase-promoting complex-Cdh1-mediated proteolysis (2003) (173)
Hem-1 Complexes Are Essential for Rac Activation, Actin Polymerization, and Myosin Regulation during Neutrophil Chemotaxis (2006) (172)
Hemichordate genomes and deuterostome origins (2015) (169)
Microtubule polymer assembly and transport during axonal elongation (1991) (168)
On the Relationship of Protein and mRNA Dynamics in Vertebrate Embryonic Development. (2015) (167)
Regulation of microtubule protein levels during cellular morphogenesis in nerve growth factor-treated PC12 cells (1988) (163)
Optimizing Optical Flow Cytometry for Cell Volume-Based Sorting and Analysis (2011) (163)
Microtubule assembly in cytoplasmic extracts of Xenopus oocytes and eggs (1987) (163)
Maturation-promoting factor induces nuclear envelope breakdown in cycloheximide-arrested embryos of Xenopus laevis (1983) (162)
Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells. (1998) (161)
Aster formation in eggs of Xenopus laevis. Induction by isolated basal bodies (1975) (161)
Mitosis in a cell with multiple centrioles (1982) (159)
Bethesda Statement on Open Access Publishing (2003) (158)
Self-Assembly of Filopodia-Like Structures on Supported Lipid Bilayers (2010) (157)
Properties of the depolymerization products of microtubules from mammalian brain. (1974) (154)
The minimum GTP cap required to stabilize microtubules (1994) (153)
Evolution at Two Levels : On Genes and Form (2005) (151)
Microtubule bending and breaking in living fibroblast cells. (1999) (149)
Studies on the expression of the microtubule-associated protein, tau, during mouse brain development, with newly isolated complementary DNA probes (1984) (147)
Structural basis for dynamic regulation of the human 26S proteasome (2016) (147)
Evidence for a functional role of the cytoskeleton in determination of the dorsoventral axis in Xenopus laevis eggs. (1983) (146)
The identification of two novel ligands of the fgf receptor by a yeast screening method and their activity in xenopus development (1995) (145)
Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1. (2001) (138)
Physiological regulation of β-catenin stability by Tcf3 and CK1ε (2001) (135)
Cyclin in fission yeast (1988) (133)
Molecular “Vitalism” (2000) (131)
Evidence for a functional role of RNA in centrioles (1977) (131)
The role of microtubules in growth cone turning at substrate boundaries (1995) (130)
Regulation of Cdc25C by ERK-MAP Kinases during the G2/M Transition (2007) (130)
Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly (2004) (128)
The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning. (1997) (127)
Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression. (2010) (126)
Immunoflourescent staining of cytoplasmic and spindle microtubules in mouse fibroblasts with antibody to tau protein. (1977) (126)
Nucleotide binding and phosphorylation in microtubule assembly in vitro. (1977) (126)
A general lack of compensation for gene dosage in yeast (2010) (125)
Role of the centrosome in organizing the interphase microtubule array: properties of cytoplasts containing or lacking centrosomes (1984) (125)
Turnover of tubulin and the N site GTP in chinese hamster ovary cells (1977) (124)
A Xenopus nodal-related gene that acts in synergy with noggin to induce complete secondary axis and notochord formation. (1996) (124)
Autoregulation of tubulin synthesis in hepatocytes and fibroblasts (1985) (123)
Kinetic Responses of β-Catenin Specify the Sites of Wnt Control (2012) (123)
Accurate multiplexed proteomics at the MS2 level using the complement reporter ion cluster. (2012) (122)
Regulation of the fibroblast growth factor receptor in early Xenopus embryos. (1990) (121)
The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity (2016) (119)
In vitro reconstitution of centrosome assembly and function: the central role of gamma-tubulin. (1994) (119)
Intracellular localization of the high molecular weight microtubule accessory protein by indirect immunofluorescence (1978) (118)
The timing of early developmental events in Xenopus (1985) (117)
Preprints for the life sciences (2016) (117)
Respective roles of centrosomes and chromatin in the conversion of microtubule arrays from interphase to metaphase (1984) (116)
CR16 forms a complex with N-WASP in brain and is a novel member of a conserved proline-rich actin-binding protein family (2001) (115)
FLEXIQuant: a novel tool for the absolute quantification of proteins, and the simultaneous identification and quantification of potentially modified peptides. (2009) (114)
Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C (2016) (113)
Direct observation of steady-state microtubule dynamics (1986) (113)
Nuclear lamin LI of Xenopus laevis: cDNA cloning, amino acid sequence and binding specificity of a member of the lamin B subfamily. (1987) (113)
APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction. (2014) (112)
A Novel Set of Wnt-Frizzled Fusion Proteins Identifies Receptor Components That Activate β-Catenin-dependent Signaling* (2002) (111)
Phosphorylation changes associated with the early cell cycle in Xenopus eggs. (1987) (109)
Characteristics of the polar assembly and disassembly of microtubules observed in vitro by darkfield light microscopy (1979) (108)
Hemichordates and the origin of chordates. (2005) (108)
Quantitative electron microscopy of microtubule assembly in vitro. (1975) (106)
A dispersed multigene family encoding tubulin in Drosophila melanogaster (1980) (105)
Specific Proteolysis of the Kinase Protein Kinase C-related Kinase 2 by Caspase-3 during Apoptosis (1997) (104)
Thiostrepton and Derivatives Exhibit Antimalarial and Gametocytocidal Activity by Dually Targeting Parasite Proteasome and Apicoplast (2011) (104)
Aggregation of microtubule initiation sites preceding neurite outgrowth in mouse neuroblastoma cells (1979) (104)
Deubiquitinase FAM/USP9X Interacts with the E3 Ubiquitin Ligase SMURF1 Protein and Protects It from Ligase Activity-dependent Self-degradation (2012) (103)
The mechanism of microtubule assembly in vitro. (1974) (103)
The Nuclear Proteome of a Vertebrate (2015) (102)
VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma (2018) (102)
Autoregulation of tubulin synthesis in enucleated cells (1985) (100)
Subunit treadmilling of microtubules or actin in the presence of cellular barriers: possible conversion of chemical free energy into mechanical work. (1982) (100)
Inhibition of cdc2 activation by INH/PP2A. (1994) (100)
Two tandem verprolin homology domains are necessary for a strong activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation by N-WASP. (2000) (99)
Resonant microchannel volume and mass measurements show that suspended cells swell during mitosis (2015) (98)
Differential expression of multiple U1 small nuclear RNAs in oocytes and embryos of Xenopus laevis (1984) (98)
The redistribution of a conserved nuclear envelope protein during the cell cycle suggests a pathway for chromosome condensation (1984) (98)
Quantitative reconstitution of mitotic CDK1 activation in somatic cell extracts. (2010) (98)
A new lamin in Xenopus somatic tissues displays strong homology to human lamin A. (1987) (97)
Cell cycle adaptations of embryonic stem cells (2011) (97)
Multiple sites for the initiation of microtubule assembly in mammalian cells (1979) (96)
The fate of cells in the tailbud of Xenopus laevis. (2000) (95)
Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays (2009) (93)
Profiling of Ubiquitin-like Modifications Reveals Features of Mitotic Control (2013) (92)
Control of mitotic transitions by the anaphase-promoting complex. (1999) (91)
Different phosphorylation states of the anaphase promoting complex in response to antimitotic drugs: A quantitative proteomic analysis (2008) (88)
β-Catenin specifies the endomesoderm and defines the posterior organizer of the hemichordate Saccoglossus kowalevskii (2011) (88)
Axonal transport of tubulin in tit pioneer neurons in situ (1995) (86)
Isolation of separate mRNAs for α- and β-Tubulin and characterization of the corresponding in vitro translation products (1978) (84)
[26] Isolation of mammalian centrosomes (1986) (83)
Gap 1 phase length and mouse embryonic stem cell self-renewal (2012) (83)
Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity (2018) (83)
A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions (2001) (83)
Initiation of the Cell Cycle and Establishment of Bilateral Symmetry in Xenopus Eggs (1980) (83)
Need-Based Up-Regulation of Protein Levels in Response to Deletion of Their Duplicate Genes (2010) (82)
Small nuclear RNA transcription and ribonucleoprotein assembly in early Xenopus development (1983) (80)
Antiplasmodial thiostrepton derivatives: proteasome inhibitors with a dual mode of action. (2010) (80)
Size homeostasis in adherent cells studied by synthetic phase microscopy (2013) (80)
Exploiting polypharmacology for drug target deconvolution (2014) (78)
Proteolysis and DNA replication: the CDC34 requirement in the Xenopus egg cell cycle. (1997) (77)
The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm (2003) (77)
Molecular ties between the cell cycle and differentiation in embryonic stem cells (2014) (77)
A microtubule-binding Rho-GEF controls cell morphology during convergent extension of Xenopus laevis (2005) (76)
Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. (2009) (75)
Molecular targets of vertebrate segmentation: two mechanisms control segmental expression of Xenopus hairy2 during somite formation. (2001) (73)
The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium (2014) (72)
Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. (2006) (71)
Xbra functions as a switch between cell migration and convergent extension in the Xenopus gastrula (2003) (68)
SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression. (2013) (66)
The mechanism and pattern of yolk consumption provide insight into embryonic nutrition in Xenopus (2009) (66)
Anaphase specific auto‐cleavage of separase (2002) (65)
The cell cycle then and now. (1992) (64)
Monoclonal antibodies specific for thiophosphorylated proteins recognize Xenopus MPF. (1988) (64)
Conservation of microtubule associated proteins. Isolation and characterization of tau and the high molecular weight microtubule associated protein from chicken brain and from mouse fibroblasts and comparison to the corresponding mammalian brain proteins. (1979) (63)
Specificity of the anaphase-promoting complex: A single-molecule study (2015) (63)
Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase promoting complex (2013) (61)
What controls the cell cycle? (1991) (60)
Cloning of Mix-related homeodomain proteins using fast retrieval of gel shift activities, (FROGS), a technique for the isolation of DNA-binding proteins. (1998) (60)
Conformational changes in proteins as measured by difference sedimentation studies. II. Effect of stereospecific ligands on the catalytic subunit of aspartate transcarbamylase. (1971) (60)
Remodeling of the Metabolome during Early Frog Development (2011) (60)
The polarity and stability of microtubule capture by the kinetochore (1988) (59)
Small pool expression screening: identification of genes involved in cell cycle control, apoptosis, and early development. (1997) (59)
Isolation of mammalian centrosomes. (1986) (58)
The surface contraction waves of Xenopus eggs reflect the metachronous cell-cycle state of the cytoplasm (1997) (57)
Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9 (2013) (57)
Timing of Events in Mitosis (2002) (56)
Conformational changes in proteins as measured by difference sedimentation studies. I. A technique for measuring small changes in sedimentation coefficient. (1971) (56)
Noncanonical open reading frames encode functional proteins essential for cancer cell survival (2021) (54)
Characterization of a new qQq-FTICR mass spectrometer for post-translational modification analysis and top-down tandem mass spectrometry of whole proteins (2005) (54)
Mouse embryonic stem cells can differentiate via multiple paths to the same state (2017) (53)
Hippo pathway mediates resistance to cytotoxic drugs (2017) (53)
Hemichordate embryos: procurement, culture, and basic methods. (2004) (52)
Domain structure of separase and its binding to securin as determined by EM (2005) (52)
Induced formation of asters and cleavage furrows in oocytes of Xenopus laevis during in vitro maturation. (1978) (51)
The production of cleaved, trimeric human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein vaccine antigens and infectious pseudoviruses using linear polyethylenimine as a transfection reagent. (2006) (51)
Graded Positional Information Interpretation for Both Fate and Guidance (2003) (51)
Quantitative Lys-ϵ-Gly-Gly (diGly) Proteomics Coupled with Inducible RNAi Reveals Ubiquitin-mediated Proteolysis of DNA Damage-inducible Transcript 4 (DDIT4) by the E3 Ligase HUWE1 (2014) (50)
The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function. (2017) (49)
Opinion: Addressing systemic problems in the biomedical research enterprise (2015) (48)
Identification of multiple CDH1 homologues in vertebrates conferring different substrate specificities (2001) (47)
Multiple alpha and beta tubulin genes represent unlinked and dispersed gene families. (1981) (47)
cDNA Sequences for Transcription Factors and Signaling Proteins of the Hemichordate Saccoglossus kowalevskii: Efficacy of the Expressed Sequence Tag (EST) Approach for Evolutionary and Developmental Studies of a New Organism (2008) (47)
Cyclin B and E2F-1 expression in prostate carcinoma cells treated with the novel retinoid CD437 are regulated by the ubiquitin-mediated pathway. (2002) (45)
FUNCTIONAL GENOMICS: Expression Cloning in the Test Tube (1997) (45)
Normal Table of Xenopus Laevis (Daudin) (2020) (45)
Morphogenesis and the Control of Microtubule Dynamics in Cells (1986) (42)
Identical Genomic Organization of Two Hemichordate Hox Clusters (2012) (42)
Anteroposterior axis patterning by early canonical Wnt signaling during hemichordate development (2018) (42)
The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo (2007) (41)
M-phase promoting factors from eggs of Xenopus laevis. (1985) (41)
Molecular cloning of tyrosine kinases in the early Xenopus embryo: Identification of eck‐related genes expressed in cranial neural crest cells of the second (Hyoid) Arch (1995) (40)
Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy. (2012) (40)
The relationship between evolutionary and physiological variation in hemoglobin (2007) (40)
An inhibitor of p34cdc2/cyclin B that regulates the G2/M transition in Xenopus extracts. (1996) (40)
The role of biomedical research in health care reform. (1994) (39)
A new method of local vital staining of amphibian embryos using ficoll and "crystals" of Nile Red. (1980) (38)
A nontranscriptional role for Oct4 in the regulation of mitotic entry (2014) (37)
[5] Aspartate transcarbamoylase (Escherichia coli): Preparation of subunits (1978) (37)
Regulated proteolysis of Xom mediates dorsoventral pattern formation during early Xenopus development. (2002) (37)
Proteomics of phosphorylation and protein dynamics during fertilization and meiotic exit in the Xenopus egg (2017) (36)
Nucleotide specificity in microtubule assembly in vitro. (1978) (35)
Control of b-Catenin Stability : Reconstitution of the Cytoplasmic Steps of the Wnt Pathway in Xenopus Egg Extracts (2000) (35)
Microarray Discovery of New OGT Substrates: The Medulloblastoma Oncogene OTX2 Is O-GlcNAcylated (2014) (33)
Expression cloning in the test tube. (1997) (33)
The Plausibility of Life (2017) (33)
Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication (2013) (33)
Some thoughts on the partitioning of tubulin between monomer and polymer under conditions of dynamic instability (1987) (32)
Identification of ubiquitin ligase substrates by in vitro expression cloning. (2005) (32)
G1 cyclin-dependent activation of p34CDC28 (Cdc28p) in vitro. (1995) (32)
THE ROLE OF RINGS IN THE ASSEMBLY OF MICROTUBULES IN VITRO * (1975) (31)
Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss. (2020) (31)
Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation. (2017) (30)
Regulation of Cdc 25 C by ERK-MAP Kinases during the G 2 / M Transition (2007) (30)
On a possible evolutionary link of the stomochord of hemichordates to pharyngeal organs of chordates (2014) (30)
Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. (2017) (29)
Structure of the Mad 2 spindle assembly checkpoint protein and its interaction with Cdc 20 (2000) (29)
Nucleotide and corresponding amino acid sequences encoded by alpha and beta tubulin mRNAs. (1981) (28)
The genome of the giant Nomura’s jellyfish sheds light on the early evolution of active predation (2019) (27)
Computationally enhanced quantitative phase microscopy reveals autonomous oscillations in mammalian cell growth (2019) (27)
Regulation of microtubule and actin filament assembly--disassembly by associated small and large molecules. (1983) (26)
Local and gross conformational changes in aspartate transcarbamylase. (1973) (25)
Neuronal differentiation and patterning in Xenopus: the role of cdk5 and a novel activator xp35.2. (1999) (25)
Single-molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation (2020) (24)
Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bb as a cell cycle regulator. (2005) (24)
Protein microarrays for genome‐wide posttranslational modification analysis (2011) (24)
Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates (2017) (23)
[16] Purification of tau protein from brain (1986) (21)
A Perverted View of “Impact” (2013) (21)
Autoregulatory control of the expression of alpha- and beta-tubulins: implications for microtubule assembly. (1982) (20)
YAP regulates cell size and growth dynamics via non-cell autonomous mediators (2020) (20)
Use of an oocyte expression assay to reconstitute inductive signaling. (1995) (19)
Isolation of separate mRNAs for alpha- and beta-tubulin and characterization of the corresponding in vitro translation products. (1978) (17)
Oligonucleotide microarray data mining: search for age-dependent gene expression. (2002) (17)
Biological implications of microtubule dynamics. (1987) (17)
Conformational studies on the nitrated catalytic subunit of aspartate transcarbamylase. (1973) (17)
An inducible Tet-Off-H2B-GFP lentiviral reporter vector for detection and in vivo isolation of label-retaining cells. (2010) (16)
Cdc42 and PI(4,5)P2-induced actin assembly in Xenopus egg extracts. (2006) (16)
In vitro reconstitution of cdc42-mediated actin assembly using purified components. (2006) (16)
The protein repertoire in early vertebrate embryogenesis (2019) (16)
Erratum: Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates (Mulecular Cell 18 (185-200)) (2005) (16)
Toca-1 Mediates Cdc 42-Dependent Actin Nucleation by Activating the N-WASP-WIP (2004) (16)
Beyond Darwin: evolvability and the generation of novelty (2013) (15)
Protein and lipid mass concentration measurement in tissues by stimulated Raman scattering microscopy (2019) (14)
Control of p34cdc2 activation. (1991) (14)
Purification of tau protein from brain. (1986) (14)
An approach to increased polyplex gene delivery by peptides selected from a phage display library. (2002) (14)
Autoregulation of tubulin synthesis (1986) (14)
Spatial and Temporal Changes in Early Amphibian Development (1980) (13)
Aspartate transcarbamoylase (Escherichia coli): preparation of subunits. (1978) (13)
Intracellular proteolysis. (1999) (12)
Conformational landscape of the p28-bound human proteasome regulatory particle (2016) (12)
Single molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation (2019) (12)
In situ measurement of absolute concentrations by Normalized Raman Imaging (2019) (12)
Spatial and Temporal Changes in the Amphibian Egg (1981) (12)
Long-Term Culture of Human Gingival Keratinocyte Progenitor Cells by Down-regulation of 14-3-3σ (2006) (9)
Quantitative measurement of the catastrophe rate of dynamic microtubules. (1999) (9)
Science and the new administration. (1993) (9)
The biochemical nature of the cell cycle. (1992) (8)
Long-term culture of human gingival keratinocyte progenitor cells by down-regulation of 14-3-3 sigma. (2006) (8)
Analysis of association-dissociation equilibria in proteins by difference and differential sedimentation. (1973) (8)
Beyond G1/S regulation: how cell size homeostasis is tightly controlled throughout the cell cycle? (2022) (8)
An optimal set of inhibitors for Reverse Engineering via Kinase Regularization (2020) (7)
Erratum: Targeting cell division: Small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality (Proceedings of the National Academy of Sciences of the United States of America (August 10, 2004) 101, 32 (11821-11826)) (2004) (6)
Fifty years after Jacob and Monod: what are the unanswered questions in molecular biology? (2011) (6)
A difference sedimentation equilibrium technique for measuring small changes in molecular weight. I. Theory and computer simulation. (1974) (5)
Phylogenomic analyses of the genus Drosophila reveals genomic signals of climate adaptation (2021) (5)
Easy passage: germline transgenesis in frogs. (1999) (5)
Perspective Evolvability (1998) (5)
A Protein Factor Essential forMicrotubule Assembly (taufactor/tubulin/electron microscopy/phosphocellulose) (1975) (4)
Optimization of Quantitative Phase Microscopy reveals new features of the growth rate of adherent mammalian cells (2019) (4)
Cell size sensing in animal cells coordinates anabolic growth rates with cell cycle progression to maintain uniformity of cell size (2017) (4)
Mobilization of cytoskeleton elements during nerve growth factor induced neurite outgrowth in pc 12 cells (1984) (4)
Non-canonical open reading frames encode functional proteins essential for cancer cell survival (2020) (4)
Intelligent high‐throughput intervention testing platform in Daphnia (2022) (4)
Inhibition of cdc 2 Activation by INH / PP 2 A (2003) (4)
Emi 1 preferentially inhibits ubiquitin chain elongation by the anaphase promoting complex (2013) (4)
Microtubule dynamics in vivo (1987) (4)
Post‐Translational Modification Profiling—a High‐Content Assay for Identifying Protein Modifications in Mammalian Cellular Systems (2014) (3)
The Road to Facilitated Variation (2015) (3)
Cdc 42 and PI ( 4 , 5 ) P 2 ‐ Induced Actin Assembly in Xenopus Egg Extracts (3)
Lack of age-related respiratory changes in Daphnia (2021) (3)
Influence of the Centrosome of Nucleated Microtubules on the Structure (1985) (3)
Inducible APOBEC3G-Vif Double Stable Cell Line as a High-Throughput Screening Platform To Identify Antiviral Compounds (2009) (3)
YAP independently regulates cell size and population growth dynamics via non-cell autonomous mediators (2018) (3)
"Smart Tanks": An Intelligent High-Throughput Intervention Testing Platform in Daphnia (2021) (3)
Dual RING E 3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC / C Graphical (3)
Cell Biology as a World View (2010) (2)
Transitions in the proteome and phospho-proteome during Xenopus laevis development (2021) (2)
6. Evolution of the Cell (1992) (2)
The nonredundant nature of the Axin2 regulatory network in the canonical Wnt signaling pathway (2022) (2)
Obituary: Reinhart Heinrich (1946–2006) (2006) (2)
A visit to the Hubrecht laboratory. (1999) (2)
Corrigendum to: Anaphase specific auto‐cleavage of separase (FEBS 26464) (2002) (2)
The jellyfish genome sheds light on the early evolution of active predation (2018) (2)
Cell multiplication. (1993) (2)
Direct Visualization of Steady State Microtubule Dynamics in Vitro (1986) (2)
In Situ Measurement of Protein and Lipid Mass by Normalized Raman Imaging (2020) (2)
Tau ProteinBindstoMicrotubulesthrough A Flexible ArrayofDistributed Weak Sites (1991) (2)
Quantitative proteomics reveals remodeling of protein repertoire across life phases of Daphnia pulex (2019) (1)
Correction: Dorsoventral Patterning in Hemichordates: Insights into Early Chordate Evolution (2015) (1)
The genome of the giant Nomura’s jellyfish sheds light on the early evolution of active predation (2019) (1)
No money, no research (2014) (1)
One-Seq: A Highly Scalable Sequencing-Based Diagnostic for SARS-CoV-2 and Other Single-Stranded Viruses (2021) (1)
Inverse Lansing effect: maternal age and provisioning affecting daughters’ longevity and male offspring production (2021) (1)
BIME joins the destruction team. (1997) (1)
John Newport 1951–2005 (2006) (1)
The non-redundant nature of the Axin2 regulatory network in the canonical Wnt signaling pathway (2021) (1)
The uniformity and stability of cellular mass density in mammalian cell culture (2022) (1)
Author response: Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity (2018) (1)
Wnt11 family dependent morphogenesis during frog gastrulation is marked by the cleavage furrow protein anillin (2022) (1)
Examination of the Genes Coding for α - and β -Tubulin (1981) (1)
Public Library of Science Initiative - Open Letter (2000) (1)
Howard Schachman (1918–2016) (2016) (0)
Microtubules from Mammalian Brain: Soy Depolymerization Products and a Propose Assembly and Disassembly (electron microscopy/sedimentation analysis/protofilame (2016) (0)
Comment on “Epigenetic inheritance in evolution” (1998) (0)
Double inhibition de la separation de chromatides soeurs en metaphase (2002) (0)
Regulation of the Eukaryotic Cell-Cycle - Final Discussion (1992) (0)
Abstract A115: A novel therapy targeting Wnt receptor in metastatic solid tumors (2015) (0)
A cell type annotation Jamboree-Revival of а communal science forum. (2020) (0)
TBIO-26. NON-CANONICAL OPEN READING FRAMES ENCODE FUNCTIONAL PROTEINS ESSENTIAL FOR CANCER CELL SURVIVAL (2020) (0)
The Nuclear Proteome of a Vertebrate Graphical (2015) (0)
NUCLEAR EXPORT AND INTERACTION WITH CYTOPLASMIC CHAPERONE COMPLEXES OF TOMATO HEAT STRESS TRANSCRIPTION FACTOR HSFA2 (2000) (0)
Binding of the Wnt ligand to the extracellular domains of two transmembrane receptors leads to the inhibition of the activity of the destruction complex in the cytosol ( Bhanot (2010) (0)
Bruce Alberts, Science's New Editor (2008) (0)
In Memoriam: John Newport (1951–2005) (2006) (0)
Editorial Board (2008) (0)
Easy passage: Germline tro (2016) (0)
Robustness of Biological Circuits (2012) (0)
From the archive (2018) (0)
The role of exploratory mechanisms in evolution (1995) (0)
From the archive (2018) (0)
The role of cyclin-dependent kinase 5 and a novel regulatory subunit in 1 g muscle differentiation regu atin . and patterning (2007) (0)
The self-regulated response of the Wnt pathway to an oncogenic mutation in β-catenin (2021) (0)
What makes the cell cycle tick? a celebration of the awesome power of biochemistry and the frog egg. (2020) (0)
A : Specific Biological Rationales for the Utility of New Sequence Data (2003) (0)
In memory of harold weintraub. (1995) (0)
Unpolymerized tubulin levels modulate the expression of alpha tubulin and beta tubulin (1982) (0)
Corrections: The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway (2004) (0)
New approaches to studying the growth and size regulation of mammalian cells (2012) (0)
The Evolution of Evolution Theory and Its Controversies (2008) (0)
Letter from J. Michael Bishop, Marc Kirschner, Elizabeth Marincola, and Harold Varmus to Paul Berg, Donald D. Brown, and Maxine Singer (1992) (0)
The Human Genome Contains Numerous Clusters of Adjacent Co-Regulated Genes (2004) (0)
Cytoplasm and cell motility overview. (1989) (0)
Marc Kirschner-Protein Degradation and the Timing of Events in the Cell Cycle (2007) (0)
Four. Weak Regulatory Linkage (2017) (0)
Incubation of Eggs and Oocytes in D ~ (2003) (0)
. 5 Angstroms from Microcrystals Grown in Lipidic X-ray (2008) (0)
A Touch Cell@@@Cells, Embryos, and Evolution. (1998) (0)
MULTIPLE TAU FORMS GENERATED FROM A SINGLE GENE: FUNCTION IN NEURONAL CELL DIFFERENTIATION (1988) (0)
Microtubules K. Roberts and J. S. Hyams, eds. London and New York: Academic Press. 595 pp. $78.50 (1980) (0)
Interpretation: Hemichordates may have no "notochord". (2008) (0)
Dorsal lip maturation and initial archenteron extension depend on Wnt11 family ligands. (2022) (0)
Ligase HUWE 1 DNA Damage-inducible Transcript 4 Reveals Ubiquitin-mediated Proteolysis of Proteomics Coupled with Inducible RNAi Quantitative Lys-?-Gly-Gly ( diGly ) Protein Synthesis and Degradation : (2014) (0)
Identification of kinases activated by multiple pro-angiogenic growth factors (2022) (0)
Seven. Facilitated Variation (2017) (0)
Cellular Models and Spatial Complexity (2004) (0)
ASCB 50TH ANNIVERSARY ESSAY Cell Biology as a World View (2010) (0)
Author response: YAP regulates cell size and growth dynamics via non-cell autonomous mediators (2019) (0)
Solution structure of the Wiskott-Aldrich Syndrome Protein (WASP) autoinhibited core domain complexed with (S)-wiskostatin, a small molecule inhibitor (2004) (0)

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