Stuart Orkin

Q: What Schools Are Affiliated With Stuart Orkin

Stuart Orkin is affiliated with the following schools: Indiana University, MD Anderson Cancer Center, University of Oxford, University of Massachusetts Medical School, Massachusetts General Hospital, Washington University in St. Louis, Indiana University Bloomington, Hebrew University of Jerusalem, Massachusetts Institute of Technology, University of Washington, University of Zurich, Harvard University

Stuart Orkin's AcademicInfluence.com Rankings

Stuart Orkin

Medical

#128

World Rank

#200

Historical Rank

#66

USA Rank

Hematology

World Rank

Historical Rank

USA Rank

medical Degrees

Download Badge

Medical

Stuart Orkin's Degrees

Doctorate Medicine Harvard University

Why Is Stuart Orkin Influential?

(Suggest an Edit or Addition)

According to Wikipedia, Stuart Holland Orkin is an American physician, stem cell biologist and researcher in pediatric hematology-oncology. He is the David G. Nathan Distinguished Professor of Pediatrics at Harvard Medical School. Orkin's research has focused on the genetic basis of blood disorders. He is a member of the National Academy of Sciences and the Institute of Medicine, and an Investigator of the Howard Hughes Medical Institute.

(See a Problem?)

Stuart Orkin's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology (2008) (2288)
An early haematopoietic defect in mice lacking the transcription factor GATA-2 (1994) (1470)
An Extended Transcriptional Network for Pluripotency of Embryonic Stem Cells (2008) (1400)
A comparative encyclopedia of DNA elements in the mouse genome (2014) (1337)
Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1 (1991) (1313)
Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping (1990) (1288)
A protein interaction network for pluripotency of embryonic stem cells (2006) (1178)
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis (2007) (1084)
Mapping the Mouse Cell Atlas by Microwell-Seq (2018) (994)
Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL (1995) (991)
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. (2008) (929)
Mouse model of X–linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production (1995) (918)
A Critical Role for Eosinophils in Allergic Airways Remodeling (2004) (881)
Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. (2004) (862)
E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation (1996) (858)
Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells (1989) (818)
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. (2004) (807)
Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor BCL11A (2008) (800)
The T Cell Leukemia Oncoprotein SCL/tal-1 Is Essential for Development of All Hematopoietic Lineages (1996) (795)
Cloning the gene for an inherited human disorder—chronic granulomatous disease—on the basis of its chromosomal location (1986) (774)
FOG, a Multitype Zinc Finger Protein, Acts as a Cofactor for Transcription Factor GATA-1 in Erythroid and Megakaryocytic Differentiation (1997) (768)
Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression (2003) (753)
Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart (1993) (752)
Linkage of β-thalassaemia mutations and β-globin gene polymorphisms with DNA polymorphisms in human β-globin gene cluster (1982) (735)
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. (2011) (735)
Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoeitin/MGDF in megakaryocyte development (1995) (719)
A lineage‐selective knockout establishes the critical role of transcription factor GATA‐1 in megakaryocyte growth and platelet development (1997) (717)
DNA-binding specificity of GATA family transcription factors (1993) (675)
A Critical Role for DNA End-Joining Proteins in Both Lymphogenesis and Neurogenesis (1998) (674)
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis (2015) (672)
Diversification of haematopoietic stem cells to specific lineages (2000) (659)
The placenta is a niche for hematopoietic stem cells. (2004) (653)
A Myc Network Accounts for Similarities between Embryonic Stem and Cancer Cell Transcription Programs (2010) (643)
Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF (1995) (642)
The E2F1–3 transcription factors are essential for cellular proliferation (2001) (641)
The transcriptional control of hematopoiesis. (1996) (630)
Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein (1993) (622)
Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation. (1997) (610)
Transcriptional regulation of erythropoiesis: an affair involving multiple partners (2002) (604)
The SWI/SNF complex — chromatin and cancer (2004) (590)
Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells. (1994) (587)
Targeted Deletion of a High-Affinity GATA-binding Site in the GATA-1 Promoter Leads to Selective Loss of the Eosinophil Lineage In Vivo (2002) (581)
Activity and tissue-specific expression of the transcription factor NF-E1 multigene family. (1990) (574)
Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells (2004) (571)
Developmental Origin of a Bipotential Myocardial and Smooth Muscle Cell Precursor in the Mammalian Heart (2006) (554)
Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of β-thalassemia (2008) (548)
The journey of developing hematopoietic stem cells (2006) (539)
GATA-binding transcription factors in hematopoietic cells. (1992) (535)
Specific transcription and RNA splicing defects in five cloned β-thalassaemia genes (1983) (533)
DNA polymorphisms at the BCL11A, HBS1L-MYB, and β-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease (2008) (529)
Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation. (2010) (521)
An essential role in liver development for transcription factor XBP-1. (2000) (510)
An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level (2013) (510)
Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krüppel family proteins Sp1 and EKLF (1995) (505)
Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1 (2000) (503)
MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways (2012) (482)
Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia. (1984) (475)
GATA transcription factors: key regulators of hematopoiesis. (1995) (468)
Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages (1990) (467)
Clonal analysis using recombinant DNA probes from the X-chromosome. (1987) (457)
Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain (1986) (455)
Jumonji Modulates Polycomb Activity and Self-Renewal versus Differentiation of Stem Cells (2009) (454)
High fat diet enhances stemness and tumorigenicity of intestinal progenitors (2016) (442)
GATA-binding transcription factors in hematopoietic cells (1992) (433)
FOG-2, a Cofactor for GATA Transcription Factors, Is Essential for Heart Morphogenesis and Development of Coronary Vessels from Epicardium (2000) (429)
Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene (2003) (424)
Differentiation in erythroleukemic cells and their somatic hybrids. (1975) (421)
Rb Regulates Interactions between Hematopoietic Stem Cells and Their Bone Marrow Microenvironment (2007) (419)
Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1. (1990) (410)
Development of homozygosity for chromosome 11p markers in Wilms' tumour (1984) (406)
Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene (1995) (404)
PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding. (2000) (401)
A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. (2009) (395)
Globin gene regulation and switching: Circa 1990 (1990) (395)
Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. (2007) (390)
Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. (2003) (385)
Human von Willebrand factor (vWF): isolation of complementary DNA (cDNA) clones and chromosomal localization. (1985) (384)
Development of hematopoietic cells lacking transcription factor GATA-1. (1995) (384)
Chromatin Connections to Pluripotency and Cellular Reprogramming (2011) (383)
Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. (2003) (382)
CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation. (1998) (381)
Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG. (1998) (380)
The mutation and polymorphism of the human beta-globin gene and its surrounding DNA. (1984) (376)
GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression. (1999) (376)
Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice. (1999) (372)
Developmental and species-divergent globin switching are driven by BCL11A (2009) (370)
Analyzing CRISPR genome-editing experiments with CRISPResso (2016) (369)
ADAR1 is essential for maintenance of hematopoiesis and suppression of interferon signaling (2008) (367)
Heme‐regulated eIF2α kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency (2001) (367)
Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line (1997) (366)
The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex (1987) (364)
Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development. (1998) (362)
DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells. (2009) (358)
Early Asymmetry of Gene Transcription in Embryonic Human Left and Right Cerebral Cortex (2005) (356)
Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2. (2002) (351)
Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6. (2010) (349)
Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease. (1990) (338)
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma (2014) (335)
Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos. (2008) (335)
Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis. (1995) (332)
MicroRNA-21 Limits In Vivo Immune Response-Mediated Activation of the IL-12/IFN-γ Pathway, Th1 Polarization, and the Severity of Delayed-Type Hypersensitivity (2011) (330)
Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter. (1991) (322)
Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors. (2001) (319)
GATA-2 Plays Two Functionally Distinct Roles during the Ontogeny of Hematopoietic Stem Cells (2004) (317)
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2 (2015) (314)
PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos (2008) (312)
The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation. (2008) (311)
MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets (2012) (310)
Targeted Disruption of the EZH2/EED Complex Inhibits EZH2-dependent Cancer (2013) (309)
Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain. (2001) (305)
Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. (2009) (305)
The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow. (1998) (299)
Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis. (2005) (299)
Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing (2011) (298)
Yolk sac angiogenic defect and intra‐embryonic apoptosis in mice lacking the Ets‐related factor TEL (1997) (297)
Developmental stage–selective effect of somatically mutated leukemogenic transcription factor GATA1 (2005) (294)
Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5. (2002) (290)
Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia. (2012) (290)
Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. (2004) (287)
Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells. (1992) (285)
Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome b. (1988) (285)
Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner. (2014) (283)
Hematopoiesis and stem cells: plasticity versus developmental heterogeneity (2002) (279)
Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. (2008) (274)
Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse. (2003) (269)
Characterization of Genomic Deletion Efficiency Mediated by Clustered Regularly Interspaced Palindromic Repeats (CRISPR)/Cas9 Nuclease System in Mammalian Cells*♦ (2014) (268)
CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter. (1991) (267)
Anion Exchanger 1 (Band 3) Is Required to Prevent Erythrocyte Membrane Surface Loss but Not to Form the Membrane Skeleton (1996) (267)
Abnormal RNA processing due to the exon mutation of βE-globin gene (1982) (262)
Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch (2018) (260)
Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis (1985) (259)
Rescue of erythroid development in gene targeted GATA–1− mouse embryonic stem cells (1992) (258)
Myc requires distinct E2F activities to induce S phase and apoptosis. (2001) (258)
Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation (2010) (257)
Cdc42 is required for PIP2-induced actin polymerization and early development but not for cell viability (2000) (250)
A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1. (1997) (249)
The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages. (2002) (248)
MicroRNA-21 Integrates Pathogenic Signaling to Control Pulmonary Hypertension: Results of a Network Bioinformatics Approach (2012) (248)
The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival (2003) (246)
The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. (1993) (245)
Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex. (1999) (245)
Transcription Factors and Hematopoietic Development (*) (1995) (241)
Basic fibroblast growth factor positively regulates hematopoietic development. (2000) (240)
Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells (1996) (238)
Increased γ-globin expression in a nondeletion HPFH mediated by an erythroid-specif ic DNA-binding factor (1989) (236)
Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin (2016) (233)
Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system. (1999) (232)
The switch from fetal to adult hemoglobin. (2013) (232)
miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. (2010) (232)
Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire. (2013) (231)
Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution (2014) (230)
Opposing Roles for the lncRNA Haunt and Its Genomic Locus in Regulating HOXA Gene Activation during Embryonic Stem Cell Differentiation. (2015) (228)
PRC2 directly methylates GATA4 and represses its transcriptional activity. (2012) (227)
Association of a Ras-related protein with cytochrome b of human neutrophils (1989) (225)
Sox2 maintains self-renewal of tumor initiating cells in osteosarcomas (2011) (224)
Challenges and emerging directions in single-cell analysis (2017) (223)
Gene targeting of X chromosome-linked chronic granulomatous disease locus in a human myeloid leukemia cell line and rescue by expression of recombinant gp91phox. (1993) (222)
Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut (1992) (221)
Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation (2013) (220)
Activation of the erythropoietin receptor promoter by transcription factor GATA-1. (1991) (218)
GATA-1 as a Regulator of Mast Cell Differentiation Revealed by the Phenotype of the GATA-1low Mouse Mutant (2003) (216)
MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13 (2011) (216)
Polycomb repressive complex 2 is required for MLL-AF9 leukemia (2012) (214)
The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. (2016) (213)
By the book (1990) (213)
Hematopoietic development: a balancing act. (2001) (210)
Molecular characterization of seven beta‐thalassemia mutations in Asian Indians. (1984) (210)
Phenotype of recovering lymphoid cell populations after marrow transplantation (1985) (210)
Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2. (1995) (210)
Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production (2014) (209)
GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo. (1997) (207)
Transcription control by the ENL YEATS domain in acute leukemia (2016) (207)
Self-association of the erythroid transcription factor GATA-1 mediated by its zinc finger domains (1995) (204)
X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction. (2002) (203)
Partial Correction of the Phagocyte Defect in Patients with X-Linked Chronic Granulomatous Disease by Subcutaneous Interferon Gamma (1988) (202)
Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A (2013) (199)
Consequences of GATA-1 Deficiency in Megakaryocytes and Platelets (1999) (198)
Advances in the understanding of haemoglobin switching (2010) (198)
Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding. (1999) (196)
The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1. (2002) (196)
Structure of pre-pro-von Willebrand factor and its expression in heterologous cells (1986) (193)
Reprogramming Committed Murine Blood Cells to Induced Hematopoietic Stem Cells with Defined Factors (2014) (193)
Polycomb Repressive Complex 2 Regulates Normal Development of the Mouse Heart (2012) (191)
Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex (1984) (190)
Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity. (2001) (187)
Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling. (2006) (186)
Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis. (2012) (184)
Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis. (2016) (184)
GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis (2002) (182)
TIF1γ Controls Erythroid Cell Fate by Regulating Transcription Elongation (2010) (182)
Thalassemia due to a mutation in the cleavage‐polyadenylation signal of the human beta‐globin gene. (1985) (181)
Retrovirus-mediated transfer of human adenosine deaminase gene sequences into cells in culture and into murine hematopoietic cells in vivo. (1986) (181)
Application of endonuclease mapping to the analysis and prenatal diagnosis of thalassemias caused by globin-gene deletion. (1978) (179)
Reverse genetics and human disease (1986) (177)
Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. (1996) (176)
GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. (1991) (176)
Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner (1993) (175)
A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development (1997) (175)
Consequences of GATA-1 deficiency in megakaryocytes and platelets. (1999) (174)
Expression of GATA-binding proteins during embryonic development in Xenopus laevis. (1991) (173)
Long-term in vivo expression of a murine adenosine deaminase gene in rhesus monkey hematopoietic cells of multiple lineages after retroviral mediated gene transfer into CD34+ bone marrow cells. (1993) (172)
Mapping the Mouse Cell Atlas by Microwell-Seq (2018) (171)
Targeted Disruption of the Basic Krüppel-Like Factor Gene (Klf3) Reveals a Role in Adipogenesis (2008) (171)
Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube (2005) (170)
Role of SCL/Tal-1, GATA, and ets transcription factor binding sites for the regulation of flk-1 expression during murine vascular development. (2000) (169)
Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing. (1988) (168)
Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF. (1996) (168)
The Friend of GATA proteins U-shaped, FOG-1, and FOG-2 function as negative regulators of blood, heart, and eye development in Drosophila (2001) (167)
A Human Stem Cell Model of Early Alzheimer’s Disease Pathology in Down Syndrome (2012) (167)
A nonerythroid GATA-binding protein is required for function of the human preproendothelin-1 promoter in endothelial cells (1990) (167)
Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders. (2012) (166)
The propeptide of von Willebrand Factor independently mediates the assembly of von Willebrand multimers (1988) (166)
ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. (2013) (166)
The C-terminal zinc finger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line (1995) (165)
Hematopoiesis: how does it happen? (1995) (165)
beta-Thalassemia in Chinese: use of in vivo RNA analysis and oligonucleotide hybridization in systematic characterization of molecular defects. (1984) (165)
Absence of both the 91kD and 22kD subunits of human neutrophil cytochrome b in two genetic forms of chronic granulomatous disease. (1989) (164)
Regulated expression of globin chains and the erythroid transcription factor GATA-1 during erythropoiesis in the developing mouse (1990) (162)
The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. (1997) (162)
Recombinant interferon gamma augments phagocyte superoxide production and X-chronic granulomatous disease gene expression in X-linked variant chronic granulomatous disease. (1987) (161)
Differential Roles of Sall4 Isoforms in Embryonic Stem Cell Pluripotency (2010) (161)
ABC‐me: a novel mitochondrial transporter induced by GATA‐1 during erythroid differentiation (2000) (158)
Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA‐2 in urogenital development (1998) (157)
Dysregulation of protein modification by ISG15 results in brain cell injury. (2002) (157)
Dissecting super-enhancer hierarchy based on chromatin interactions (2017) (157)
Requirement of Nanog dimerization for stem cell self-renewal and pluripotency (2008) (156)
Improved detection of the sickle mutation by DNA analysis: application to prenatal diagnosis. (1982) (156)
Dependence of globin gene expression in mouse erythroleukemia cells on the NF-E2 heterodimer (1995) (156)
A functional element necessary for fetal hemoglobin silencing. (2011) (155)
Cell cycle-dependent initiation and lineage-dependent abrogation of GATA-1 expression in pure differentiating hematopoietic progenitors. (1992) (154)
Scl Represses Cardiomyogenesis in Prospective Hemogenic Endothelium and Endocardium (2012) (154)
Development of the hematopoietic system. (1996) (152)
In vitro differentiation of murine embryonic stem cells. New approaches to old problems. (1996) (151)
Coregulation of GATA factors by the Friend of GATA (FOG) family of multitype zinc finger proteins. (2005) (151)
Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene. (1999) (149)
Propolypeptide of von Willebrand factor circulates in blood and is identical to von Willebrand antigen II. (1986) (148)
Boundaries of gene conversion within the duplicated human alpha-globin genes. Concerted evolution by segmental recombination. (1983) (147)
Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development. (2004) (147)
Pathogenesis of B cell lymphoma in a patient with AIDS. (1986) (146)
Coregulator-dependent facilitation of chromatin occupancy by GATA-1. (2004) (146)
Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription (1993) (145)
Regulation of globin gene expression in erythroid cells. (1995) (143)
Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1 (2011) (143)
The molecular basis of α-thalassemias: Frequent occurrence of dysfunctional α loci among non-Asians with Hb H disease (1979) (141)
Use of in vivo biotinylation to study protein–protein and protein–DNA interactions in mouse embryonic stem cells (2009) (141)
Quantification of the close association between DNA haplotypes and specific β-thalassaemia mutations in Mediterraneans (1984) (141)
A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease. (1989) (140)
Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis. (2007) (137)
Mutation in an intervening sequence splice junction in man. (1981) (136)
Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen receptor (1995) (136)
ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex. (2007) (136)
Induction of phagocyte cytochrome b heavy chain gene expression by interferon gamma. (1988) (135)
Placenta as a site for hematopoietic stem cell development. (2005) (135)
Base substitution at position -88 in a beta-thalassemic globin gene. Further evidence for the role of distal promoter element ACACCC. (1984) (134)
Reprogramming Committed Murine Blood Cells to Induced Hematopoietic Stem Cells with Defined Factors (2014) (134)
Nathan and Oski's hematology of infancy and childhood (2013) (133)
E2F1 and E2F2 Determine Thresholds for Antigen-Induced T-Cell Proliferation and Suppress Tumorigenesis (2001) (132)
The Zebrafish moonshine Gene Encodes Transcriptional Intermediary Factor 1γ, an Essential Regulator of Hematopoiesis (2004) (131)
Partial deletion of beta-globin gene DNA in certain patients with beta 0-thalassemia. (1979) (131)
The major human erythroid DNA-binding protein (GF-1): primary sequence and localization of the gene to the X chromosome. (1990) (131)
Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease. (2016) (130)
Nucleotide sequence of pre-pro-von Willebrand factor cDNA. (1986) (130)
Long-term expression of human adenosine deaminase in mice transplanted with retrovirus-infected hematopoietic stem cells. (1989) (129)
Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells (2011) (129)
Loss of erythropoietin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid-transforming gene. (1993) (127)
Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis. (2010) (126)
Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions. (2015) (125)
The duplicated human alpha globin genes lie close together in cellular DNA. (1978) (125)
Defective Neural Tube Closure and Anteroposterior Patterning in Mice Lacking the LIM Protein LMO4 or Its Interacting Partner Deaf-1 (2004) (123)
Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells. (2013) (123)
Antagonism between C/EBPbeta and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors. (2000) (123)
Functional footprinting of regulatory DNA (2015) (123)
BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations. (2015) (123)
Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells. (2008) (122)
Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1. (1994) (121)
Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. (2012) (120)
Generation of genomic deletions in mammalian cell lines via CRISPR/Cas9. (2014) (120)
Phosphorylation of the erythroid transcription factor GATA-1. (1994) (118)
Supplemental Data EZH 1 Mediates Methylation on Histone H 3 Lysine 27 and Complements EZH 2 in Maintaining Stem Cell Identity and Executing Pluripotency (2008) (118)
Molecular analysis of the high-hemoglobin-F phenotype in Saudi Arabian sickle cell anemia. (1987) (118)
Nathan and Oski's hematology and oncology of infancy and childhood / (2015) (118)
Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity (2015) (117)
Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype. (2016) (117)
Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine (2011) (116)
DNA polymorphism and molecular pathology of the human globin gene clusters (2004) (115)
Estrogen-induced apoptosis by inhibition of the erythroid transcription factor GATA-1 (1996) (115)
Infrequent mutation of the WT1 gene in 77 Wilms' tumors (1994) (115)
Regulated expression of endothelin 1 in glomerular capillary endothelial cells. (1991) (112)
Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development. (2005) (111)
Direct detection of the common Mediterranean beta-thalassemia gene with synthetic DNA probes. An alternative approach for prenatal diagnosis. (1983) (110)
Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity. (2014) (108)
Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain (1987) (108)
DNA linkage analysis of X chromosome-linked chronic granulomatous disease. (1986) (108)
Friend of GATA-1 Represses GATA-3–dependent Activity in CD4+ T Cells (2001) (106)
Update on fetal hemoglobin gene regulation in hemoglobinopathies (2011) (106)
Combinatorial interactions of Serpent, Lozenge, and U-shaped regulate crystal cell lineage commitment during Drosophila hematopoiesis (2003) (105)
Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells (2016) (105)
Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer. (2011) (103)
TEL-AML1 corrupts hematopoietic stem cells to persist in the bone marrow and initiate leukemia. (2009) (103)
FOG acts as a repressor of red blood cell development in Xenopus. (2000) (101)
Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number. (2012) (101)
Rescue of GATA-1-deficient embryonic stem cells by heterologous GATA-binding proteins (1995) (99)
Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease. (1991) (98)
Differentiation of erythroleukemic cells in the presence of inhibitors of DNA synthesis (1975) (98)
Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer. (2016) (97)
Genetics of erythropoiesis: induced mutations in mice and zebrafish. (1997) (97)
An upstream, DNase I hypersensitive region of the hematopoietic-expressed transcription factor GATA-1 gene confers developmental specificity in transgenic mice. (1997) (97)
GATA-2 Reinforces Megakaryocyte Development in the Absence of GATA-1 (2009) (96)
Distinct Domains of the GATA-1 Cofactor FOG-1 Differentially Influence Erythroid versus Megakaryocytic Maturation (2002) (96)
The duplicated human α-globin genes: Their relative expression as measured by RNA analysis (1981) (95)
Primitive erythropoiesis in the Xenopus embryo: the synergistic role of LMO-2, SCL and GATA-binding proteins. (2001) (95)
Origin of cell populations after bone marrow transplantation. Analysis using DNA sequence polymorphisms. (1985) (95)
miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction. (2015) (95)
Molecular genetics of chronic granulomatous disease. (1988) (94)
ATA box transcription mutation in β-thalassemia (1983) (93)
Cloning the gene for the inherited disorder chronic granulomatous disease on the basis of its chromosomal location. (1986) (93)
Molecular heterogeneity of inherited antithrombin III deficiency. (1983) (92)
Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci (2017) (91)
Zinc-finger transcription factor Gfi-1: versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells (2006) (91)
Evidence for multiple origins of the beta E-globin gene in Southeast Asia. (1982) (91)
Linkage of beta-thalassaemia mutations and beta-globin gene polymorphisms with DNA polymorphisms in human beta-globin gene cluster. (1982) (90)
Loss of Ezh2 synergizes with JAK2-V617F in initiating myeloproliferative neoplasms and promoting myelofibrosis (2016) (90)
Nonsense and frameshift mutations in beta 0-thalassemia detected in cloned beta-globin genes. (1981) (89)
The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes (2017) (89)
In vivo protein-DNA interactions at hypersensitive site 3 of the human beta-globin locus control region. (1992) (88)
Hemoglobin switching's surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin. (2015) (87)
Structure and transcription of the mouse erythropoietin receptor gene (1990) (87)
Abnormal RNA splicing causes one form of α thalassemia (1982) (86)
Retrovirus-mediated gene transfer of human adenosine deaminase: expression of functional enzyme in murine hematopoietic stem cells in vivo (1987) (86)
On the origin and spread of beta-thalassemia: recurrent observation of four mutations in different ethnic groups. (1986) (85)
Transcription factor GATA‐1 in megakaryocyte development (1998) (85)
Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci (2017) (84)
Zfp281 Functions as a Transcriptional Repressor for Pluripotency of Mouse Embryonic Stem Cells (2011) (84)
Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F (2014) (84)
In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction (1992) (84)
SCL/tal‐1‐dependent process determines a competence to select the definitive hematopoietic lineage prior to endothelial differentiation (2002) (84)
Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage (2008) (84)
p45 NF‐E2 regulates expression of thromboxane synthase in megakaryocytes (1997) (83)
Embryonic stem cells and transgenic mice in the study of hematopoiesis. (1998) (82)
An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells (2020) (82)
Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS. (2018) (81)
Emerging Genetic Therapy for Sickle Cell Disease. (2019) (81)
Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells. (2006) (81)
Abnormal RNA processing due to the exon mutation of beta E-globin gene. (1982) (80)
Regulation of the β-globin locus (1993) (80)
Author Correction: High-fat diet enhances stemness and tumorigenicity of intestinal progenitors (2018) (80)
EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression. (2015) (80)
CUT&RUNTools: a flexible pipeline for CUT&RUN processing and footprint analysis (2019) (78)
Recent progress in understanding and manipulating haemoglobin switching for the haemoglobinopathies (2018) (78)
An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells (2019) (77)
Networking erythropoiesis (2010) (76)
Serum-Based Culture Conditions Provoke Gene Expression Variability in Mouse Embryonic Stem Cells as Revealed by Single-Cell Analysis. (2016) (75)
The 3′ untranslated regions of the duplicated human α-globin genes are unexpectedly divergent (1980) (75)
BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells (2019) (75)
The polymerase chain reaction colony miniprep. (1989) (74)
Analysis of chromatin-state plasticity identifies cell-type–specific regulators of H3K27me3 patterns (2014) (74)
Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription. (1993) (73)
Partial correction of the phagocyte defect in patients with X-linked chronic granulomatous disease by subcutaneous interferon gamma. (1989) (73)
Notch Signaling Requires GATA-2 to Inhibit Myelopoiesis from Embryonic Stem Cells and Primary Hemopoietic Progenitors1 (2006) (72)
Bcl11a Deficiency Leads to Hematopoietic Stem Cell Defects with an Aging-like Phenotype. (2016) (72)
Polymorphism and molecular pathology of the human beta-globin gene. (1983) (71)
Interaction between FOG-1 and the Corepressor C-Terminal Binding Protein Is Dispensable for Normal Erythropoiesis In Vivo (2002) (69)
Characterization of the homopolymer tailing reaction catalyzed by terminal deoxynucleotidyl transferase. Implications for the cloning of cDNA. (1982) (69)
Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence (2015) (68)
Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of rb, mimics the human disease (2008) (68)
Transforming Acidic Coiled-coil Protein 3 (TACC3) Controls Friend of GATA-1 (FOG-1) Subcellular Localization and Regulates the Association between GATA-1 and FOG-1 during Hematopoiesis* (2004) (68)
Knock-in mutation of transcription factor GATA-3 into the GATA-1 locus: partial rescue of GATA-1 loss of function in erythroid cells. (1998) (67)
Differential expression of alpha- and beta-globin genes during differentiation of cultured erythroleukemic cells. (1975) (67)
Stem cell alchemy (2000) (67)
Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis (2019) (66)
Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells. (2016) (66)
Gata4 is necessary for normal pulmonary lobar development. (2007) (65)
A Functional Initiator Element in the Human β-Globin Promoter (*) (1995) (64)
Beta-thalassemia due to two novel nucleotide substitutions in consensus acceptor splice sequences of the beta-globin gene. (1989) (64)
Fetal expression of a human Agamma globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos. (2000) (64)
Chronic Myelogenous Leukemia- Initiating Cells Require Polycomb Group Protein EZH2. (2016) (63)
Intron structure of the human antithrombin III gene differs from that of other members of the serine protease inhibitor superfamily. (1985) (63)
Duplication followed by deletion accounts for the structure of an Indian deletion beta (0)-thalassemia gene. (1982) (62)
Regulation of the serum concentration of thrombopoietin in thrombocytopenic NF-E2 knockout mice. (1997) (62)
PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells. (2015) (62)
Partial deletion of the α-globin structural gene in human α-thalassaemia (1980) (62)
THE MOLECULAR BASIS FOR THE CLINICAL DIVERSITY OF β THALASSAEMIA IN CYPRIOTS (1983) (61)
Gene deletion in a patient with chronic granulomatous disease and McLeod syndrome: fine mapping of the Xk gene locus. (1988) (61)
Phosphatidylinositol 3-Kinase/Akt Induced by Erythropoietin Renders the Erythroid Differentiation Factor GATA-1 Competent for TIMP-1 Gene Transactivation (2005) (60)
Chronic granulomatous disease. (1992) (60)
Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer (2018) (60)
SnapShot: Hematopoiesis (2008) (59)
Nitrosoguanidine mutagenesis in synchronized hamster cells (1971) (59)
Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments (2017) (59)
Cloning and direct examination of a structurally abnormal human beta 0-thalassemia globin gene. (1980) (59)
Early pre-B cells from normal and X-linked agammaglobulinaemia produce Cμ without an attached VH region (1983) (59)
Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome. (2010) (58)
Characterizing heterogeneity in leukemic cells using single-cell gene expression analysis (2014) (58)
GATA1-Cre mediates Piga gene inactivation in the erythroid/megakaryocytic lineage and leads to circulating red cells with a partial deficiency in glycosyl phosphatidylinositol-linked proteins (paroxysmal nocturnal hemoglobinuria type II cells). (2001) (58)
Organization and expression of globin genes (1982) (57)
Transcriptional silencing of fetal hemoglobin by BCL11A (2010) (57)
Corrigendum: ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling (2009) (57)
Biomedicine: Stem-cell competition (2002) (56)
High fetal hemoglobin production in sickle cell anemia in the eastern province of Saudi Arabia is genetically determined (1986) (56)
Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation (2014) (55)
Restoration of phagocyte function by interferon-gamma in X-linked chronic granulomatous disease occurs at the level of a progenitor cell. (1990) (55)
The entire beta-globin gene cluster is deleted in a form of gamma delta beta-thalassemia (1983) (55)
Increased platelet-derived growth factor A-chain expression in human uterine smooth muscle cells during the physiologic hypertrophy of pregnancy. (1990) (55)
The human phosphoglycerate kinase multigene family. HLA-associated sequences and an X-linked locus containing a processed pseudogene and its functional counterpart. (1985) (54)
Localization of the beta-globin gene by chromosomal in situ hybridization. (1984) (54)
Context-dependent function of "GATA switch" sites in vivo. (2011) (54)
Characterization of genomic deletion efficiency mediated by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells. (2017) (53)
TMEM14C is required for erythroid mitochondrial heme metabolism. (2014) (53)
The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. (2016) (53)
Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia (2016) (53)
The hypomorphic Gata1low mutation alters the proliferation/differentiation potential of the common megakaryocytic-erythroid progenitor. (2006) (52)
A Single cis Element Maintains Repression of the Key Developmental Regulator Gata2 (2010) (52)
Flow-induced protein kinase A–CREB pathway acts via BMP signaling to promote HSC emergence (2015) (52)
Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis. (2008) (52)
Complexity of the erythroid transcription factor NF-E2 as revealed by gene targeting of the mouse p18 NF-E2 locus. (1996) (51)
Chipping away at the Embryonic Stem Cell Network (2005) (51)
Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation (2018) (51)
The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability (2015) (51)
Targeting of transgene expression to monocyte/macrophages by the gp91-phox promoter and consequent histiocytic malignancies. (1991) (50)
Regulation of haematopoietic multipotency by EZH1 (2017) (50)
Priming the hematopoietic pump. (2003) (50)
The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells (2016) (50)
Active human erythropoietin expressed in insect cells using a baculovirus vector: a role for N-linked oligosaccharide. (1987) (49)
Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA. (2019) (49)
Customizing the genome as therapy for the β-hemoglobinopathies. (2016) (48)
Isolation of mouse x-chromosome specific DNA from an x-enriched lambda phage library derived from flow sorted chromosomes. (2005) (47)
Inactivation of an acceptor RNA splice site by a short deletion in beta-thalassemia. (1983) (47)
Regulation of Peripheral Nerve Myelin Maintenance by Gene Repression through Polycomb Repressive Complex 2 (2015) (46)
Characterization of a spontaneous mutation to a beta-thalassemia allele. (1986) (46)
Abnormal processing of beta Knossos RNA (1984) (46)
Splice site mutations are a common cause of X-linked chronic granulomatous disease (1992) (46)
Oncology of infancy and childhood (2009) (45)
Increased gamma-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor. (1989) (45)
Decoding Hematopoietic Specificity in the Helix-Loop-Helix Domain of the Transcription Factor SCL/Tal-1 (2004) (44)
High fetal hemoglobin production in sickle cell anemia in the eastern province of Saudi Arabia is genetically determined. (1986) (44)
The search for the hemangioblast. (2002) (44)
Unraveling the transcriptional network controlling ES cell pluripotency (2006) (44)
Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2 (1993) (44)
Hematopoietic development of vav-/- mouse embryonic stem cells. (1994) (43)
Sickle Cell Disease at 100 Years (2010) (43)
beta-Thalassemia due to a deletion of the nucleotide which is substituted in the beta S-globin gene. (1983) (43)
Bone marrow transplantation for paroxysmal nocturnal hemoglobinuria: eradication of the PNH clone and documentation of complete lymphohematopoietic engraftment (1985) (42)
Failure to replicate the STAP cell phenomenon (2015) (42)
Sequential requirements for SCL/tal-1, GATA-2, macrophage colony-stimulating factor, and osteoclast differentiation factor/osteoprotegerin ligand in osteoclast development. (2000) (42)
Deletion of the A gamma-globin gene in G gamma-delta beta-thalassemia. (1979) (42)
Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis. (2016) (42)
Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development (2003) (41)
Paying for future success in gene therapy (2016) (40)
Restriction of neuroblastoma to the prostate gland in transgenic mice (1991) (40)
The duplicated human a globin genes lie close together in cellular DNA ( restriction enzyme mapping / molecular hybridization / gene linkage / a-thalassemia ) (40)
The CACCC-Binding Protein KLF3/BKLF Represses a Subset of KLF1/EKLF Target Genes and Is Required for Proper Erythroid Maturation In Vivo (2012) (40)
EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent (2017) (39)
Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling (2016) (39)
GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors. (2008) (39)
Prenatal diagnosis of hemoglobin disorders by DNA analysis. (1984) (39)
Comprar Nathan and Oski's Hematology of Infancy and Childhood, 7th Edition | David E. Fisher | 9781416034308 | Saunders (2009) (39)
Targeted Disruption of the EZH 2 / EED Complex Inhibits EZH 2-dependent Cancer (2013) (39)
Bone marrow transplantation for paroxysmal nocturnal hemoglobinuria: eradication of the PNH clone and documentation of complete lymphohematopoietic engraftment. (1985) (38)
Somatic gene therapy. Current status and future prospects. (1986) (38)
Modifier genes in Mendelian disorders: the example of hemoglobin disorders (2010) (37)
Heterogeneity of DNA deletion in gamma delta beta-thalassemia. (1981) (37)
Dnmt3a silences hematopoietic stem cell self-renewal (2011) (37)
LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice (2015) (36)
TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes. (2013) (36)
Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator* (2015) (36)
First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor (2017) (36)
An alpha-globin gene initiation codon mutation in a black family with HbH disease. (1987) (36)
The human von Willebrand factor gene. Structure of the 5' region. (1988) (35)
The transcription factor GATA2 regulates differentiation of brown adipocytes (2005) (35)
An Extended Transcriptional Network for Pluripotency of Embryonic Stem Cells (DOI:10.1016/j.cell.2008.02.039) (2008) (35)
Glimpses of the epigenetic landscape. (2009) (34)
Prenatal diagnosis of hemoglobinopathies. (1979) (33)
Hemoglobin genetics: recent contributions of GWAS and gene editing. (2016) (33)
Erythropoietin signaling regulates heme biosynthesis (2016) (33)
GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia (2013) (32)
DNA methylation in adult stem cells: New insights into self-renewal (2010) (32)
Strict in vivo specificity of the Bcl11a erythroid enhancer. (2016) (32)
Genome-wide association studies of hematologic phenotypes: a window into human hematopoiesis. (2013) (32)
Mutagenesis to aminopterin resistance in cultured hamster cells. (1971) (32)
Expression of c-MYC under the control of GATA-1 regulatory sequences causes erythroleukemia in transgenic mice (1995) (32)
Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis. (2021) (32)
Interferon-α signaling promotes embryonic HSC maturation. (2016) (32)
The use of altered specificity mutants to probe specific protein-protein interactions involved in the activation of GATA-1 target genes. (2002) (31)
TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network. (2019) (30)
Transcription factor competition at the γ-globin promoters controls hemoglobin switching (2021) (30)
Regulation of the myeloid-cell-expressed human gp91-phox gene as studied by transfer of yeast artificial chromosome clones into embryonic stem cells: suppression of a variegated cellular pattern of expression requires a full complement of distant cis elements (1997) (30)
Chronic granulomatous disease. Molecular genetics. (1988) (29)
Calpain 2 activation of P-TEFb drives megakaryocyte morphogenesis and is disrupted by leukemogenic GATA1 mutation. (2013) (29)
In vivo transcription of a human antithrombin III "minigene". (1984) (29)
Exome sequencing identifies GATA 1 mutations resulting in Diamond-Blackfan anemia (2012) (28)
PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia (2018) (28)
Site-directed, virus-free, and inducible RNAi in embryonic stem cells (2007) (28)
Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling (2015) (28)
PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer. (2017) (27)
Expression of the X-CGD gene during induced differentiation of myeloid leukemia cell line HL-60 (1988) (27)
Sumoylation Regulates Interaction of FOG1 with C-terminal-binding Protein (CTBP)* (2010) (26)
The molecular genetics of thalassemia. (1981) (26)
FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity (2018) (26)
Regional localization of the CCAAT displacement protein gene (CUTL1) to 7q22 by analysis of somatic cell hybrids. (1993) (26)
CRISPR-SURF: discovering regulatory elements by deconvolution of CRISPR tiling screen data (2018) (26)
Direct Detection of the Common Mediterranean (1983) (25)
Alternatively spliced platelet-derived growth factor A-chain transcripts are not tumor specific but encode normal cellular proteins (1990) (25)
Apoptosis: Cutting red-cell production (1999) (25)
14q32 and let-7 microRNAs regulate transcriptional networks in fetal and adult human erythroblasts (2018) (25)
Phosphorylation of Gata1 at serine residues 72, 142, and 310 is not essential for hematopoiesis in vivo. (2006) (25)
Abnormal processing of beta Knossos RNA. (1984) (25)
Erythroid Krüppel-Like Factor Is Essential for β-Globin Gene Expression Even in Absence of Gene Competition, But Is Not Sufficient to Induce the Switch From γ-Globin to β-Globin Gene Expression (1998) (24)
Mathematical modeling of erythrocyte chimerism informs genetic intervention strategies for sickle cell disease (2016) (24)
Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation (2018) (24)
Functional interrogation of non-coding DNA through CRISPR genome editing. (2017) (24)
Rb and hematopoiesis: stem cells to anemia (2008) (24)
Corepressor Rcor1 is essential for murine erythropoiesis. (2014) (23)
Enhancer dependence of cell-type–specific gene expression increases with developmental age (2020) (23)
Analysis of hemoglobin F production in Saudi Arabian families with sickle cell anemia. (1987) (23)
Corrigendum: LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice (2016) (22)
Preparing for the next generation. (1990) (22)
Translational Isoforms of FOG1 Regulate GATA1-interacting Complexes* (2009) (21)
Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model. (2015) (21)
Generation of a genomic reporter assay system for analysis of γ‐ and β‐globin gene regulation (2012) (21)
Cell-specific transcription and cell differentiation in the erythroid lineage. (1990) (20)
Xp21 DNA microdeletion in a patient with chronic granulomatous disease, retinitis pigmentosa, and McLeod phenotype (1988) (20)
Deficiency of the CACC-element binding protein, BKLF, leads to a progressive myeloproliferative disease and impaired expression of SHP-1. (1997) (20)
Transcriptional control of erythropoiesis. (1994) (20)
Multiplexed capture of spatial configuration and temporal dynamics of locus-specific 3D chromatin by biotinylated dCas9 (2020) (19)
Selective restriction endonuclease cleavage of human globin genes. (1978) (19)
Analysis of Hemoglobin F Production in Saudi Arabian Families With Sickle Cell Anemia (1987) (19)
CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types (2016) (19)
Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression. (2015) (19)
Sequence of the human GATA-1 promoter. (1992) (19)
Splice site mutations are a common cause of X-linked chronic granulomatous disease. (1992) (19)
Gene correction of HAX1 reversed Kostmann disease phenotype in patient-specific induced pluripotent stem cells. (2017) (18)
Nonsense and Frameshift Mutations in fI*-Thalassemia Detected in Cloned P-Globin (1981) (18)
Recent advances in globin research using genome‐wide association studies and gene editing (2016) (17)
Distinct and Combinatorial Functions of Jmjd 2 b / Kdm 4 b and Jmjd 2 c / Kdm 4 c in Mouse Embryonic Stem Cell Identity (2014) (17)
The molecular basis of alpha-thalassemias: frequent occurrence of dysfunctional alpha loci among non-Asians with Hb H disease. (1979) (17)
Erratum: Characterization of genomic deletion efficiency mediated by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells (The Journal of Biological Chemistry (2014) 289 (21312-21324) DOI: 10.1074/jbc.M114.564625) (2017) (17)
A Protein Roadmap to Pluripotency and Faithful Reprogramming (2008) (17)
Hydroxyurea increases fetal hemoglobin production in sickle cell anemia. (1984) (16)
Genetic diagnosis of the fetus (1982) (16)
More than blood, a Novel Gene Required for Mammalian Postimplantation Development (2004) (16)
Gene targeting and transgenic strategies for the analysis of hematopoietic development in the mouse. (2005) (16)
Centennial of Wilhelm Waldeyer’s introduction of the term “chromosome” (1988) (16)
Characterization of a Megakaryocyte-specific Enhancer of the Key Hemopoietic Transcription Factor GATA1* (2006) (16)
essential for cellular proliferation (2001) (15)
Linkage of the erythroid transcription factor gene (Gf-1) to the proximal region of the X chromosome of mice. (1991) (15)
Tandem affinity purification of protein complexes in mouse embryonic stem cells using in vivo biotinylation. (2009) (15)
A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations (2017) (15)
A unified model of human hemoglobin switching through single-cell genome editing (2021) (15)
required for self-renewal A genome-wide RNAi screen identifies a new transcriptional module Material (2009) (14)
MOLECULAR MEDICINE: Found in Translation. (2021) (14)
Rapid amplification of lambda gt11 bacteriophage library inserts from plaques using the polymerase chain reaction (PCR). (1989) (14)
Reactivation of a developmentally silenced embryonic globin gene (2021) (14)
Aberrant expression of platelet-derived growth factor A-chain cDNAs due to cryptic splicing of RNA transcripts in COS-1 cells. (1989) (14)
Enforced Expression of PU.1 Rescues Osteoclastogenesis from Embryonic Stem Cells Lacking Tal‐1 (2005) (14)
PRENATAL DIAGNOSIS OF HEMOGLOBINOPATHIES: THE NEW ENGLAND APPROACH * (1980) (14)
ATA box transcription mutation in beta-thalassemia. (1983) (14)
The thalassemias. (1976) (14)
Erythroid Krüppel-like factor is essential for beta-globin gene expression even in absence of gene competition, but is not sufficient to induce the switch from gamma-globin to beta-globin gene expression. (1998) (13)
CRISPResso: sequencing analysis toolbox for CRISPR genome editing (2015) (13)
Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells (2018) (13)
Regulation of the beta-globin locus. (1993) (13)
Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2 (1994) (13)
Transcriptional silencing of-globin by BCL 11 A involves long-range interactions and cooperation with SOX 6 Citation (2010) (13)
Immunology: Changed destiny (2007) (13)
Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture (2021) (13)
Fetal hemoglobin synthesis in erythroid cultures in hereditary persistence of fetal hemoglobin and beta o-thalassemia. (1984) (12)
A Transient Transgenic RNAi Strategy for Rapid Characterization of Gene Function during Embryonic Development (2010) (12)
ISOLATION OF DNA FRAGMENTS FROM CHROMOSOME 13 (1983) (12)
A rapid method for characterizing transgenic mice. (1990) (12)
The LSD1 Family of Histone Demethylases and the Pumilio Posttranscriptional Repressor Function in a Complex Regulatory Feedback Loop (2015) (12)
Lambda-chain production in human lymphoblast-mouse fibroblast hybrids. (1973) (12)
DNA polymorphism and molecular pathology of the human globin gene clusters (2004) (12)
Haploinsufficiency of Dnmt1 Impairs Leukemia Stem Cell Function Through Derepression of Bivalent Chromatin Domains (2011) (12)
13 Hematopoietic Stem Cells: Molecular Diversification and Developmental Interrelationships (2001) (12)
Molecular genetics of chronic granulomatous disease. (1989) (11)
Structural and functional defects in beta-thalassemia. (1983) (11)
Transcription Factors Regulating Early Hematopoietic Development and Lineage Commitment (1998) (10)
Guanine-adenine ligation-mediated PCR in vivo footprinting. (1997) (10)
Reduced Erg Dosage Impairs Survival of Hematopoietic Stem and Progenitor Cells (2017) (10)
The 3' untranslated regions of the duplicated human alpha-globin genes are unexpectedly divergent. (1980) (10)
GATA 1-Cre mediates Piga gene inactivation in the erythroid / megakaryocytic lineage and leads to circulating red cells with a partial deficiency in glycosyl phosphatidylinositol – linked proteins ( paroxysmal nocturnal hemoglobinuria type II cells ) (2001) (10)
Abnormal RNA splicing causes one form of alpha thalassemia. (1982) (10)
Localization of the human X-linked gene for chronic granulomatous disease to the mouse X chromosome: implications for X-chromosome evolution. (1988) (10)
Proteomic studies of stem cells (2008) (10)
Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids (2018) (10)
A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations (2017) (10)
MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets (2012) (10)
Post-meiotic transcription of phosphoglycerate-kinase 2 in mouse testes (1985) (10)
Mapping the evolving landscape of super-enhancers during cell differentiation (2021) (9)
Gene Transfer into Murine Hematopoietic Stem Cells and Bone Marrow Stromal Cells (1990) (9)
X-linked chronic granulomatous disease: from chromosomal position to the in vivo gene product (1987) (9)
PRC 2 Is Required to Maintain Expression of the Maternal Gtl 2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells (2015) (9)
Molecular genetics and potential gene therapy. (1986) (9)
Genetic Diagnosis by DNA Analysis (1987) (8)
Saudi Arabian Sickle Cell Anemia a (1989) (8)
Owl monkey gene mapping: the assignment of gene loci for catalase, beta-globin gene cluster, HRAS1, insulin, and parathyroid hormone. (1986) (8)
A Congenital Anemia Reveals Distinct Targeting Mechanisms for Master Transcription Factor GATA1. (2022) (8)
Gene therapy: Controlling the fetal globin switch in man (1983) (8)
Perturbed hematopoiesis in the Tc 1 mouse model of Down syndrome (2010) (7)
The duplicated human alpha-globin genes: their relative expression as measured by RNA analysis. (1981) (7)
A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia (2021) (7)
Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis (2022) (7)
Stem cells: The road not taken (2005) (7)
Chronic Myelogenous Leukemia – Initiating Cells Require Polycomb Group Protein EZH 2 (2016) (7)
Fidelity of globin ribonucleic acid synthesis in vitro by isolated nuclei: asymmetric gene expression. (1978) (7)
Musings on genome medicine: genome wide association studies (2009) (7)
A saturating mutagenesis CRISPR-Cas9–mediated functional genomic screen identifies cis- and trans-regulatory elements of Oct4 in murine ESCs (2019) (6)
Proposed Changes for NIH's Center for Scientific Review (1999) (6)
Arid4b is critical for mouse embryonic stem cell differentiation towards mesoderm and endoderm, linking epigenetics to pluripotency exit. (2020) (6)
Differentiation of murine erythroleukemic (friend) cells: An in vitro model of erythropoiesis (2007) (6)
Musings on genome medicine: enzyme-replacement therapy of the lysosomal storage diseases (2009) (6)
Stem cells down under-ISSCR 2007. (2007) (6)
Precise localization of human / 3-globin gene complex on chromosome 11 * ( DNA hybridization / hemoglobin ft chain / hemoglobin 6 chain / regional gene mapping ) (6)
Crispr-Cas9 Saturating Mutagenesis Reveals an Achilles Heel in the BCL11A Erythroid Enhancer for Fetal Hemoglobin Induction (by Genome Editing) (2015) (6)
An Achilles' Heel for MLL-Rearranged Leukemias: Writers and Readers of H3 Lysine 36 Dimethylation. (2016) (5)
interactions and cooperation with SOX 6-globin by BCL 11 A involves long-range γ Transcriptional silencing of Material Supplemental (2010) (5)
Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2 (2021) (5)
The co-repressor Rcor1 is essential for murine erythropoiesis (2014) (5)
Microcytic anemia in mk/mk mice is not corrected by retroviral-mediated gene transfer of wild-type p45 NF-E2. (1995) (5)
Deletion of the Ay-Globin Gene in G.-8,f-Thalassemia (1979) (5)
Cell differentiation: Plasticity and commitment — developmental decisions in the life of a cell (2001) (5)
Analysis of high fetal hemoglobin production in sickle cell anemia patients from the Eastern Province of Saudi Arabia. (1987) (5)
Gene therapy of somatic cells: status and prospects. (1988) (5)
Chromosome 21-Encoded miR-125b and Its Role in the Development of Myeloid Leukemia in Children with Down’s Syndrome. (2007) (4)
ErratumEpigenetic Antagonism between Polycomb and SWI/SNF Complexes during Oncogenic Transformation (2011) (4)
Transcriptional Plasticity Drives Leukemia Immune Escape (2021) (4)
Control of Hemoglobin Switching by BCL11A. (2009) (4)
LSD 1 is essential for oocyte meiotic progression by regulating CDC 25 B expression in mice (2015) (4)
Guanine-adenine ligation-mediated polymerase chain reaction in vivo footprinting. (1999) (4)
Live-animal imaging of native haematopoietic stem and progenitor cells (2020) (4)
Heterogeneity of DNA Deletion in y8,6-Thalassemia (2003) (4)
The Use of Cloned DNA Fragments to Study Human Disease (1981) (4)
Inability to Express HOXA Cluster and BCL11A Genes Compromises Self-Renewal and Multipotency of hESC-Derived Hematopoietic Cells (2012) (4)
Polycomb Repressive Complex 2 is essential for development and maintenance of a functional TEC compartment (2018) (4)
Identification Of BCL11A Structure-Function Domains For Fetal Hemoglobin Silencing (2013) (4)
Absence of Both the 9 lkD and 22 kD Subunits of Human Neutrophil Cytochrome b in Two Genetic Forms of Chronic Granulomatous Disease (2005) (4)
The LRF/ZBTB7A Transcription Factor Is a BCL11A-Independent Repressor of Fetal Hemoglobin (2015) (4)
Erythroid Kruppel-Like Factor (Eklf) Knock-Out Mice Exhibit Selective Beta-Globin Deficiency and Die Prenatally From Anemia (1994) (3)
Gene correction of HAX 1 reversed Kostmann disease phenotype in patient-speci fi c induced pluripotent stem cells (2017) (3)
Reawakening of Human Fetal Hemoglobin and an Epigenetic Path to the Clinic for Sickle Cell Disease and Beta-Thalassemia: Identification of an Orally-Available, Potent, and Selective Euchromatic Histone Lysine Methyltransferase 1 and 2 (EHMT1/2) Inhibitor (2017) (3)
Controlling the fetal globin switch in man. (1983) (3)
Musings on genome medicine: gene therapy (2009) (3)
Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells (2022) (3)
Training program in cancer and blood diseases: Pediatric Hematology/Oncology Fellowship Program, Children's Hospital Boston/Dana‐Farber Cancer Institute (2010) (3)
Studies on the overproduction of dihydrofolate reductase by variant hamster cells in culture. (1976) (3)
Chapter 12. Prenatal Analysis of Human DNA-Sequence Variation (1982) (3)
Fine-Mapping and Genome Editing Reveal An Essential Erythroid Enhancer At The HbF-Associated BCL11A Locus (2013) (3)
the mouse embryo Expression of CD 41 marks the initiation of definitive hematopoiesis in (2002) (3)
Optimization of Bcl11a Knockdown By miRNA Scaffold Embedded Shrnas Leading to Enhanced Induction of Fetal Hemoglobin in Erythroid Cells for the Treatment of Beta-Hemoglobinopathies (2014) (3)
Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells. (2022) (3)
Fetal Hemoglobin (HbF) Silencer BCL11A Acts through a Novel DNA-Motif in the Gamma-Globin Promoters, Simplifying the Model for Hemoglobin Switching (2017) (3)
Functional Defects In Neutrophils Derived From Ezh2 Null Mice (2013) (3)
Challenges and emerging directions in single-cell analysis (2017) (3)
Placenta Is a Niche for Hematopoietic Stem Cells. (2004) (3)
Unleashing Cell-Intrinsic Inflammation As a Strategy to Kill AML Blasts (2021) (3)
Functional proteomic analysis of repressive histone methyltransferase complexes PRC2 and G9A reveals ZNF518B as a G9A regulator (2015) (3)
Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer (2021) (3)
The entire beta-globin gene cluster is deleted in a form of gamma delta beta-thalassemia. (1983) (3)
Cyclin D 3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number Citation (2012) (3)
Hematopoietic SIN Lentiviral Micro RNA-Mediated Silencing of BCL11A: Pre-Clinical Evidence for a Sickle Cell Disease Gene-Therapy Trial (2012) (3)
Partial deletion of the alpha-globin structural gene in human alpha-thalassaemia. (1980) (3)
High-efficiency knock-in of degradable tags (dTAG) at endogenous loci in cell lines. (2023) (3)
cDNA and Amino Acid Sequence of Human Adenosine Deaminase a (1985) (3)
A Cell-Permeant Nanobody-Based Degrader That Induces Fetal Hemoglobin (2022) (2)
Eradication of Chronic Myelogenous Leukemia By Inactivation of the Polycomb Group Protein EZH2 (2014) (2)
Targeting of transgene expression to monocyte / macrophages by the gp 9 l-phox promoter and consequent histiocytic malignancies ( myeloid differentiation / cis-regulatory elements / neutrophfl cytochrome b ) (2)
Prostaglandin E2 Is a Potent Regulator of Vertebrate Hematopoietic Stem Cell Homeostasis. (2006) (2)
MOLECULAR CHARACTERIZATION OF SEVEN BETA THALASSEMIA IN ASIAN INDIAN (1984) (2)
Molecular analysis of human disease: dissection of beta-thalassemia. (1984) (2)
In vitro synthesis of a DNA probe for antisense globin sequences. (1977) (2)
A Genome-Wide Retroviral Insertional Mutagenesis Screen for Genes Cooperating with Truncated, Oncogenic GATA1s. (2005) (2)
CD49b identifies functionally and epigenetically distinct subsets of lineage-biased hematopoietic stem cells (2022) (2)
Transcriptional Control of Hematopoietic Development (1995) (2)
The pitfalls of sequencing: revised sequence of the X-CGD gene (1987) (2)
Primary Hemopoietic Progenitors andMyelopoiesis from Embryonic Stem Cells Notch Signaling Requires GATA-2 to Inhibit (2006) (2)
An erythroid-specific DNA binding factor mediates increased gamma-globin expression in hereditary persistence of fetal hemoglobin (HPFH). (1989) (2)
Delineating the mixed lineage leukemia gene expression network in hematopoietic stem cells (2013) (2)
InVivoFootprinting oftheHumano-Globin LocusUpstream Regulatory Element byGuanine andAdenineLigation- Mediated Polymerase ChainReaction (1992) (2)
Author response: Erythropoietin signaling regulates heme biosynthesis (2017) (2)
Fam210b Is Required for Optimal Cellular and Mitochondrial Iron Uptake during Erythroid Differentiation (2015) (2)
A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations (2017) (2)
X-linked chronic granulomatous disease: more than two years later. (1989) (2)
Brief Communication I-Thalassemia Due to a Deletion of the Nucleotide Which Is Substituted in the Ps5-Globin Gene (2006) (2)
Transcription factor competition at the γ-globin promoters controls hemoglobin switching (2021) (2)
Restriction site polymorphism in the phosphoglycerate kinase gene on the X chromosome (2004) (2)
Partial deletion of ,3-globin gene DNA in certain patients with f#-thalassemia (2)
Analysis of TIF1gamma Conditional Knockout Establishes a Requirement for the Differentiation of Multiple Hematopoietic Lineages (2010) (2)
14 – Role of Transcription Factor GATA-1 in the Differentiation of Hemopoietic Cells (1993) (1)
Genome Medicine: stem cells, genomics and translational research (2011) (1)
GATA- Binding Transcript ion Factors in Hema to poie t ic Cells (2016) (1)
SPECIFIC ABNORMALITIES OF GLOBIN GENE ORGANIZATION IN THE THALASSEMIA SYNDROMES * (1980) (1)
High-efficiency HDR in immortalized cell lines by crude rAAV mediated donor template delivery (2022) (1)
Where does the message begin? (1986) (1)
Characterization of a Megakaryocyte-Specific Enhancer of the Key Hemopoietic Transcription Factor GATA1. (2005) (1)
Reduced Erg Dosage Perturbs Fetal and Adult Hematopoiesis (2012) (1)
CUT&RUNTools: a flexible pipeline for CUT&RUN processing and footprint analysis (2019) (1)
The transcription factor, EKLF, is required for completion of the developmental switch from human gamma- to beta-globin gene expression (1995) (1)
Fetal Hemoglobin Regulation in Beta-Thalassemia. (2023) (1)
Musings on genome medicine: Hepatitis C (2010) (1)
Lin28b-Let-7-PRC1 Axis Guides Developmental Maturation of the Hematopoietic System (2021) (1)
The erythroid/myeloid lineage fate paradigm takes a new player (2011) (1)
Genetic diagnosis by DNA analysis: progress through amplification. (1987) (1)
cytochrome b in two genetic forms of chronic granulomatous disease Absence of both the 91kD and 22kD subunits of human neutrophil (2011) (1)
Characterizing heterogeneity in leukemic cells using single-cell gene expression analysis (2014) (1)
843 Potential role of the hematopoietic DNA-binding protein gata-1 in control of eosinophil specific gene transcription (1991) (1)
Transfer and expression of human ADA in murine hematopoietic stem cells. (1987) (1)
Functional Evaluation of HbF-Associated Region of BCL11A Locus (2011) (1)
Reactions to the Hwang scandal. (2006) (1)
mTOR Pathway Links Suppressed Autophagy to HDAC Inhibitor-Induced Apoptosis in Myeloid Leukemia, (2011) (1)
Enhancer-dependence of gene expression increases with developmental age (2019) (1)
Construction of an x-enriched lambda phage library from sorted mouse chromosomes. Abstr. (1981) (1)
ARID4B is critical for mouse embryonic stem cell differentiation towards mesoderm and endoderm, linking epigenetics to pluripotency exit. (2020) (1)
Oncogenic Potential of miR-125b-2 and its Target Genes in Normal and Malignant Hematopoesis (2009) (1)
Differentiation in Erythroleukemic Cells a (2016) (1)
Targeting Regulators of Hemoglobin F (2011) (1)
Correction of Murine Sickle Cell Disease Through Interference with Fetal Hemoglobin Silencing (2011) (1)
The Role of GATA‐1 and FOG in Erythroid and Megakaryocytic Differentiation (2002) (1)
A Molecular Signature of the Transcription Factor GATA1 in Acute Megakaryoblastic Leukemia of Childhood. (2004) (1)
Embryonic stem cells as sources of donor-independent platelets. (2015) (1)
The Role Of Sall4 In Embryonic Stem Cell Pluripotency (2010) (1)
review X-linked chronic granulomatous disease: from chromosomal position to the (1987) (1)
Unleashing cell-intrinsic inflammation as a strategy to kill AML blasts. (2022) (1)
Inflammatory signaling regulates the number of lymphoid progenitors and HSCs in the embryo (2014) (1)
Haploinsufficiency of GAtA-2 effects adult stem cell homeostasis. (2003) (1)
Corrigendum: Failure to replicate the STAP cell phenomenon (2015) (1)
Prenatal analysis of human DNA-sequence variation. (1982) (1)
Identity of different mutations for deleterious genes (reply) (1983) (1)
JAK2V617F and Loss of Ezh2 in Hematopoietic Cells Contribute Synergistically to Myeloproliferative Neoplasm Initiation Potential, and Accelerate Progression of Disease (2014) (1)
Production in Sickle Cell Anemia (1984) (0)
Matrin3 mediates differentiation through stabilizing chromatin accessibility and chromatin loop-domain interactions, and YY1 mediated enhancer-promoter interactions (2023) (0)
Decreased mRNA Expression and Altered Chromatin Configuration of Non-Globin Erythroid Krupple-Like Factor Target Genes in EKLF-Deficient Mice (2002) (0)
Figure 6, Strategies for mapping protein-protein and protein-DNA interactions in mESCs. (2008) (0)
"Forward" and "reverse" genetics of inherited human disorders: the thalassemia syndromes and chronic granulomatous disease. (1987) (0)
Abstract B157: Understanding the role of transcription factor ETV1 in metabolic reprogramming of prostate cells as a route to novel therapeutics. (2013) (0)
Gene expression-based chemical genomics identifies VPA to revert the oncogenic effect of GATA1s in Down syndrome leukemia (2009) (0)
3017 – MECHANISMS OF FLOW-DRIVEN TRANSCRIPTIONAL CONTROL OF HEMATOPOIETIC STEM CELL DEVELOPMENT VIA YAP/TAZ REGULATION (2022) (0)
domains . factor GATA-1 mediated by its zinc finger Self-association of the erythroid transcription (1995) (0)
Type 1 inositol polyphosphate-4-phosphatase influences growth of primary megakaryocytes and other cell types and is differentially expressed in the absence of GATA-1. (1999) (0)
Abstract 13395: A Systems-Biology Approach Reveals That MicroRNA-21 Integrates Diverse Pathogenic Signaling to Control Pulmonary Hypertension (2011) (0)
MUTATION OF THE WTl GENE IN WILMS ' TUMORS (2009) (0)
Genetic or Pharmacological Reductions in DNA Methylation Selectively Inhibit Peripheral T-Cell Lymphomagenesis. (2012) (0)
The 2017 ASPHO distinguished career award goes to Holcombe E. Grier, MD (2017) (0)
Running title: EKLF/KLF1 and KLF3 in erythropoiesis 3 (2012) (0)
Histone Demethylase LSD1 Is Required to Repress Hematopoietic Stem Cell Signatures in Mature Blood Cells to Permit Terminal Differentiation (2011) (0)
Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci (2017) (0)
Chapter 9 – Hematopoietic Stem Cell Biology (2018) (0)
AN INITIATION CODON MUTATION IN THE α1 GLOBIN GENE OF A BLACK FAMILY WITH HbH DISEASE (1987) (0)
progenitor cell production Inflammatory signaling regulates embryonic hematopoietic stem and Material (2014) (0)
Structure and Transcription of the Mouse Erythropoietin (0)
The Prevention of Thalassemia Antonio Cao and Yuet Wai Kan Classification of the Disorders of Hemoglobin (2013) (0)
PRC2 Inactivation Induces Resistance to Chemotherapy-Induced Apoptosis By Upregulating the TRAP1 Mitochondrial Chaperone in T-ALL (2018) (0)
Rapid Publication Hydroxyurea Enhances Fetal Hemoglobin Production in Sickle Cell Anemia (2013) (0)
Abstract PR03: Prmt1 and Prmt1-dependent translation initiation are critical vulnerabilities of osteosarcoma (2016) (0)
Generation of a genomic reporter assay system for analysis of (cid:1) - and (cid:2) -globin gene regulation (2020) (0)
Hg-123An Epigenomic Screen Reveals The Chromatin Remodeling Protein Bptf As A Driver Of High-Grade Glioma And Diffuse Intrinsic Pontine Glioma Growth In Vitro And In Vivo (2016) (0)
Gene Expression-Based Chemical Genomics Identifies Valproic Acid to Revert the Oncogenic Effect of GATA1s In Down Syndrome Megakaryoblastic Leukemia. (2010) (0)
Inner Nuclear Protein Matrin-3 Coordinates Hematopoietic Cell Transcription and Differentiation By Stabilizing Chromatin Architecture (2021) (0)
Author response: Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation (2018) (0)
Developmental Control of Polycomb Subunit Composition Mediates a Switch to Non-Canonical Functions during Hematopoiesis (2014) (0)
Compositions combinatoires et méthodes de traitement d'hémoglobinopathies (2012) (0)
Abstract IA05: Polycomb repressive complex-2 is a barrier to Kras-driven inflammation and epithelial-mesenchymal transition in non-small cell lung cancer (2016) (0)
Direct Promoter Repression by BCL 11 A Controls the Fetal to Adult Hemoglobin Switch Graphical Abstract Highlights (2018) (0)
This information is current as Hypersensitivity the Severity of Delayed-Type Pathway , Th 1 Polarization , and γ IL-12 / IFN-Response-Mediated Activation of the MicroRNA-21 Limits In Vivo Immune (2011) (0)
Protein interaction network for pluripotency of ES cells: Possible clues to organization of self-renewal machinery in other stem cells (2007) (0)
Retrovirus-Mediated GeneTransfer ofHumanAdenosine Deaminase: Expression ofFunctional EnzymeinMurine Hematopoietic StemCells InVivo (1987) (0)
Musings on genome medicine: the Obama effect (2009) (0)
Correction (1998) (0)
Abstract 3092: Deregulation of miR-10b in osteosarcoma. (2013) (0)
BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells (2019) (0)
Multiplexed capture of spatial configuration and temporal dynamics of locus-specific 3D chromatin by biotinylated dCas9 (2020) (0)
BCL11A modulation for the treatment of hemoglobinopathies (2009) (0)
Systematic tracking of cell fate changes (2010) (0)
3126 – HEMATOPOIETIC STEM CELLS WITH LYMPHOID BIAS ARE MARKED BY CD49B (2021) (0)
granulomatous disease Splice site mutations are a common cause of X-linked chronic (2011) (0)
Development of a Dominant Negative Model and a Proteoliposome Based Transport Assay for the Study of ABC-me, a Mitochondrial Transporter Involved in Heme Biosynthesis (2002) (0)
activity PRC 2 directly methylates GATA 4 and represses its transcriptional Material Supplemental (2012) (0)
Abstract LB076: Unleashing cell-intrinsic inflammation as a strategy to kill AML blasts (2022) (0)
Abstract 5393: ETV1 directs androgen metabolism and confers aggressive prostate cancer in engineered mice and patients. (2013) (0)
A myeloproliferative disorder in the Tc1 mouse model of Down syndrome (2008) (0)
Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells (2018) (0)
Calpain Drives Megakaryopoiesis by Targeting the 7SK snRNP Complex: A Connection to Down Syndrome Megakaryocytic Neoplasia (2011) (0)
ells lacking transcription factor GATA-1 (0)
Abstract LB-275: Single cell analysis identified LY6D as a novel marker of castration-resistant multipotent luminal progenitors (2016) (0)
Erythroid Cells Adapt to L-Leucine Scarcity By Reducing Hemoglobin Production Via the mTORC1/4E-BP Pathway (2014) (0)
An SCF-FBXW7 Ubiquitin Ligase Mediated Feedback Loop Facilitates GATA Factor Switching and Reinforces Commitment to Terminal Erythroid Maturation (2014) (0)
Genetics and Epigenetics of Fetal Hemoglobin Control (2013) (0)
potential of the common megakaryocytic-erythroid progenitor mutation alters the proliferation / differentiationlowThe hypomorphic (2006) (0)
RED CELLS , IRON , AND ERYTHROPOIESIS Strict in vivo speci fi city of the Bcl 11 a erythroid enhancer (2016) (0)
GATA1-Cre mediatesPigagene inactivation in the erythroid/megakaryocytic lineage and leads to circulating red cells with a partial deficiency in glycosyl phosphatidylinositol–linked proteins (paroxysmal nocturnal hemoglobinuria type II cells) (2001) (0)
Developmental Stage-Selective Effect of Somatically Mutated GATA-1 in Down Syndrome AML M7--a Potential Basis for Transient Myeloproliferative Disorder. (2004) (0)
Musings on genome medicine: abuse of genetic tests (2009) (0)
High throughput sequencing recovers the novel gene Megf8 as the ENU induced mutation causing single ventricle cardiac defect associated with randomized left-right patterning (2008) (0)
MicroRNA-21 Deficiency Leads to an Attenuated Asthma Response in Mice (2011) (0)
Scl represses cardiogenesis via distant enhancers during hemogenic endothelium specification (2013) (0)
Evolution of nanobodies specific for BCL11A (2023) (0)
314. Mathematical Modeling of Erythrocyte Chimerism Informs Clinical Strategies for Sickle Cell Disease (2016) (0)
Erythroid colony formation from mouse embryos lacking the erythropoietin receptor is rescued by thrombopoietin (1996) (0)
Neutrophils Derived from Ezh2 -/- Progenitor Cells Demonstrate Aberrant Erythroid Lineage Gene Expression (2015) (0)
DISNEYLAND HOTEL MAP OF FACILITIES (1987) (0)
Target of Erythropoietin, Fam210b, Regulates Erythroid Heme Synthesis By Control of Mitochondrial Iron Import and Regulation of Fech Activity (2018) (0)
Supplementary Information for : Fetal hemoglobin persistence and neurodevelopmental alterations due to BCL 11 A deletions (2015) (0)
Histone demethylome map reveals combinatorial gene regulatory functions in embryonic stem cells (2020) (0)
Figure 2, Schematic depiction of LC-MS/MS procedure. (2008) (0)
Genomic Determinants of Human Fetal and Adult Erythroid Gene Expression (2012) (0)
Figure 5A, A protein interaction network in mESCs. (2008) (0)
DARIC, a Computational Framework for Identifying Quantitatively Differential Compartments from Hi-C Data (2022) (0)
New Strategies to Define Regulators of Fetal Hemoglobin (2010) (0)
Leukemia core transcriptional circuitry is a sparsely interconnected hierarchy stabilized by incoherent feed-forward loops (2023) (0)
Polycomb deficiency drives a FOXP2-high aggressive state targetable by epigenetic inhibitors (2023) (0)
785 PREMATURE TERMINATION OF OXIDATIVE BURST IN GLUTATHI-ONE PEROXIDASE DEFICIENT RAT NEUTROPHILS (1981) (0)
Molecular dissection of SCL helix-loop-helix domain. (2003) (0)
Reactivation of fetal hemoglobin for therapy: From GWAS to the clinic (2018) (0)
Dietary suppression of MHC-II expression in intestinal stem cells enhances intestinal tumorigenesis (2020) (0)
HbF-Associated Genetic Variation Marks an Erythroid Regulatory Element Essential for BCL11A Transcription and Subsequent Stage-Specific Globin Expression (2012) (0)
Exploring the Mechanisms of Pathogenesis in Prostate Cancer Involving TMPRSS2-ERG (Or ETV1) Gene Rearrangement (2008) (0)
748 RELATIVE EXPRESSION OF THE α-GLOBIN GENES IN MAN DURING DEVELOPMENT (1981) (0)
I N ormal commitment but impaired maturation of cardiomyocytes from induced pluripotent stem cells (2009) (0)
Musings on genome medicine: the Obama effect redux (2009) (0)
Rational Targeting of a NuRD Sub-Complex for Fetal Hemoglobin Induction Following Comprehensive in Situ Mutagenesis (2018) (0)
Comprar Oncology of Infancy and Childhood - Expert Consult - Online and Print | David E. Fisher | 9781416034315 | Saunders (2008) (0)
Developmental Stage-Specific Interplay Between GATA1 and IGF Signaling in Fetal Hematopoiesis and Leukemogenesis. (2009) (0)
Fetal Hemoglobin Silencing Correction of Sickle Cell Disease in Adult Mice by Interference with (2014) (0)
Musings on genome medicine: Crohn's disease (2009) (0)
Targeting of transgene expression to monocytes by cytochrome b heavy chain gene 5'-flanking sequences induces histiocytic malignancies. (1990) (0)
RED CELLS , IRON , AND ERYTHROPOIESIS Corepressor Rcor 1 is essential for murine erythropoiesis (2014) (0)
CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types (2016) (0)
Dissecting super-enhancer hierarchy based on chromatin interactions (2018) (0)
Inflammatory Signaling Regulates Embryonic Hematopoietic Stem and Lymphoid Progenitor Cell Formation (2014) (0)
Activity of X-linked genes in stem and differentiated Mus musculus X Mus caroli hybrid cells. (1984) (0)
Genome-Wide CRISPR/Cas9 Screen Reveals That the Dcps Scavenger Decapping Enzyme Is Essential for AML Cell Survival (2017) (0)
2014 William Allan Award: A hematologist's pursuit of hemoglobin genetics. (2015) (0)
William Allan Award : A Hematologist ’ s Pursuit of Hemoglobin Genetics 1 (2015) (0)
Abstract 2965: ERG and ETV1 regulate a common transcriptional network in prostate cells but in an opposite fashion (2012) (0)
Abstract LB-35: ETV6-NTRK3 basal-like breast cancers originating from Wap+ breast cells progress through a premalignant stage enriched in luminal progenitors (2011) (0)
Transcriptional Immunoediting of AML Cells after Allogeneic Hematopoietic Stem Cell Transplantation (2021) (0)
Musings on genome medicine: cholesterol and coronary artery disease (2009) (0)
Animal cloning and related embryo research: implications for medicine. (1997) (0)
Proffered Paper: Exploring prostate progenitor compartment complexity as a route of targeting prostate cancer heterogeneity (2016) (0)
X-Chromosome Clonal Analysis Using Recombinant DNA Probes from the Updated (2006) (0)
Cell Rb and hematopoiesis: stem cells to anemia (2008) (0)
HEMATOPOIESIS AND STEM CELLS Interferon- a signaling promotes embryonic HSC maturation (2016) (0)
erythrocyte size and number Cyclin D 3 coordinates the cell cycle during differentiation to regulate Material Supplemental (2012) (0)
Rapid-kinetics degron benchmarking reveals off-target activities and mixed agonism-antagonism of MYB inhibitors (2023) (0)
p 45 NF-E 2 regulates expression of thromboxane synthase in megakaryocytes 1991 (2013) (0)
Hematopoietic Stem Cells Emerge in the Placental Vasculature in the Absence of Circulation. (2007) (0)
Molecular Regulation of the State of Embryonic Stem Cells (2009) (0)
First occurrence of Hb H in Hungary. (1986) (0)
Musings on genome medicine: the slow but inexorable process of medical care reform in the United States (2009) (0)
GATA1s Mutant Protein Contributes to “Down” Syndrome Megakaryoblastic Leukemia by Derepression of E2F Targets. (2008) (0)
locus in ES cells Oct 4 dependence of chromatin structure within the extended Nanog (2007) (0)
PRC 2 Is Required to Maint ain Expression of the Maternal Gtl 2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells Graphical (2015) (0)
Polycomb Repressive Complex 2 is essential for development and maintenance of a functional TEC compartment (2018) (0)
Integrated genomic analysis of AgRP neurons reveals that IRF3 regulates leptin’s hunger-suppressing effects (2022) (0)
Analysis of the GATA-1 Gene Promoter and Globin Locus Control Region Elements by in Vivo Footprinting (1997) (0)
ADAR1 Is Essential For Erythroid Development (2013) (0)
Basic Kruppel-like factor recruits multiple co-repressors to silence gene expression (2003) (0)
Figure 4, Strategy for affinity purification of Nanog associated protein complexes in mESCs. (2008) (0)
Defining the structure, signals, and cellular elements of the gastric mesenchymal niche (2023) (0)
Reactivation of Silenced Human HbF In Adult Mice by Inactivation of BCL11A (2010) (0)
Figure 1, Summary of proteomic approaches utilized in the study of stem cells. (2008) (0)
Haig H. Kazazian, Jr. (1937–2022) (2022) (0)
Targeted deletion of Eed arrests thymus development (HEM7P.225) (2015) (0)
Networking Erythropoiesis The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters (2010) (0)
Musings on genome medicine: cancer genetics and the promise of effective treatment (2009) (0)
282. Circumventing Hematopoietic Toxicities and Reversing Sickle Phenotype by Lineage-Specific BCL11A Knock Down and γ-Globin Induction (2016) (0)
Latent Cardiogenic Potential in Endocardium and Hemogenic Endothelium Revealed in the Absence of Scl/tal1 (2011) (0)
Figure 3A, Schematic depiction of two affinity purification approaches. (2008) (0)
Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-PRC1 axis (2022) (0)
Optimized Beta-Globin Expression and Enucleation from Induced Red Blood Cells for In Vitro Modeling of Sickle Cell Disease (2018) (0)
Mouse Model of Human Breast Cancer Initiated by a Fusion Oncogene (2006) (0)
Induction of Fetal Hemoglobin by Inactivation of HDAC1 or HDAC2 without Altering Cellular Proliferation (2011) (0)
Author Correction: Transcription factor competition at the γ-globin promoters controls hemoglobin switching (2021) (0)
lymphohematopoietic engraftment eradication of the PNH clone and documentation of complete Bone marrow transplantation for paroxysmal nocturnal hemoglobinuria (2011) (0)
549 VISUALIZATION OF HUMAN GLOBIN GENES BY RESTRICTION ENDONUCLEASE MAPPING: A NEW APPROACH TO THE PRENATAL DIAGNOSIS OF GLOBIN GENE DELETION (1978) (0)
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors (2016) (0)
High-Resolution CRISPR Functional Genomics Reveals Critical Vulnerabilities of the NuRD Complex for Fetal Hemoglobin Control (2017) (0)
Core Transcriptional Regulatory Circuitries in AML (2019) (0)
Scl/Tal1 Directly Activates Hematopoiesis and Represses Cardiogenesis During Mesodermal Diversification (2012) (0)
functional interaction with Sp1 expression in hematopoietic cells through c-kit The SCL complex regulates (2010) (0)
Abstract 4234: A genome-wide RNAi screen implicates histone deacetylases as a therapeutic target for osteosarcoma (2012) (0)
The molecular genetics of thalassemia. (1976) (0)
Context Dependent Role of Polycomb Repressive Complex 2 in Acute Leukemia (2014) (0)
Identification of critical residues for the function of the bHLH transcription factor SCL in hematopoietic stem cells. (2003) (0)
Targeting a Putative Intronic Splicing Silencer Salvages Expression from the Recurrent SBDS C.258+2T>C Mutant Allele in Shwachman-Diamond Syndrome Patient Cells and Mouse Model (2022) (0)
Abstract PR14: Polycomb repressive complex 2 inactivation induces primary chemotherapy resistance in T-ALL by upregulating the TRAP1 mitochondrial chaperone (2017) (0)
Genetic heterogeneity is extensive in beta thalassemia (1983) (0)
Abstract LB-237: Epigenetic antagonism between Polycomb and SWI/SNF complexes duringoncogenic transformation (2010) (0)

This paper list is powered by the following services:

Other Resources About Stuart Orkin

en.wikipedia.org

What Schools Are Affiliated With Stuart Orkin?

Stuart Orkin is affiliated with the following schools:

Stuart Orkin's Academic­Influence.com Rankings