Elizabeth Blackburn
#1,311
Most Influential Person
Australian-born American biological researcher
Why Is Elizabeth Blackburn Influential?
(Suggest an Edit or Addition)Elizabeth Blackburn is a researcher at the University of California at San Francisco, studying the impacts of stress on telomerase and telomeres. She is the former president of the Salk Institute for Biological Studies and the first Australian woman to win a Nobel prize. She earned a bachelor of science and a master of science from the University of Melbourne. She went on to earn a Ph.D. from the University of Cambridge. She is best known for her co-discovery of the telomerase, which is the enzyme that replenishes telomere. She and colleagues Carol W. Greider and Jack Szostak were awarded the Nobel Prize in Physiology or Medicine in 2009 for this work. Her research on telomerase has explored ways that mental health can impact physical health, investigating the impacts of meditation and social bonds.
She has received numerous awards for her work, including the Eli Lilly Research Award for Microbiology and Immunology, California Scientist of the Year for 1999, an American Cancer Society Medal of Honor, Wiley Prize in Biomedical Sciences, and the Royal Medal of the Royal Society.
She was named a Companion of the Order of Australia for her service as a leader in biomedical research, and the discovery of telomerase.
Featured in Top Influential Biologists Today
According to Wikipedia, Elizabeth Helen Blackburn, is an Australian-American Nobel laureate who is the former president of the Salk Institute for Biological Studies. Previously she was a biological researcher at the University of California, San Francisco, who studied the telomere, a structure at the end of chromosomes that protects the chromosome. In 1984, Blackburn co-discovered telomerase, the enzyme that replenishes the telomere, with Carol W. Greider. For this work, she was awarded the 2009 Nobel Prize in Physiology or Medicine, sharing it with Greider and Jack W. Szostak, becoming the first Australian woman Nobel laureate. She also worked in medical ethics, and was controversially dismissed from the Bush administration's President's Council on Bioethics.
Elizabeth Blackburn's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Papers
- Identification of a specific telomere terminal transferase activity in tetrahymena extracts (1985) (3196)
- Accelerated telomere shortening in response to life stress. (2004) (2715)
- Switching and Signaling at the Telomere (2001) (2009)
- Structure and function of telomeres (1991) (1691)
- A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis (1989) (1569)
- Telomere states and cell fates (2000) (1273)
- The telomere terminal transferase of tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity (1987) (1092)
- Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System (2013) (1063)
- An alternative pathway for yeast telomere maintenance rescues est1− senescence (1993) (925)
- A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena. (1978) (922)
- Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection (2015) (911)
- Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging (2006) (801)
- The telomere syndromes (2012) (790)
- Telomeres and telomerase: their mechanisms of action and the effects of altering their functions (2005) (727)
- Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System (2014) (724)
- Telomeres and their control. (2000) (689)
- Telomeres and telomerase. (2002) (649)
- The rate of telomere sequence loss in human leukocytes varies with age. (1998) (620)
- In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs (1990) (619)
- The molecular structure of centromeres and telomeres. (1984) (585)
- Cloning yeast telomeres on linear plasmid vectors (1982) (583)
- Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine·guanine base pairs (1987) (571)
- DNA sequences of telomeres maintained in yeast (1984) (512)
- Cell aging in relation to stress arousal and cardiovascular disease risk factors (2006) (437)
- Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. (1999) (417)
- Increased telomerase activity and comprehensive lifestyle changes: a pilot study. (2008) (413)
- Intensive meditation training, immune cell telomerase activity, and psychological mediators (2011) (391)
- Leukocyte Telomere Length in Major Depression: Correlations with Chronicity, Inflammation and Oxidative Stress - Preliminary Findings (2011) (379)
- Functional evidence for an RNA template in telomerase. (1990) (367)
- Telomere length is paternally inherited and is associated with parental lifespan (2007) (357)
- Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance. (2010) (355)
- Stress exposure in intrauterine life is associated with shorter telomere length in young adulthood (2011) (354)
- Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines (1996) (349)
- Runaway telomere elongation caused by telomerase RNA gene mutations (1995) (337)
- Ku is associated with the telomere in mammals. (1999) (327)
- Impartial comparative analysis of measurement of leukocyte telomere length/DNA content by Southern blots and qPCR (2011) (323)
- Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease. (2010) (318)
- Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study. (2013) (316)
- The Power of Exercise: Buffering the Effect of Chronic Stress on Telomere Length (2010) (310)
- Telomeres: No end in sight (1994) (306)
- New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin (2002) (300)
- The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men (2008) (299)
- Telomerase in yeast. (1995) (298)
- Telomerase: an RNP enzyme synthesizes DNA. (2011) (287)
- An overhanging 3' terminus is a conserved feature of telomeres (1989) (285)
- Can Meditation Slow Rate of Cellular Aging? Cognitive Stress, Mindfulness, and Telomeres (2009) (278)
- Socioeconomic status, health behavior, and leukocyte telomere length in the National Health and Nutrition Examination Survey, 1999-2002. (2013) (277)
- Cumulative Inflammatory Load Is Associated with Short Leukocyte Telomere Length in the Health, Aging and Body Composition Study (2011) (273)
- A pilot study of yogic meditation for family dementia caregivers with depressive symptoms: effects on mental health, cognition, and telomerase activity (2013) (250)
- Telomeres and lifestyle factors: roles in cellular aging. (2012) (241)
- Childhood Trauma Associated with Short Leukocyte Telomere Length in Posttraumatic Stress Disorder (2011) (237)
- A conserved secondary structure for telomerase RNA (1991) (236)
- Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) (235)
- Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase. (1996) (230)
- Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study. (2009) (229)
- Telomeres, telomerase and cancer. (1996) (210)
- Block in Anaphase Chromosome Separation Caused by a Telomerase Template Mutation (1997) (205)
- Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: A randomized controlled trial (2013) (202)
- Dynamics of telomerase activity in response to acute psychological stress (2010) (198)
- Telomere Length Trajectory and Its Determinants in Persons with Coronary Artery Disease: Longitudinal Findings from the Heart and Soul Study (2010) (198)
- Recognition and elongation of telomeres by telomerase. (1989) (197)
- Race-Ethnicity, Poverty, Urban Stressors, and Telomere Length in a Detroit Community-based Sample (2015) (196)
- Rapid Inhibition of Cancer Cell Growth Induced by Lentiviral Delivery and Expression of Mutant-Template Telomerase RNA and Anti-telomerase Short-Interfering RNA (2004) (191)
- Maternal psychosocial stress during pregnancy is associated with newborn leukocyte telomere length. (2013) (191)
- Does cellular aging relate to patterns of allostasis? An e`xamination of basal and stress reactive HPA axis activity and telomere length (2012) (190)
- Developmentally programmed healing of chromosomes by telomerase in tetrahymena (1991) (189)
- Telomeres and telomerase: the means to the end (Nobel lecture). (2010) (188)
- Discrimination, racial bias, and telomere length in African-American men. (2014) (185)
- Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining. (2003) (177)
- The nucleotide sequence of the 17S ribosomal RNA gene of Tetrahymena thermophila and the identification of point mutations resulting in resistance to the antibiotics paromomycin and hygromycin. (1985) (174)
- Functionally interacting telomerase RNAs in the yeast telomerase complex. (1997) (164)
- Identification of a telomeric DNA sequence in Trypanosoma brucei (1984) (163)
- Cellular and Gene Expression Responses Involved in the Rapid Growth Inhibition of Human Cancer Cells by RNA Interference-mediated Depletion of Telomerase RNA* (2005) (159)
- The end of the (DNA) line (2000) (158)
- Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro. (1997) (157)
- Anatomy and Dynamics of DNA Replication Fork Movement in Yeast Telomeric Regions (2004) (156)
- A bulged stem tethers Est1p to telomerase RNA in budding yeast. (2002) (150)
- Changes in stress, eating, and metabolic factors are related to changes in telomerase activity in a randomized mindfulness intervention pilot study (2012) (148)
- Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats (1996) (146)
- Generation of telomere-length heterogeneity in Saccharomyces cerevisiae. (1988) (146)
- A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation (2001) (145)
- Counting of Rif1p and Rif2p on Saccharomyces cerevisiae Telomeres Regulates Telomere Length (2004) (144)
- Template boundary in a yeast telomerase specified by RNA structure. (2000) (142)
- Telomeres and adversity: Too toxic to ignore (2012) (141)
- Stress appraisals and cellular aging: A key role for anticipatory threat in the relationship between psychological stress and telomere length (2012) (139)
- The major reverse transcriptase-incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis. (2013) (138)
- Climate change and the integrity of science. (2010) (135)
- Cdk1-Dependent Phosphorylation of Cdc13 Coordinates Telomere Elongation during Cell-Cycle Progression (2009) (134)
- Visualization of actin filaments and monomers in somatic cell nuclei (2013) (134)
- Shorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resources (2014) (134)
- Short Leukocyte Telomere Length Predicts Risk of Diabetes in American Indians: the Strong Heart Family Study (2013) (133)
- Altering telomere structure allows telomerase to act in yeast lacking ATM kinases (2001) (133)
- Genes and pathways downstream of telomerase in melanoma metastasis. (2006) (130)
- Telomeres: structure and synthesis. (1990) (127)
- Transforming Cancer Prevention through Precision Medicine and Immune-oncology (2016) (127)
- Leukocyte Telomere Length and Mortality in the National Health and Nutrition Examination Survey, 1999–2002 (2015) (126)
- Developmentally controlled telomere addition in wild-type and mutant paramecia (1988) (126)
- Determinants of telomere attrition over one year in healthy older women: Stress and health behaviors matter (2014) (125)
- Resting leukocyte telomerase activity is elevated in major depression and predicts treatment response (2012) (122)
- Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres. (2007) (120)
- The effects of nucleoside analogs on telomerase and telomeres in Tetrahymena. (1994) (119)
- A molecular switch underlies a human telomerase disease (2002) (118)
- Educational attainment but not measures of current socioeconomic circumstances are associated with leukocyte telomere length in healthy older men and women (2011) (117)
- Dynamics of telomere length variation in tetrahymena thermophila (1987) (117)
- A conserved sequence motif within the exceptionally diverse telomeric sequences of budding yeasts. (1994) (115)
- Telomeres: Do the ends justify the means? (1984) (115)
- Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort (2015) (114)
- A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein. (2004) (113)
- Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules (2004) (112)
- Depression and Leukocyte Telomere Length in Patients With Coronary Heart Disease: Data From The Heart and Soul Study (2011) (112)
- Depression, anxiety, and telomere length in young adults: Evidence from the National Health and Nutrition Examination Survey (2014) (110)
- Sequence-specific DNA primer effects on telomerase polymerization activity (1993) (108)
- DNA damage signalling prevents deleterious telomere addition at DNA breaks (2009) (108)
- Leukocyte Telomere Length in Relation to 17 Biomarkers of Cardiovascular Disease Risk: A Cross-Sectional Study of US Adults (2016) (104)
- Shorter telomeres are associated with obesity and weight gain in the elderly (2012) (104)
- Telomere terminal transferase activity from Euplotes crassus adds large numbers of TTTTGGGG repeats onto telomeric primers (1989) (104)
- The telomerase RNA pseudoknot is critical for the stable assembly of a catalytically active ribonucleoprotein. (1999) (103)
- Socioeconomic status and cell aging in children. (2012) (103)
- Educational attainment and late life telomere length in the Health, Aging and Body Composition Study (2013) (102)
- The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae (2002) (100)
- Telomeric protein distributions and remodeling through the cell cycle in Saccharomyces cerevisiae. (2003) (98)
- Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length (2015) (97)
- Telomere Shortening in Formerly Abused and Never Abused Women (2012) (96)
- Control of rDNA replication in Tetrahymena involves a cis-acting upstream repeat of a promoter element (1986) (96)
- Comprehensive Structure-Function Analysis of the Core Domain of Human Telomerase RNA (2003) (96)
- Altering specific telomerase RNA template residues affects active site function. (1995) (93)
- Shorter Leukocyte Telomere Length in Midlife Women with Poor Sleep Quality (2011) (89)
- De novo telomere addition by Tetrahymena telomerase in vitro (1997) (88)
- Soda and cell aging: associations between sugar-sweetened beverage consumption and leukocyte telomere length in healthy adults from the National Health and Nutrition Examination Surveys. (2014) (86)
- A novel pseudoknot element is essential for the action of a yeast telomerase. (2003) (84)
- The internally located telomeric sequences in the germ-line chromosomes of tetrahymena are at the ends of transposon-like elements (1985) (83)
- Autonomic and Adrenocortical Reactivity and Buccal Cell Telomere Length in Kindergarten Children (2011) (81)
- Specific RNA residue interactions required for enzymatic functions of Tetrahymena telomerase (1996) (81)
- Chronic stress elevates telomerase activity in rats (2012) (80)
- Systematic and Cell Type-Specific Telomere Length Changes in Subsets of Lymphocytes (2016) (79)
- Telomeres and their synthesis. (1990) (78)
- Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA. (2004) (77)
- Chorismate mutase-prephenate dehydratase from Escherichia coli K-12. I. Purification, molecular weight, and amino acid composition. (1972) (76)
- Non-nucleosomal packaging of a tandemly repeated DNA sequence at termini of extrachromosomal DNA coding for rRNA in Tetrahymena. (1981) (74)
- Specific telomerase RNA residues distant from the template are essential for telomerase function. (1998) (74)
- Wandering Minds and Aging Cells (2013) (70)
- Greater endogenous estrogen exposure is associated with longer telomeres in postmenopausal women at risk for cognitive decline (2011) (70)
- Genomic reorganization in ciliated protozoans. (1986) (69)
- Associations of cadmium and lead exposure with leukocyte telomere length: findings from National Health and Nutrition Examination Survey, 1999-2002. (2015) (69)
- Sequence-specific fragmentation of macronuclear DNA in a holotrichous ciliate (1981) (68)
- Molecular manifestations and molecular determinants of telomere capping. (2000) (66)
- Telomeric sequence diversity within the genus Saccharomyces (1998) (65)
- RNA-dependent polymerase motifs in EST1: Tentative identification of a protein component of an essential yeast telomerase (1990) (65)
- The telomere and telomerase: nucleic acid-protein complexes acting in a telomere homeostasis system. A review. (1997) (65)
- Cancer Interception (2011) (64)
- Meditation and vacation effects have an impact on disease-associated molecular phenotypes (2016) (64)
- Architecture of telomerase RNA. (1994) (64)
- Telomere fusions caused by mutating the terminal region of telomeric DNA. (2000) (63)
- Tired telomeres: Poor global sleep quality, perceived stress, and telomere length in immune cell subsets in obese men and women (2015) (63)
- Uncapping and Deregulation of Telomeres Lead to Detrimental Cellular Consequences in Yeast (1999) (62)
- Short leukocyte telomere length is associated with obesity in American Indians: The strong heart family study (2014) (62)
- Single extrachromosomal ribosomal rna gene copies are synthesized during amplification of the rDNA in tetrahymena (1981) (62)
- Reproducible and variable genomic rearrangements occur in the developing somatic nucleus of the ciliate Tetrahymena thermophila (1985) (61)
- Telomerase: Dr Jekyll or Mr Hyde? (1999) (61)
- Telomerase and Cancer (2005) (60)
- Associations of ghrelin with eating behaviors, stress, metabolic factors, and telomere length among overweight and obese women: Preliminary evidence of attenuated ghrelin effects in obesity? (2014) (59)
- Physical Fitness and Telomere Length in Patients with Coronary Heart Disease: Findings from the Heart and Soul Study (2011) (59)
- Mitochondrial DNA copy number is reduced in male combat veterans with PTSD (2016) (59)
- An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity. (2014) (58)
- Rapid telomere motions in live human cells analyzed by highly time-resolved microscopy (2008) (58)
- Discrimination, mental health, and leukocyte telomere length among African American men (2016) (56)
- Cord blood telomere length in Latino infants: relation with maternal education and infant sex (2016) (55)
- Multisystem resiliency moderates the major depression–Telomere length association: Findings from the Heart and Soul Study (2013) (55)
- Telomerase in kinetoplastid parasitic protozoa. (1999) (55)
- An Investigation of the Effects of the Core Protein Telomerase Reverse Transcriptase on Wnt Signaling in Breast Cancer Cells (2013) (55)
- Short leukocyte telomere length predicts incidence and progression of carotid atherosclerosis in American Indians: The Strong Heart Family Study (2014) (55)
- Hostility and Cellular Aging in Men from the Whitehall II Cohort (2012) (55)
- Rap1 protein regulates telomere turnover in yeast. (1998) (54)
- A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity. (2003) (54)
- Chromatin structure of the telomeric region and 3'-nontranscribed spacer of Tetrahymena ribosomal RNA genes. (1986) (53)
- Catalytically active human telomerase mutants with allele-specific biological properties. (2003) (53)
- Identification of the telomeric sequence of the acellular slime molds Didymium iridis and Physarum polycephalum. (1987) (52)
- A role for a novel 'trans-pseudoknot' RNA-RNA interaction in the functional dimerization of human telomerase. (2003) (52)
- Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break. (2008) (52)
- Accelerated Cell Aging in Female APOE-ε4 Carriers: Implications for Hormone Therapy Use (2013) (51)
- Antitumor Activity of Systemically Delivered Ribozymes Targeting Murine Telomerase RNA (2004) (51)
- Identification of Kluyveromyces lactisTelomerase: Discontinuous Synthesis along the 30-Nucleotide-Long Templating Domain (1998) (51)
- Allele-specific, selective amplification of a ribosomal RNA gene in tetrahymena thermophila (1982) (49)
- Telomerase RNA Template Mutations Reveal Sequence-Specific Requirements for the Activation and Repression of Telomerase Action at Telomeres (2000) (49)
- Change in Leukocyte Telomere Length Predicts Mortality in Patients with Stable Coronary Heart Disease from the Heart and Soul Study (2016) (48)
- Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita. (2005) (47)
- Maternal Folate Concentration in Early Pregnancy and Newborn Telomere Length (2015) (47)
- Assembly of mutant-template telomerase RNA into catalytically active telomerase ribonucleoprotein that can act on telomeres is required for apoptosis and cell cycle arrest in human cancer cells. (2006) (47)
- Bioethics and the political distortion of biomedical science. (2004) (46)
- Aspergillus nidulans maintains short telomeres throughout development. (1997) (46)
- Telomerase, telomere length, and coronary artery calcium in black and white men in the CARDIA study. (2012) (46)
- A drug-resistant mutation in the ribosomal DNA of Tetrahymena. (1985) (45)
- A functional telomerase RNA swap in vivo reveals the importance of nontemplate RNA domains. (1997) (45)
- Cdk 1-Dependent Phosphorylation of Cdc 13 Coordinates Telomere Elongation during Cell-Cycle Progression (2009) (45)
- Conserved arrangements of repeated DNA sequences in nontranscribed spacers of ciliate ribosomal RNA genes: evidence for molecular coevolution. (1985) (45)
- Relationship between leukocyte telomere length, telomerase activity, and hippocampal volume in early aging. (2014) (44)
- Adverse childhood experiences and leukocyte telomere maintenance in depressed and healthy adults. (2014) (44)
- The telomere and telomerase: how do they interact? (1999) (44)
- Mutant telomere sequences lead to impaired chromosome separation and a unique checkpoint response. (2004) (44)
- Longer leukocyte telomere length in Costa Rica's Nicoya Peninsula: A population-based study (2013) (43)
- Transformation of Tetrahymena thermophila with a mutated circular ribosomal DNA plasmid vector. (1989) (42)
- Not so peculiar: fission yeast telomere repeats. (1998) (40)
- Peripheral telomere length and hippocampal volume in adolescents with major depressive disorder (2015) (40)
- An unusual sequence arrangement in the telomeres of the germ-line micronucleus in Tetrahymena thermophila. (1995) (39)
- The Longitudinal Relationship Between Cortisol Responses to Mental Stress and Leukocyte Telomere Attrition (2016) (39)
- Telomerase core components protect Candida telomeres from aberrant overhang accumulation (2007) (39)
- A Common Variant in the Telomerase RNA Component Is Associated with Short Telomere Length (2010) (39)
- Methylation of ribosomal RNA genes in the macronucleus of Tetrahymena thermophila. (1983) (38)
- Amplification of tandemly repeated origin control sequences confers a replication advantage on rDNA replicons in Tetrahymena thermophila (1990) (38)
- Lack of telomere shortening during senescence in Paramecium. (1994) (38)
- Validation of Minimally-Invasive Sample Collection Methods for Measurement of Telomere Length (2017) (38)
- Circular ribosomal DNA plasmids transform Tetrahymena thermophila by homologous recombination with endogenous macronuclear ribosomal DNA. (1988) (37)
- ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells. (2008) (37)
- PBMC telomerase activity, but not leukocyte telomere length, correlates with hippocampal volume in major depression (2015) (37)
- In vivo and in vitro studies of telomeres and telomerase. (1993) (35)
- A novel specificity for the primer–template pairing requirement in Tetrahymena telomerase (1998) (34)
- Dietary Restraint and Telomere Length in Pre- and Postmenopausal Women (2008) (34)
- Gene F of bacteriophage phiX174. Correlation of nucleotide sequences from the DNA and amino acid sequences from the gene product. (1976) (33)
- Processive Utilization of the Human Telomerase Template (2004) (33)
- Three telomerases with completely non‐telomeric template replacements are catalytically active (2000) (32)
- Movement-Based Behaviors and Leukocyte Telomere Length among US Adults. (2015) (32)
- Maternal estriol concentrations in early gestation predict infant telomere length. (2015) (32)
- Association of dimensional psychological health measures with telomere length in male war veterans. (2016) (32)
- Association between Kidney Function and Telomere Length: The Heart and Soul Study (2012) (31)
- Leukocyte Telomere Length Predicts SSRI Response in Major Depressive Disorder: A Preliminary Report (2016) (30)
- S1 nuclease sensitivity of a double-stranded telomeric DNA sequence. (1987) (30)
- Cytomegalovirus is associated with reduced telomerase activity in the Whitehall II cohort (2013) (29)
- Tracking telomerase (2004) (29)
- A Novel Tel1/ATM N-Terminal Motif, TAN, Is Essential for Telomere Length Maintenance and a DNA Damage Response (2008) (29)
- The replication advantage of a free linear rRNA gene is restored by somatic recombination in Tetrahymena thermophila (1989) (29)
- Early exclusive breastfeeding is associated with longer telomeres in Latino preschool children. (2016) (29)
- Walking the Walk from Genes through Telomere Maintenance to Cancer Risk (2011) (29)
- Maternal pro-inflammatory state during pregnancy and newborn leukocyte telomere length: A prospective investigation (2019) (28)
- Telomere length is associated with oppositional defiant behavior and maternal clinical depression in Latino preschool children (2015) (28)
- Dynamics of telomeric DNA turnover in yeast. (2002) (28)
- Analysis of Paramecium macronuclear DNA using pulsed field gel electrophoresis. (1989) (26)
- Telomere length change plateaus at 4 years of age in Latino children: associations with baseline length and maternal change (2016) (26)
- Two types of telomeric chromatin in Tetrahymena thermophila. (1998) (26)
- Developmentally regulated telomere addition in Tetrahymena thermophila. (1988) (25)
- Characterization of the Yeast Telomere Nucleoprotein Core (2010) (25)
- The terminal telomeric DNA sequence determines the mechanism of dysfunctional telomere fusion. (2010) (25)
- DNA bound by the Oxytricha telomere protein is accessible to telomerase and other DNA polymerases. (1994) (25)
- The nucleotide and amino acid sequences of the N (5′) terminal region of gene G of bacteriophage φX174 (1975) (25)
- A weak germ-line excision mutation blocks developmentally controlled amplification of the rDNA minichromosome of Tetrahymena thermophila. (1994) (23)
- Telomere length as a predictor of response to Pioglitazone in patients with unremitted depression: a preliminary study (2016) (23)
- Reason as Our Guide (2004) (22)
- Correction: Change in Leukocyte Telomere Length Predicts Mortality in Patients with Stable Coronary Heart Disease from the Heart and Soul Study (2016) (22)
- Replication of an rRNA gene origin plasmid in the Tetrahymena thermophila macronucleus is prevented by transcription through the origin from an RNA polymerase I promoter (1995) (22)
- Maternal Psychological Resilience During Pregnancy and Newborn Telomere Length: A Prospective Study. (2020) (21)
- Metabolic profiles of biological aging in American Indians: The strong heart family study (2014) (21)
- QTL mapping of leukocyte telomere length in American Indians: The Strong Heart Family Study (2013) (20)
- Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection (2018) (20)
- Unprecedented Opportunities and Promise for Cancer Prevention Research (2010) (19)
- Shorter preschool, leukocyte telomere length is associated with obesity at age 9 in Latino children (2018) (19)
- The Telotype Defines the Telomere State in Saccharomyces cerevisiae and Is Inherited as a Dominant Non-Mendelian Characteristic in Cells Lacking Telomerase (2008) (19)
- Artificial chromosomes in yeast (1985) (19)
- Telomeres and telomerase. (2000) (19)
- Telomere Length and the Risk of Atrial Fibrillation: Insights Into the Role of Biological Versus Chronological Aging (2014) (19)
- Seasonal variation of peripheral blood leukocyte telomere length in Costa Rica: A population‐based observational study (2014) (19)
- Telomeres, Telomerase, Stress, and Aging (2009) (19)
- Telomerase Targeted Therapy in Cancer and Cancer Stem Cells (2013) (18)
- In vitro proinflammatory gene expression predicts in vivo telomere shortening: A preliminary study (2018) (17)
- Conservation of sequences adjacent to the telomeric C4A2 repeats of ciliate macronuclear ribosomal RNA gene molecules. (1986) (17)
- Tetrahymena micronuclear sequences that function as telomeres in yeast. (1989) (17)
- Replacement of the macronuclear ribosomal RNA genes of a mutant Tetrahymena using electroporation. (1988) (17)
- Highlighting the Science of Cancer Prevention (2010) (16)
- Cell biology: Shaggy mouse tales (2005) (16)
- Leukocyte telomere length and ideal cardiovascular health in American Indians: the Strong Heart Family Study (2016) (16)
- Circular rDNA Replicons Persist in Tetrahymena thermophila Transformants Synthesizing GGGGTC Telomeric Repeats (1995) (16)
- Tetrahymena thermophila mutants defective in the developmentally programmed maturation and maintenance of the rDNA minichromosome. (1994) (15)
- Tandem repeats of the 5' non-transcribed spacer of Tetrahymena rDNA function as high copy number autonomous replicons in the macronucleus but do not prevent rRNA gene dosage regulation. (1995) (15)
- Harmful Moratorium on Stem Cell Research (2002) (15)
- HIV Infection Is Associated with Shortened Telomere Length in Ugandans with Suspected Tuberculosis (2016) (15)
- Sugary beverage and food consumption, and leukocyte telomere length maintenance in pregnant women (2016) (15)
- A Promoter Region Mutation Affecting Replication of the Tetrahymena Ribosomal DNA Minichromosome (1998) (15)
- 7 Developmentally Programmed Healing of Chromosomes (1995) (14)
- An investigation of racial/ethnic and sex differences in the association between experiences of everyday discrimination and leukocyte telomere length among patients with coronary artery disease (2019) (14)
- Telomeres and their synthesis. (1990) (14)
- Telomere length and socioeconomic status at neighborhood and individual levels among 80,000 adults in the Genetic Epidemiology Research on Adult Health and Aging cohort (2019) (14)
- Early Loss of Telomerase Action in Yeast Creates a Dependence on the DNA Damage Response Adaptor Proteins (2016) (13)
- Mec1 function in the DNA damage response does not require its interaction with Tel2 (2008) (13)
- Interview with Elizabeth Blackburn, Ph.D. Interview by Vicki Glaser. (2008) (13)
- Chronic Obesity and Incident Hypertension in Latina Women Are Associated with Accelerated Telomere Length Loss over a 1-Year Period. (2018) (13)
- Telomere lengthening after three weeks of an intensive insight meditation retreat (2015) (12)
- Transcription by Escherichia coli RNA polymerase of a single-stranded fragment by bacteriophage phiX174 DNA 48 residues in length. (1975) (12)
- Telomere attrition is associated with declines in medial temporal lobe volume and white matter microstructure in functionally independent older adults (2018) (12)
- Metabolism of glutamine and glutamate by rat liver mitochondria. (1972) (11)
- Impact of biological aging on arterial aging in American Indians: findings from the Strong Heart Family Study (2016) (11)
- Tel-1 transposon-like elements of Tetrahymena thermophila are associated with micronuclear genome rearrangements. (1991) (11)
- A Trypanosoma brucei Protein Complex That Binds G-overhangs and Co-purifies with Telomerase Activity* (2002) (11)
- Molecular insights into the pathways underlying naked mole-rat eusociality (2017) (11)
- Metabolism of glutamine and ammonia in rat liver: the effects of N-acetylglutamate and phosphate. (1972) (11)
- Socioeconomic Status, Financial Strain, and Leukocyte Telomere Length in a Sample of African American Midlife Men (2018) (11)
- A 'full range' of bioethical views just got narrower. (2004) (10)
- Transcription and sequence analysis of a fragment of bacteriophage phiX174 DNA. (1976) (9)
- Structure and Formation of Telomeres in Holotrichous Ciliates (1986) (9)
- Telomerase RNA Structure and Function (1998) (8)
- A novel DNA deletion-ligation reaction catalyzed in vitro by a developmentally controlled activity from tetrahymena cells (1989) (8)
- Telomeres and Telomerase in Human Health and Disease (2008) (8)
- Telomere length is inversely correlated with urinary stress hormone levels in healthy controls but not in un-medicated depressed individuals-preliminary findings. (2017) (7)
- The telomere and telomerase: how Do they interact? (1999) (6)
- Rapid inhibition of cancer cell growth induced by lentiviral expression of mutant-template telomerase RNA constructs and anti-telomerase siRNA (2004) (6)
- Telomeres sans frontieres (1990) (6)
- 33 DNA Replication in Tetrahymena (1996) (5)
- Expression and suppression of human telomerase RNA. (2006) (5)
- Prenatal programming of newborn and infant telomere length (2012) (5)
- Abstract 1834: Psychological stress and its relationship to telomere length maintenance (2011) (4)
- Copy editing what's the U's? (1990) (4)
- Corrigendum to “Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women” [Brain Behav. Immun. 23 (2009) 446–449] (2012) (4)
- Studying the telomerase RNA in Tetrahymena. (2000) (4)
- 1 A History of Telomere Biology (2006) (4)
- Erratum: The telomere syndromes (2013) (4)
- Genomic rearrangements in macronuclear development of tetrahymena (1985) (3)
- Consequences of Mutations that Alter Telomeres in the Yeast K. lactis (1997) (3)
- Cell aging and resilience: associations between daily emotion regulation and increased telomerase activity (2012) (3)
- Developmentally controlled DNA excision in ciliates (1987) (3)
- Abstract 02: Brain Regions Activation During Stress and Accelerated Biological Aging (2020) (2)
- Telomere length, proviral load and neurologic impairment in HTLV-1-and HTLV-2-infected humans (2014) (2)
- Cell biology: telomeres sans frontières. (1990) (2)
- Thoughts of a Former Council Member (2005) (2)
- A Personal Account of the Discovery of Telomerase (2006) (2)
- Do common underlying mechanisms make the ovary a window onto general heatlh risk for disease development (2014) (2)
- 2009 Nobels: break or breakthrough for women? Interview by Jeffrey Mervis and Kate Travis. (2009) (2)
- Maternal psychological resilience during pregnancy and fetal cellular aging (2019) (2)
- Inhibition of telomerase by mutant template telomerase RNA and anti-telomerase short interfering RNA induces ALT in immortalized human esophageal epithelial cells (2006) (1)
- Telomere Length, Proviral Load and Neurologic Impairment in HTLV-1 and HTLV-2-Infected Subjects (2016) (1)
- Joint insurance issues in the Ocean Victory: The roads not taken (2018) (1)
- Telomere length is inversely correlated with urinary stress hormone levels in healthy controls but not in un-medicated depressed individuals – Preliminary findings (2015) (1)
- Telomeres and Tetrahymena: an interview with Elizabeth Blackburn. (2009) (1)
- Extension of Telomeres (2006) (1)
- The Longitudinal Relationship Between Cortisol Responses to Mental Stress and Leukocyte Telomere Attrition (2017) (1)
- Systemic telomerase gene therapy delivered via targeted lipidic nanoparticles. (2006) (1)
- Corrigendum to “Socioeconomic status, health behavior, and leukocyte telomere length in the National Health and Nutrition Examination Survey, 1999–2002” [Soc. Sci. Med. 85 (2013) 1–8] (2015) (1)
- Policy on Title to Intellectual Property under Crown Procurement Contracts in Canada (2003) (1)
- Neighborhood Deprivation and Telomere Length (TL): The Genetic Epidemiology of Research In Aging (GERA) Cohort (2016) (1)
- Telomere length in caregivers of allogeneic hematopoietic stem cell transplant patients: Relationship to psychological distress and aging (2015) (1)
- Racial differences in biomarkers of stress and cell aging: Latent transition analysis of 5-year change among patients in the heart and soul study (2015) (1)
- Telomeres, Telomerase and Cancer An unusual enzyme called telomerase acts on parts of chromosomes known as telomeres. The enzyme has recently been found in many human tumors and is being eyed as a new target for cancer therapy (1996) (1)
- Telomerase and cell senescence: modulation by telomerase of cellular responses to damage in normal human primary skin keratinocytes and fibroblasts (2004) (1)
- Positive life events during pregnancy and cellular aging in infants (2019) (0)
- Abstract IA-22: Cellular responses to telomerase perturbations (2009) (0)
- Abstract B64: Telomeric DNA sequence determines the mechanism of dysfunctional telomere fusion in human cancer cells (2009) (0)
- Coiled Bodies without Coilin (1997) (0)
- Abstract LB-161: Exploiting non-canonical heterochromatin-mediated telomere protection mechanisms in human cells (2016) (0)
- Telomeres and telomerase: their implication in human age-related diseases (2009) (0)
- Prospective association between maternal pro-inflammatory state during pregnancy and newborn telomere length (2017) (0)
- Nonchromosomal genes: extrachromosomal elements in lower eukaryotes. (1987) (0)
- University of Groningen Depression and Leukocyte Telomere Length in Patients With Coronary Heart Disease (2011) (0)
- Erratum: A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein (Proceedings of the National Academy of Sciences of the United States of America (October 12, 2004) 101, 41 (14713-14718)) (2005) (0)
- Characteristics of 944 participants with coronary heart disease by exercise capacity (METS). (2013) (0)
- Comments for Submission to the FDA Regarding Required Warnings for Cigarette Packages and Advertisements Docket No. FDA-2010-N-0568 RIN 0910-AG41 Submitted electronically to http:/www.regulations.gov (2011) (0)
- Identification of the First Telomerase RNA from the Filamentous Fungus Aspergillus oryzae and Related Organisms (2013) (0)
- Abstract LB-253: TRAPing telomerase activity using droplet digital PCR. (2013) (0)
- Abstract A26: Telomere length in normal and tumor breast tissue from BRCA2 mutation carriers and sporadic breast cancer cases (2016) (0)
- THE RNA COMPONENT OF TELOMERASE : AN UNUSUAL NONCODING RNA (2007) (0)
- PBMC telomerase activity correlates with hippocampal volume in major depression (2012) (0)
- tual cellular senescence , phenotypes characteristic of yeast cells unable to replenish their telomeric DNA (1997) (0)
- Differential Replication andDNA Elimination inthe Polytene Chromosomes ofEuplotes crassus (1996) (0)
- Omega-3 fatty acids , oxidative stress , and leukocyte telomere length : A randomized controlled trial q (2017) (0)
- Distribution ofB52Within athromosomal Locus Depends ontheLevel ofTranscription (1994) (0)
- An anti-apoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity Short title An anti-apoptotic role for telomerase RNA in CD4 T cells Authors and affiliations (2014) (0)
- A Template-proximal RNA Paired Element Contributes to S. cerevisiae Telomerase Activity (2017) (0)
- A New Role for Telomerase in Promoting Meiotic Homolog Pairing Fidelity (2019) (0)
- Abstract P285: Adherence to the Mediterranean Diet is Associated with Longer Telomere Length in Patients with Coronary Artery Disease (2016) (0)
- Serum leptin concentrations and telomere length in MDD and in controls (2012) (0)
- Actuary of the cell. Interview by Thea Singer. (2011) (0)
- Glimpses of Phoenix: The Desert Metropolis in Written and Visual Media by David William Foster (review) (2014) (0)
- John More’s “A Sermon of the… Aulter” (1964) (0)
- Damaging revelations :: compensation and giving credit where credit is due (2017) (0)
- The Christian Empire of Prester John : Goes’ Account and John More’s English Versio (1967) (0)
- The Hayflick Limit (2017) (0)
- More Than a Textbook: The Impact of Survivors on Holocaust Education (2014) (0)
- World Health Summit ; Berlin, Germany, October 14-16, 2018: Program (2018) (0)
- embryonic development to death , including the discovery of the effects of shortening repetitive sequences of DNA , called telomeres , on the ends of chromosomes (2019) (0)
- Nobel Prize for Medicine Awarded (2009) (0)
- Q&A: Elizabeth Blackburn on telomerase and tumors. (2013) (0)
- A conversation with Elizabeth Blackburn. Interview by Misia Landau. (2009) (0)
- Elizabeth Blackburn, Carol Greider and Jack Szostak's Telomere and Telomerase Experiments (1982-1989) (2017) (0)
- Elizabeth Blackburn: because science is worth it. Interview by Ruth Williams. (2008) (0)
- Stem cell science and politics: a talk with Elizabeth Blackburn. (2005) (0)
- The Yeast Telomerase RNA , TLC 1 , Participates in Two Distinct Modes of TLC 1-TLC 1 1 Association Processes in vivo 2 3 (2017) (0)
- SHORTER TELOMERE LENGTH IS ASSOCIATED WITH LOWER LEVELS OF CIRCULATING PROGENITOR CELLS (2016) (0)
- Observations de paramètres d'ordre multiples dans les systèmes d'électrons 5ƒ (2005) (0)
- 検出方法およびテロメラ―ゼ活性調節剤のスクリ―ニング方法 (1999) (0)
- Télomères, télomérase et cancer (1996) (0)
- Methodes de modulation de la proliferation des cellules par la modulation des telomerases (1993) (0)
- Les nouveaux aspects biologie (2006) (0)
- Abstract #4331 Maternal psychological resilience during pregnancy and fetal cellular aging (2019) (0)
- Abstracts of papers presented at the 2001 Meeting on Telomeres & Telomerase, March 28-April 1, 2001 (2001) (0)
- Abstract 18090: Telomere Shortening, Regenerative Capacity, and Cardiovascular Outcomes (2016) (0)
- Telomere length change plateaus at 4 years of age in Latino children: associations with baseline length and maternal change (2016) (0)
- Decreased Telomerase Activity Is Associated with Reduced Diffusing Capacity (DLCO) in a Cohort of Persons Living with HIV (2019) (0)
- Telomere biology as a mechanism in developmental programming of health and disease risk (2016) (0)
- Broken chromosomes and telomeres. (1992) (0)
- 1 Telomeres and telomerase: their roles in human health and disease (2010) (0)
- 159. Socioeconomic factors and leukocyte telomere length in a sample of African American men (2013) (0)
- SodaandCellAging:AssociationsBetween Sugar-SweetenedBeverageConsumptionandLeukocyte TelomereLengthinHealthyAdultsFromtheNational HealthandNutritionExaminationSurveys (2014) (0)
- Molecular genetics of simple developmental systems. (1991) (0)
- Kathleen Collins Telomerase : An RNP Enzyme Synthesizes DNA service (2010) (0)
- Genetic inhibition of telomerase induces alternative lengthening of telomeres (ALT) in genetically defined human esophageal epithelial cells (2008) (0)
- Pines and ponies plantation : (a planned-unit development with equestrian activities as nucleus) (1973) (0)
- Implication of Telomerase in Functions Besides Telomere Elongation in Human Cells (2011) (0)
- Contents Vol. 66, 2015 (2015) (0)
- WOMEN IN BIOCHEMISTRY PORTRAIT GALLERY (2012) (0)
- Abstract #4338 Maternal pro-inflammatory state during pregnancy and newborn leukocyte telomere length: A prospective investigation (2019) (0)
- Commentary Cancer Interception (2011) (0)
- Telomerase and the Causes of Aging (2008) (0)
- How stress gets under the skin: Exaggerated threat appraisals as a mediator of the relationship between chronic stress and short leukocyte telomere length (2011) (0)
- RNA editing. Copy editing--what's the U's? (1990) (0)
- Reviewer list for 2003 (2003) (0)
- Telomere DNA protects the chromosomes (2010) (0)
- Abstract P123: Life’s Simple 7 and Leukocyte Telomere Length in American Indians: The Strong Heart Study (2015) (0)
- From sadness to senescence: cellular effects of psychiatric syndromes (2012) (0)
- Lackoftelomere shortening during senescence inParamecium (1994) (0)
- Abstract 15170: Telomere Length and Incident Carotid Atherosclerosis (2013) (0)
- Mutational and kinetic analysis of the ribonucleoprotein reverse transcriptase telomerase (1993) (0)
- Abstract A58: Wnt signaling pathway components are associated with telomerase activity in breast cancer (2011) (0)
- 15 Telomerase RNA (2006) (0)
- Regulation of chromosome dynamics in microorganisms. (1993) (0)
- Responses of human cancer cells to telomerase interference (2007) (0)
- 2P-105 Structure analysis of S. cerevisiae Rap1-telomeric DNA complex by Electron microscopy(The 46th Annual Meeting of the Biophysical Society of Japan) (2008) (0)
- Identifi'cation of the telomerk sequence of the acellular slime molds D dymium &ids and Physarum polycephalum (0)
- 105. Telomere length and pessimistic attitudes in older women (2008) (0)
- The yeast telomerase RNA, TLC1, participates in two distinct modes of TLC1-TLC1 association processes in vivo (2016) (0)
- Early life obesity, maternal depression, and telomere length in Latino children (2012) (0)
- W1975 Genetic Inhibition of Telomerase Leads to Induction of ALT in Immortalized Human Esophageal Epithelial Cells and in Generated Human Squamous Cancer Cells (2008) (0)
- Assessment of the Association between Environmental Justice Data for Air Pollution and Telomere Length (2018) (0)
- The nucleotide and amino acid sequences of the N (5') terminal region of gene G of bacteriophage phiphiX 174. (1975) (0)
- Novel Strategies Targeting Telomere Maintenance for the Treatment and Prevention of Breast Cancer (1998) (0)
- Abstracts of papers presented at the 1999 Meeting on Telomeres & Telomerase, March 25-March 28, 1999 (1999) (0)
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