Svante Pääbo
Swedish geneticist
Svante Pääbo's AcademicInfluence.com Rankings
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Biology
Svante Pääbo's Degrees
- PhD Cellular Immunology Uppsala University
Why Is Svante Pääbo Influential?
(Suggest an Edit or Addition)Svante Pääbo is the director of the Department of Genetics at the Max Planck Institute for Evolutionary Anthropology and an expert in the field of evolutionary genetics. He earned his Ph.D. from Uppsala University.
Among the founders of the field of paleogenetics, Pääbo has conducted significant research into early human genetics and has successfully sequenced Neanderthal mitochondrial DNA from a sample found in modern-day Germany. In 2009, he and his colleagues announced that they had completed their first attempt at a complete mapping of the Neanderthal genome. This discovery was followed in 2010 by findings that a fingerbone found in Siberia belonged to a previously undiscovered human ancestor, the Denisova hominin.
He has been honored with the Gottfried Wilhelm Leibniz Prize of the Deutsche Forschungsgemeinschaft, the Louis-Jeantet Prize for Medicine, the Kistler Prize, the Theodor Bucher Medal for outstanding achievements in biochemistry and molecular biology, the Gruber Prize in Genetics, and the Princess of Asturias Award.
Although his findings are not always immediately accepted by the scientific community, particularly as it pertains to interbreeding between early Neanderthals and Denisovans, he has contributed vastly to our understanding of early human ancestry. He published a book that was half-memoir, half-science called Neanderthal Man: In Search of Lost Genomes, in which he talks about his scientific work and his own life.
Featured in Top Influential Biologists Today
According to Wikipedia, Svante Pääbo is a Swedish geneticist and Nobel Laureate who specialises in the field of evolutionary genetics. As one of the founders of paleogenetics, he has worked extensively on the Neanderthal genome. In 1997, he became founding director of the Department of Genetics at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany. Since 1999, he has been an honorary professor at Leipzig University; he currently teaches molecular evolutionary biology at the university. He is also an adjunct professor at Okinawa Institute of Science and Technology, Japan.
Svante Pääbo's Published Works
Published Works
- Dynamics of mitochondrial DNA evolution in animals: amplification and sequencing with conserved primers. (1989) (4850)
- A Draft Sequence of the Neandertal Genome (2010) (3419)
- Initial sequence of the chimpanzee genome and comparison with the human genome (2005) (2222)
- Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome (2007) (2091)
- The complete genome sequence of a Neandertal from the Altai Mountains (2013) (1644)
- A High-Coverage Genome Sequence from an Archaic Denisovan Individual (2012) (1587)
- Genetic history of an archaic hominin group from Denisova Cave in Siberia (2010) (1503)
- Mitochondrial genome variation and the origin of modern humans (2000) (1416)
- Molecular evolution of FOXP2, a gene involved in speech and language (2002) (1358)
- Neandertal DNA Sequences and the Origin of Modern Humans (1997) (1260)
- Genetic analyses from ancient DNA. (2004) (1163)
- Ancient human genomes suggest three ancestral populations for present-day Europeans (2013) (1082)
- The evolution of gene expression levels in mammalian organs (2011) (1052)
- The Simons Genome Diversity Project: 300 genomes from 142 diverse populations (2016) (1009)
- Complete mitochondrial genome sequence of a Middle Pleistocene cave bear reconstructed from ultrashort DNA fragments (2013) (1001)
- Ancient DNA: extraction, characterization, molecular cloning, and enzymatic amplification. (1989) (958)
- Deep proteome and transcriptome mapping of a human cancer cell line (2011) (935)
- Intra- and Interspecific Variation in Primate Gene Expression Patterns (2002) (840)
- Genome sequence of a 45,000-year-old modern human from western Siberia (2014) (768)
- Human cerebral organoids recapitulate gene expression programs of fetal neocortex development (2015) (761)
- Patterns of damage in genomic DNA sequences from a Neandertal (2007) (743)
- Analysis of one million base pairs of Neanderthal DNA (2006) (706)
- The genetic history of Ice Age Europe (2016) (678)
- The complete mitochondrial DNA genome of an unknown hominin from southern Siberia (2010) (637)
- DNA sequences from multiple amplifications reveal artifacts induced by cytosine deamination in ancient DNA. (2001) (627)
- Parallel Patterns of Evolution in the Genomes and Transcriptomes of Humans and Chimpanzees (2005) (594)
- Amino Acid Analysis and Enzymatic Sequence Determination of Peptides by an Improved o-Phthaldialdehyde Precolumn Labeling Procedure (1981) (585)
- Global Patterns of Linkage Disequilibrium at the CD4 Locus and Modern Human Origins (1996) (579)
- Sequencing and Analysis of Neanderthal Genomic DNA (2006) (575)
- An early modern human from Romania with a recent Neanderthal ancestor (2015) (544)
- Molecular cloning of Ancient Egyptian mummy DNA (1985) (541)
- A Complete Neandertal Mitochondrial Genome Sequence Determined by High-Throughput Sequencing (2008) (539)
- Denisova admixture and the first modern human dispersals into Southeast Asia and Oceania. (2011) (520)
- The Derived FOXP2 Variant of Modern Humans Was Shared with Neandertals (2007) (518)
- DNA damage promotes jumping between templates during enzymatic amplification. (1990) (506)
- DNA extraction from Pleistocene bones by a silica-based purification method. (1993) (501)
- A Revised Timescale for Human Evolution Based on Ancient Mitochondrial Genomes (2013) (497)
- Targeted Retrieval and Analysis of Five Neandertal mtDNA Genomes (2009) (496)
- Extensive mitochondrial diversity within a single Amerindian tribe. (1991) (491)
- Multiplexed DNA Sequence Capture of Mitochondrial Genomes Using PCR Products (2010) (484)
- Sympatric speciation suggested by monophyly of crater lake cichlids (1994) (472)
- The genomic landscape of Neanderthal ancestry in present-day humans. (2014) (469)
- A Humanized Version of Foxp2 Affects Cortico-Basal Ganglia Circuits in Mice (2009) (465)
- The landscape of Neandertal ancestry in present-day humans (2014) (464)
- Molecular coproscopy: dung and diet of the extinct ground sloth Nothrotheriops shastensis. (1998) (462)
- Generation times in wild chimpanzees and gorillas suggest earlier divergence times in great ape and human evolution (2012) (459)
- Mitochondrial DNA sequences from a 7000-year old brain. (1988) (458)
- DNA analysis of an early modern human from Tianyuan Cave, China (2013) (458)
- The bonobo genome compared with the chimpanzee and human genomes (2012) (455)
- Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion (2015) (454)
- Loss of Olfactory Receptor Genes Coincides with the Acquisition of Full Trichromatic Vision in Primates (2004) (442)
- Complete Mitochondrial Genomes of Ancient Canids Suggest a European Origin of Domestic Dogs (2013) (424)
- A mitochondrial genome sequence of a hominin from Sima de los Huesos (2013) (423)
- Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico (2013) (419)
- Accelerated Evolution of Conserved Noncoding Sequences in Humans (2006) (416)
- A high-coverage Neandertal genome from Vindija Cave in Croatia (2017) (410)
- No Evidence of Neandertal mtDNA Contribution to Early Modern Humans (2004) (409)
- The Date of Interbreeding between Neandertals and Modern Humans (2012) (399)
- Removal of deaminated cytosines and detection of in vivo methylation in ancient DNA (2009) (397)
- DNA damage and DNA sequence retrieval from ancient tissues. (1996) (397)
- A genome-wide comparison of recent chimpanzee and human segmental duplications (2005) (396)
- Evidence for gradients of human genetic diversity within and among continents. (2004) (390)
- Temporal Patterns of Nucleotide Misincorporations and DNA Fragmentation in Ancient DNA (2012) (389)
- Nuclear DNA sequences from the Middle Pleistocene Sima de los Huesos hominins (2016) (389)
- Ancient DNA and the polymerase chain reaction. The emerging field of molecular archaeology. (1989) (385)
- Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells (2006) (384)
- Amino Acid Racemization and the Preservation of Ancient DNA (1996) (379)
- Organoid single-cell genomic atlas uncovers human-specific features of brain development (2019) (374)
- Excavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals (2016) (362)
- A Neutral Model of Transcriptome Evolution (2004) (361)
- Genomewide comparison of DNA sequences between humans and chimpanzees. (2002) (355)
- The major genetic risk factor for severe COVID-19 is inherited from Neanderthals (2020) (350)
- A view of Neandertal genetic diversity (2000) (349)
- Ancient gene flow from early modern humans into Eastern Neanderthals (2016) (339)
- Excrement analysis by PCR (1992) (333)
- Transcriptional neoteny in the human brain (2009) (330)
- Impaired intracellular transport of class I MHC antigens as a possible means for adenoviruses to evade immune surveillance (1985) (327)
- The retrieval of ancient human DNA sequences. (1996) (323)
- Separating endogenous ancient DNA from modern day contamination in a Siberian Neandertal (2014) (323)
- Regional patterns of gene expression in human and chimpanzee brains. (2004) (323)
- DNA sequence of the mitochondrial hypervariable region II from the neandertal type specimen. (1999) (322)
- The marsupial mitochondrial genome and the evolution of placental mammals. (1994) (321)
- Evolution of primate gene expression (2006) (313)
- A neutral explanation for the correlation of diversity with recombination rates in humans. (2003) (297)
- Neanderthals in central Asia and Siberia (2007) (295)
- Early Allelic Selection in Maize as Revealed by Ancient DNA (2003) (291)
- Fine-scale recombination patterns differ between chimpanzees and humans (2005) (288)
- Mitochondrial genomes reveal an explosive radiation of extinct and extant bears near the Miocene-Pliocene boundary (2008) (280)
- The genome of the offspring of a Neandertal mother and a Denisovan father (2018) (280)
- A Complete mtDNA Genome of an Early Modern Human from Kostenki, Russia (2010) (277)
- Targeted Investigation of the Neandertal Genome by Array-Based Sequence Capture (2010) (277)
- Human specific loss of olfactory receptor genes (2003) (276)
- Impaired Synaptic Plasticity and Motor Learning in Mice with a Point Mutation Implicated in Human Speech Deficits (2008) (274)
- Ancient DNA damage. (2013) (272)
- Genes and languages in Europe: an analysis of mitochondrial lineages. (1995) (264)
- Reconstructing Prehistoric African Population Structure (2017) (256)
- Transcriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal (2012) (254)
- Unreliable mtDNA data due to nuclear insertions: a cautionary tale from analysis of humans and other great apes (2004) (254)
- Independent origins of New Zealand moas and kiwis. (1992) (252)
- Paternal and maternal DNA lineages reveal a bottleneck in the founding of the Finnish population. (1996) (247)
- Neandertal and Denisovan DNA from Pleistocene sediments (2017) (245)
- DNA phylogeny of the extinct marsupial wolf (1989) (241)
- Genomic Sequencing of Pleistocene Cave Bears (2005) (240)
- DNA sequence variation in a non-coding region of low recombination on the human X chromosome (1999) (239)
- Multiplex amplification of the mammoth mitochondrial genome and the evolution of Elephantidae (2006) (238)
- Conflict Among Individual Mitochondrial Proteins in Resolving the Phylogeny of Eutherian Orders (1998) (234)
- A nuclear 'fossil' of the mitochondrial D-loop and the origin of modern humans (1995) (229)
- DNA sequence and comparative analysis of chimpanzee chromosome 22 (2004) (227)
- Conservation genetics of the European brown bear ‐ a study using excremental PCR of nuclear and mitochondrial sequences (1995) (225)
- Lack of phylogeography in European mammals before the last glaciation. (2004) (223)
- mtDNA analysis of Nile River Valley populations: A genetic corridor or a barrier to migration? (1999) (222)
- Great ape DNA sequences reveal a reduced diversity and an expansion in humans (2001) (222)
- The Neandertal type site revisited: Interdisciplinary investigations of skeletal remains from the Neander Valley, Germany (2002) (221)
- Extensive nuclear DNA sequence diversity among chimpanzees. (1999) (216)
- Demographic history and linkage disequilibrium in human populations (1997) (213)
- MicroRNA-Driven Developmental Remodeling in the Brain Distinguishes Humans from Other Primates (2011) (213)
- Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques. (2012) (212)
- Amplifying ancient DNA (1990) (208)
- Patterns of coding variation in the complete exomes of three Neandertals (2014) (207)
- Ancient DNA: Methodological challenges (1994) (203)
- Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne (2016) (201)
- A recent evolutionary change affects a regulatory element in the human FOXP2 gene. (2013) (196)
- Genetic and linguistic differentiation in the Americas. (1993) (196)
- Mitochondrial DNA sequencing of shed hairs and saliva on robbery caps: sensitivity and matching probabilities. (1998) (194)
- Reconstructing the DNA Methylation Maps of the Neandertal and the Denisovan (2014) (192)
- Ancient DNA (2001) (190)
- Patterns of nucleotide misincorporations during enzymatic amplification and direct large-scale sequencing of ancient DNA (2006) (185)
- Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline (2010) (183)
- Minisatellite diversity supports a recent African origin for modern humans (1996) (182)
- A short sequence in the COOH-terminus makes an adenovirus membrane glycoprotein a resident of the endoplasmic reticulum (1987) (180)
- FUNC: a package for detecting significant associations between gene sets and ontological annotations (2007) (179)
- Aging and Gene Expression in the Primate Brain (2005) (173)
- Why do human diversity levels vary at a megabase scale? (2005) (173)
- Differences and similarities between human and chimpanzee neural progenitors during cerebral cortex development (2016) (171)
- Reconstructing the Genetic History of Late Neandertals (2018) (170)
- Transfer RNA editing in land snail mitochondria. (1995) (163)
- Identification of Farnesoid X Receptor β as a Novel Mammalian Nuclear Receptor Sensing Lanosterol (2003) (163)
- A molecular analysis of ground sloth diet through the last glaciation (2000) (163)
- The mosaic that is our genome (2003) (161)
- The Neandertal genome and ancient DNA authenticity (2009) (161)
- Mapping Genes through the Use of Linkage Disequilibrium Generated by Genetic Drift: ‘Drift Mapping’ in Small Populations with No Demographic Expansion (1998) (161)
- Polymerase chain reaction reveals cloning artefacts (1988) (159)
- Demographic History and Genetic Differentiation in Apes (2006) (157)
- Natural selection on the olfactory receptor gene family in humans and chimpanzees. (2003) (157)
- mtDNA sequence diversity in Africa. (1996) (156)
- Nuclear and mitochondrial DNA sequences from two Denisovan individuals (2015) (150)
- The makers of the Protoaurignacian and implications for Neandertal extinction (2015) (147)
- Insulinoma-Associated 1 Has a Panneurogenic Role and Promotes the Generation and Expansion of Basal Progenitors in the Developing Mouse Neocortex (2008) (147)
- Sex determination of ancient human skeletons using DNA. (1996) (146)
- Molecular phylogeny of the extinct ground sloth Mylodon darwinii. (1996) (145)
- Evolution of maize inferred from sequence diversity of an Adh2 gene segment from archaeological specimens. (1993) (142)
- 40,000-Year-Old Individual from Asia Provides Insight into Early Population Structure in Eurasia (2017) (141)
- Phylogenetic relationships among eutherian orders estimated from inferred sequences of mitochondrial proteins: Instability of a tree based on a single gene (1994) (139)
- The complex evolutionary history of gorillas: insights from genomic data. (2006) (137)
- The Origin of Planetary Impactors in the Inner Solar System (2005) (137)
- The Human Condition—A Molecular Approach (2014) (136)
- Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance (2014) (135)
- Nuclear Gene Sequences from a Late Pleistocene Sloth Coprolite (2003) (134)
- A molecular analysis of dietary diversity for three archaic Native Americans (2001) (134)
- Nuclear DNA sequences from late Pleistocene megafauna. (1999) (133)
- Absence of the TAP2 Human Recombination Hotspot in Chimpanzees (2004) (132)
- Evidence for a complex demographic history of chimpanzees. (2004) (132)
- Phenotypic differences in behavior, physiology and neurochemistry between rats selected for tameness and for defensive aggression towards humans (2008) (130)
- Limits of long-term selection against Neandertal introgression (2019) (128)
- Ancient DNA analyses reveal high mitochondrial DNA sequence diversity and parallel morphological evolution of late pleistocene cave bears. (2002) (127)
- MicroRNA Expression and Regulation in Human, Chimpanzee, and Macaque Brains (2011) (127)
- The population history of extant and extinct hyenas. (2005) (126)
- Pleistocene North African genomes link Near Eastern and sub-Saharan African human populations (2018) (125)
- Identification of a new hominin bone from Denisova Cave, Siberia using collagen fingerprinting and mitochondrial DNA analysis (2016) (125)
- From micrograms to picograms: quantitative PCR reduces the material demands of high-throughput sequencing (2007) (125)
- Editing of a tRNA anticodon in marsupial mitochondria changes its codon recognition. (1993) (124)
- Age estimates for hominin fossils and the onset of the Upper Palaeolithic at Denisova Cave (2019) (122)
- Molecular breeding of polymerases for amplification of ancient DNA (2007) (122)
- Evolution of bitter taste receptors in humans and apes. (2005) (120)
- Evidence for Reproductive Isolation between Cave Bear Populations (2004) (119)
- A high-coverage Neandertal genome from Chagyrskaya Cave (2020) (119)
- A Comparison of Brain Gene Expression Levels in Domesticated and Wild Animals (2012) (119)
- Organization and Evolution of Brain Lipidome Revealed by Large-Scale Analysis of Human, Chimpanzee, Macaque, and Mouse Tissues (2015) (118)
- Genetic Architecture of Tameness in a Rat Model of Animal Domestication (2009) (117)
- Humanized Foxp2 specifically affects cortico-basal ganglia circuits (2011) (117)
- Initial Upper Palaeolithic Homo sapiens from Bacho Kiro Cave, Bulgaria (2020) (116)
- The genetical archaeology of the human genome (1996) (115)
- A genomic region associated with protection against severe COVID-19 is inherited from Neandertals (2021) (115)
- The Human Genome and Our View of Ourselves (2001) (112)
- Toward a Neutral Evolutionary Model of Gene Expression (2005) (112)
- Computational challenges in the analysis of ancient DNA (2010) (109)
- Molecular analysis of H-2-deficient lymphoma lines. Distinct defects in biosynthesis and association of MHC class I heavy chains and beta 2-microglobulin observed in cells with increased sensitivity to NK cell lysis. (1989) (107)
- Muscular Thin Films for Building Actuators and Powering Devices (2007) (102)
- The genetical history of humans and the great apes (2002) (100)
- Nuclear insertion sequences of mitochondrial DNA predominate in hair but not in blood of elephants (1999) (100)
- Lineage-Specific Expansions of Retroviral Insertions within the Genomes of African Great Apes but Not Humans and Orangutans (2005) (98)
- The mitochondrial genome of the hemichordate Balanoglossus carnosus and the evolution of deuterostome mitochondria. (1998) (97)
- Metabolic changes in schizophrenia and human brain evolution (2008) (97)
- Adenoviruses of subgenera B, C, D, and E modulate cell-surface expression of major histocompatibility complex class I antigens. (1986) (96)
- Mitochondrial DNA sequences from Switzerland reveal striking homogeneity of European populations. (1994) (96)
- Gene expression becomes heterogeneous with age (2006) (94)
- A late Neandertal femur from Les Rochers-de-Villeneuve, France. (2005) (92)
- Miocene DNA sequences — a dream come true? (1991) (91)
- tRNA editing in metazoans (1995) (90)
- Spatial and temporal continuity of kangaroo rat populations shown by sequencing mitochondrial DNA from museum specimens (1990) (89)
- Decreased aminoacylation of mutant tRNAs in MELAS but not in MERRF patients. (2000) (88)
- Direct dating of Neanderthal remains from the site of Vindija Cave and implications for the Middle to Upper Paleolithic transition (2017) (87)
- Complete DNA sequence of the mitochondrial genome of the ascidian Halocynthia roretzi (Chordata, Urochordata). (1999) (85)
- Functionality of Intergenic Transcription: An Evolutionary Comparison (2006) (85)
- Extensive linkage disequilibrium in small human populations in Eurasia. (2002) (85)
- Foxp2 Controls Synaptic Wiring of Corticostriatal Circuits and Vocal Communication by Opposing Mef2C (2016) (85)
- Evidence for import of a lysyl-tRNA into marsupial mitochondria. (2001) (85)
- Rapid metabolic evolution in human prefrontal cortex (2011) (84)
- Individual A High-Coverage Genome Sequence from an Archaic Denisovan (2012) (82)
- Structural and functional dissection of an MHC class I antigen‐binding adenovirus glycoprotein. (1986) (82)
- Rearrangements of mitochondrial transfer RNA genes in marsupials (1991) (82)
- Heteroplasmy in the control region of human mitochondrial DNA. (1995) (82)
- Ancient Fennoscandian genomes reveal origin and spread of Siberian ancestry in Europe (2018) (81)
- Exceptional Evolutionary Divergence of Human Muscle and Brain Metabolomes Parallels Human Cognitive and Physical Uniqueness (2014) (80)
- Codon reassignment and amino acid composition in hemichordate mitochondria. (1998) (80)
- Complete Mitochondrial Genomes Reveal Neolithic Expansion into Europe (2012) (79)
- Comparison of Protein and mRNA Expression Evolution in Humans and Chimpanzees (2007) (79)
- Paternity assessment and population subdivision in a natural population of the larger mouse‐eared bat Myotis myotis (1997) (79)
- Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans. (2000) (77)
- Polyadenylation creates the discriminator nucleotide of chicken mitochondrial tRNA(Tyr). (1997) (76)
- Mitochondrial DNA of an Iberian Neandertal suggests a population affinity with other European Neandertals (2006) (75)
- Neandertal Introgression Sheds Light on Modern Human Endocranial Globularity (2018) (74)
- RNA editing changes the identity of a mitochondrial tRNA in marsupials. (1996) (74)
- Sudden replacement of cave bear mitochondrial DNA in the late Pleistocene (2007) (73)
- Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains (2019) (73)
- C to U editing and modifications during the maturation of the mitochondrial tRNA(Asp) in marsupials. (1995) (72)
- Long-term balancing selection in LAD1 maintains a missense trans-species polymorphism in humans, chimpanzees and bonobos (2014) (70)
- A molecular phylogeny of two extinct sloths. (2001) (70)
- Bonobos Fall within the Genomic Variation of Chimpanzees (2011) (70)
- Differences in DNA methylation patterns between humans and chimpanzees (2004) (69)
- Bacterial DNA in Clarkia fossils. (1991) (68)
- Initial Upper Palaeolithic humans in Europe had recent Neanderthal ancestry (2021) (68)
- The diverse origins of the human gene pool (2015) (68)
- A single splice site mutation in human-specific ARHGAP11B causes basal progenitor amplification (2016) (68)
- Preservation of DNA in ancient Egyptian mummies (1985) (67)
- The genetics of traditional living: Y-chromosomal and mitochondrial lineages in the Sinai Peninsula. (1996) (67)
- Simultaneous precise editing of multiple genes in human cells (2019) (66)
- Denisovan DNA in Late Pleistocene sediments from Baishiya Karst Cave on the Tibetan Plateau (2020) (64)
- The Y chromosome and the origin of all of us (men) (1995) (63)
- Point-of-care bulk testing for SARS-CoV-2 by combining hybridization capture with improved colorimetric LAMP (2021) (63)
- Intergenic and Repeat Transcription in Human, Chimpanzee and Macaque Brains Measured by RNA-Seq (2010) (62)
- Positive selection on gene expression in the human brain (2006) (61)
- A fourth Denisovan individual (2017) (61)
- Mitochondrial DNA sequences in prehistoric human remains from the Alps (2000) (61)
- Disruption of an Evolutionarily Novel Synaptic Expression Pattern in Autism (2016) (61)
- Mutational hot spots in the mitochondrial microcosm. (1996) (59)
- Polyphyletic origin of the small-bodied, high-arctic subspecies of tundra reindeer (Rangifer tarandus). (1998) (56)
- Genetic Influences on Brain Gene Expression in Rats Selected for Tameness and Aggression (2014) (56)
- Sequencing and Analysis of (2006) (55)
- Primate iPS cells as tools for evolutionary analyses. (2014) (54)
- Lipidome determinants of maximal lifespan in mammals (2017) (53)
- Optimization of 454 sequencing library preparation from small amounts of DNA permits sequence determination of both DNA strands. (2009) (52)
- RNA editing in metazoan mitochondria: staying fit without sex (1997) (52)
- Language replacement in Scandinavia (1995) (52)
- Evolution of mitochondrial ribosomal RNA in insects as shown by the polymerase chain reaction (1990) (51)
- Human and Chimpanzee Gene Expression Differences Replicated in Mice Fed Different Diets (2008) (51)
- Extreme sequence heteroplasmy in bat mitochondrial DNA. (1996) (50)
- Sequential DEXAS: a method for obtaining DNA sequences from genomic DNA and blood in one reaction. (2003) (50)
- Adenovirus proteins and MHC expression. (1989) (49)
- Neanderthal Man: In Search of Lost Genomes (2014) (48)
- X-chromosome as a marker for population history: linkage disequilibrium and haplotype study in Eurasian populations (2005) (44)
- Compound-specific radiocarbon dating and mitochondrial DNA analysis of the Pleistocene hominin from Salkhit Mongolia (2019) (44)
- Effects of Flow Rate and Eluant Composition on the High Performance Liquid Chromatography of Proteins (1980) (43)
- Molecular genetic investigations of ancient human remains. (1986) (42)
- The mitochondrial genome of a monotreme—the platypus (Ornithrohynchus anatinus) (1996) (42)
- Comparative population genomics of the ejaculate in humans and the great apes. (2013) (40)
- Association between transplantation antigens and a viral membrane protein synthesized from a mammalian expression vector (1983) (40)
- Pleistocene sediment DNA reveals hominin and faunal turnovers at Denisova Cave (2021) (40)
- Analysis of Human Accelerated DNA Regions Using Archaic Hominin Genomes (2012) (40)
- Complex formation of class I transplantation antigens and a viral glycoprotein. (1983) (40)
- Mapping genes by drift-generated linkage disequilibrium. (1998) (39)
- Linkage disequilibrium extends across putative selected sites in FOXP2. (2009) (39)
- Denisovan ancestry and population history of early East Asians (2020) (39)
- Primer Extension Capture: Targeted Sequence Retrieval from Heavily Degraded DNA Sources (2009) (37)
- Nuclear DNA from two early Neandertals reveals 80,000 years of genetic continuity in Europe (2019) (37)
- Systematic analysis of gene expression in human brains before and after death (2005) (37)
- Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees. (2003) (36)
- Novel mitochondrial DNA insertion polymorphism and its usefulness for human population studies. (1996) (35)
- The Rise and Fall of the Chemoattractant Receptor GPR33* (2005) (30)
- The Neandertal Progesterone Receptor (2020) (30)
- Expression of the human isoform of glutamate dehydrogenase, hGDH2, augments TCA cycle capacity and oxidative metabolism of glutamate during glucose deprivation in astrocytes (2017) (30)
- Targeted resequencing of a genomic region influencing tameness and aggression reveals multiple signals of positive selection (2011) (30)
- The major genetic risk factor for severe COVID-19 is inherited from Neanderthals (2020) (28)
- correction: Mitochondrial genome variation and the origin of modern humans (2001) (28)
- The Joint Allele-Frequency Spectrum in Closely Related Species (2007) (27)
- Which home for coelacanth? (1993) (27)
- Improved cycle sequencing of GC-rich templates by a combination of nucleotide analogs. (2000) (27)
- A locus for an auditory processing deficit and language impairment in an extended pedigree maps to 12p13.31-q14.3 (2010) (26)
- Identification of Putative Target Genes of the Transcription Factor RUNX2 (2013) (26)
- "Colony sequencing": direct sequencing of plasmid DNA from bacterial colonies. (1997) (26)
- Changes in Lipidome Composition during Brain Development in Humans, Chimpanzees, and Macaque Monkeys (2017) (26)
- A humanized version of Foxp2 does not affect ultrasonic vocalization in adult mice (2015) (26)
- A Neanderthal Sodium Channel Increases Pain Sensitivity in Present-Day Humans (2020) (25)
- Functional analysis of human and chimpanzee promoters (2005) (24)
- Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals (2022) (24)
- Mutations induced by ancient DNA extracts? (2004) (24)
- Molecular Analyses of Oral Polio Vaccine Samples (2001) (23)
- A genetic analysis of the Gibraltar Neanderthals (2019) (23)
- Genetic Time Travel (2016) (23)
- Mice carrying a human GLUD2 gene recapitulate aspects of human transcriptome and metabolome development (2016) (23)
- Suggested guidelines for invasive sampling of hominid remains. (2008) (22)
- DNA sequences from old tissue remains. (1993) (22)
- The association between class-I transplantation antigens and an adenovirus membrane protein. (1985) (21)
- Correction: Loss of Olfactory Receptor Genes Coincides with the Acquisition of Full Trichromatic Vision in Primates (2007) (21)
- Differentially expressed genes in hypothalamus in relation to genomic regions under selection in two chicken lines resulting from divergent selection for high or low body weight (2011) (21)
- Martian Surface Paleotemperatures from Thermochronology of Meteorites (2005) (20)
- Direct primer walking on P1 plasmid DNA. (1997) (19)
- Microstratigraphic preservation of ancient faunal and hominin DNA in Pleistocene cave sediments (2021) (19)
- Evolutionary fixation of RNA editing (1996) (19)
- Direct radiocarbon dating and DNA analysis of the Darra-i-Kur (Afghanistan) human temporal bone. (2017) (19)
- Expression of carnitine palmitoyl-CoA transferase-1B is influenced by a cis-acting eQTL in two chicken lines selected for high and low body weight. (2013) (18)
- Chance marsupial relationships (1990) (18)
- Of bears, conservation genetics, and the value of time travel. (2000) (18)
- Molecular characterization of ancient maize: Potentials and pitfalls (1991) (17)
- Improved gRNA secondary structures allow editing of target sites resistant to CRISPR-Cas9 cleavage (2022) (17)
- A direct RT-qPCR approach to test large numbers of individuals for SARS-CoV-2 (2020) (17)
- The genome of the offspring of a Neanderthal mother and a Denisovan father (2018) (16)
- Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes (2016) (16)
- Functional Analyses of Transcription Factor Binding Sites that Differ between Present-Day and Archaic Humans (2015) (16)
- Recent regulatory changes shaped human facial and vocal anatomy (2017) (14)
- The fate of European Neanderthals: results and perspectives from ancient DNA analyses (2006) (14)
- Human Stem Cell Resources Are an Inroad to Neandertal DNA Functions (2018) (14)
- Foxp 2 controls synaptic wiring of corticostriatal circuits and vocal communication by opposing Mef 2 c (2016) (14)
- Evolution of Neuronal and Endothelial Transcriptomes in Primates (2010) (14)
- Recreating the Past by PCR (1994) (14)
- Longer metaphase and fewer chromosome segregation errors in modern human than Neanderthal brain development (2022) (13)
- Direct DNA sequence determination from total genomic DNA. (1997) (13)
- Is allograft rejection a clue to the mechanism promoting MHC polymorphism? (1987) (13)
- Extensive Regulatory Changes in Genes Affecting Vocal and 1 Facial Anatomy Separate Modern from Archaic Humans 2 (2017) (13)
- Agriculture: Neolithic genetic engineering (1999) (11)
- Nucleotide sequence of a marsupial LINE-1 element and the evolution of placental mammals. (1995) (11)
- Neandertal Introgression Sheds Light on Modern Human Endocranial Globularity (2019) (11)
- Decreased mitochondrial gene expression in isolated islets of rats injected neonatally with streptozotocin (1991) (10)
- Human versus chimpanzee chromosome-wide sequence comparison and its evolutionary implication. (2003) (10)
- Amplifying DNA from archeological remains: a meeting report. (1991) (10)
- Neandertal genetics. (1997) (10)
- Genetic insights into the social organization of Neanderthals (2022) (9)
- The molecular evolution of spermatogenesis across mammals (2021) (9)
- Analysis of candidate genes for lineage-specific expression changes in humans and primates. (2014) (9)
- The earliest Denisovans and their cultural adaptation (2021) (8)
- Comment on “Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment” (2021) (8)
- Direct Exponential Amplification and Sequencing (DEXAS) of Genomic DNA (1997) (8)
- The Predecessors Within . . . (2018) (7)
- The MERS-CoV receptor gene is among COVID-19 risk factors inherited from Neandertals (2020) (7)
- A molecular approach to the study of Egyptian history (1993) (7)
- A comprehensive functional analysis of ancestral human signal peptides. (2011) (7)
- Corrigendum: Fine-scale recombination patterns differ between chimpanzees and humans (2005) (7)
- Direct purification of tRNAs using oligonucleotides coupled to magnetic beads (1994) (7)
- A chimpanzee millenium (Guest Editorial) (1999) (7)
- Human evolution. (1999) (7)
- Molecular Analyses of MHC Antigens (1983) (7)
- The limits of long-term selection against Neandertal introgression (2018) (7)
- Molecular genetic methods in archaeology. A prospect. (1987) (7)
- Single-cell genomic atlas of great ape cerebral organoids uncovers human-specific features of brain development (2019) (6)
- On the use of museum collections for molecular genetic studies (1992) (6)
- A parietal fragment from Denisova cave (2019) (6)
- Lineage-Specific Changes in Biomarkers in Great Apes and Humans (2015) (6)
- Cloning and characterization of the platypus mitochondrial genome (1994) (5)
- Reduced purine biosynthesis in humans after their divergence from Neandertals (2020) (5)
- A genetic variant protective against severe COVID-19 is inherited from Neandertals (2020) (5)
- Mitochondrial diversity and heteroplasmy in two European populations of the large mouse-eared bat, Myotis myotis (1995) (5)
- FINDER project: collagen fingerprinting (ZooMS) for the identification of new human fossils (2019) (4)
- A chimpanzee millennium. (1999) (4)
- Author response: Differences and similarities between human and chimpanzee neural progenitors during cerebral cortex development (2016) (4)
- Organoid single-cell genomic atlas uncovers human-specific features of brain development (2019) (4)
- The Neandertal genome and ancient DNA authenticity This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.Thislicensedoesnot permit commercial exploita (2009) (3)
- Ancient DNA. (1993) (3)
- The contribution of ancient hominin genomes from Siberia to our understanding of human evolution (2015) (3)
- Identification of FXR as a novel mammalian nuclear receptor sensing lanosterol (2003) (3)
- Extensive Regulatory Changes in Genes Affecting Vocal and Facial Anatomy Separate Modern Humans from Neanderthals and Denisovans (2017) (3)
- High-throughput muscle fiber typing from RNA sequencing data (2021) (3)
- Molecular comparison of Neanderthal and Modern Human adenylosuccinate lyase (2018) (3)
- Molecular Anthropology? : Book review of "Molecular applications in biological anthropology" ed. by Eric J. Devor (1993) (2)
- The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals (2022) (2)
- The evolutionary history of human spindle genes includes back-and-forth gene flow with Neandertals (2021) (2)
- Reply to Gibb and Hills: Divergence times, generation lengths and mutation rates in great apes and humans (2013) (2)
- The Rise and Fall of the Chemoattractant Receptor GPR 33 * (2005) (2)
- “Ancestralization” of human pluripotent stem cells by multiplexed precise genome editing (2018) (2)
- Imagine: an interview with Svante Pääbo. Interview by Jane Gitschier. (2008) (2)
- Neandertal genetic diversity (2014) (2)
- Denisovan Reconstructing the DNA Methylation Maps of the Neandertal and the (2014) (2)
- Linkage disequilibrium extends across putative selected sites in FOXP 2 Submission for a letter (2009) (2)
- Reply to Bandelt and Forster (1997) (2)
- A functional test of Neandertal and modern human mitochondrial targeting sequences. (2010) (2)
- Molecular systematics: edited by D.M. Hillis and C. Moritz, Sinauer Associates, 1990. £52.00 hbk, £29.95 pbk (xvi + 588 pages) ISBN 0 87893 280 1 (1991) (1)
- DNA is preserved in ancient Egyptian mummies (1986) (1)
- Isolation, culture and transplantation of human pancreatic islets (1980) (1)
- Dorcas Cummings Lecture. (2015) (1)
- Functional genomics in the chimpanzee (2002) (1)
- What's new in Central Asia? (2013) (1)
- metabolism during exercise in humans Effect of endurance training on muscle TCA cycle (2015) (1)
- Improved gRNA secondary structures allow editing of target sites resistant to CRISPR-Cas9 cleavage (2022) (1)
- The complex evolutionary history of gorillas (2007) (1)
- Neuron Report Organization and Evolution of Brain Lipidome Revealed by Large-Scale Analysis of Human , Chimpanzee , Macaque , andMouse Tissues (2015) (1)
- Publisher Correction: Lipidome determinants of maximal lifespan in mammals (2019) (1)
- A substitution in the glutathione reductase lowers electron leakage and inflammation in modern humans (2022) (1)
- Thalmann European Origin of Domestic Dogs Complete Mitochondrial Genomes of Ancient Canids Suggest a (1)
- A Neanderthal Perspective on Human Origins (2020) (1)
- Population history of late Neandertals (2017) (1)
- Ancient human DNA recovered from a Palaeolithic pendant. (2023) (1)
- A revolution in evolution (1997) (1)
- Insights about the effect of X-ray imaging on recent fossils : Facts, deductions, speculations and phantasms (2013) (1)
- Assessing the real effects of X-ray imaging on recent fossils: Facts vs. speculations (2014) (0)
- Response to Comment on “Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals” (2023) (0)
- Genomy drevnich gominin iz Sibiri = Genomes of ancient hominins from Siberia (2015) (0)
- The earliest Denisovans and their cultural adaptation (2021) (0)
- Article an Evolution Based on Ancient Mitochondrial Genomes (2013) (0)
- Differences and similarities between human and chimpanzee neural 1 progenitors during cerebral cortex development 2 3 (2016) (0)
- Method for the direct, exponential amplification and sequencing of DNA molecules and its application. European patent: EP 0 849 364 and EP 1 004 677; US application: 991347, 311723, 33104; Japanese application: 9-351817 (1998) (0)
- Genetic variation as a means to reconstruct human history (1997) (0)
- Method for the uncoupled, direct, exponential amplification and sequencing of DNA molecules with the addition of a second thermostable DNA polymerase and its application. European patent: EP 0 854196; US applications: 08/991184, 357166, 339103; Japanese application: 9-353367 (1998) (0)
- Domestication and modern human evolution: A look at rats selected for tameness and aggression (2014) (0)
- Ancient dna analysis of middle pleistocene faunal remains from Qesem Cave, Israel (2014) (0)
- Intracellular Transport Of Human Class I Antigens And An Adenoviral Glycoprotein (1987) (0)
- from chimpanzees and macaques Extension of cortical synaptic development distinguishes humans Material Supplemental (2012) (0)
- FOXP2 in the nucleus accumbens regulates reward signaling and social behavior (2013) (0)
- Benchmarks Direct Primer Walking on P 1 Plasmid DNA (1999) (0)
- Paleoepigenetics : Reconstructing the DNA methylation maps of archaic hominins (2013) (0)
- New single amino acid radiocarbon dating and DNA analysis of the Vindija Cave Neanderthals (2017) (0)
- Denisova 11: The daughter of a Neandertal and a Denisovan (2018) (0)
- Neanderthal introgression sheds light on modern human brain globularity (2018) (0)
- Efficacy in the Dorsal Striatum Activity-Dependent Long-Term Changes in Synaptic Regional and Postnatal Heterogeneity of (2015) (0)
- Compound-specific radiocarbon dating and mitochondrial DNA analysis of the Pleistocene hominin from Salkhit Mongolia (2019) (0)
- Neanderthal man : In search of lost genomes (Translated into 14 languages) (2014) (0)
- selected for growth in an intercross between chicken lines divergently QTL analysis of body composition and metabolic traits (2015) (0)
- Sequencing and analysis of a complete Neandertal mitochondrial genome. (2008) (0)
- High-throughput muscle fiber typing from RNA sequencing data (2022) (0)
- What is research (2005) (0)
- How the E19 protein of adenoviruses modulates the immune system (1986) (0)
- GENE EXPRESSION A neutral model of transcriptome evolution (2005) (0)
- Title Differences and similarities between human and chimpanzeeneural progenitors during cerebral cortex development (2018) (0)
- Deter-minations for the 3 ′ and 5 ′ Ends of Viral RNAs (0)
- Reconstructing Prehistoric African Population Structure Graphical Abstract Highlights (2018) (0)
- Differential expression of genes in the hypothalamus of chicken lines with extremely different behaviours established by divergent selection for high and low body weight (2009) (0)
- Ancient Fennoscandian genomes reveal origin and spread of Siberian ancestry in Europe (2018) (0)
- Impaired Synaptic Plasticity and Motor t Mutation Implicated in Human Speech Deficits (0)
- Publisher Correction: Lipidome determinants of maximal lifespan in mammals (2019) (0)
- Accelerated Evolution of Conserved Noncoding Sequences in theHuman Genome (2006) (0)
- The mummy of Ramses II reconsidered : Book review of "La Momie de Ramsès II : contribution scientifique à l'égyptologie" sous la dir. [de] Lionel Balout ... (1988) (0)
- Age estimates for hominin fossils and the onset of the Upper Palaeolithic at Denisova Cave (2019) (0)
- DNA sequence variation on the X chromosome of humans and great apes (2001) (0)
- Abstracts of papers presented at the 1999 Meeting on Human Evolution, April 21-April 25, 1999 (1999) (0)
- Reconstructing Prehistoric African Population Structure Graphical (2018) (0)
- Abstracts from the 8th Congress of the German Primate Society 8. Kongress der Gesellschaft für Primatologie (2003) (0)
- Conserved Primers Dynamics of Mitochondrial DNA Evolution in Animals: Amplification and Sequencing with (2007) (0)
- Neanderthal adenylosuccinate lyase: insights in catalysis and link with disease-causing mutation (2018) (0)
- selected for high and low body weight influenced by a cis-acting eQTL in two chicken lines Expression of carnitine palmitoyl-CoA transferase-1B is (2013) (0)
- Editing of a tRNA anticodon in marsupial mitochondria (1993) (0)
- Khaitovich Humans and Chimpanzees Parallel Patterns of Evolution in the Genomes and Transcriptomes of (2014) (0)
- Analyses of pleistocene genomes (2010) (0)
- Evaluation of the influence of computed tomography imaging on ancient DNA recovery (2013) (0)
- We present a parametric analysis of the data that is based on the Poisson random field ( PRF ) model (2007) (0)
- Genetic analyses of the Neanderthals from the Feldhofer Caves (2006) (0)
- Crystal Structure of Foxp2 bound Specifically to DNA. (2006) (0)
- Role of glutamate dehydrogenase in astrocyte energy and glutamate metabolism (2013) (0)
- Molecular comparison of Neanderthal and Modern Human adenylosuccinate lyase (2018) (0)
- Candidate genes for several bone QTL in chicken revealed by gene expression analysis (2008) (0)
- Brains Regional Patterns of Gene Expression in Human and Chimpanzee Material (2004) (0)
- Lessons from our inner Neanderthal : How extinct hominins live on in people today ; the genomes of now-extinct archaic humans can help us understand more about what makes us modern-day humans truly unique (2019) (0)
- Abstracts of the 35th FEBS Congress. Gothenburg, Sweden. June 26-July 1, 2010. (2010) (0)
- Lipidome determinants of maximal lifespan in mammals (2017) (0)
- Finding hominin bones from the Palaeolithic using collagen peptide mass sequencing (ZooMS) (2017) (0)
- Methodchallenges in the analysis of ancient DNA (2010) (0)
- Poster: Interdisciplinary investigations of the late glacial double burial from Bonn-Oberkassel (2015) (0)
- Detection of unintended on-target effects in CRISPR genome editing by DNA donors carrying diagnostic substitutions (2023) (0)
- DNA sequence variation among humans and apes (abstract only) (2000) (0)
- Genetic evidence for gene flow among late pleistocene hominins (2014) (0)
- Insights from sequencing the Neanderthal genome (2009) (0)
- Patterns of heterozygosity and inbreeding in Neandertals across Eurasia (2014) (0)
- A sensational discovery: Denisova (2022) (0)
- Chapter 3.1.1. DNA (2007) (0)
- A genetic characterization of the fossils from Sima de los Huesos (2014) (0)
- Title : Differential Gene Expression in the Hypothalamus of Two Chicken Lines with Different Feeding Behaviours Resulting from Divergent Selection for High or Low Body Weight (2011) (0)
- Functional dissection of two amino acid substitutions unique to the human FOXP2 protein (2023) (0)
- Hormone content of mouse pancreatic islets subjected to different in vivo and in vitro functional demands (1981) (0)
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