Harold E. Varmus | Academic Influence

Harold E. Varmus's AcademicInfluence.com Rankings

Harold E. Varmus

Biology

#235

World Rank

#428

Historical Rank

#138

USA Rank

Microbiology

#9

World Rank

#17

Historical Rank

#6

USA Rank

biology Degrees

Harold E. Varmus

Philosophy

#1114

World Rank

#2094

Historical Rank

#465

USA Rank

Logic

#148

World Rank

#340

Historical Rank

#67

USA Rank

philosophy Degrees

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Biology
Philosophy

Harold E. Varmus's Degrees

Doctorate Medicine Columbia University

Why Is Harold E. Varmus Influential?

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According to Wikipedia, Harold Eliot Varmus is an American Nobel Prize-winning scientist. He is currently the Lewis Thomas University Professor of Medicine at Weill Cornell Medicine and a senior associate at the New York Genome Center.

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Harold E. Varmus's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

A new initiative on precision medicine. (2015) (3897)
Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain (2005) (3427)
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. (2004) (3411)
Somatic mutations affect key pathways in lung adenocarcinoma (2008) (2640)
Proceedings of the National Academy of Sciences of the United States of America. Annual subject and author indexes. (1990) (2482)
Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. (1984) (2232)
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome (1982) (1759)
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour (1983) (1404)
DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA (1976) (1283)
KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib (2005) (1226)
Characterizing the cancer genome in lung adenocarcinoma (2007) (1122)
The molecular biology of the hepatitis B viruses. (1987) (1021)
Toward a Shared Vision for Cancer Genomic Data. (2016) (1017)
Characterization of ribosomal frameshifting in HIV-1 gag-pol expression (1988) (956)
Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. (1988) (867)
Structure and variability of human chromosome ends (1990) (864)
Gene Mutations in Human Hæmoglobin: the Chemical Difference Between Normal and Sickle Cell Hæmoglobin (1957) (823)
Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice (1988) (753)
A Specific Chemical Difference Between the Globins of Normal Human and Sickle-Cell Anæmia Hæmoglobin (1956) (738)
The molecular genetics of cellular oncogenes. (1984) (692)
Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma. (1983) (677)
Subtype-specific genomic alterations define new targets for soft tissue sarcoma therapy (2010) (653)
Rescuing US biomedical research from its systemic flaws (2014) (640)
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. (2001) (602)
Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15 (1984) (600)
Signals for ribosomal frameshifting in the rous sarcoma virus gag-pol region (1988) (580)
The Knockout Mouse Project (2004) (574)
Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein (1978) (554)
A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. (1998) (550)
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells (2003) (550)
Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. (2005) (532)
Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas (1982) (528)
Form and function of retroviral proviruses. (1982) (524)
A Member of the Frizzled Protein Family Mediating Axis Induction by Wnt-5A (1997) (514)
Abnormal human haemoglobins. (1958) (508)
Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos (1995) (506)
Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors. (2006) (467)
Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting. (1985) (441)
Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. (1999) (440)
Definition of regions in human c-myc that are involved in transformation and nuclear localization (1987) (436)
Correct integration of retroviral DNA in vitro (1987) (419)
A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells (1983) (419)
Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. (1997) (417)
Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma. (1984) (400)
Three decades of Wnts: a personal perspective on how a scientific field developed (2012) (388)
A nucleoprotein complex mediates the integration of retroviral DNA. (1989) (379)
Induction of ovarian cancer by defined multiple genetic changes in a mouse model system. (2002) (369)
Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein. (1989) (367)
Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA. (1983) (356)
A receptor for subgroup A Rous sarcoma virus is related to the low density lipoprotein receptor (1993) (356)
Wnt signals across the plasma membrane to activate the β-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP (2004) (355)
Ethical complexities of conducting research in developing countries. (1997) (355)
Human immunodeficiency viruses. (1986) (346)
A new nomenclature for int-1 and related genes: The Wnt gene family (1991) (338)
c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism. (1995) (332)
Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins (2012) (331)
FGF‐20 and DKK1 are transcriptional targets of β‐catenin and FGF‐20 is implicated in cancer and development (2005) (330)
Mapping unintegrated avian sarcoma virus DNA: Termini of linear DNA bear 300 nucleotides present once or twice in two species of circular DNA (1978) (323)
Regulation of dorsal fate in the neuraxis by Wnt-1 and Wnt-3a. (1997) (321)
Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as well as for reverse transcription (1990) (313)
Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc (1984) (311)
Seeding and Propagation of Untransformed Mouse Mammary Cells in the Lung (2008) (307)
Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice. (1998) (304)
Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. (1995) (304)
Epstein-Barr Virus: An Important Vaccine Target for Cancer Prevention (2011) (303)
Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src). (1979) (297)
Molecular cloning and characterization of avian sarcoma virus circular DNA molecules (1980) (294)
Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites (1978) (294)
Biochemical and genetic evidence for the hepatitis B virus replication strategy. (1986) (293)
Analysis of avian leukosis virus DNA and RNA in bursal tumors: Viral gene expression is not required for maintenance of the tumor state (1981) (293)
Mutations associated with familial melanoma impair p16INK4 function (1995) (288)
Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice. (1997) (285)
Nucleosomes, DNA-binding proteins, and DNA sequence modulate retroviral integration target site selection (1992) (278)
Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product (1980) (275)
The New Era in Cancer Research (2006) (273)
Gene Evolution and the Hæmoglobins (1961) (268)
What to call the AIDS virus? (1986) (262)
Association of the amino‐terminal half of c‐Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527. (1994) (260)
Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells (1987) (258)
Grand Challenges in Global Health (2003) (258)
Casein kinase 2 associates with and phosphorylates Dishevelled (1997) (257)
Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer (2000) (256)
Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection (1996) (249)
Regulation of Wnt Signaling by Sox Proteins: XSox17α/β and XSox3 Physically Interact with β-catenin (1999) (244)
Molecular biology of tumor viruses. RNA tumor viruses. (1982) (238)
Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture (1985) (238)
Dexamethasone-mediated induction of mouse mammary tumor virus RNA: a system for studying glucocorticoid action (1975) (237)
Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. (1994) (236)
Expression of the proto-oncogene int-1 is restricted to postmeiotic male germ cells and the neural tube of mid-gestational embryos (1987) (235)
Purification of DNA complementary to nucleotide sequences required for neoplastic transformation of fibroblasts by avian sarcoma viruses. (1976) (235)
Association of p60c-src with endosomal membranes in mammalian fibroblasts (1992) (228)
The structure of haemoglobin - IV. Sign determination by the isomorphous replacement method (1954) (221)
Nucleotide sequences at host–proviral junctions for mouse mammary tumour virus (1981) (220)
Cellular functions are required for the synthesis and integration of avian sarcoma virus-specific DNA (1977) (218)
The hemoglobins in genetics and evolution (1963) (216)
Nucleotide sequences related to the transforming gene of avian sarcoma virus are present in DNA of uninfected vertebrates. (1978) (215)
Inhibition of secretion of hepatitis B surface antigen by a related presurface polypeptide. (1986) (214)
Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin. (2004) (210)
Retroviruses as mutagens: Insertion and excision of a nontransforming provirus alter expression of a resident transforming provirus (1981) (208)
Endogenous mammary tumour virus DNA varies among wild mice and segregates during inbreeding (1979) (206)
DNA bending creates favored sites for retroviral integration: an explanation for preferred insertion sites in nucleosomes. (1994) (204)
Isolation of a chicken gene that confers susceptibility to infection by subgroup A avian leukosis and sarcoma viruses (1993) (200)
Glucocorticoid-stimulated accumulation of mouse mammary tumor virus RNA: increased rate of synthesis of viral RNA. (1977) (192)
Mitosis-specific phosphorylation of p60c-src by p34 cdc2-associated protein kinase (1989) (192)
The size and genetic composition of virus-specific RNAs in the cytoplasm of cells producing avian sarcoma-leukosis viruses (1977) (192)
The erythroid cells and haemoglobins of the chick embryo. (1973) (192)
Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin. (1999) (191)
Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA (1983) (190)
The purified product of the transforming gene of avian sarcoma virus phosphorylates tyrosine. (1980) (189)
Abnormal human haemoglobins. III. The chemical difference between normal and sickle cell haemoglobins. (1959) (188)
Why PLoS Became a Publisher (2003) (188)
Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody. (2004) (185)
Proposal for Naming Host Cell-Derived Inserts in Retrovirus Genomes (1981) (183)
A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line (1986) (181)
Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development. (1986) (180)
Integration of the DNA of mouse mammary tumor virus in virus-infected normal and neoplastic tissue of the mouse (1979) (179)
Two efficient ribosomal frameshifting events are required for synthesis of mouse mammary tumor virus gag-related polyproteins. (1987) (176)
Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro. (1993) (175)
Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer. (2014) (173)
Development of a flexible and specific gene delivery system for production of murine tumor models (1999) (173)
Human immunodeficiency virus type 1 gag-pol frameshifting is dependent on downstream mRNA secondary structure: demonstration by expression in vivo (1992) (173)
Enhanced: The Need for a Global HIV Vaccine Enterprise (2003) (168)
The evolution of a protein. (1962) (166)
The preS1 protein of hepatitis B virus is acylated at its amino terminus with myristic acid (1987) (166)
An RNA pseudoknot and an optimal heptameric shift site are required for highly efficient ribosomal frameshifting on a retroviral messenger RNA. (1992) (162)
A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration. (1984) (162)
Expression of the precore region of an avian hepatitis B virus is not required for viral replication (1987) (162)
A small region of the mouse mammary tumor virus long terminal repeat confers glucocorticoid hormone regulation on a linked heterologous gene. (1983) (161)
Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation (1996) (160)
Hemoglobin synthesis during amphibian metamorphosis. I. Chemical studies on the hemoglobins from the larval and adult stages of Rana catesbeiana. (1968) (159)
Effect of n-Butyrate on DNA synthesis in chick fibroblasts and HeLa cells (1977) (159)
Gene deletion as the cause of α thalassaemia: Genetic lesion in homozygous α thalassaemia (hydrops fetalis) (1974) (159)
The int-1 proto-oncogene products are glycoproteins that appear to enter the secretory pathway (1987) (158)
Bethesda Statement on Open Access Publishing (2003) (158)
Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. (2011) (158)
The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells (1992) (154)
Transcription of mouse mammary tumor virus genes in tissues from high and low tumor incidence mouse strains. (1973) (154)
A joint product of the genes gag and pol of Avian Sarcoma Virus: a possible precursor of reverse transcriptase (1977) (154)
Retroviral integration into minichromosomes in vitro. (1992) (153)
Transduction of a cellular oncogene: the genesis of Rous sarcoma virus. (1983) (153)
Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule. (2004) (151)
Genetic Basis of the Thalassæmia Diseases (1959) (151)
Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60 v-src and pp60 c-src (1984) (148)
Structural studies on chick embryonic hemoglobins. (1974) (147)
Wnt/Wingless signaling through β-catenin requires the function of both LRP/Arrow and frizzled classes of receptors (2003) (146)
A system for tissue-specific gene targeting: transgenic mice susceptible to subgroup A avian leukosis virus-based retroviral vectors. (1994) (145)
Production of mouse mammary tumor virus by cultured cells in the absence and presence of hormones: assay by molecular hybridization. (1975) (144)
Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice (1992) (141)
A Mouse Mammary Tumor Virus-Wnt-1 Transgene Induces Mammary Gland Hyperplasia and Tumorigenesis in Mice Lacking Estrogen Receptor-α (1999) (140)
Deletion of α-globin genes in haemoglobin-H disease demonstrates multiple α-globin structural loci (1975) (140)
Mouse mammary tumor virus infection accelerates mammary carcinogenesis in Wnt-1 transgenic mice by insertional activation of int-2/Fgf-3 and hst/Fgf-4. (1993) (140)
Compromised mitochondrial function leads to increased cytosolic calcium and to activation of MAP kinases. (1997) (136)
Casein Kinase Iε Modulates the Signaling Specificities of Dishevelled (2004) (134)
Biosynthesis of the reverse transcriptase of hepatitis B viruses involves de novo translational initiation not ribosomal frameshifting (1989) (133)
Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes. (1998) (132)
Regulation of inducible enzyme synthesis in Escherichia coli by cyclic adenosine 3', 5'-monophosphate. (1969) (132)
Nucleotide sequencing of an apparent proviral copy of env mRNA defines determinants of expression of the mouse mammary tumor virus env gene (1983) (132)
9 Functions and Origins of Retroviral Transforming Genes (1982) (131)
Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras (2008) (129)
The first seven amino acids encoded by the v-src oncogene act as a myristylation signal: lysine 7 is a critical determinant (1988) (129)
Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys. (1996) (129)
Mapping of linear and circular forms of mouse mammary tumor virus DNA with restriction endonucleases: evidence for a large specific deletion occurring at high frequency during circularization. (1978) (129)
Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma (2016) (127)
Nucleotide sequence of an infectious molecularly cloned genome of ground squirrel hepatitis virus (1984) (126)
Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma (2015) (126)
Regulation of HIV and HTLV gene expression. (1988) (125)
Overview of the Alliance for Cellular Signaling (2002) (125)
Detection of avian tumor virus-specific nucleotide sequences in avian cell DNAs (reassociation kinetics-RNA tumor viruses-gas antigen-Rous sarcoma virus, chick cells). (1972) (124)
Binding of the Src SH2 domain to phosphopeptides is determined by residues in both the SH2 domain and the phosphopeptides (1993) (124)
Brain protein kinase PK40erk converts TAU into a PHF-like form as found in Alzheimer's disease. (1993) (124)
Heterogeneity of genetic loci in chickens: analysis of endogenous viral and nonviral genes by cleavage of DNA with restriction endonucleases (1979) (124)
Mutational analysis of mouse Wnt-1 identifies two temperature-sensitive alleles and attributes of Wnt-1 protein essential for transformation of a mammary cell line. (1992) (124)
Mammary tumour virus specific nucleotide sequences in mouse DNA. (1972) (123)
The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer. (2003) (123)
Methylation patterns of HeLa cell ribosomal RNA and its nucleolar precursors (1967) (123)
Comparison of mouse mammary tumor virus-specific DNA in inbred, wild and Asian mice, and in tumors and normal organs from inbred mice. (1977) (121)
Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis. (1996) (121)
Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS (2008) (120)
Integration of Deoxyribonucleic Acid Specific for Rous Sarcoma Virus after Infection of Permissive and Nonpermissive Hosts (1973) (120)
Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines (2011) (119)
The Absence of p53 Promotes Metastasis in a Novel Somatic Mouse Model for Hepatocellular Carcinoma (2005) (119)
Ethidium bromide inhibits appearance of closed circular viral DNA and integration of virus-specific DNA in duck cells infected by avian sarcoma virus (1975) (117)
MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family (2009) (116)
Effects of insertional and point mutations on the functions of the duck hepatitis B virus polymerase (1990) (116)
Kinetics of synthesis, structure and purification of avian sarcoma virus-specific DNA made in the cytoplasm of acutely infected cells. (1978) (115)
Hormonal regulation of the rous sarcoma virus src gene via a heterologous promoter defines a threshold dose for cellular transformation (1984) (114)
The src protein contains multiple domains for specific attachment to membranes (1990) (113)
Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models (2006) (113)
Genes and the Biology of Cancer (1992) (110)
Both substrate and target oligonucleotide sequences affect in vitro integration mediated by human immunodeficiency virus type 1 integrase protein produced in Saccharomyces cerevisiae (1992) (110)
Development of a human light chain variable domain (V(L)) intracellular antibody specific for the amino terminus of huntingtin via yeast surface display. (2004) (110)
Augmented expression of normal c-myc is sufficient for cotransformation of rat embryo cells with a mutant ras gene (1985) (109)
Mapping the major transcripts of ground squirrel hepatitis virus: the presumptive template for reverse transcriptase is terminally redundant (1985) (109)
Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival. (2001) (109)
Structural and functional studies of retroviral RNA pseudoknots involved in ribosomal frameshifting: nucleotides at the junction of the two stems are important for efficient ribosomal frameshifting. (1995) (108)
The Interactions of Retroviruses and their Hosts (1997) (107)
Identification of genes from pattern formation, tyrosine kinase, and potassium channel families by DNA amplification. (1989) (106)
Virus-specific DNA in the cytoplasm of avian sarcoma virus-infected cells is a precursor to covalently closed circular viral DNA in the nucleus (1978) (105)
A characteristic bent conformation of RNA pseudoknots promotes -1 frameshifting during translation of retroviral RNA. (1996) (104)
Appearance of virus-specific DNA in mammalian cells following transformation by Rous sarcoma virus. (1973) (104)
Efficient incorporation of human CD4 protein into avian leukosis virus particles. (1990) (104)
Nucleotide sequence of cloned unintegrated avian sarcoma virus DNA: viral DNA contains direct and inverted repeats similar to those in transposable elements. (1981) (103)
Corrections to the nucleotide sequence of the src gene of Rous sarcoma virus (1983) (102)
RNA-directed DNA synthesis by virions of Rous sarcoma virus: further characterization of the templates and the extent of their transcription. (1973) (99)
Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src (1990) (98)
Uninfected avian cells contain RNA related to the transforming gene of avian sarcoma viruses (1978) (98)
Nucleotide sequence and expression in vitro of cDNA derived from mRNA of int-1, a provirally activated mouse mammary oncogene (1985) (97)
Construction of a clonable, infectious, and tumorigenic mouse mammary tumor virus provirus and a derivative genetic vector. (1988) (94)
Casein kinase Iepsilon modulates the signaling specificities of dishevelled. (2004) (93)
Abnormal human haemoglobins. I. The comparison of normal human and sickle-cell haemoglobins by fingerprinting. (1958) (93)
Integration and transcription of mouse mammary tumor virus DNA in rat hepatoma cells. (1979) (93)
rlk/TXK Encodes Two Forms of a Novel Cysteine String Tyrosine Kinase Activated by Src Family Kinases (1999) (93)
Differentiation of two mouse cell lines is associated with hypomethylation of their genomes (1984) (92)
Embryonic Red Blood Cell Formation (1972) (92)
Cellular homologue (c-src) of the transforming gene of Rous sarcoma virus: isolation, mapping, and transcriptional analysis of c-src and flanking regions. (1981) (91)
Organization of mouse mammary tumor virus-specific DNA endogenous to BALB/c mice (1979) (90)
Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice (2001) (89)
Identification of protein products encoded by the proto-oncogene int-1 (1987) (88)
Ten years on--the human genome and medicine. (2010) (88)
Closed circular viral DNA and asymmetrical heterogeneous forms in livers from animals infected with ground squirrel hepatitis virus (1983) (88)
Structure of viral DNA and RNA in mammalian cells infected with avian sarcoma virus. (1980) (88)
Synthesis of viral DNA in the cytoplasm of duck embryo fibroblasts and in enucleated cells after infection by avian sarcoma virus. (1974) (87)
Development of an Avian Leukosis-Sarcoma Virus Subgroup A Pseudotyped Lentiviral Vector (2001) (87)
Fv-1 restriction and its effects on murine leukemia virus integration in vivo and in vitro (1992) (87)
Regulation of lac mRNA synthesis in a soluble cell-free system. (1971) (87)
Two cellular proteins that immunoprecipitate with the transforming protein of Rous sarcoma virus. (1981) (87)
The Molecular Biology of RNA Tumor Viruses (1975) (85)
Mutational Analysis of EGFR and Related Signaling Pathway Genes in Lung Adenocarcinomas Identifies a Novel Somatic Kinase Domain Mutation in FGFR4 (2007) (85)
Transcription of the hepatitis B surface antigen gene in cultured murine cells initiates within the presurface region (1984) (81)
Getting ready for gene-based medicine. (2002) (81)
Organization of the endogenous proviruses of chickens: implications for origin and expression. (1981) (81)
Hemoglobin synthesis during amphibian metamorphosis. II. Synthesis of adult hemoglobin following thyroxine administration. (1968) (80)
The vertebrate homolog of the putative transforming gene of avian myelocytomatosis virus: characteristics of the DNA locus and its RNA transcript. (1980) (79)
Proviral deletions and oncogene base-substitutions in insertionally mutagenized c-myc alleles may contribute to the progression of avian bursal tumors. (1984) (79)
Mutations in src homology regions 2 and 3 of activated chicken c-src that result in preferential transformation of mouse or chicken cells. (1990) (78)
5'-terminal sequences influence the segregation of ground squirrel hepatitis virus RNAs into polyribosomes and viral core particles (1987) (77)
The repression and induction by thyroxin of hemoglobin synthesis during amphibian metamorphosis. (1965) (76)
Peptide chain synthesis of human hemoglobins A and A2. (1966) (76)
Abnormal human haemoglobins. V. Chemical investigation of haemoglobins A, G, C, X from one individual. (1961) (76)
Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival (2016) (75)
Sulphydryl groups in haemoglobins. (1955) (75)
Extent of transcription by the RNA-dependent DNA polymerase of Rous sarcoma virus. (1971) (75)
Revertants of an ASV-transformed rat cell line have lost the complete provius or sustained mutations in src. (1981) (75)
Erlotinib resistance in mouse models of epidermal growth factor receptor-induced lung adenocarcinoma (2010) (75)
A protein knockdown strategy to study the function of β-catenin in tumorigenesis (2003) (74)
Oncogenes and transcriptional control. (1987) (73)
Characteristics of cellular RNA related to the transforming gene of avian sarcoma viruses (1978) (73)
Isolation of duplicated human c-src genes located on chromosomes 1 and 20 (1985) (73)
Chemical Studies on Amino Acid Acceptor Ribonucleic Acids.*I. Some Properties of Yeast Amino Acid Acceptor Ribonucleic Acid and Mapping of the Oligonucleotides Produced by Ribonuclease Digestion (1962) (72)
5 Replication of Retroviruses (1982) (72)
Requirement for a Nuclear Function of β-Catenin in Wnt Signaling (2003) (72)
Assessing Tumor Progression Factors by Somatic Gene Transfer into a Mouse Model: Bcl-xL Promotes Islet Tumor Cell Invasion (2007) (71)
Simian virus 40 minichromosomes as targets for retroviral integration in vivo. (1992) (70)
Synthesis, structure and function of avian sarcoma virus-specific DNA in permissive and nonpermissive cells. (1975) (70)
Genetic lesion in homozygous alpha thalassaemia (hydrops fetalis). (1974) (70)
The structure and protein kinase activity of proteins encoded by nonconditional mutants and back mutants in the sec gene of avian sarcoma virus. (1981) (69)
Demonstration of a DNA provirus in the lytic growth of visna virus. (1973) (68)
Amplification and enhanced expression of the c-myc oncogene in mouse SEWA tumour cells (1985) (68)
Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1 (2012) (68)
Abnormal human haemoglobins. IV. The chemical difference between normal human haemoglobin and haemoglobin C. (1960) (67)
Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction. (2009) (67)
Infection of cultured rat hepatoma cells by mouse mammary tumor virus (1977) (66)
The receptor for the subgroup A avian leukosis-sarcoma viruses binds to subgroup A but not to subgroup C envelope glycoprotein (1994) (66)
Proviruses of mouse mammary tumor virus in normal and neoplastic tissues from GR and C3Hf mouse strains (1980) (65)
A mouse mammary tumor virus-Wnt-1 transgene induces mammary gland hyperplasia and tumorigenesis in mice lacking estrogen receptor-alpha. (1999) (65)
A comparative evaluation of β-catenin and plakoglobin signaling activity (2000) (63)
Chicken macrochromosomes contain an endogenous provirus and microchromosomes contain sequences related to the transforming gene of ASV (1977) (63)
Stochastic kinetics of intracellular huntingtin aggregate formation (2006) (63)
A Rous sarcoma virus provirus is flanked by short direct repeats of a cellular DNA sequence present in only one copy prior to integration. (1981) (63)
Mechanism of membrane depolarization caused by the Alzheimer Abeta1-42 peptide. (2002) (62)
Mechanism and prevention of neurotoxicity caused by β-amyloid peptides: relation to Alzheimer's disease (1997) (61)
Unintegrated viral DNA is synthesized in the cytoplasm of avian sarcoma virus-transformed duck cells by viral DNA polymerase (1976) (61)
Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs (2008) (61)
The cloned genome of ground squirrel hepatitis virus is infectious in the animal. (1984) (60)
Erythrocyte Transfer RNA: Change during Chick Development (1967) (59)
Homologies among the nucleotide sequences of the genomes of C-type viruses. (1974) (59)
Reverse transcription. (1987) (59)
Diversity among Purkinje cells in the monkey cerebellum. (1985) (59)
Aggregates of a β-amyloid peptide are required to induce calcium currents in neuron-like human teratocarcinoma cells: relation to Alzheimer's disease (1997) (59)
Gene localization by chromosome fractionation: globin genes are on at least two chromosomes and three estrogen-inducible genes are on three chromosomes. (1979) (59)
Use of avian retroviral vectors to introduce transcriptional regulators into mammalian cells for analyses of tumor maintenance (2003) (59)
The leader sequence of the subgenomic mRNA's of Rous sarcoma virus is approximately 390 nucleotides (1982) (58)
The action of fluorodinitrobenzene on bacterial cell walls. (1957) (58)
Abnormal human haemoglobins. II. The chymotryptic digestion of the trypsin-resistant core of haemoglobins A and S. (1958) (58)
Membrane-anchored plakoglobins have multiple mechanisms of action in Wnt signaling. (1999) (57)
ERYTHROPOIESIS DURING AMPHIBIAN METAMORPHOSIS : III. Immunochemical Detection of Tadpole and Frog Hemoglobins (Rana catesbeiana) in Single Erythrocytes. (1971) (57)
Abnormal human haemoglobins. VI. The chemical difference between haemoglobins A and E. (1961) (57)
Generation of pulmonary neuroendocrine cells and SCLC-like tumors from human embryonic stem cells (2019) (57)
Demonstration of non-functional beta-globin mRNA in homozygous beta (0) thalassemia. (1975) (57)
Woodchuck hepatitis virus is a more efficient oncogenic agent than ground squirrel hepatitis virus in a common host (1991) (56)
Virus-specific messenger RNAs in permissive cells infected by avian sarcoma virus. (1979) (55)
Absence of p53 in a mouse mammary tumor model promotes tumor cell proliferation without affecting apoptosis. (1997) (55)
Frameshift and intragenic suppressor mutations in a rous sarcoma provirus suggest src encodes two proteins (1983) (55)
A frameshift mutation in the pre-S region of the human hepatitis B virus genome allows production of surface antigen particles but eliminates binding to polymerized albumin. (1985) (55)
Human haemoglobin A2: I. Comparison of haemoglobins A2 and A (1962) (55)
Mouse mammary tumor virus DNA in infected rat cells: Characterization of unintegrated forms (1977) (55)
Building A "GenBank" of the Published Literature (2001) (55)
Detection and enumeration of transformation-defective strains of avian sarcoma virus with molecular hybridization. (1977) (55)
Statement on Scientific Publication and Security (2003) (55)
Genetic basis of the thalassaemia diseases. (1959) (55)
Identification of a provirally activated c‐Ha‐ras oncogene in an avian nephroblastoma via a novel procedure: cDNA cloning of a chimaeric viral‐host transcript. (1986) (55)
Human Hæmoglobin A2: Chemistry, Genetics and Evolution (1961) (54)
Mouse Mammary Tumors Express Elevated Levels of RNA Encoding the Murine Homolog of SKY, a Putative Receptor Tyrosine Kinase (*) (1995) (54)
Structural analysis of the intracellular RNAs of murine mammary tumor virus (1979) (53)
The Wnt-1 proto-oncogene induces changes in morphology, gene expression, and growth factor responsiveness in PC12 cells (1993) (53)
Evaluating the burden of disease and spending the research dollars of the National Institutes of Health. (1999) (53)
Chemistry of the abnormal human haemoglobins. (1959) (53)
Use of DNA-DNA Annealing to Detect New Virus-Specific DNA Sequences in Chicken Embryo Fibroblasts After Infection by Avian Sarcoma Virus (1974) (53)
Synthesis, Assembly, and Processing of Viral Proteins -- Retroviruses (1997) (52)
Differences in erythrocyte membrane proteins and glycoproteins in sickle cell disease. (1977) (52)
Retrotransposons, Endogenous Retroviruses, and the Evolution of Retroelements -- Retroviruses (1997) (52)
Constituents of Human Hæmoglobin: Separation of the Peptide Chains of Human Globin (1959) (52)
Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype (2004) (52)
Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis (2011) (52)
Characteristics of virus-specific RNA in avian sarcoma virus-transformed BHK-21 cells and revertants. (1977) (51)
The National Institutes of Health and clinical research: a progress report (2000) (51)
A mutation in v-src that removes a single conserved residue in the SH-2 domain of pp60v-src restricts transformation in a host-dependent manner (1989) (51)
The nucleotide sequence of an untranslated but conserved domain at the 3' end of the avian sarcoma virus genome (1980) (51)
Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma. (2015) (50)
Regulation of lac transcription in antibiotic-treated E. coli. (1971) (50)
Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells (2018) (50)
At least 104 nucleotides are transposed from the 5′ terminus of the avian sarcoma virus genome to the 5′ termini of smaller viral mrnas (1978) (50)
Erythropoiesis in the developing chick embryo. (1973) (50)
Origin and function of avian retrovirus transforming genes. (1980) (50)
Regulation of lac messenger ribonucleic acid synthesis by cyclic adenosine 3',5'-monophosphate and glucose. (1970) (50)
ERYTHROPOIESIS DURING AMPHIBIAN METAMORPHOSIS : I. Site of Maturation of Erythrocytes in Rana catesbeiana. (1971) (49)
Three Varieties of Human Hæmoglobin D (1958) (49)
The persistence and expression of virus-specific DNA in revertants of Rous sarcoma virus-transformed BHK-21 cells. (1974) (48)
Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk (2001) (48)
Opinion: Addressing systemic problems in the biomedical research enterprise (2015) (48)
Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice (2005) (47)
Addressing the Growing International Challenge of Cancer: A Multinational Perspective (2013) (47)
Multiple alpha and beta tubulin genes represent unlinked and dispersed gene families. (1981) (47)
ERYTHROPOIETIC CELL CULTURES FROM CHICK EMBRYOS (1972) (47)
Synthesis of plus strands of retroviral DNA in cells infected with avian sarcoma virus and mouse mammary tumor virus (1981) (46)
Nucleotide sequence of the 5' noncoding region and part of the gag gene of Rous sarcoma virus (1982) (46)
Activity of Wnt-1 as a transmembrane protein. (1993) (46)
Growth-dependent expression of multiple species of DNA methyltransferase in murine erythroleukemia cells. (1985) (46)
Overexpression of the Sky receptor tyrosine kinase at the cell surface or in the cytoplasm results in ligand-independent activation. (1995) (45)
Requirement for a nuclear function of beta-catenin in Wnt signaling. (2003) (45)
Analysis of endogenous avian retrovirus DNA and RNA: viral and cellular determinants of retrovirus gene expression. (1981) (44)
Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene U2af1 (2018) (44)
DEVELOPMENTAL CHANGES OF ERYTHROPOIESIS IN CULTURED CHICK BLASTODERMS (1971) (44)
Interaction of Wnt-1 proteins with the binding protein BiP (1992) (44)
Mechanism of translation of the hepadnaviral polymerase (P) gene. (1990) (43)
Genetic Mapping of the Cloned Subgroup A Avian Sarcoma and Leukosis Virus Receptor Gene to the TVALocus (1998) (42)
Use of alkaline sucrose gradients in a zonal rotor to detect integrated and unintegrated avian sarcoma virus-specific DNA in cells (1976) (42)
Statement on the consideration of biodefence and biosecurity (2003) (41)
A genetic screen identifies cellular factors involved in retroviral -1 frameshifting. (1995) (41)
The terminal redundancy of the retrovirus genome facilitates chain elongation by reverse transcriptase. (1981) (41)
Characterization of DNA complementary to nucleotide sequences at the 5'-terminus of the avian sarcoma virus genome. (1977) (41)
Recommendations for the nomenclature of hemoglobins. (1961) (40)
Regulation of mouse mammary tumor virus gene expression by glucocorticoid hormones. (1979) (40)
DNA methylation in chicken alpha-globin gene expression. (1982) (40)
Ribonucleic acid directed deoxyribonucleic acid synthesis by the purified deoxyribonucleic acid polymerase of Rous sarcoma virus. Characterization of the enzymatic product. (1972) (40)
Human immunodeficiency viruses [letter] (1986) (39)
Two wnt genes in Caenorhabditis elegans. (1993) (39)
Stimulation of lac mRNA synthesis by cyclic AMP in cell free extracts of Escherichia coli. (1970) (39)
Integrating Cancer Control into Global Health (2011) (39)
Tadpole Antibodies against Frog Hemoglobin and Their Effect on Development (1969) (38)
Chemical Modification of Yeast Alanine-tRNA with a Radioactive Carbodiimide (1967) (38)
Virion DNA of ground squirrel hepatitis virus: structural analysis and molecular cloning (1982) (38)
Oncogenes come of age. (2005) (38)
Amplification of N-myc sequences in primary human neuroblastomas: correlation with advanced disease stage. (1985) (38)
Histones in chick embryonic erythropoiesis. (1973) (37)
Characterization of DNA complementary to nucleotide sequences adjacent to poly(A) at the 3'-terminus of the avian sarcoma virus genome. (1977) (37)
Hyperphosphorylation of human TAU by brain kinase PK40erk beyond phosphorylation by cAMP-dependent PKA: relation to Alzheimer's disease. (1994) (36)
Persistence and expression of Marek's disease virus DNA in tumour cells and peripheral nerves studied by in situ hybridization. (1981) (36)
Nucleotide sequence homologies among mouse mammary tumor viruses. (1976) (36)
YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics (2018) (35)
Endogenous mouse mammary tumor virus DNA is distributed among multiple mouse chromosomes. (1979) (35)
Human haemoglobin A2. II. The chemistry of some peptides peculiar to haemoglobin A2. (1962) (35)
Regulation of gal messenger ribonucleic acid synthesis in Escherichia coli by 3',5'-cyclic adenosine monophosphate. (1971) (35)
Molecular biology: Reverse transcriptase rides again (1985) (33)
Retroviral Virions and Genomes -- Retroviruses (1997) (33)
A comparative evaluation of beta-catenin and plakoglobin signaling activity. (2000) (33)
Purification and translation of murine mammary tumor virus mRNA's (1981) (33)
Biological characterization of acute infection with ground squirrel hepatitis virus (1982) (33)
CHEMICAL STUDIES ON AMINO ACID ACCEPTOR RIBONUCLEIC ACIDS. II. ATTEMPTS AT PARTIAL DIGESTION OF YEAST AMINO ACID ACCEPTOR RIBONUCLEIC ACID WITH PANCREATIC RIBONUCLEASE. (1964) (32)
Reverse transcription in bacteria (1989) (32)
Synthesis of polymeric peptides in proteinase-catalyzed transamidation reactions. (1953) (32)
SYNTHESIS OF VIRAL RNA IN CELLS INFECTED BY AVIAN SARCOMA VIRUSES (1976) (32)
Purification of DNA complementary to the env gene of avian sarcoma virus and analysis of relationships among the env genes of avian leukosis-sarcoma viruses (1977) (32)
Retroviral Pathogenesis -- Retroviruses (1997) (31)
Nuclear protein synthesis and phosphorylation in Friend erythroleukemia cells stimulated with DMSO. (1978) (31)
In vitro transcription of chromatin containing histones hyperacetylated in vivo. (1980) (31)
Activation of a neurofilament kinase, a tau kinase, and a tau phosphatase by decreased ATP levels in nerve growth factor-differentiated PC-12 cells. (1995) (31)
In vitro recombinants of ground squirrel and woodchuck hepatitis viral DNAs produce infectious virus in squirrels (1987) (31)
ERYTHROPOIESIS DURING AMPHIBIAN METAMORPHOSIS : II. Immunochemical Study of Larval and Adult Hemoglobins of Rana catesbeiana. (1971) (30)
Hemoglobin and its Abnormalities (1962) (30)
Synthesis, structure, and integration of the DNA of RNA tumor viruses. (1979) (30)
Sickle-Cell Anemia Hemoglobin: The Molecular Biology of the First “Molecular Disease”—The Crucial Importance of Serendipity (2004) (30)
[E-Biomed: A Proposal for Electronic Publications in the Biomedical Sciences (Draft and Addendum)] (1999) (30)
Accelerating progress on non-communicable diseases (2013) (30)
DNA of Rous Sarcoma Virus: Its Nature and Significance (1972) (30)
Rearrangement at the 5' end of amplified c-myc in human COLO 320 cells is associated with abnormal transcription (1986) (30)
Atomic force microscopy analysis of the Huntington protein nanofibril formation. (2005) (29)
Uncensored exchange of scientific results (2003) (29)
Dexamethasone Induction of the Intracellular RNAs of Mouse Mammary Tumor Virus (1981) (29)
Transcription of ribonucleic acid by the ribonucleic acid directed deoxyribonucleic acid polymerase of Rous sarcoma virus and deoxyribonucleic acid polymerase I of Escherichia coli. (1973) (29)
Antibodies to pre-S and X determinants arise during natural infection with ground squirrel hepatitis virus (1986) (29)
Biosynthesis of macromolecules (1965) (28)
Integration of avian sarcoma virus DNA in chicken cells. (1981) (28)
Retroviruses and Oncogenes I (1990) (27)
The Regulation of lac Operon Transcription by Cyclic Adenosine 3′, 5′-Monophosphate (1970) (27)
RNA aggregation during sulfhydryl-agarose chromatography of mercurated RNA. (1977) (27)
Cancer genes and hematopoiesis. (1994) (27)
Identification and Preliminary Characterization of Novel Small Molecules That Inhibit Growth of Human Lung Adenocarcinoma Cells (2009) (26)
Differentiation in the early chick embryo: effects of bromodeoxyuridine on erythropoiesis. (1974) (26)
The spirit of Dakar: a call for action on malaria (1997) (26)
Extrachromosomal DNA forms of copia-like transposable elements, F elements and middle repetitive DNA sequences in Drosophila melanogaster. Variation in cultured cells and embryos. (1985) (26)
Reverse Transcriptase and the Generation of Retroviral DNA -- Retroviruses (1997) (26)
Proteins and glycoproteins of membranes from developing chick red cells. (1976) (26)
Hemoglobin synthesis at elevated temperatures. (1972) (25)
CHEMICAL STUDIES ON AMINO ACID ACCEPTOR RIBONUCLEIC ACIDS. 3. THE DEGRADATION OF PURIFIED ALANINE- AND VALINE-SPECIFIC YEAST S-RNA'S BY PANCREATIC RIBONUCLEASE. (1964) (25)
Alfred P. Sloan prize. Viruses, genes, and cancer. I. The discovery of cellular oncogenes and their role in neoplasia (1985) (25)
Chemical studies on amino acid acceptor ribonucleic acids. IV. Position of the amino acid residue in aminoacyl srna; chemical approach. (1965) (25)
Hyperphosphorylation of the cytoskeletal protein Tau by the MAP-kinase PK40erk2: regulation by prior phosphorylation with cAMP-dependent protein kinase A. (1995) (25)
Reaction of 5 s RNA with a radioactive carbodiimide. (1969) (25)
Mutants of Rous sarcoma virus with extensive deletions of the viral genome. (1979) (25)
Differences between genomes of two strains of mouse mammary tumor virus as shown by partial RNA sequence analysis. (1976) (24)
Acetylated peptide chains in bullfrog hemoglobins. (1967) (24)
Concrete steps to diversify the scientific workforce (2021) (24)
ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcinomas. (2015) (24)
Production of p60c-src by baculovirus expression and immunoaffinity purification. (1991) (24)
Science funding: Provocative questions in cancer research (2012) (24)
Retroviral DNA integrated during infection by an integration-deficient mutant of murine leukemia virus is oligomeric (1987) (24)
Gene evolution in the chicken β-globin cluster (1982) (24)
Integration and expression of several molecular forms of Rous sarcoma virus DNA used for transfection of mouse cells (1984) (24)
Characterization of "early" temperature-sensitive mutants of avian sarcoma viruses: biological properties, thermolability of reverse transcriptase in vitro, and synthesis of viral DNA in infected cells. (1976) (23)
The role of p53 loss in genomic instability and tumor progression in a murine mammary cancer model. (1996) (23)
Recent Evidence for Oncogenesis by Insertion Mutagenesis and Gene Activation (1982) (23)
The identification of peptide end-groups as dimethylamino acids. (1953) (23)
Aggregates of a beta-amyloid peptide are required to induce calcium currents in neuron-like human teratocarcinoma cells: relation to Alzheimer's disease. (1997) (22)
DOK2 Inhibits EGFR-Mutated Lung Adenocarcinoma (2013) (22)
Transmission of ground squirrel hepatitis virus to homologous and heterologous hosts (1985) (21)
Biochemical mechanisms of oncogene activity: proteins encoded by oncogenes. Introduction. (1986) (21)
The importance of DNA size for successful transfection of chicken embryo fibroblasts. (1974) (21)
SH2 mutants of c-src that are host dependent for transformation are trans-dominant inhibitors of mouse cell transformation by activated c-src. (1990) (21)
Atomic force microscopy analysis of the Huntington protein nanofibril formation. (2005) (21)
Restriction endonuclease mapping of the DNA of Rous-associated virus O reveals extensive homology in structure and sequence with avian sarcoma virus DNA. (1981) (20)
Regulation of lac transcription in Escherichia coli by cyclic adenosine 3',5'-monophosphate. Studies with deoxyribonucleic acid-ribonucleic acid hybridization and hybridization competition. (1970) (20)
Ca(2+), within the physiological concentrations, selectively accelerates Abeta42 fibril formation and not Abeta40 in vitro. (2009) (20)
Genesis of a virus-transforming gene. (1978) (19)
Shattuck Lecture--biomedical research enters the steady state. (1995) (19)
The Interactions of Retroviruses and their Hosts -- Retroviruses (1997) (19)
Isolation and transformation of primary mesenchymal cells of the chick embryo (1979) (19)
Function, location, and regulation of the src protein-tyrosine kinase. (1989) (18)
Biological and biochemical studies on the inactivation of avian oncoviruses by ultraviolet irradiation. (1977) (18)
Insurance for broad genomic tests in oncology (2017) (18)
Detection of antibodies against hepatitis B virus polymerase antigen in hepatitis B virus‐infected patients (1989) (18)
How do Genes Act (1958) (18)
Mechanism and prevention of neurotoxicity caused by beta-amyloid peptides: relation to Alzheimer's disease. (1997) (18)
CHAPTER 10 – Retroviruses (1983) (18)
Viral Entry and Receptors -- Retroviruses (1997) (18)
Regulation of specific gene expression during embryonic development: Synthesis of globin messenger RNA during red cell formation in chick embryos. (1974) (18)
env Gene of Chicken RNA Tumor Viruses: Extent of Conservation in Cellular and Viral Genomes (1978) (18)
[118] Sequence methods☆ (1963) (18)
Chemical studies on amino acid acceptor ribonucleic acids. VI. Partial digestion of alanine soluble ribonucleic acid from yeast with pancreatic ribonuclease. (1966) (18)
Activation of PyMT in β Cells Induces Irreversible Hyperplasia, but Oncogene-Dependent Acinar Cell Carcinomas When Activated in Pancreatic Progenitors (2009) (18)
CULTURE OF ERYTHROPOIETIC CELLS FROM CHICK BLASTODERMS (1973) (18)
DISTRIBUTION AND FUNCTION OF DEFINED REGIONS OF AVIAN TUMOR VIRUS GENOMES IN VIRUSES AND UNINFECTED CELLS (1976) (17)
A Molecular Model for Thalassemia * (1964) (17)
Features of the chicken c-myc gene that influence the structure of c-myc RNA in normal cells and bursal lymphomas (1986) (17)
Nucleosome-associated proteins and phosphoproteins of differentiating Friend erythroleukemia cells. (1978) (17)
Isoelectric Point of Chymotrypsinogen by a Donnan Equilibrium Method (1952) (17)
Chemical studies on amino acid acceptor ribonucleic acids. VII. Partial ribonuclease digestion of alanine and valine soluble ribonucleic acid from yeast. (1966) (17)
Factors affecting phenotypic reversion of rat cells transformed by avian sarcoma virus. (1980) (17)
Structure of a replication intermediate in the synthesis of Rous sarcoma virus DNA in vivo (1982) (16)
How Cancer Genomics Drives Cancer Biology: Does Synthetic Lethality Explain Mutually Exclusive Oncogenic Mutations? (2016) (16)
Homologous recombination between hepadnaviral genomes following in vivo DNA transfection: implications for studies of viral infectivity. (1987) (16)
RNA viruses: Reverse transcription in plants? (1983) (16)
Detection and characterization of RNA tumor virus-specific DNA in cells. (1975) (16)
Evolution of karyotypic abnormalities and C-MYC oncogene amplification in human colonic carcinoma cell lines (1985) (16)
Studies on the Structure of Purified Alanine and Valine Transfer RNA from Yeast (1963) (16)
Reverse transcriptase rides again. (1985) (15)
Identification of a novel casein kinase activity in HeLa cell nuclei. (1989) (15)
Stimulation of heme accumulation and erythroid colony formation in cultures of chick bone marrow cells by chicken plasma (1978) (15)
1 An Historical Overview of Oncogenes (1989) (15)
Eliminating membrane depolarization caused by the Alzheimer peptide Abeta(1-42, aggr.). (2002) (15)
Genomic empowerment: the importance of public databases (2002) (15)
The genesis of Rous sarcoma virus messenger RNAs. (1981) (15)
Endogenous proviruses of random-bred chickens and ring-necked pheasants: analysis with restriction endonucleases. (1981) (15)
The impact of physics on biology and medicine (1999) (15)
DNA intermediates in the replication of retroviruses are structurally (and perhaps functionally) related to transposable elements. (1981) (15)
Identification of ovotransferrin as a heme-, colony- and burst-stimulating factor in chick erythroid cell cultures. (1981) (14)
Aminoacyl Position in Aminoacyl sRNA (1964) (14)
Harvard University Commencement Address (1996) (14)
Of birds and mice and men: Comments on the use of animal models and molecular hybridization in the search for human tumor viruses (1974) (14)
Elimination of Amyloid β Neurotoxicity (2000) (14)
Characterization of the nucleic acid product of the visna virus RNA dependent DNA polymerase. (1974) (14)
Ontogeny of hemoglobins: evidence for hemoglobin M. (1974) (13)
The sulphydryl groups of sickle-cell haemoglobin. (1957) (13)
A Micro End-Group Method for Peptides (1950) (13)
Abnormal human haemoglobins. VII. The comparison of normal human haemoglobin and haemoglobin D-Chicago. (1961) (13)
Using retroviruses as insertional mutagens to identify cellular oncogenes. (1983) (13)
RNA complementary to the genome of RNA tumor viruses in virions and virus-producing cells (1976) (13)
Change in a nuclear phosphoprotein during in vitro myogenesis. (1978) (13)
Identification and characterization of dimeric and trimeric circular forms of avian sarcoma virus-specific DNA. (1980) (13)
Is there specific transcription from isolated chromatin? (1978) (12)
Nucleosome-associated protein kinases in murine erythroleukemia cells. (1979) (12)
Elimination of Amyloid beta Neurotoxicity. (2000) (12)
ERRATUM: Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos (1995) (12)
Statement of Harold Varmus, MD, Director, National Institutes of Health, before the Senate Appropriations Subcommittee on Labor, Health and Human Services, Education and Related Agencies (1998) (11)
Deletion of alpha-globin genes in haemoglobin-H disease demonstrates multiple alpha-globin structural loci. (1975) (11)
Support for the Human Cancer Genome Project (2005) (11)
Principles of Retroviral Vector Design (1997) (10)
The Place of Retroviruses in Biology (1997) (10)
LEARNING ABOUT THE REPLICATION OF RETROVIRUSES FROM A SINGLE CLONED PROVIRUS OF MOUSE MAMMARY TUMOR VIRUS (1980) (10)
Proliferation of National Institutes of Health (2001) (10)
The presence and expression of RNA tumor virus genes in normal and infected cells: detection by molecular hybridization. (1973) (10)
Autolysis Products of Pepsin (1951) (10)
A growing role for reverse transcription (1982) (10)
CONTROL MECHANISMS IN HEMOGLOBIN SYNTHESIS (1964) (10)
Some Characteristics of Binding of Vitamin B12 by Normal Human Serum (1960) (9)
Genomic empowerment: the importance of public databases (2002) (9)
PLoS Medicine— A Medical Journal for the Internet Age (2004) (9)
Historical Introduction to the General Properties of Retroviruses -- Retroviruses (1997) (9)
Chemical studies on amino acid acceptor ribonucleic acids. 8. Degradation of purified alanine Escherichia coli B transfer ribonucleic acid by pancreatic ribonuclease. (1969) (9)
Electrophoresis: an accident and some precautions. (1966) (9)
Re-Aim Blame for NIH's Hard Times (2006) (9)
The birth of molecular biology (2002) (9)
Synthesis and Processing of Viral RNA -- Retroviruses (1997) (9)
Nobel lecture. Retroviruses and oncogenes. I. (1990) (9)
Chemical modification of yeast alanine transfer ribonucleic acid with a radioactive carbodiimide. (1970) (9)
cDNA sequence of a new chicken embryonic rho-globin. (1981) (9)
Tau domains, phosphorylation, and interaction with microtubules (1995) (9)
Modified histones in HeLa and Friend erythroleukemia cells treated with n-butyrate. (1978) (9)
Science and the new administration. (1993) (9)
The synthesis of macromolecules (1965) (8)
DNA of a chicken herpesvirus is associated with at least two chromosomes in a chicken lymphoblastoid cell line. (1980) (8)
Purification, Composition, and Morphology of Virions (1997) (8)
Highly conserved amino acids in the SH2 and catalytic domains of v-src are altered in naturally occurring, transformation-defective alleles. (1994) (8)
The transformation of oncology (2016) (8)
Organization of endogenous and exogenous viral and linked nonviral sequences. (1980) (8)
Hemoglobin: Molecular Structure and Function, Biosynthesis, Evolution and Genetics. (1962) (8)
Amino acids in yeast acceptor ribonucleic acid (1962) (8)
Origins and Beginnings (2003) (8)
Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene ( c-mnc ) in malignant neuroendocrine cells from a human colon carcinoma ( double minute chromosomes / chromosome aberrations / retroviruses / tumorigenesis ) (8)
Globin synthesis in fibroblasts fused with erythroblasts. I. avian fibroblasts (1975) (8)
Erratum: The Classic: Integration of Deoxyribonucleic Acid Specific for Rous Sarcoma Virus after Infection of Permissive and Nonpermissive Hosts (1973) (8)
Effect of phenylhydrazine-induced anemia on the appearance of adult hemoglobin in Rana catesbeiana tadpoles. (1972) (8)
An aberrant avian leukosis virus provirus inserted downstream from the chicken c-myc coding sequence in a bursal lymphoma results from intrachromosomal recombination between two proviruses and deletion of cellular DNA (1987) (8)
Expression and partial DNA sequence of the chicken beta H-globin gene. (1983) (8)
Integration of avian sarcoma virus specific DNA in mammalian chromatin. (1975) (8)
An active National Institute of Mental Health. (1995) (8)
Improving support for young biomedical scientists (2018) (7)
Detection of nucleotide sequences associated with transformation by avian sarcoma viruses. (1976) (7)
Science as a Way of Thinking. (1996) (7)
A prospective study to correlate EGFR mutations with gefitinib response (2005) (7)
Readings in tumor virology (1983) (7)
Moloney murine leukemia virus integration protein produced in yeast binds specifically to viral att sites (1990) (7)
Building a global culture of science (2002) (7)
Author response: Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma (2015) (7)
Defining the steps in a multistep mouse model for mammary carcinogenesis. (1994) (7)
How Tumor Virology Evolved into Cancer Biology and Transformed Oncology (2017) (7)
Biochemical genetics at the molecular level. (1963) (7)
Revitalization of the Warren G. Magnuson Clinical Center at the National Institutes of Health (1998) (7)
ERYTHROPOIESIS DURING AMPHIBIAN METAMORPHOSIS (1971) (7)
The application of Edman's peptide degradation method to horse myoglobin and haemoglobin. (1955) (7)
Cell-free translation of purified avian sarcoma virus src mRNA. (1981) (7)
Retroviruses and Oncogenes I (Nobel Lecture) (1990) (7)
The impact of open access on biomedical research (2000) (7)
Retroviral integration machinery as a probe for DNA structure and associated proteins. (1993) (6)
Hæmoglobin F and the Genetic Control of Protein Structure (1961) (6)
Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells. (2022) (6)
Lessons from the life cycle of retroviruses. (1987) (6)
Uncoupling of mitochondria activates protein phosphatases and inactivates MBP protein kinases. (2001) (6)
Development and Applications of Retroviral Vectors -- Retroviruses (1997) (6)
Repair of lesions which cause premature termination of transcription in chicken embryo cells irradiated with ultraviolet light. (1981) (6)
The role of Alzheimer Abeta peptides in ion transport across cell membranes. (2005) (6)
Tumor Viruses and Oncogenes (1973) (6)
DETERMINATION AND DIFFERENTIATION OF ERYTHROPOIESIS IN THE EARLY CHICK EMBRYO * (1974) (6)
YES1 amplification as a mechanism of acquired resistance (AR) to EGFR tyrosine kinase inhibitors (TKIs) identified by a transposon mutagenesis screen and clinical genomic testing. (2017) (6)
ERYTHROID CELL DIFFERENTIATION AND THE INHIBITION OF CYTOKINESIS BY CYTOCHALASIN (1971) (6)
Human haemoglobin E: the chemical effect of gene mutation. (1959) (5)
Course of Infection with HIV and SIV (1997) (5)
Harold Varmus [interview by Karen Birmingham]. (2001) (5)
Recommendations for the nomenclature of hemoglobins. (1961) (5)
Histones of chick embryonic lens nuclei. (1974) (5)
The Pastorian: a legacy of Louis Pasteur. (1996) (5)
Naming the AIDS Virus (1986) (5)
NIH review of gene therapy protocols. (1995) (5)
Public-access group supports PubMed Central (2002) (5)
Progenitor cells of the definitive erythroid series in the chick embryo. (1973) (5)
The int-1 proto-oncogene. (1986) (5)
Mouse mammary tumor virus genes: regulation of expression by glucocorticoids and structural analysis with restriction endonucleases. (1978) (4)
The Classic: Integration of Deoxyribonucleic Acid Specific for Rous Sarcoma Virus after Infection of Permissive and Nonpermissive Hosts (2008) (4)
A simple screening procedure for hemoglobin S. (1973) (4)
The replication of subgroup E avian retroviruses is blocked at or before viral DNA synthesis in restrictive chicken cells. (1979) (4)
Synthesis and Organization of Env Glycoproteins (1997) (4)
Alzheimer tangles and abnormal phosphorylation. (1995) (4)
Oncogenes and cell proliferation. (1992) (4)
Characteristics of the Transcription of RNA by the DNA Polymerase of Rous Sarcoma Virus (1973) (4)
Pathogenesis of HIV and SIV -- Retroviruses (1997) (4)
National Cancer Institute-supported clinical trials networks. (2015) (4)
Processing of Retroviral RNA (1997) (4)
The stepwise reductive cleavage of DNP-peptides. (1956) (3)
Progress toward Public Access to Science (2008) (3)
Genetic control of foetal and adult human haemoglobin. (1961) (3)
Mutations of Cellular Oncogenes as a Basis for Neoplastic Change (1984) (3)
Impaired hematopoiesis and leukemia development in mice with a conditional “knock-in” allele of a mutant splicing factor gene U2af1 (2018) (3)
Varmus: the view from Bethesda. Interview by Eliot Marshall. (1993) (3)
ERYTHROPOIESIS DURING AMPHIBIAN METAMORPHOSIS (1971) (3)
METHODS OF SEQUENCE ANALYSIS IN PROTEINS (1960) (3)
Transgenic mice and host cell mutants resistant to transformation as model systems for identifying multiple components in oncogenesis. (1989) (3)
Overview of Reverse Transcription (1997) (3)
Transcription of the Rous sarcoma virus genome in vitro and in vivo. (1975) (3)
Comparison of normal adult human haemoglobin with haemoglobin I by 'fingerprinting'. (1959) (3)
Cell-Specific Transduction of Prdm1-Expressing Lineages Mediated by a Receptor for Avian Leukosis Virus Subgroup B (2009) (3)
A Brief Chronicle of Retrovirology (1997) (3)
A tubulin identified by a monoclonal antibody is not present in mitotic spindles. (1989) (3)
[Varmus's testimony before the Subcommittee on Health and Environment, Committee on Commerce, U.S. House of Representatives] (1998) (2)
Recommendations for the nomenclature of hemoglobins. (1961) (2)
NIH cancer chief wants more with less: by Meredith Wadman. (2011) (2)
Experimental approaches to embryonic erythropoiesis. (1977) (2)
A mover in the biomedical community (2001) (2)
National Institutes of Health in the tropics. (1998) (2)
Gene evolution in the chicken beta-globin cluster. (1982) (2)
New York’s Polyethnic-1000: a regional initiative to understand how diverse ancestries influence the risk, progression, and treatment of cancers (2021) (2)
Abnormal human haemoglobins. I. The comparison of normal human and sickle-cell haemoglobins by "fingerprinting". 1958. (1989) (2)
Tadpole antibodies against frog hemoglobin and their effect on development. (1968) (2)
Sachi Prasad Ray-Chaudhuri (1987) (2)
Create a COVID-19 commission. (2021) (2)
Ushering in a new age of scientific publishing (2000) (2)
Sequence variation at the 5-terminal region in yeast s-RNA. (1965) (2)
An In Vivo Model To Investigate the Identity of the Cell-of-Origin of Multiple Myeloma. (2005) (2)
The mutational landscape of EGFR-, MYC-, and Kras- driven genetically-engineered mouse models of lung adenocarcinoma (2016) (2)
The challenge of making laws on the shifting terrain of science. (2000) (2)
Embryos, Cloning, Stem Cells, and the Promise of Reprogramming (2009) (2)
The weaknesses of science for profit. (2002) (2)
Abstracts of papers presented at the 1985 Meeting on Molecular Biology of Hepatitis B Viruses, May 2-May 5, 1985 (1985) (2)
Retroviral “Lifestyles”: Simple versus Complex (1997) (2)
Synthesis ofPlusStrands ofRetroviral DNA inCells Infected withAvianSarcoma Virus andMouseMammaryTumor Virust (1981) (2)
Binding in vitro of phosphotyrosine-containing proteins to pp60c-src SH2 domain does not correlate with CEF transformation. (1995) (2)
Taxonomy and Sequence Relatedness of Retroviruses (1997) (2)
Harold Varmus. Interview by Errol C. Friedberg. (2008) (2)
The Genetical Control of Protein Structure: The Abnormal Human Haemoglobins (2008) (2)
Synthesis of Gag and Gag-Pro-Pol Proteins (1997) (2)
Tadpoles, chicks, and red cells: a study of development. (1968) (2)
The molecular origins of the disease are coming to light, suggesting several novel therapies (2003) (2)
Regulation of gene expression in Escherichia coli by cyclic AMP. (1971) (2)
Control of hemoglobin expression in chick embryonic development. (1982) (1)
Of oncogenes and open science: an interview with Harold Varmus (2019) (1)
Science Publishing and Science Libraries in the Internet Age (2009) (1)
Abstract B35: Activation of Putative Compensatory Pathways upon Deletion of Erbb3 in Mutant EGFR-driven Lung Cancer (2012) (1)
Overview of Retroviral Assembly (1997) (1)
Small DNA Viruses (1993) (1)
Structural Classes of Retroelements and Replication Strategies (1997) (1)
Testimony Before the Special Committee on Aging United States Senate Statement of (2014) (1)
Public Library of Science Initiative - Open Letter (2000) (1)
Reverse Transcription of the Viral Genome in vivo (1997) (1)
Globin expression in Rous sarcoma virus-transformed quail myoblasts. (1983) (1)
Special Biological Features of Reverse Transcription (1997) (1)
A Conversation with Michael Bishop & Harold Varmus (1992) (1)
US support for malaria research (1997) (1)
Growth and Assay of Pathogenic Retroviruses (1997) (1)
The DNA-methylating system of murine erythroleukemia cells. (1985) (1)
Runx1 Deficiency and MDS-Associated U2af1 Mutation Cooperate for Leukemia Development in a New Mouse Model (2016) (1)
YES1 amplification: a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics (2018) (1)
Selective distribution of a novel tubulin in the developing and mature rat brain. (1990) (1)
Globin synthesis in fibroblasts fused with erythroblasts. II. Human fibroblasts (1975) (1)
A Prize for Cancer Prevention (2017) (1)
cDNA sequence of a new chicken embryonic p-globin ( recombinant DNA / pBR 322 plasmid vector / DNA sequence determination / mRNA structure / hemoglobin switching ) (1)
Erratum: Uncensored exchange of scientific results (Proceedings of the National Academy of Sciences (2003) 100, 4, (1464) DOI: 10.1073/pnas.0630491100) (2012) (1)
No one is really immune (1993) (1)
The challenges of an HIV vaccine enterprise - Response (2004) (1)
Outline of the Integration Process (1997) (1)
Non-conserved metabolic regulation by LKB1 distinguishes human and mouse lung adenocarcinoma (2021) (1)
Dangers in EST Patent Law (2004) (1)
Principles of Particle Assembly (1997) (1)
How Proto-oncogenes Participate in Cancer (2009) (1)
Author response: Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells (2018) (1)
Immune Responses to HIV and SIV (1997) (1)
Progress on All Fronts in Race to Map Genes (1998) (1)
Retroviral Env Gene Products: Receptor Binding and Host-Range Determinants (1997) (1)
Erythropoiesis: Cellular and Molecular Mechanisms (1985) (1)
The crucial link between laboratory animal research and human health. (1991) (1)
A Prize for Cancer Prevention (2017) (1)
No money, no research (2014) (1)
Embryonic determination and differentiation. (1980) (1)
Newsmaker interview: Harold Varmus. Piloting cancer research with a shrinking budget. Interview by Jocelyn Kaiser. (2011) (1)
Transcription of chromatin in isolated nuclei by exogenous RNA polymerases (1978) (1)
Biochemistry of Reverse Transcription (1997) (1)
Evolution of Retroelements and their Hosts (1997) (1)
A novel small molecule that induces cytotoxicity in lung cancer cells inhibits disulfide reductases GSR and TXNRD1 (2021) (1)
Synthesis and Integration of Rous Sarcoma Virus Proviral DNA in Duck Embryo Fibroblast Cells (1975) (1)
Testimony of Harold Varmus, MD. . . . House Committee on Energy and Commerce and Senate Committee on Health, Education, Labor, and Pensions: "Managing Biomedical Research to Prevent and Cure Disease in the 21st Century: Matching NIH Policy with Science" (2003) (1)
THE WILLIAM ALLAN MEMORIAL AWARD LECTURE Human and Medical Genetics: A Scientific Discipline and an Expanding Horizon (2006) (1)
Normal and Neoplastic Hematopoiesis. Proceedings of the UCLA Symposium Held at Steamboat Springs, Colorado, March 27-April 1, 1983.David W. Golde , Paul A. Marks (1984) (1)
Membrane Fusion and Viral Entry (1997) (1)
Homage to Howard Temin (1997) (1)
Cellular Targets of Infection (1997) (1)
Immunological and Pharmacological Approaches to the Control of Retroviral Infections -- Retroviruses (1997) (1)
Viral Replication and Genetics (1973) (1)
Basic science and the NIH. (1994) (1)
Varmus Returns to His Roots in Cancer Genetics. (2015) (1)
Under the Influence: from the Provirus Hypothesis to Multistep Carcinogenesis (1995) (0)
Letter from Harold Varmus to Michael G. P. Stoker, Imperial Cancer Research Fund Laboratories (1977) (0)
Memorandum from Harold Varmus to members of the human retrovirus subcommittee of the Retrovirus Study Group [on the latest poll regarding the nomenclature of the AIDS virus] (1985) (0)
Letter from Harold Varmus to Jean Marx, Science Magazine (1984) (0)
Memorandum from Harold Varmus to members of the human retrovirus subcommittee of the Retrovirus Study Group [on their final response on the nomenclature of the AIDS virus] (1986) (0)
Mutational analysis of EGFR signaling pathway genes in lung adenocarcinomas (2007) (0)
CONTROL MECHANISMS IN HEMOGLOBIN SYNTHESIS. (1964) (0)
An overview of the FY-1996 budget for the National Institutes of Health. (1995) (0)
Letter from Harold Varmus to Paul Neiman, Providence Hospital (1975) (0)
Effects of Proviral Integration on Host Gene Expression (1997) (0)
Letter from Harold Varmus to Joyce Wallace (1985) (0)
Abstract 2328: Polyethnic-1000: Advancing cancer genomics by studying ethnically diverse, underserved patient populations in New York (2020) (0)
Transmission and Epidemiology (1997) (0)
Replication, Differentiation, and the Cell Cycle (1997) (0)
Immunological Approaches to Controlling Retroviral Infection (1997) (0)
Political Scientist (2009) (0)
View from the top of a biomedical empire. Interview by Eliot Marshall. (1999) (0)
THE ETHICSOFHIVRESEARCH IN DEVELOPINGNATIONS (1998) (0)
Letter from Harold Varmus to Barbara H. Sanford, The Jackson Laboratory (1982) (0)
Letter from Harold Varmus to Efraim Racker, Cornell University (1989) (0)
Letter from Harold Varmus to T. Ando, Institute of Physical and Chemical Research (Japan) (1971) (0)
[Varmus' remarks at the unveiling of his portrait at NIH] (2003) (0)
Harold Varmus, director, National Institutes of Health. Interview by Richard Horton. (1994) (0)
THE GENESIS OF AVIAN RETROVIRUS ONCOGENES (1980) (0)
Retroviruses as Agents of Genetic Change (1997) (0)
From Problems and Politics to the Communal Experience in Science : An Interview with (2016) (0)
Retroviruses and Their Replication Cycle (2009) (0)
Models for Virion Structure (1997) (0)
Abstract A072: Polyethnic-1000: Advancing cancer genomics by studying ethnically diverse, underserved patient populations in New York (2020) (0)
Tissue-Specific Disease and Organ System Failure (1997) (0)
Letter from J. Michael Bishop, Marc Kirschner, Elizabeth Marincola, and Harold Varmus to Paul Berg, Donald D. Brown, and Maxine Singer (1992) (0)
Viruses as Vehicles of Genetic Change (1976) (0)
Epilogue: A Life in Science (2009) (0)
Chinese scientists and US leadership in the life sciences (2019) (0)
Public health. Proliferation of National Institutes of Health. (2001) (0)
Letter from Harold Varmus to Ed Southern, Medical Research Council of Great Britain (1977) (0)
Planning of US AIDS research (1996) (0)
[Transcript of Varmus's testimony at Congressional Hearing "Biotechnology and the Ethics of Cloning: How Far Should We Go?"] (1997) (0)
Report of the 3rd International Congress of Virology (1975) (0)
Letter from Harold Varmus to Julius R. Krevans (1980) (0)
(retrovirus DNA/circular DNA/terminal repeat/control regions/prim (2016) (0)
Letter from Harold Varmus and Stephen Hughes to Ed Southern, Medical Research Council of Great Britain (1978) (0)
Being NIH Director (2009) (0)
Letter from Harold Varmus to Lloyd J. Old, Sloan-Kettering Institute for Cancer Research (1972) (0)
Immune Response to Retroviral Infection (1997) (0)
Letter from Harold Varmus to J. Michael Bishop (1985) (0)
Retroviruses and their Interactions with Multicellular Hosts (1997) (0)
Is Science Under Siege (2005) (0)
Letter from Harold Varmus to David Boettiger, Imperial Cancer Research Fund Laboratories (1974) (0)
A conversation with Harold Varmus. Interview by Ushma S. Neill. (2012) (0)
Letter from Harold Varmus to John S. Cole III, National Institutes of Health (1982) (0)
The United States needs a department of technology and science policy (2021) (0)
Letter from Harold Varmus to Edward Fritsch, McArdle Laboratory for Cancer Research (1976) (0)
Gene Regulation and Oncogenesis by Retroviruses (1981) (0)
envGeneofChicken RNATumorViruses: Extent of Conservation inCellular andViral Genomes (1978) (0)
Profiling Oncology Drug Candidates Through Complementary in vitro Assays and in vivo Models to Better Understand Their Potential Clinical Applications (2019) (0)
The Best of Retrotrivia (1997) (0)
Letter from Harold Varmus to Michael I. Goldberg (1999) (0)
NIH Plan for Research in Spinal Cord Injury and Regeneration (1996) (0)
Letter from Harold Varmus to the Passano Foundation (1983) (0)
Letter from Harold Varmus to Paul Neiman, University of Washington Department of Medicine (1972) (0)
Letter from Harold Varmus to Edward Fritsch and Howard M. Temin, McArdle Laboratory for Cancer Research (1976) (0)
Viral RNA Packaging (1997) (0)
Site of integration of oncogenic viruses in mammalian chromatin. Abstr. (1974) (0)
Accessory Proteins and Assembly (1997) (0)
A Mutation inv-srcThatRemovesa Single Conserved Residue in theSH-2Domainofpp6Ov-src Restricts Transformation ina Host-Dependent Manner (1989) (0)
Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung 1 adenocarcinoma cells 2 3 4 (0)
Pathogenesis of Kaposi's Sarcoma and Other Opportunistic Neoplasms (1997) (0)
Letter from Harold Varmus to Ian Macpherson, Imperial Cancer Research Fund Laboratories (1972) (0)
Generation of pulmonary neuro-endocrine cells and tumors resembling small cell lung cancers from human embryonic stem cells (2018) (0)
Letter from Harold Varmus to Tim Gorski (1975) (0)
Synthesis and Integration of Virus-specific DNA in Cells Infected by RNA Tumor Viruses (1978) (0)
Biochemical Activities and Assays (1997) (0)
Impaired hematopoiesis and leukemia development in mice with a "knock-in" allele of U2af1(S34F) (2018) (0)
Receptor-Mediated Barriers to Retroviral Infection (1997) (0)
Letter from Harold Varmus to fellow clinicians who work with AIDS patients on their suggestions for naming the AIDS virus (1985) (0)
EMail from Patrick O. Brown, Michael Eisen and Harold Varmus to Edward S. Yoon (2002) (0)
Abstract C037: Polyethnic-1000: A New York-based initiative to advance cancer genomics through recruitment of diverse racial & ethnic populations (2023) (0)
Abstract LB-151: Targeted gene resequencing in a K-ras-dependent mouse model of metastatic lung adenocarcinoma (2010) (0)
Letter from Harold Varmus to Robert A. Weinberg, Massachusetts Institute of Technology (1983) (0)
Memorandum from Harold Varmus to members of the human retrovirus subcommittee of the Retrovirus Study Group [on a response to a letter from Robert Gallo] (1986) (0)
Update from the Hill: budget battle. (2011) (0)
[Progress report from "Molecular Analysis of Retroviruses and Oncogenes" grant project] (1985) (0)
Host Genes that Influence Pathogenesis (1997) (0)
Letter from Harold Varmus to Howard M. Temin, McArdle Laboratory for Cancer Research (1985) (0)
Letter from Harold Varmus to Senator Tom Harkin (1997) (0)
Letter from Harold Varmus to Natalie Teich, Imperial Cancer Research Fund Laboratories (1982) (0)
Testimony by Harold Varmus, MD, to the Senate Judiciary Committee Hearing on Human Cloning (2003) (0)
Partnerships in Science (2009) (0)
Arlen Specter: A retrospective (2012) (0)
Correct Integration of Rettwiral DNA In Vitro - (2003) (0)
From Literature to Medicine to Science (2009) (0)
B13 Selectively Targeting Lung Cancer with a Novel Small Molecule that Induces Lethality Through Dual Inhibition of Disulfide Reductases (2020) (0)
Figure 16, [Retroviral 3′-end processing and polyadenylation...]. (1997) (0)
Summary and Perspectives (1997) (0)
Letter from Harold Varmus to Erling Norrby, Department of Virology, Karolinska Institute (1987) (0)
Letter from Harold Varmus to James D. Watson, Cold Spring Harbor Laboratory (1983) (0)
Rearrangement atthe5'EndofAmplified c-mycinHumanCOLO 320Cells IsAssociated withAbnormal Transcription (1986) (0)
Letter from Herbert W. Boyer, Philip Coffino, and Harold Varmus to Daphne Kamely, National Institute of General Medical Sciences (1977) (0)
Letter from John M. Coffin and Harold Varmus to their colleagues (1981) (0)
Structures of unintegrated and integrated forms of the deoxyribonucleic acid of ribonucleic acid tumour viruses. (1979) (0)
Memorandum from Harold Varmus to members of the human retrovirus subcommittee of the Retrovirus Study Group [on the results of the initial straw poll on the nomenclature of the AIDS virus] (1985) (0)
Global Science and Global Health (2009) (0)
Washington University Record, February 12, 1998 (2014) (0)
Letter from Harold Varmus to Jon Beckwith, Department of Microbiology and Molecular Genetics, Harvard Medical School (1986) (0)
Cell-Speciﬁc Transduction of Prdm1 -Expressing Lineages Mediated by a Receptor for Avian Leukosis Virus Subgroup B (cid:1) † (2009) (0)
Targeted Therapies for Human Cancers (2009) (0)
Letter from Harold Varmus to Dani P. Bolognesi, Duke University Medical Center (1985) (0)
Letter from Harold Varmus to Don Robertson, Washington University (1976) (0)
Mammary-Specific Gene Transfer for Modeling Breast Cancer (2000) (0)
Stanford Medical School Graduation Speech (1997) (0)
Harold E. Varmus, MD. (1995) (0)
EP08.02-055 Targeting Lung Adenocarcinoma Cells with a Novel Disulfide Reductase Inhibitor (2022) (0)
Letter from Harold Varmus to Maxine Singer (1990) (0)
Letter from Harold Varmus to Yoji Ikawa, Japanese Foundation for Cancer Research (1981) (0)
Winning the arguments on Capitol Hill (2009) (0)
Memorandum from Harold Varmus to members of the human retrovirus subcommittee of the Retrovirus Study Group [with the initial set of proposals on the nomenclature of the AIDS virus] (1985) (0)
Letter from Harold Varmus to Hisayuki Yamamura, Japan Medical Research Foundation (1981) (0)
Oncogenesis without Viral Oncogenes by Avian Leukosis and Mouse Mammary Tumor Viruses (1983) (0)
Letter from Harold Varmus to John Z. Bowers, Josiah Macy, Jr. Foundation (1977) (0)
The Development of Retrovirology as Intellectual History (1997) (0)
Mutational Consequences of Retroelements in the Germ Line (1997) (0)
BECOMING A SCIENTIST (2009) (0)
The Use of cDNA Microarray to Study Gene Expression in Wnt-1 Induced Mammary Tumors (2002) (0)
Letter from Harold Varmus to Howard Young, National Cancer Institute (1979) (0)
Incorporation of Env into the Viral Particle (1997) (0)
Letter from Harold Varmus to Howard B. Hamilton, Radation Effects Research Foundation (1982) (0)
MOLECULAR AND GENETIC APPROACHES TO RETROVIRUSES AND ONCOGENES (0)
Memorandum from Harold Varmus to members of the human retrovirus subcommittee of the Retrovirus Study Group [on the final proposal to the medical journals on the nomenclature of the AIDS virus] (1986) (0)
NIH funds support more than a researcher's own lab (2008) (0)
Should the Endless Frontier of Federal Science be Expanded? (2021) (0)
Abstract 3166: Lung cancer bio-signatures in plasma based on the analysis of mouse models (2011) (0)
Letter from Harold Varmus to Kalman Perk, School of Veterinary Medicine, Hebrew University of Jerusalem (1984) (0)
Letter from Harold Varmus to Peter K. Vogt, University of Southern California School of Medicine (1975) (0)
Basic Science andTheNIH (1994) (0)
Organization of Genes in Prototypic Retroviruses (1997) (0)
Analysis of DNA sequence copy number variations by comparative genomic hybridization (CGH) (1995) (0)
[Career summary and research proposal sent to the Josiah Macy, Jr. Foundation] (1977) (0)
Letter from Harold Varmus to David W. Kingsbury, Sir William Dunn School of Pathology, University of Oxford (1984) (0)
Letter from Harold Varmus to Marilyn Kozak, University of Pittsburgh (1983) (0)
The RSV Oncogene and Its Progenitor (2009) (0)
Abstract LB-398: Identification of novel mechanisms of resistance to EGFR tyrosine kinase inhibitors in non-small cell lung cancer (2011) (0)
Memorandum from Harold Varmus to the Secretary of Health and Human Services (1997) (0)
P1.02-073 Characterizing the Genomes of Lung Adenocarcinomas from Never Smokers Reveals SHPRH as a Novel Candidate Tumor Suppressor Gene: Topic: Other Mutations in Thoracic Malignancies (2017) (0)
EMail from Harold Varmus to Christopher Reeve (1996) (0)
EMail from Harold Varmus to Richard Klausner et al (2003) (0)
Abstract A39: Initial characterization of genetically engineered mice carrying a conditional allele of a splicing factor gene (U2AF1) commonly mutated in myeloid disorders. (2015) (0)
[Excerpt from Varmus' notebook from the Gordon Conference on Animal Cells and Viruses] (1975) (0)
For the ICRF Annual Report, 1979: III. Co-Transfection with Papovavirus and Retrovirus DNA Using Recombinant DNA Prepared In vitro (1979) (0)
Letter from J. Michael Bishop and Harold Varmus to Harry D. Williams II, American Business Cancer Research Foundation (1983) (0)
An overview of the FY‐1996 budget for the National Institutes of Health (1995) (0)
Retroviruses and their Interactions with the Host Cell (1997) (0)
Comparison to Other Gene Transfer Systems (1997) (0)
Role of Lymphoid Organs in Immunopathogenesis (1997) (0)
Letter from Harold Varmus to U.S. Senator Arlen Specter (1996) (0)
Figure 13, [Ribbon diagram of the dimeric...]. (1997) (0)
Letter from Harold Varmus to Alan C. Davis, American Cancer Society (1982) (0)
The Integration Reaction (1997) (0)
Figure 3, [Three distinct pathways for retroviral...]. (1997) (0)
Letter from Harold Varmus to Mike Fried, Imperial Cancer Research Fund Laboratories (1977) (0)
Figure 5, [Strategies for packaging cell line...]. (1997) (0)
The First Taste of Scientific Success (2009) (0)
SH 2 mutants of csrc that are host dependent for transformation are trans-dominant inhibitors of mouse cell transformation by activated csrc (2007) (0)
A Conversation with Harold Varmus. (2016) (0)
Hyperactivation of extracellular signal-regulated kinase (ERK) by RAS-mediated signaling or inhibition of dual specificity phosphatase 6 (DUSP6) is associated with toxicity in lung adenocarcinoma cells with mutations in KRAS or EGFR (2017) (0)
Letter: Evidence for non-repetitive subunits in the genome of Rous sarcoma virus. (1974) (0)
The Road to Building One (2009) (0)
Letter from Harold Varmus to George F. Vande Woude, National Institutes of Health (1980) (0)
Letter from Harold Varmus to Mike Scott, Imperial College of Science and Technology (1982) (0)
Basic fibroblast growth factor ii proliferation after glia-specific { (2016) (0)
Isolation ofDuplicated Humanc-src GenesLocated on Chromosomes 1and20 (1985) (0)
Letter from Harold Varmus to Lennert Phillipson, Waltenberg Labs (1971) (0)
Letter from Harold Varmus to U.S. Senator Dick Durbin (2006) (0)
Figure 11, [Linear representation of the ASLV...]. (1997) (0)
Maturation of Viral Particles (1997) (0)
The Retroviral Protease (1997) (0)
Letter from Paul Berg, Lawrence S. B. Goldstein, H. Robert Horvitz, Thomas D. Pollard, and Harold Varmus to U.S. President Bill Clinton (2000) (0)
Letter from Harold Varmus to Robert C. Gallo, National Institutes of Health (1982) (0)
Mutational profiling of the oncogenome in non-small cell lung cancer (NSCLC) (2005) (0)
How popular TV shows shape public perceptions of medical scientists. (2001) (0)
TO ADDRESS THE 37 th ANNUAL MACUB CONFERENCE AT LONG ISLAND UNIVERSITY (2004) (0)
Effect of Infection on Cell Division and Differentiation (1997) (0)
Letter from Harold Varmus to Anthony L. Schincariol, Duke University Medical Center (1974) (0)
LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma (2023) (0)
Session 6: Stem Cells (2004) (0)
Letter from Harold Varmus to Dominique Stehelin (1976) (0)
P1.02-055 Synthetic Lethality Dictates the Mutual Exclusivity of Oncogenic Mutations in Lung Adenocarcinoma: Topic: Driver Genes in NSCLC, Resistance, and Other (2017) (0)
Wild-type Splicing Factor U2AF1 inhibits splicing associated with a recurrent U2AF1 mutant in human lung cancers and is required for cell survival (2016) (0)
Retrovirus-Induced Immunodeficiencies (1997) (0)
Memorandum from Harold Varmus to Keith Hadley, Campus Biosafety Committee, University of California, San Francisco (1979) (0)
Letter from Harold Varmus to Robin Weiss, National Cancer Institute (1974) (0)
Letter from Harold Varmus, Warren Levinson, and J. Michael Bishop to Peter K. Vogt, University of Washington School of Medicine (1971) (0)
Immunopathogenic Mechanisms of HIV Infection (1997) (0)
Memorandum from Harold Varmus to Gladys Kist and Susan Shultz [on grant application for 1985 Hepatitis B Virus Meeting] (1984) (0)
Letter from Harold Varmus to Charles A. Thomas, Jr., Harvard Medical School (1971) (0)
For the ICRF Annual Report, 1979: II. Retroviruses as Mutagens: Isolation of Revertants with Deletions and/or Insertions in the ASV Provirus in B31 Cells after Superinfection with MuLV (1979) (0)
The Enlightenment Returns (2009) (0)
Science Policy in the Next Forty Years (1999) (0)
Retraction (2021) (0)
Abstract 5128: Polyethnic-1000: Advancing cancer genomics by studying ethnically diverse, underserved patient populations in New York (2019) (0)
Letter from Harold Varmus to David Baltimore, Institute of Cancer Research (1980) (0)
Abstract 4163: Molecular and physiological effects of splicing factor mutant U2AF1 in human lung cell lines and in mice (2016) (0)
Borne on the Winds of War (2002) (0)
Letter from Harold Varmus to D. P. Georgiev, Academy of Sciences (U.S.S.R.) (1982) (0)
Letter from Harold Varmus to Girish N. Vyas (1977) (0)
Letter from Harold Varmus to Peter Bentvelzen, Radiobiological Institute of the Organization for Health Research (The Netherlands) (1975) (0)
Abstract C113: ERBB3 independent activation of the PI3K pathway in EGFR mutant lung adenocarcinomas. (2013) (0)
Letter from Harold Varmus to Mike Fried, Art, Herman and Nancy Quintrell (1978) (0)
Table 3, Other HIV-1 Vaccine Approaches (1997) (0)
Letter from Harold Varmus to Max Essex, Harvard School of Public Health (1985) (0)
Letter from Harold Varmus to Benjamin Lewin, Massachusetts Institute of Technology Press (1976) (0)
Memorandum from Harold Varmus to the Grand Challenges in Global Health Scientific Advisory Board (2007) (0)
For the ICRF Annual Report, 1979: I. The Rare Revertants of an ASV-Transformed Rat Cell Have Lost Proviral DNA or Bear Mutations in SRC (1979) (0)
Letter from Harold Varmus to Salvador E. Luria (1975) (0)
Letter from Harold Varmus to E. C. C. Lin, Harvard Medical School (1973) (0)
Recommendations for nomenclature of hemoglobins. (1961) (0)
457. A molecular compound of anthraquinone and dianthron-9-yl (1950) (0)
Embryonic Erythropoiesis: Some Experimental Systems (2008) (0)
Definition ofRegions inHumanc-mycThatAreInvolved in Transformation andNuclear Localization (1987) (0)
How the US can best support the careers of promising young biomedical scientists (2018) (0)
Letter from Harold Varmus to David W. Kingsbury, St. Jude Children's Research Hospital (1984) (0)
Letter from Harold Varmus and J. Michael Bishop to Robert J. Huebner, National Cancer Institute (1972) (0)
The Hemoglobins of the Fetus (1971) (0)
[Excerpt from UCSF School of Medicine's Department of Biochemistry and Biophysics' 1982-1983 Annual Report] (1992) (0)
Discussion Points for NIH Technology Transfer Advisory Committee (1994) (0)
ERYTHROPOIESIS DURING AMPHIBIAN METAMORPHOSIS (1971) (0)
Letter from Harold Varmus to Paul Hough, Cold Spring Harbor Laboratory (1973) (0)
Letter from Harold Varmus to Lawrence A. Donehower, National Institutes of Health (1981) (0)
Applications of TAU / neurofilamentproteinkinasen PK40 (1992) (0)
Letter from Harold Varmus to prospective Scientific Advisory Board members (2003) (0)
RECOMMENDATIONS FOR THE NOMENCLATURE OF HÆMOGLOBINS (1961) (0)
NIH R&D priorities. (1994) (0)
Letter from Harold Varmus to Richard Lerner, Scripps Clinic and Research Foundation (1983) (0)
Letter from Harold Varmus to Bill McGuire, United States Information Agency (1989) (0)
Letter from Harold Varmus to Kumao Toyoshima, Institute of Medical Science (Japan) (1982) (0)
9.110J / 7.92J Neurology, Neuropsychology, and Neurobiology of Aging, Spring 2003 (2003) (0)
Retraction. Moloney murine leukemia virus integration protein produced in yeast binds specifically to viral att sites (1991) (0)
The biosynthesis of macromolecules / by Vernon M. Ingran (1966) (0)
475. The stereochemistry of 10-benzylideneanthrone and 9-benzylidenefluorene (1950) (0)
Reversing the Formation of Alzheimer Amyloid Fibrils and Blocking Toxic Ca2+ Influx (2004) (0)
Foreword to National Sleep Disorders Research Plan, National Institutes of Health, March 1996 (1997) (0)
Using Recombinant DNA Technology to Study the Behavior of Retroviruses (1983) (0)
DNA Methylation and Epigenetic Inheritance in Plants and Filamentous Fungi (2001) (0)
Analogues de daph et inhibition d'agregation de proteines (2005) (0)
[The structure of abnormal hemoglobins]. (1958) (0)
Letter from Harold Varmus to John Garamendi, California State Senate (1987) (0)
Plenary Address: Molecular Disease (1981) (0)
On the biosynthesis of hemoglobin. (1967) (0)
SH groups in haemoglobins. (1954) (0)
Recommendations for the nomenclature of hemoglobins (2005) (0)
Other Retrovirus-Induced Diseases (1997) (0)
Functional Characterization of Mammary Stem Cells (2004) (0)
Abstract B063: Polyethnic-1000: Advancing cancer genomics by studying ethnically diverse, underserved patient populations in New York (2020) (0)
Embryo research guidelines. (1994) (0)
Letter from Harold Varmus to F. Kisseljou, D. I. Ivanovsky Virology Institute (1972) (0)
Electron Solvation in Finite Systems : Femtosecond Dynamics of Iodide z ( Water ) n Anion Clusters (1999) (0)
INDUCTION BY THYROXIN OF HEMOGLOBIN SYNTHESIS DURING AMPHIBIAN METAMORPHOSIS BY BERNARD MOSS (0)
Utilizations neurofilament protein kinase / tau PK40. (1992) (0)
Letter from Harold Varmus to Philip Leder, Harvard Medical School (1983) (0)
Forum for Agricultural Biotechnology Debates (2001) (0)
Active Immunization of Tadpoles against Frog Hemoglobin and Developmental Consequences (1971) (0)
Letter from Harold Varmus to Donald S. Fredrickson, National Institutes of Health (1979) (0)
Abstract A18: Reduced NF1 expression in resistance to EGF receptor inhibitory drugs in lung adenocarcinoma (2012) (0)
Nucleic Acids Research Is There Specific Transcription from Isolated Chromatin? Nucleic Acids Research (0)
Letter from Vernon M. Ingram to Francis Crick (1965) (0)
Memorandum from Harold Varmus to members of the human retrovirus subcommittee of the Retrovirus Study Group [on the latest status on the efforts to name the AIDS virus] (1985) (0)
Bad Times and Good Times as NIH Director (2009) (0)
P1-191 Blocking the initial molecular mechanism of Alzheimer's disease (2004) (0)
Recommendations for the nomenclature of haemoglobins. (1961) (0)
DNA methylation of remote sequences in chicken alpha-globin gene expression. (1983) (0)
Letter from Harold Varmus to Hsing-Jien Kung, Michigan State University (1982) (0)
Gordon Tomkins (1975) (0)
Letter from Harold Varmus to Luis M. de la Maza, University of Minnesota (1974) (0)

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