Lewis C. Cantley

Q: What Schools Are Affiliated With Lewis C. Cantley

Lewis C. Cantley is affiliated with the following schools: Tufts University, Weill Cornell Medicine, North Carolina State University, University of California, San Diego, Kumamoto University, Cornell University, University of Toronto, Massachusetts General Hospital, Thomas Jefferson University, Aristotle University of Thessaloniki, McGill University, Yale University, University of Ottawa, Sungkyunkwan University, Rockefeller University, West Virginia Wesleyan College, Harvard University

Lewis C. Cantley's AcademicInfluence.com Rankings

Lewis C. Cantley

Biology

#331

World Rank

#599

Historical Rank

#194

USA Rank

Biochemistry

#43

World Rank

#57

Historical Rank

#29

USA Rank

biology Degrees

Lewis C. Cantley

Philosophy

#1123

World Rank

#2107

Historical Rank

#468

USA Rank

Logic

#143

World Rank

#329

Historical Rank

#64

USA Rank

philosophy Degrees

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Biology
Philosophy

Lewis C. Cantley's Degrees

PhD Biophysical Chemistry Cornell University
Doctorate Medicine Cornell University

Why Is Lewis C. Cantley Influential?

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According to Wikipedia, Lewis C. Cantley is an American cell biologist and biochemist who has made significant advances to the understanding of cancer metabolism. Among his most notable contributions are the discovery and study of the enzyme PI-3-kinase, now known to be important to understanding cancer and diabetes mellitus. He is currently Meyer Director and Professor of Cancer Biology at the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine in New York City. He was formerly a professor in the Departments of Systems Biology and Medicine at Harvard Medical School, and the Director of Cancer Research at the Beth Israel Deaconess Medical Center, in Boston, Massachusetts. In 2016, he was elected Chairman of the Board for the Hope Funds for Cancer Research.

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Lewis C. Cantley's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation (2009) (12169)
AKT/PKB Signaling: Navigating Downstream (2007) (5611)
The phosphoinositide 3-kinase pathway. (2002) (5482)
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling (2007) (3564)
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate (2009) (3374)
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism (2006) (2993)
SH2 domains recognize specific phosphopeptide sequences (1993) (2618)
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth (2008) (2530)
Oncogenes and signal transduction (1991) (2476)
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. (1999) (2045)
Ras, PI(3)K and mTOR signalling controls tumour cell growth (2006) (2017)
The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin (2005) (1899)
PI3K pathway alterations in cancer: variations on a theme (2008) (1779)
PI3K: Downstream AKTion Blocks Apoptosis (1997) (1778)
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. (2004) (1747)
Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs (2003) (1642)
The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity (1997) (1575)
Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate (1997) (1573)
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. (2002) (1547)
Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism (2012) (1527)
Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy (2009) (1523)
Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway (2013) (1473)
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. (2008) (1410)
Signalling through the lipid products of phosphoinositide-3-OH kinase (1997) (1401)
Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains (1997) (1397)
Targeting the PI3K-Akt pathway in human cancer: rationale and promise. (2003) (1380)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (2004) (1363)
The PI3K Pathway in Human Disease (2017) (1338)
Effective Use of PI3K and MEK Inhibitors to Treat Mutant K-Ras G12D and PIK3CA H1047R Murine Lung Cancers (2008) (1294)
Phosphoinositide kinases. (1998) (1193)
Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb (2003) (1183)
The LKB1 tumor suppressor negatively regulates mTOR signaling. (2004) (1084)
The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function* (1999) (1054)
Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses (2011) (983)
Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals (1995) (980)
Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis (2011) (942)
Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate (1988) (934)
Pyruvate kinase M2 is a phosphotyrosine-binding protein (2008) (932)
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function (2014) (927)
Catalytic specificity of protein-tyrosine kinases is critical for selective signalling (1995) (916)
Cancer metabolism: fatty acid oxidation in the limelight (2013) (867)
A colorectal cancer classification system that associates cellular phenotype and responses to therapy (2013) (854)
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling (2002) (817)
PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells (1989) (803)
Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. (1997) (788)
Phosphatidylinositol 3‐kinase (1994) (777)
Chromosomal instability drives metastasis through a cytosolic DNA response (2017) (766)
Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle. (1977) (765)
Vascular Dysmorphogenesis Caused by an Activating Mutation in the Receptor Tyrosine Kinase TIE2 (1996) (751)
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion (2016) (744)
The Molecular Basis for Phosphodependent Substrate Targeting and Regulation of Plks by the Polo-Box Domain (2003) (740)
Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity. (1994) (740)
Distinct macrophage phenotypes contribute to kidney injury and repair. (2011) (726)
Proteomic Screen Finds pSer/pThr-Binding Domain Localizing Plk1 to Mitotic Substrates (2003) (701)
Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation (1985) (699)
Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. (1999) (698)
Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth (2009) (681)
TAZ: a novel transcriptional co‐activator regulated by interactions with 14‐3‐3 and PDZ domain proteins (2000) (680)
Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling (2011) (665)
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect (2012) (650)
Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome (2014) (648)
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH (2015) (646)
A neu acquaintance for ErbB3 and ErbB4: A role for receptor heterodimerization in growth signaling (1994) (641)
Use of an oriented peptide library to determine the optimal substrates of protein kinases (1994) (636)
The conserved phosphoinositide 3‐kinase pathway determines heart size in mice (2000) (626)
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis (2012) (624)
The PX domains of p47phox and p40phox bind to lipid products of PI(3)K (2001) (617)
Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation. (1986) (598)
Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine. (2017) (597)
Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. (1999) (594)
Determination of the Specific Substrate Sequence Motifs of Protein Kinase C Isozymes* (1997) (582)
ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor (1994) (561)
A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1 (1996) (560)
A motif-based profile scanning approach for genome-wide prediction of signaling pathways (2001) (550)
Bone marrow stem cells contribute to repair of the ischemically injured renal tubule. (2003) (550)
Targeting the PI3K signaling pathway in cancer. (2010) (549)
A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity (2002) (544)
Regulation of mTORC1 by PI3K signaling. (2015) (544)
Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells (2010) (543)
Purification and characterization of phosphoinositide 3-kinase from rat liver. (1990) (534)
Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation (2001) (531)
Akt/Protein Kinase B Promotes Organ Growth in Transgenic Mice (2002) (529)
ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines. (2005) (527)
Determination of protease cleavage site motifs using mixture-based oriented peptide libraries (2001) (522)
Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity (1987) (518)
Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation (2013) (517)
Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3. (1994) (516)
NRF2 regulates serine biosynthesis in non-small cell lung cancer (2015) (512)
Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding. (1999) (503)
Stem cell metabolism in tissue development and aging (2013) (500)
Rho Family GTPases Bind to Phosphoinositide Kinases (*) (1995) (496)
Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. (2005) (492)
The PHD Finger of the Chromatin-Associated Protein ING2 Functions as a Nuclear Phosphoinositide Receptor (2003) (489)
A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains* (1997) (487)
Stromal cells protect against acute tubular injury via an endocrine effect. (2007) (487)
The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4 (2013) (482)
Rheb fills a GAP between TSC and TOR. (2003) (479)
AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1. (2013) (477)
Phosphatidylinositol‐3,4,5‐trisphosphate (PtdIns‐3,4,5‐P3)/Tec kinase‐dependent calcium signaling pathway: a target for SHIP‐mediated inhibitory signals (1998) (470)
Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer. (2006) (461)
Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. (2009) (451)
A characterization of vanadate interactions with the (Na,K)-ATPase. Mechanistic and regulatory implications. (1978) (451)
A characterization of vanadate interactions with the (Na,K)-ATPase. Mechanistic and regulatory implications. (1978) (451)
Activation of phosphatidylinositol 3-kinase by insulin. (1990) (450)
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response (2012) (439)
PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells (2013) (430)
A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate (1997) (430)
Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase. (1997) (427)
MicroRNA-Antagonism Regulates Breast Cancer Stemness and Metastasis via TET-Family-Dependent Chromatin Remodeling (2013) (426)
High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability. (2011) (415)
The Crohn's Disease Protein, NOD2, Requires RIP2 in Order to Induce Ubiquitinylation of a Novel Site on NEMO (2004) (404)
Peptide and Protein Library Screening Defines Optimal Substrate Motifs for AKT/PKB* (2000) (403)
Interleukin 3-dependent survival by the Akt protein kinase. (1997) (399)
The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism (2010) (384)
Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer. (2012) (381)
The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape. (2005) (380)
Suppression of insulin feedback enhances the efficacy of PI3K inhibitors (2018) (375)
Recognition and specificity in protein tyrosine kinase-mediated signalling. (1995) (374)
ras-transformed cells: altered levels of phosphatidylinositol-4,5-bisphosphate and catabolites. (1986) (367)
Lipid second messengers (1994) (366)
Metabolic flux and the regulation of mammalian cell growth. (2011) (365)
Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit. (1993) (365)
Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol. (1984) (358)
In vivo near-infrared fluorescence imaging of osteoblastic activity (2001) (355)
The erbB3 gene product is a receptor for heregulin. (1994) (353)
Vanadate inhibits the red cell (Na+, K+) ATPase from the cytoplasmic side (1978) (351)
Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation. (2009) (351)
Activation of Phospholipase C-γ by Phosphatidylinositol 3,4,5-Trisphosphate* (1998) (346)
Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State (2012) (345)
Heterogeneity of tumor-induced gene expression changes in the human metabolic network (2013) (345)
Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. (2008) (340)
A rapid method for determining protein kinase phosphorylation specificity (2004) (339)
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. (2001) (333)
PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer. (2009) (325)
SRPK2: A Differentially Expressed SR Protein-specific Kinase Involved in Mediating the Interaction and Localization of Pre-mRNA Splicing Factors in Mammalian Cells (1998) (323)
The Increasing Dominance of Teams in Production of Knowledge (2011) (317)
Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation. (1993) (316)
Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α (2000) (313)
Identification of SARS-CoV-2 Inhibitors using Lung and Colonic Organoids (2020) (311)
Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins (1995) (306)
Cell surface glypicans are low-affinity endostatin receptors. (2001) (305)
Biochemical Interactions Integrating Itk with the T Cell Receptor-initiated Signaling Cascade* (2000) (304)
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus (2014) (301)
Recovery of kidney function after acute kidney injury in the elderly: a systematic review and meta-analysis. (2008) (299)
T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif. (1994) (298)
The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment (2018) (297)
Akt–RSK–S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases (2010) (297)
Lin28 Enhances Tissue Repair by Reprogramming Cellular Metabolism (2013) (289)
Molecular Balance between the Regulatory and Catalytic Subunits of Phosphoinositide 3-Kinase Regulates Cell Signaling and Survival (2002) (288)
Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells (1997) (285)
Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. (2006) (278)
PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex. (2015) (275)
Sequence requirements for the recognition of tyrosine‐based endocytic signals by clathrin AP‐2 complexes. (1996) (273)
Diverse Biochemical Properties of Shp2 Mutants (2005) (270)
Structure and Mechanism of the (Na,K)-ATPase (1981) (270)
Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis (2014) (268)
Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D. (1994) (267)
Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase (2007) (264)
Phosphoinositide 3-Kinase regulates glycolysis through mobilization of Aldolase A from the actin cytoskeleton (2014) (264)
Metabolic pathway alterations that support cell proliferation. (2011) (263)
Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition. (1999) (260)
Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. (2010) (259)
Signal transduction and membrane traffic: The PITP/phosphoinositide connection (1995) (259)
Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts (1993) (258)
Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2. (2005) (256)
Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. (2002) (256)
Increased insulin sensitivity in mice lacking p85β subunit of phosphoinositide 3-kinase (2001) (256)
Cancer Cell Metabolism (2012) (250)
Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size. (2011) (248)
The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase (1989) (247)
The fate of cytoplasmic vanadium. Implications on (NA,K)-ATPase inhibition. (1979) (246)
Protein Sequences from Mastodon and Tyrannosaurus Rex Revealed by Mass Spectrometry (2007) (246)
Phosphoinositide 3-kinase in immunological systems. (2002) (244)
Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1. (2008) (243)
Type Iα phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly (2000) (242)
The SH3 Domain of Amphiphysin Binds the Proline-rich Domain of Dynamin at a Single Site That Defines a New SH3 Binding Consensus Sequence* (1997) (242)
Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx (1985) (238)
Glutathione reduces cytoplasmic vanadate. Mechanism and physiological implications. (1980) (234)
Regulatory interactions in the recognition of endocytic sorting signals by AP‐2 complexes (1997) (233)
Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis. (2004) (231)
p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake. (2012) (231)
Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth factor receptor mutations. (2005) (231)
MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. (2017) (231)
Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase. (1992) (230)
mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. (2011) (230)
Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation. (2009) (229)
The Cbl Phosphotyrosine-binding Domain Selects a D(N/D)XpY Motif and Binds to the Tyr292Negative Regulatory Phosphorylation Site of ZAP-70* (1997) (229)
The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase. (1991) (229)
Identification of small molecule inhibitors of pyruvate kinase M2. (2010) (228)
Conditional Inhibition of the Mitogen-activated Protein Kinase Cascade by Wortmannin (1997) (227)
Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis. (2003) (227)
Isolation of a potent (Na-K)ATPase inhibitor from striated muscle. (1977) (224)
Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. (2011) (223)
A label‐free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen (2008) (222)
United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling. (2003) (221)
A Phase Ib Study of Alpelisib (BYL719), a PI3Kα-Specific Inhibitor, with Letrozole in ER+/HER2− Metastatic Breast Cancer (2016) (220)
Use of RNA Interference-mediated Gene Silencing and Adenoviral Overexpression to Elucidate the Roles of AKT/Protein Kinase B Isoforms in Insulin Actions* (2003) (218)
Class IA Phosphoinositide 3-Kinase Regulates Heart Size and Physiological Cardiac Hypertrophy (2005) (215)
Phosphoinositide 3-Kinase Regulates Phospholipase Cγ-mediated Calcium Signaling* (1998) (214)
Phosphoinositide 3-Kinase Regulates Phospholipase Cγ-mediated Calcium Signaling* (1998) (214)
PtdIns(5)P activates the host cell PI3‐kinase/Akt pathway during Shigella flexneri infection (2006) (213)
Biomolecular Characterization and Protein Sequences of the Campanian Hadrosaur B. canadensis (2009) (212)
The C2 Domain of PKCδ Is a Phosphotyrosine Binding Domain (2005) (211)
Regulation of c-Src tyrosine kinase activity by the Src SH2 domain. (1993) (210)
Clathrin-coated vesicles contain an ATP-dependent proton pump. (1983) (210)
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate (2010) (209)
A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity (1993) (207)
Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation. (1987) (206)
PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice (2010) (205)
Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2 (2013) (205)
Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers. (2011) (202)
Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis. (2006) (202)
Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants (1991) (202)
The Inositol 5′-Phosphatase SHIP Binds to Immunoreceptor Signaling Motifs and Responds to High Affinity IgE Receptor Aggregation* (1996) (201)
Granulocyte macrophage‐colony stimulating factor stimulates both association and activation of phosphoinositide 3OH‐kinase and src‐related tyrosine kinase(s) in human myeloid derived cells. (1993) (199)
Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer (2015) (199)
Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. (2013) (198)
Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival (2011) (198)
Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers (2016) (198)
Corequirement of Specific Phosphoinositides and Small GTP-binding Protein Cdc42 in Inducing Actin Assembly in Xenopus Egg Extracts (1998) (197)
Apoptosis: A Bad kinase makes good (1997) (197)
Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. (2009) (197)
The SH3 Domain-binding T Cell Tyrosyl Phosphoprotein p120 (1995) (197)
Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. (1997) (196)
Phenformin enhances the therapeutic benefit of BRAFV600E inhibition in melanoma (2013) (194)
SYK Is Upstream of Phosphoinositide 3-Kinase in B Cell Receptor Signaling* (1999) (193)
SH2 domain specificity and activity modified by a single residue (1994) (190)
Targeting cancer vulnerabilities with high-dose vitamin C (2019) (189)
PtdIns(4,5)P2 Functions at the Cleavage Furrow during Cytokinesis (2005) (188)
Macrophages in Renal Injury and Repair. (2017) (187)
Utilization of Oriented Peptide Libraries to Identify Substrate Motifs Selected by ATM* (2000) (186)
Macrophages promote cyst growth in polycystic kidney disease. (2011) (186)
Subcellular Locations of Phosphatidylinositol 4-Kinase Isoforms* (1997) (184)
Obesity and Cancer Mechanisms: Cancer Metabolism. (2016) (184)
Phosphoinositide 3-Kinase Catalytic Subunit Deletion and Regulatory Subunit Deletion Have Opposite Effects on Insulin Sensitivity in Mice (2005) (184)
Coordinated Regulation of Toll-Like Receptor and NOD2 Signaling by K63-Linked Polyubiquitin Chains (2007) (183)
High-fructose corn syrup enhances intestinal tumor growth in mice (2019) (183)
The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor (2004) (183)
Activation of P2Y2 Receptors by UTP and ATP Stimulates Mitogen-activated Kinase Activity through a Pathway That Involves Related Adhesion Focal Tyrosine Kinase and Protein Kinase C* (1998) (182)
Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrates for phospholipases C from rat liver and bovine brain. (1989) (180)
Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex. (2013) (178)
Glutathione biosynthesis is a metabolic vulnerability in PI3K/Akt-driven breast cancer (2016) (177)
Hem-1 Complexes Are Essential for Rac Activation, Actin Polymerization, and Myosin Regulation during Neutrophil Chemotaxis (2006) (172)
The Phosphotyrosine Interaction Domain of SHC Recognizes Tyrosine-phosphorylated NPXY Motif (*) (1995) (169)
Cloning and Characterization of a Wortmannin-sensitive Human Phosphatidylinositol 4-Kinase* (1997) (168)
Phosphatidylinositol metabolism and polyoma-mediated transformation. (1986) (168)
Hepatocyte Growth Factor Induces ERK-dependent Paxillin Phosphorylation and Regulates Paxillin-Focal Adhesion Kinase Association* (2002) (168)
Expression of Neutrophil Gelatinase-associated Lipocalin Regulates Epithelial Morphogenesis in Vitro* (2005) (167)
Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells. (1993) (165)
Internalization of activated platelet-derived growth factor receptor-phosphatidylinositol-3' kinase complexes: potential interactions with the microtubule cytoskeleton (1993) (165)
Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation. (1998) (162)
A Multi-enzyme Cascade of Hemoglobin Proteolysis in the Intestine of Blood-feeding Hookworms* (2004) (162)
Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer. (2018) (160)
Ubiquitination of K-Ras Enhances Activation and Facilitates Binding to Select Downstream Effectors (2011) (159)
Phase I dose escalation study of the PI3kinase pathway inhibitor BKM120 and the oral poly (ADP ribose) polymerase (PARP) inhibitor olaparib for the treatment of high-grade serous ovarian and breast cancer (2016) (159)
Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturation (2003) (159)
Characterization of a Rac1- and RhoGDI-Associated Lipid Kinase Signaling Complex (1998) (158)
p120 Is a Major Substrate of Tyrosine Phosphorylation upon B Cell Antigen Receptor Stimulation and Interacts in Vivo with Fyn and Syk Tyrosine Kinases, Grb2 and Shc Adaptors, and the p85 Subunit of Phosphatidylinositol 3-Kinase (*) (1996) (157)
Stand up to cancer phase Ib study of pan-phosphoinositide-3-kinase inhibitor buparlisib with letrozole in estrogen receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer. (2014) (157)
Phosphoinositide 3-kinase regulatory subunit p85α suppresses insulin action via positive regulation of PTEN (2006) (156)
Altered metabolism in cancer (2010) (153)
The impact of aging on kidney repair. (2008) (153)
Regulation of GRP1-catalyzed ADP Ribosylation Factor Guanine Nucleotide Exchange by Phosphatidylinositol 3,4,5-Trisphosphate* (1998) (152)
p120 Is a Cytosolic Adapter Protein That Associates with Phosphoinositide 3-Kinase in Response to Epidermal Growth Factor in PC12 and Other Cells (*) (1996) (152)
The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex (2005) (152)
Small molecule activation of PKM2 in cancer cells induces serine auxotrophy. (2012) (151)
Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase (1993) (150)
Depletion of a Putatively Druggable Class of Phosphatidylinositol Kinases Inhibits Growth of p53-Null Tumors (2013) (148)
Increased P85α Is a Potent Negative Regulator of Skeletal Muscle Insulin Signaling and Induces in Vivo Insulin Resistance Associated with Growth Hormone Excess* (2005) (148)
ERK Negatively Regulates the Epidermal Growth Factor-mediated Interaction of Gab1 and the Phosphatidylinositol 3-Kinase* (2002) (148)
Heregulin Stimulates Mitogenesis and Phosphatidylinositol 3-Kinase in Mouse Fibroblasts Transfected with erbB2/neu and erbB3(*) (1995) (148)
Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange. (1984) (147)
Evidence that a Na+/Ca2+ antiport system regulates murine erythroleukemia cell differentiation. (1982) (147)
Role of endothelin and prostaglandins in radiocontrast-induced renal artery constriction. (1993) (146)
Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors (2019) (144)
Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. (2010) (144)
Phosphoinositide kinases. (1990) (144)
Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity (1996) (143)
Positive and Negative Roles of p85α and p85β Regulatory Subunits of Phosphoinositide 3-Kinase in Insulin Signaling* (2003) (143)
Differential Effects of Gefitinib and Cetuximab on Non–small-cell Lung Cancers Bearing Epidermal Growth Factor Receptor Mutations (2005) (142)
Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase. (1994) (142)
The Lipid Products of Phosphoinositide 3-Kinase Increase Cell Motility through Protein Kinase C* (1997) (141)
The Lipid Products of Phosphoinositide 3-Kinase Increase Cell Motility through Protein Kinase C* (1997) (141)
Olaparib and α-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial. (2019) (141)
Role of Phosphoinositide 3-Kinase Regulatory Isoforms in Development and Actin Rearrangement (2005) (140)
Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation. (1991) (140)
Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer. (2016) (139)
IκB Kinase β Phosphorylates the K63 Deubiquitinase A20 To Cause Feedback Inhibition of the NF-κB Pathway (2007) (138)
Phosphoinositide metabolism and the control of cell proliferation. (1989) (138)
Phosphoinositide Binding Domains Embracing 3-Phosphate (1999) (136)
Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen‐activated protein Kinase (MAPK) and Phosphatidylinositol‐3‐kinase (PI3K)/AKT pathways (2012) (136)
What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway. (2013) (135)
The C2 domain of PKCdelta is a phosphotyrosine binding domain. (2005) (135)
A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer (2013) (135)
Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin. (2017) (135)
Identification of small molecule inhibitors of anthrax lethal factor (2004) (134)
Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression (1994) (133)
Growth Factor-specific Signaling Pathway Stimulation and Gene Expression Mediated by ErbB Receptors* 210 (2001) (132)
D3 Phosphoinositides and Outside-in integrin Signaling by Glycoprotein IIb-IIIa Mediate Platelet Actin Assembly and Filopodial Extension Induced by Phorbol 12-Myristate 13-Acetate* (1996) (131)
A fluorescent reporter of AMPK activity and cellular energy stress. (2011) (129)
A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics. (2015) (129)
Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling (2017) (128)
Phosphoinositide 3-kinase and the regulation of cell growth. (1996) (128)
Interleukin-2 receptor regulates activation of phosphatidylinositol 3-kinase. (1991) (127)
Interferon regulatory factor-3 is an in vivo target of DNA-PK (2002) (126)
Macrophage-mediated injury and repair after ischemic kidney injury (2015) (125)
Structural aspects of the red cell anion exchange protein. (1986) (125)
Type I Phosphatidylinositol-4-phosphate 5-Kinases Synthesize the Novel Lipids Phosphatidylinositol 3,5-Bisphosphate and Phosphatidylinositol 5-Phosphate* (1998) (125)
Overview of the Alliance for Cellular Signaling (2002) (125)
Diverting Glycolysis to Combat Oxidative Stress (2015) (124)
Binding Specificity and Regulation of the Serine Protease and PDZ Domains of HtrA2/Omi* (2003) (121)
Regulation of mitogenesis, motogenesis, and tubulogenesis by hepatocyte growth factor in renal collecting duct cells. (1994) (121)
The APL paradigm and the "co-clinical trial" project. (2011) (120)
The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation (2003) (120)
Adult stem cells in the repair of the injured renal tubule (2005) (120)
Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation. (2013) (120)
Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis. (2001) (120)
Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain. (2015) (119)
Ligand Discrimination in Signaling through an ErbB4 Receptor Homodimer* (2000) (119)
Marked Differences between Metalloproteases Meprin A and B in Substrate and Peptide Bond Specificity* (2001) (117)
The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling. (2010) (116)
PHGDH amplification and altered glucose metabolism in human melanoma (2011) (116)
MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. (2017) (116)
FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells (2013) (115)
Increased Insulin Sensitivity and Reduced Adiposity in Phosphatidylinositol 5-Phosphate 4-Kinase β−/− Mice (2004) (114)
Fetal Deficiency of Lin28 Programs Life‐Long Aberrations in Growth and Glucose Metabolism (2013) (114)
Cancer's Fuel Choice: New Flavors for a Picky Eater. (2015) (113)
Rapid release of bound glucose-6-phosphate dehydrogenase by growth factors. Correlation with increased enzymatic activity. (1991) (113)
Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit. (1996) (112)
Hitting the Target: Emerging Technologies in the Search for Kinase Substrates (2002) (111)
Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. (2013) (111)
Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation (2019) (111)
Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia. (2006) (108)
Deletion of the phosphoinositide 3-kinase p110γ gene attenuates murine atherosclerosis (2007) (108)
A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. (1996) (107)
Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. (2010) (107)
Phosphatidylinositol 4,5-Bisphosphate Synthesis Is Required for Activation of Phospholipase D in U937 Cells (*) (1995) (106)
Bone marrow plasticity revisited: protection or differentiation in the kidney tubule? (2005) (106)
Lipopolysaccharide and phorbol esters induce differentiation but have opposite effects on phosphatidylinositol turnover and Ca2+ mobilization in 70Z/3 pre-B lymphocytes. (1985) (106)
Structural Organization and Alternative Splicing of the Murine Phosphoinositide 3-Kinase p85α Gene (1996) (105)
Met and the epidermal growth factor receptor act cooperatively to regulate final nephron number and maintain collecting duct morphology (2009) (105)
Cell-to-Cell Variability in PI3K Protein Level Regulates PI3K-AKT Pathway Activity in Cell Populations (2011) (103)
EGF receptor ligands are a large fraction of in vitro branching morphogens secreted by embryonic kidney. (1997) (103)
Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling. (2003) (103)
Characterization of KRAS rearrangements in metastatic prostate cancer. (2011) (102)
Differential MAPK Pathways Utilized for HGF- and EGF-dependent Renal Epithelial Morphogenesis* (2001) (102)
Phosphoinositide 3-Kinase Binds Constitutively to α/β-Tubulin and Binds to γ-Tubulin in Response to Insulin (*) (1995) (101)
Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone (2015) (101)
Class 1A PI3K regulates vessel integrity during development and tumorigenesis (2008) (100)
Insulin–PI3K signalling: an evolutionarily insulated metabolic driver of cancer (2020) (98)
Specificity of LIM Domain Interactions with Receptor Tyrosine Kinases* (1996) (98)
Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin (2010) (97)
Bovine brain contains two types of phosphatidylinositol kinase. (1987) (97)
Extracellular ATP increases free cytosolic calcium in rat parotid acinar cells. Differences from phospholipase C-linked receptor agonists. (1988) (97)
Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms. (2010) (97)
Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids (2020) (97)
Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition. (2020) (96)
Mitogens and ion fluxes. (1988) (96)
Association of Protein Kinase Cμ with Type II Phosphatidylinositol 4-Kinase and Type I Phosphatidylinositol-4-phosphate 5-Kinase* (1998) (96)
Phosphatidylinositol 3-kinase and its novel product, phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae. (1989) (96)
Amiloride inhibits murine erythroleukemia cell differentiation: evidence for a Ca2+ requirement for commitment. (1980) (96)
Site–Specific Monoubiquitination Activates Ras by Impeding GTPase Activating Protein Function (2012) (96)
Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations (2011) (95)
Par3 functions in the biogenesis of the primary cilium in polarized epithelial cells (2007) (95)
Pathological Role of Serum- and Glucocorticoid-Regulated Kinase 1 in Adverse Ventricular Remodeling (2012) (94)
Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity. (2017) (94)
Location of the stilbenedisulfonate binding site of the human erythrocyte anion-exchange system by resonance energy transfer. (1979) (93)
GM-CSF Promotes Macrophage Alternative Activation after Renal Ischemia/Reperfusion Injury. (2015) (93)
Characterization of nucleotide binding sites on chloroplast coupling factor 1. (1975) (93)
The active site structure of Na+- and K+-stimulated ATPase. Location of a specific fluorescein isothiocyanate reactive site. (1982) (93)
Chitinase-like protein Brp-39/YKL-40 modulates the renal response to ischemic injury and predicts delayed allograft function. (2013) (92)
T Cell Activation-dependent Association between the p85 Subunit of the Phosphatidylinositol 3-Kinase and Grb2/Phospholipase C-γ1-binding Phosphotyrosyl Protein pp36/38 (*) (1995) (92)
Endostatin regulates branching morphogenesis of renal epithelial cells and ureteric bud (2001) (92)
Phosphatidylinositol-3 kinase activation induced upon Fc gamma RIIIA- ligand interaction (1994) (91)
EphA kinase activation regulates HGF-induced epithelial branching morphogenesis (2003) (91)
PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation (2017) (91)
The Role of the ErbB Family Members in Non–Small Cell Lung Cancers Sensitive to Epidermal Growth Factor Receptor Kinase Inhibitors (2006) (90)
A study of the vanadate-trapped state of the (Na,K)-ATPase. Evidence against interacting nucleotide site models. (1980) (90)
Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C. (1988) (90)
HGF-mediated chemotaxis and tubulogenesis require activation of the phosphatidylinositol 3-kinase. (1995) (89)
Cellular maintenance and repair of the kidney. (2010) (89)
Metabolomics of Human Cerebrospinal Fluid Identifies Signatures of Malignant Glioma* (2012) (88)
A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast (2004) (88)
Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons. (2012) (88)
Pathways for phosphoinositide synthesis. (1999) (86)
Rapidly Proliferating Cells Evidence for an Alternative Glycolytic Pathway in (2010) (86)
Differential Signaling by the Epidermal Growth Factor-like Growth Factors Neuregulin-1 and Neuregulin-2* (1998) (85)
Signals Which Build a Tubule (2005) (85)
Zag expression during aging suppresses proliferation after kidney injury. (2008) (85)
Impaired Kit- but Not FcεRI-initiated Mast Cell Activation in the Absence of Phosphoinositide 3-Kinase p85α Gene Products* (2000) (85)
A Single Point Mutation Switches the Specificity of Group III Src Homology (SH) 2 Domains to That of Group I SH2 Domains (*) (1995) (84)
Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis. (2009) (84)
Effects of muscarinic, alpha-adrenergic, and substance P agonists and ionomycin on ion transport mechanisms in the rat parotid acinar cell. The dependence of ion transport on intracellular calcium (1989) (84)
IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway. (2007) (84)
Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo (2007) (83)
Effects of extracellular ATP on ion transport systems and [Ca2+]i in rat parotid acinar cells. Comparison with the muscarinic agonist carbachol (1990) (82)
Epithelial–mesenchymal–epithelial cycling in kidney repair (2008) (81)
Extracellular Human Immunodeficiency Virus Type-1 Tat Protein Activates Phosphatidylinositol 3-Kinase in PC12 Neuronal Cells* (1996) (80)
Regulation of the Lck SH2 Domain by Tyrosine Phosphorylation* (1996) (80)
Cloning and characterization of a human phosphatidylinositol 4-kinase. (1994) (80)
Norepinephrine complexes and reduced vanadium(V) to reverse vanadate inhibition of the (sodium, potassium ion)-dependent ATPase (1978) (80)
Reactive Oxygen Species Expose Cryptic Epitopes Associated with Autoimmune Goodpasture Syndrome* (2000) (80)
Production of novel polyphosphoinositides in vivo is linked to cell transformation by polyomavirus middle T antigen (1990) (79)
Then Negative Regulation of Phosphoinositide 3-Kinase Signaling by p85 and Its Implication in Cancer (2005) (79)
Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85α Src homology-2 domains (2011) (78)
Fatty acid synthesis is required for breast cancer brain metastasis (2021) (78)
The p85α Regulatory Subunit of Phosphoinositide 3-Kinase Potentiates c-Jun N-Terminal Kinase-Mediated Insulin Resistance (2007) (77)
The negative regulation of phosphoinositide 3-kinase signaling by p85 and it's implication in cancer. (2005) (77)
Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition. (2014) (77)
Fenofibrate prevents skeletal muscle loss in mice with lung cancer (2018) (77)
Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis. (2007) (77)
Characterization and purification of membrane-associated phosphatidylinositol-4-phosphate kinase from human red blood cells. (1989) (77)
PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition. (2017) (76)
AMP-Activated Protein Kinase Regulates Neuronal Polarization by Interfering with PI 3-Kinase Localization (2011) (76)
The polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells. (2002) (75)
DNA Damage-induced Association of ATM with Its Target Proteins Requires a Protein Interaction Domain in the N Terminus of ATM* (2005) (75)
Signal transduction: Grabbing phosphoproteins (1999) (75)
Role of mitochondrial membrane potential in the regulation of murine erythroleukemia cell differentiation (1982) (75)
Calcium regulates the commitment of murine erythroleukemia cells to terminal erythroid differentiation (1981) (74)
Differential regulation of the phosphoinositide 3-kinase and MAP kinase pathways by hepatocyte growth factor vs. insulin-like growth factor-I in myogenic cells. (2004) (74)
Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance (2013) (74)
Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer (2010) (74)
Idelalisib--a PI3Kδ inhibitor for B-cell cancers. (2014) (73)
Determining protein kinase substrate specificity by parallel solution-phase assay of large numbers of peptide substrates (2006) (73)
Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins. (1995) (72)
Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase (2006) (71)
Extracellular ATP induces ion fluxes and inhibits growth of Friend erythroleukemia cells. (1984) (71)
Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins (1998) (71)
The SH2 Domain-containing Inositol 5′-Phosphatase (SHIP) Recruits the p85 Subunit of Phosphoinositide 3-Kinase during FcγRIIb1-mediated Inhibition of B Cell Receptor Signaling* (1999) (71)
BRD7, a tumor suppressor, interacts with p85α and regulates PI3K activity. (2014) (71)
Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet. (2015) (71)
Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion (2016) (70)
Mesenchymal-Epithelial Transition in epithelial response to injury: the role of Foxc2 (2009) (70)
Phosphorylation of the Platelet p47 Phosphoprotein Is Mediated by the Lipid Products of Phosphoinositide 3-Kinase (*) (1995) (70)
Association of Urinary Biomarkers of Inflammation, Injury, and Fibrosis with Renal Function Decline: The ACCORD Trial. (2016) (69)
Dietary fructose improves intestinal cell survival and nutrient absorption (2021) (69)
The carbohydrate-insulin model: a physiological perspective on the obesity pandemic (2021) (68)
Fluorescence energy transfer between ligand binding sites on chloroplast coupling factor 1. (1975) (68)
Microarray analysis of in vitro pericyte differentiation reveals an angiogenic program of gene expression (2005) (67)
Toward a better understanding of folate metabolism in health and disease (2018) (67)
ERK Regulates the Hepatocyte Growth Factor-mediated Interaction of Gab1 and the Phosphatidylinositol 3-Kinase* (2001) (67)
p85α SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation. (2012) (67)
Tubular GM-CSF Promotes Late MCP-1/CCR2-Mediated Fibrosis and Inflammation after Ischemia/Reperfusion Injury. (2019) (67)
Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis. (2019) (67)
Regional expression of hepatocyte growth factor/c-met in experimental renal hypertrophy and hyperplasia. (1994) (66)
High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif. (1997) (66)
Stimulation of the T3-T cell receptor-associated Ca2+ influx enhances the activity of the Na+/H+ exchanger in a leukemic human T cell line. (1985) (65)
Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling. (1998) (65)
Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells (2018) (65)
Specificity in recognition of phosphopeptides by src-homology 2 domains (1994) (65)
Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling. (1998) (65)
Reaction of (Na-K)ATPase with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole: evidence for an essential tyrosine at the active site. (1978) (64)
PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α (2017) (63)
Two distinct cytosolic calcium responses to extracellular ATP in rat parotid acinar cells (1993) (62)
Breathless cancer cells get fat on glutamine (2012) (62)
Peptide Substrate Specificities and Protein Cleavage Sites of Human Endometase/Matrilysin-2/Matrix Metalloproteinase-26* (2002) (62)
Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients (2013) (62)
Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fyn (1994) (61)
An 11-Amino Acid Sequence from c-met Initiates Epithelial Chemotaxis via Phosphatidylinositol 3-Kinase and Phospholipase C (*) (1996) (61)
Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis. (2019) (61)
Transformation-defective mutants of polyomavirus middle T antigen associate with phosphatidylinositol 3-kinase (PI 3-kinase) but are unable to maintain wild-type levels of PI 3-kinase products in intact cells (1992) (61)
T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling. (2007) (61)
Macrophage-specific deletion of transforming growth factor-β1 does not prevent renal fibrosis after severe ischemia-reperfusion or obstructive injury. (2013) (60)
Searching for genes that matter in acute kidney injury: a systematic review. (2009) (60)
Vascular Endothelial Growth Factor Induces Branching Morphogenesis/Tubulogenesis in Renal Epithelial Cells in a Neuropilin-Dependent Fashion (2005) (60)
Chemoprevention Meets Glucose Control (2010) (59)
AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo. (2007) (58)
Investigation of quercetin binding sites on chloroplast coupling factor 1. (1976) (57)
Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival (2016) (57)
Molecular Phylogenetics of Mastodon and Tyrannosaurus rex (2008) (57)
Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9 (2013) (57)
Activation of beef heart mitochondrial adenosine triphosphatase by 2,4-dinitrophenol. (1973) (57)
Age-induced accumulation of methylmalonic acid promotes tumour progression (2020) (57)
BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K. (2014) (57)
Polyoma virus middle T antigen-pp60c-src complex associates with purified phosphatidylinositol 3-kinase in vitro. (1992) (57)
A constitutively activated form of the p110β isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice (2010) (57)
2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. (2011) (56)
Increasing the intracellular Na+ concentration induces differentiation in a pre-B lymphocyte cell line. (1983) (56)
Hypothalamic factor inhibits the (Na,K)ATPase from the extracellular surface. Mechanism of inhibition. (1985) (56)
Metabolic syndrome: F stands for fructose and fat (2013) (56)
Novel polyphosphoinositides in cell growth and activation. (1991) (55)
Cell Confluence Regulates Hepatocyte Growth Factor-Stimulated Cell Morphogenesis in a β-Catenin-Dependent Manner (2006) (55)
Mcp1 Promotes Macrophage-Dependent Cyst Expansion in Autosomal Dominant Polycystic Kidney Disease. (2018) (55)
Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. (2018) (53)
Interactions between transport inhibitors at the anion binding sites of the band 3 dimer. (1981) (53)
Increased tubular proliferation as an adaptive response to glomerular albuminuria. (2012) (53)
Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer. (2017) (52)
Response to Comment on "Protein Sequences from Mastodon and Tyrannosaurus rex Revealed by Mass Spectrometry" (2008) (52)
A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. (2018) (52)
A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition. (2014) (52)
1,25(OH)2D3 increases calcium and phosphatidylinositol metabolism in differentiating cultured human keratinocytes. (1990) (52)
Polycystin-2 Regulates Proliferation and Branching Morphogenesis in Kidney Epithelial Cells* (2006) (51)
Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase. (2005) (50)
Hypothalamic sodium-transport inhibitor is a high-affinity reversible inhibitor of Na+-K+-ATPase. (1984) (50)
The use of peptide library for the determination of kinase peptide substrates. (1998) (50)
Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin. (1995) (50)
Blockade of ATP binding site of P2 purinoceptors in rat parotid acinar cells by isothiocyanate compounds. (1993) (49)
TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development. (2011) (49)
Erythropoietin expands a stromal cell population that can mediate renoprotection. (2008) (49)
The Polycystin 1-C-terminal Fragment Stimulates ERK-dependent Spreading of Renal Epithelial Cells* (2006) (49)
Somatic Mutations of PIK3R1 Promote Gliomagenesis (2012) (48)
Evidence that inhibitors of anion exchange induce a transmembrane conformational change in band 3. (1983) (48)
Protein Tyrosine Phosphatase 1B Regulates Pyruvate Kinase M2 Tyrosine Phosphorylation* (2013) (47)
Induction of heat-shock proteins does not prevent renal tubular injury following ischemia. (1995) (47)
Cancer's insatiable appetite (2009) (47)
Neutrophil gelatinase-associated lipocalin suppresses cyst growth by Pkd1 null cells in vitro and in vivo. (2008) (47)
Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system (2016) (46)
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. (2019) (46)
PTEN loss is a context‐dependent outcome determinant in obese and non‐obese endometrioid endometrial cancer patients (2015) (46)
YKL-40 Associates with Renal Recovery in Deceased Donor Kidney Transplantation. (2017) (45)
Organ‐specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene‐targeting of the PI3K regulatory isoforms p85α, p55α, and p50α (2009) (45)
Mechanism of anion exchange across the red cell membrane by band 3: interactions between stilbenedisulfonate and NAP-taurine binding sites. (1981) (45)
Minimal activators that bind to the KIX domain of p300/CBP identified by phage display screening (2000) (45)
A monoclonal antibody distinguishes two types of phosphatidylinositol 4-kinase. (1991) (45)
Activated ERK2 Interacts with and Phosphorylates the Docking Protein GAB1* (1999) (44)
A sweet new role for EGFR in cancer. (2008) (44)
NRF 2 regulates serine biosynthesis in non-small cell lung cancer (2016) (44)
The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study (2021) (44)
Altered Signaling and Cell Cycle Regulation in Embryonal Stem Cells with a Disruption of the Gene for Phosphoinositide 3-Kinase Regulatory Subunit p85α* (2003) (44)
Association of phosphatidylinositol 3-kinase, via the SH2 domains of p85, with focal adhesion kinase in polyoma middle t-transformed fibroblasts. (1996) (43)
Hepatocyte Growth Factor-Mediated Renal Epithelial Branching Morphogenesis Is Regulated by Glypican-4 Expression (2004) (43)
Elevation of [Ca2+]i and the Activation of Ion Channels and Fluxes by Extracellular ATP and Phospholipase C‐Linked Agonists in Rat Parotid Acinar Cells (1990) (43)
Biomarkers of inflammation and repair in kidney disease progression. (2020) (43)
Acetate Fuels the Cancer Engine (2014) (42)
A Homogeneous, High-Throughput Assay for Phosphatidylinositol 5-Phosphate 4-Kinase with a Novel, Rapid Substrate Preparation (2013) (42)
Phosphorylation by LAMMER protein kinases: determination of a consensus site, identification of in vitro substrates, and implications for substrate preferences. (2002) (42)
Interpreting Sequences from Mastodon and T. rex (2007) (42)
A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. (2000) (42)
Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription (2020) (42)
Extracellular ATP elevates intracellular free calcium in rat parotid acinar cells. (1987) (42)
Characterization of the ATP-dependent proton pump of clathrin-coated vesicles. (1984) (41)
A novel pathway for the formation of phosphatidylinositol 3,4-bisphosphate. Phosphorylation of phosphatidylinositol 3-monophosphate by phosphatidylinositol-3-monophosphate 4-kinase. (1990) (41)
α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH). (2017) (40)
Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene. (1996) (40)
Phase 2 study of buparlisib (BKM120), a pan-class I PI3K inhibitor, in patients with metastatic triple-negative breast cancer (2020) (39)
Signal transduction by the hepatocyte growth factor receptor, c-met. Activation of the phosphatidylinositol 3-kinase. (1995) (39)
Signal transduction by the hepatocyte growth factor receptor, c-met. Activation of the phosphatidylinositol 3-kinase. (1995) (39)
Phosphoinositide 3-kinase knockout mice: role of p85alpha in B cell development and proliferation. (1999) (39)
Building a human kinase gene repository: bioinformatics, molecular cloning, and functional validation. (2005) (39)
MMP-20 is predominately a tooth-specific enzyme with a deep catalytic pocket that hydrolyzes type V collagen. (2006) (39)
Death-associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death (2016) (38)
Delta endotoxin is a potent inhibitor of the (Na,K)-ATPase. (1986) (38)
Human pluripotent stem cells decouple respiration from energy production (2011) (38)
SH2 domain specificity determination using oriented phosphopeptide library. (1995) (38)
Phase I study of oral BKM120 and oral olaparib for high-grade serous ovarian cancer (HGSC) or triple-negative breast cancer (TNBC). (2014) (38)
Genetic selection for enhanced serine metabolism in cancer development (2011) (37)
Growth factors and the kidney: regulation of epithelial cell movement and morphogenesis. (1996) (37)
Impaired kit- but not FcepsilonRI-initiated mast cell activation in the absence of phosphoinositide 3-kinase p85alpha gene products. (2000) (36)
Extracellular HIV-1 Tat Protein Induces a Rapid and Selective Activation of Protein Kinase C (PKC)-α, -ϵ, and -ζ Isoforms in PC12 Cells (1998) (36)
The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility (2012) (36)
Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin. (1991) (36)
Deletion of the Met receptor in the collecting duct decreases renal repair following ureteral obstruction. (2009) (36)
Adjudication of etiology of acute kidney injury: experience from the TRIBE-AKI multi-center study (2014) (35)
Acetate Fuels the Cancer Engine (2015) (35)
A Cross-Species Study of PI3K Protein-Protein Interactions Reveals the Direct Interaction of P85 and SHP2 (2016) (35)
Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells. (2019) (35)
Active Pin 1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer (2015) (35)
Phosphorylation of the (Na,K)-ATPase by a plasma membrane-bound protein kinase in friend erythroleukemia cells. (1983) (35)
A Fundamental Trade-off in Covalent Switching and Its Circumvention by Enzyme Bifunctionality in Glucose Homeostasis* (2014) (35)
Expression of an ouabain-resistant Na,K-ATPase in CV-1 cells after transfection with a cDNA encoding the rat Na,K-ATPase alpha 1 subunit. (1988) (34)
PI3K Charges Ahead (2007) (34)
The Structure and Function of Band 3 (1983) (34)
Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer (2019) (34)
A peptide library approach identifies a specific inhibitor for the ZAP-70 protein tyrosine kinase. (2000) (34)
Peptide libraries: at the crossroads of proteomics and bioinformatics. (2003) (34)
Human erythrocyte anion exchange site characterised using a fluorescent probe (1979) (34)
EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src (2015) (34)
Development of a 2-dimensional atlas of the human kidney with imaging mass cytometry. (2019) (33)
AACR Cancer Progress Report 2012 (2012) (33)
Purification and characterization of human erythrocyte phosphatidylinositol 4-kinase. Phosphatidylinositol 4-kinase and phosphatidylinositol 3-monophosphate 4-kinase are distinct enzymes. (1992) (33)
Mapping specificity determinants for protein-protein association using protein fusions and random peptide libraries. (2000) (33)
Erratum: MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer (Cancer Cell (2017) 32(1) (71–87.e7) (S1535610817302544) (10.1016/j.ccell.2017.06.004)) (2017) (33)
Decoding key nodes in the metabolism of cancer cells: sugar & spice and all things nice (2012) (32)
Targeting a Common Collaborator in Cancer Development (2010) (32)
In-Gel Stable-Isotope Labeling (ISIL): a strategy for mass spectrometry-based relative quantification. (2006) (32)
Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKε (2012) (32)
Urine YKL-40 is associated with progressive acute kidney injury or death in hospitalized patients (2014) (31)
Prioritization schema for immunotherapy clinical trials in glioblastoma (2016) (31)
Cancer metabolism gets physical (2018) (31)
Rewiring of glycolysis in cancer cell metabolism (2010) (30)
Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation. (2017) (30)
Characterization of sulfhydryl groups on chloroplast coupling factor 1 exposed by heat activation. (1976) (30)
Covalent reactions of wortmannin under physiological conditions. (2007) (30)
Vanadium stimulates the (Na+,K+) pump in friend erythroleukemia cells and blocks erythropoiesis (1983) (30)
The chemokine KC regulates HGF-stimulated epithelial cell morphogenesis. (2004) (29)
Biomarkers of Acute Kidney Injury (2007) (28)
Casein Kinase 2 prevents mesenchymal transformation by maintaining Foxc2 in the cytoplasm (2014) (28)
The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro (2020) (28)
AACR Cancer Progress Report 2015 (2015) (28)
Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity (1994) (27)
Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer (2021) (27)
Characterization of PXK as a Protein Involved in Epidermal Growth Factor Receptor Trafficking (2010) (27)
NRF2 Rewires Cellular Metabolism to Support the Antioxidant Response (2016) (26)
Phosphatidylinositol-3 kinase and growth regulation. (1992) (26)
Using peptide libraries to identify optimal cleavage motifs for proteolytic enzymes. (2004) (26)
Phosphorylation-dependent substrate selectivity of protein kinase B (AKT1) (2020) (26)
A slow interconversion between active and inactive states of the (Na-K)ATPase. (1976) (26)
Substrate specificity and inhibitors of LRRK 2 , a protein kinase mutated in Parkinson ’ s disease (2009) (26)
Pyruvate kinase M2 is a phosphotyrosine (2008) (26)
Breast Regression Protein-39/Chitinase 3-Like 1 Promotes Renal Fibrosis after Kidney Injury via Activation of Myofibroblasts. (2017) (26)
ZIP codes for delivering SH2 domains (2004) (26)
SIRT6 Puts Cancer Metabolism in the Driver’s Seat (2012) (26)
Sequence specificity of C-terminal Src kinase (CSK)--a comparison with Src-related kinases c-Fgr and Lyn. (1997) (26)
The (Na,K)-ATPase of Friend erythroleukemia cells is phosphorylated near the ATP hydrolysis by an endogenous membrane-bound kinase. (1984) (26)
PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism (2018) (25)
Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors. (2020) (25)
Quantification and localization of M2 macrophages in human kidneys with acute tubular injury (2014) (25)
The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple Negative Breast Cancer. (2020) (25)
Phase II, 2‐stage, 2‐arm, PIK3CA mutation stratified trial of MK‐2206 in recurrent endometrial cancer (2019) (24)
Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks. (2019) (24)
Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine (2018) (24)
Epithelial morphogenesis of MDCK cells in three-dimensional collagen culture is modulated by interleukin-8. (2013) (24)
Effect of water diuresis and water restriction on expression of HSPs-27, -60 and -70 in rat kidney. (1996) (24)
Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma. (2018) (24)
The role of phosphoinositide 3-kinase in human disease. (2004) (24)
Developing dietary interventions as therapy for cancer (2022) (24)
HGF promotes adhesion of ATP-depleted renal tubular epithelial cells in a MAPK-dependent manner. (2001) (24)
Computational prediction of protein-protein interactions. (2015) (24)
A covalent small molecule inhibitor of glutamate-oxaloacetate transaminase 1 impairs pancreatic cancer growth. (2019) (24)
Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. (2018) (24)
IκB Kinase α Phosphorylation of TRAF4 Downregulates Innate Immune Signaling (2012) (24)
Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry (2021) (24)
Ion transport systems sequenced (1986) (23)
A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase (2016) (23)
Phenformin Enhances the Efficacy of ERK Inhibition in NF1-Mutant Melanoma. (2017) (23)
Signal transduction : principles, pathways, and processes (2014) (23)
Identification of small molecule inhibitors of pyruvate kinase M 2 (2010) (23)
Inositol 1,4,5-trisphosphate stimulates phosphorylation of a 62,000-dalton protein in monkey fibroblast and bovine brain cell lysates. (1984) (23)
Human primary immunodeficiency caused by expression of a kinase-dead p110δ mutant. (2019) (22)
Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy (2019) (22)
Age-induced methylmalonic acid accumulation promotes tumor progression (2020) (22)
Phase II, two-stage, two-arm, PIK3CA mutation stratified trial of MK-2206 in recurrent endometrial cancer (EC). (2013) (22)
Positive and negative roles of p85α and p85β regulatory subunits of phosphoinositide 3-kinase in insulin signaling. (2017) (22)
Identification of efficient pentapeptide substrates for the tyrosine kinase pp60c-src. (1995) (22)
Abstract CT324: Phase I of oral BKM120 or BYL719 and olaparib for high-grade serous ovarian cancer or triple-negative breast cancer: Final results of the BKM120 plus olaparib cohort (2015) (22)
Signal transduction: From the atomic age to the post-genomic era. (2014) (22)
Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer (2020) (21)
Met -/- kidneys express epithelial cells that chemotax and form tubules in response to EGF receptor ligands. (1997) (21)
Tyrosine Kinase BMX Phosphorylates Phosphotyrosine-Primed Motif Mediating the Activation of Multiple Receptor Tyrosine Kinases (2013) (21)
Brg1 determines urothelial cell fate during ureter development. (2013) (21)
Protein kinase C of human erythrocytes phosphorylates bands 4.1 and 4.9. (1986) (21)
Expression of an ouabain resistance gene in transfected cells. Ouabain treatment induces a K+-transport system. (1985) (21)
The commonly used β-actin-GFP transgenic mouse strain develops a distinct type of glomerulosclerosis (2007) (20)
Identification and Characterization of a Phosphoinositide Phosphate Kinase Homolog* (2004) (20)
Quantitative Phosphoproteomic Analysis Identifies the Adaptor Protein Grb 10 as an mTORC 1 Substrate that Negatively Regulates Insulin Signaling (2011) (20)
Phosphatidylinositol 3-Kinase Confers Resistance to Encephalomyocarditis and Herpes Simplex Virus-Induced Cell Death Through the Activation of Distinct Downstream Effectors1 (2001) (20)
Development of an intracellularly acting inhibitory peptide selective for PKN. (2010) (20)
Binding Specificity and Mutational Analysis of the Phosphotyrosine Binding Domain of the Brain-specific Adaptor Protein ShcC (*) (1996) (20)
Dietary Fat and Sugar in Promoting Cancer Development and Progression (2019) (20)
Kinetic analysis of guanosine 5'-O-(3-thiotriphosphate) effects on phosphatidylinositol turnover in NRK cell homogenates. (1987) (20)
At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy (2022) (19)
High Fructose Drives the Serine Synthesis Pathway in Acute Myeloid Leukemic Cells. (2020) (19)
Characterization of monovalent ion transport systems in an insect cell line (Manduca sexta embryonic cell line che) (1984) (19)
PIK3CA C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3Kα Inhibitors (2017) (19)
Genomic characteristics of trastuzumab-resistant Her2-positive metastatic breast cancer (2017) (18)
FoxO 3 coordinates metabolic pathways to maintain redox balance in neural stem cells (2013) (18)
Ancient Sensor for Ancient Drug (2012) (18)
Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. (2019) (17)
PIK3CA and MAP3K1 alterations imply luminal A status and are associated with clinical benefit from pan-PI3K inhibitor buparlisib and letrozole in ER+ metastatic breast cancer (2019) (17)
Erratum: Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion (2016) (17)
Met activation is required for early cytoprotection after ischemic kidney injury. (2014) (17)
Synthesis and activity of C11-modified wortmannin probes for PI3 kinase. (2005) (17)
A Glycolysis Outsider Steps into the Cancer Spotlight. (2018) (17)
Specificity in protein-tyrosine kinase signaling. (1997) (17)
Hepatocyte Growth Factor (Hgf) Stimulates Low Density Lipoprotein Receptor-related Protein (Lrp) 5/6 Phosphorylation and Promotes Canonical Wnt Signaling* (2014) (17)
Proteomic screening method for phosphopeptide motif binding proteins using peptide libraries. (2011) (16)
Ouabain-resistant transfectants of the murine ouabain resistance gene contain mutations in the alpha-subunit of the Na,K-ATPase. (1992) (16)
Modulation of c-fos and egr-1 expression in the isolated perfused kidney by agents that alter tubular work. (1997) (16)
Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells. (1998) (16)
Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase (2019) (16)
Translocating Tubby (2001) (16)
Fate of a bioactive fluorescent wortmannin derivative in cells. (2008) (16)
Ouabain-resistant transfectants of the murine ouabain resistance gene contain mutations in the alpha-subunit of the Na,K-ATPase. (1992) (16)
The antiproliferative cytostatic effects of a self-activating viridin prodrug (2009) (16)
Cancer, metabolism, fructose, artificial sweeteners, and going cold turkey on sugar (2013) (15)
The Terminator mouse is a diphtheria toxin receptor knockin mouse strain for rapid and efficient enrichment of desired cell lineages (2013) (15)
The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation (2018) (15)
An atlas of substrate specificities for the human serine/threonine kinome (2023) (15)
The era of cancer discovery. (2011) (15)
PI3K drives the de novo synthesis of coenzyme A from vitamin B5 (2022) (15)
Using tandem mass spectrometry in targeted mode to identify activators of class IA PI3K in cancer. (2011) (15)
In-gel stable isotope labeling for relative quantification using mass spectrometry (2006) (14)
VEGF Attenuates Hyperoxic Injury through Decreased Apoptosis in Explanted Rat Embryonic Lung (2008) (14)
Type 2 phosphatidylinositol 4-kinase is recruited to CD4 in response to CD4 cross-linking. (1995) (14)
Hepatocyte growth factor induces MAPK-dependent formin IV translocation in renal epithelial cells. (2000) (14)
GSK3beta plays dirty in acute kidney injury. (2010) (14)
Conformational Changes of Na,K-ATPase Necessary for Transport (1983) (14)
Par 3 functions in the biogenesis of the primary cilium in polarized epithelial cells (14)
Urine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritis. (2020) (14)
IL‐1β Drives Production of FGF‐23 at the Onset of Chronic Kidney Disease in Mice (2020) (13)
Treating cancer with phosphatidylinositol-3-kinase inhibitors: increasing efficacy and overcoming resistance (2019) (13)
Discovery and Structure-Activity Relationship Study of (Z)-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. (2020) (13)
Development of a Targeted Urine Proteome Assay for kidney diseases (2016) (13)
Modification of protein sub-nuclear localization by synthetic phosphoinositides: evidence for nuclear phosphoinositide signaling mechanisms. (2005) (13)
Biochemistry. PI3K charges ahead. (2007) (13)
Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification (2020) (13)
Characterization of a Ca2+-stimulated Mg2+-dependent adenosine triphosphatase in Friend murine erythroleukemia cell plasma membranes. (1984) (12)
Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models (2022) (12)
Anastasiou Contributes to Cellular Antioxidant Responses Inhibition of Pyruvate Kinase M 2 by Reactive Oxygen Species (2012) (12)
Mortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapy (2022) (12)
Slow self-activation enhances the potency of viridin prodrugs. (2008) (12)
Hepatocyte Growth Factor stimulated cell scattering requires ERK and Cdc42-dependent tight junction disassembly. (2010) (12)
LOCATION OF BINDING SITES ON THE (Na.K)‐ATPase FOR FLUORESCEIN‐5′‐ISOTHIOCYANATE AND OUABAIN * (1982) (11)
The Phosphoinositide 3-Kinase Regulatory Subunit p85 Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling (2010) (11)
Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. (2020) (11)
Peptide libraries: at the crossroads of proteomics and bioinformatics. (2004) (11)
Expression of c-ret promotes morphogenesis and cell survival in mIMCD-3 cells. (1999) (11)
ML285 affects reactive oxygen species’ inhibition of pyruvate kinase M2 (2013) (11)
Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis (Nature Chemical Biology (2012) 8 (839-847)) (2012) (11)
Phosphoinositide kinases. (1996) (11)
Identification and Characterization of a High-Affinity Interaction between v-Crk and Tyrosine-Phosphorylated Paxillin in CT 10-Transformed Fibroblasts (2003) (10)
Evolution of Ime 2 Phosphorylation Sites on Cdk 1 Substrates Provides a Mechanism to Limit the Effects of the Phosphatase Cdc 14 in Meiosis (10)
Phosphatidylinositol 3 kinase is activated by insulin (1990) (10)
PI3K enters beta-testing. (2008) (10)
PI 3-Kinase and Receptor-Linked Signal Transduction (1996) (10)
Polycystin 2 is increased in disease to protect against stress-induced cell death (2020) (10)
Structural changes in (Na+ + K+)-ATPase accompanying detergent inactivation. (1980) (10)
Quantification of Urinary Protein Biomarkers of Autosomal Dominant Polycystic Kidney Disease by Parallel Reaction Monitoring (2018) (9)
Suppression of Nkx3.2 by phosphatidylinositol-3-kinase signaling regulates cartilage development by modulating chondrocyte hypertrophy. (2015) (9)
Altered propionate metabolism contributes to tumor progression and aggressiveness (2022) (9)
An integrated vector system for cellular studies of phage display-derived peptides. (2002) (9)
Development of a CDK10/CycM in vitro Kinase Screening Assay and Identification of First Small-Molecule Inhibitors (2020) (9)
Corrigendum: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway (2013) (8)
Heparin binding VEGF isoforms attenuate hyperoxic embryonic lung growth retardation via a FLK1-neuropilin-1-PKC dependent pathway (2014) (8)
A global atlas of substrate specificities for the human serine/threonine kinome (2022) (8)
The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4 (2021) (8)
Results of an abbreviated phase II study of AKT inhibitor MK-2206 in the treatment of recurrent platinum-resistant high grade serous ovarian, fallopian tube, or primary peritoneal carcinoma (NCT 01283035) (2020) (8)
Targeting Metabolic Scavenging in Pancreatic Cancer (2013) (8)
Ouabain-resistant OR6 cells express the murine alpha 1-subunit of the Na,K-ATPase with a T797-I797 substitution. (1994) (8)
Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma (2021) (8)
Deletion of the phosphoinositide 3-kinase p 110 { gamma } gene attenuates murine (2007) (8)
Regulation of CD4-p56lck-associated phosphatidylinositol 3-kinase (PI 3-kinase) and phosphatidylinositol 4-kinase (PI 4-kinase). (1993) (7)
Use of a Targeted Urine Proteome Assay (TUPA) to identify protein biomarkers of delayed recovery after kidney transplant (2017) (7)
Erratum: NRF2 regulates serine biosynthesis in non–small cell lung cancer (2016) (7)
A wortmannin-cetuximab as a double drug. (2009) (7)
Cellular Control Mechanisms that Regulate Pyruvate Kinase M 2 Activity and Promote Cancer Growth (2012) (7)
Ionic regulation of MEL cell commitment (1983) (7)
AMPK mediates regulation of glomerular volume and podocyte survival (2021) (7)
Oncogenes and Phosphatidylinositol Turnover a (1986) (7)
Oncogenes and phosphatidylinositol turnover. (1986) (7)
Phase 1b Clinical Trial with Alpelisib plus Olaparib for Patients with Advanced Triple-Negative Breast Cancer. (2022) (7)
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect (2012) (7)
Mapping Post-Translational Modifications of de Novo Purine Biosynthetic Enzymes: Implications for Pathway Regulation. (2019) (7)
Arginase-1 Is Required for Macrophage-Mediated Renal Tubule Regeneration (2022) (6)
The Phosphoinositide 3-Kinase Regulatory Subunit p 85 Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling (2011) (6)
Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry (2022) (6)
Mouse phosphoinositide 3-kinase p110alpha gene: cloning, structural organization, and localization to chromosome 3 band B. (1999) (6)
Erratum: Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers (Proceedings of the National Academy of Sciences of the United States of America (2016) 113 (1778-1783) DOI:10.1073/pnas.1521548113) (2016) (6)
Comparison with the Muscarinic Agonist Carbachol (1990) (6)
Double PIK3CA mutations in cis enhance PI3Kα oncogene activation and sensitivity to PI3Kα inhibitors in breast cancer. (2019) (6)
Targeting cancer vulnerabilities with high-dose vitamin C (2019) (6)
Isolated MTAL cells produce an inhibitor of ouabain-sensitive oxygen consumption. (1991) (6)
A phase II study of MK-2206, an AKT inhibitor, in uterine serous carcinoma (2022) (6)
Sugar free, cancer free? (2012) (6)
Ion fluxes and differentiation in transformed cell lines. (1985) (6)
A flattened face for membranes (1998) (6)
Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer (2022) (6)
Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication (2022) (5)
Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition (2022) (5)
Phosphatidylinositol 4-Kinases (1998) (5)
CV-1 cell recipients of the mouse ouabain resistance gene express a ouabain-insensitive Na,K-ATPase after growth in cardioactive steroids. (1988) (5)
Delta endotoxin inhibits Rb+ uptake, lowers cytoplasmic pH and inhibits a K+-ATPase inManduca sexta CHE cells (2005) (5)
Cell cycle dependence of inositol phosphate levels in neuroblastoma cells. (1988) (5)
Publisher Correction: Suppression of insulin feedback enhances the efficacy of PI3K inhibitors (2018) (5)
Growth Factor and Oncogene Influences on Cell Growth Regulation (1988) (5)
Vulnerabilities of PTEN – TP 53-Defi cient Prostate Cancers to Compound PARP – PI 3 K Inhibition (2019) (4)
Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb (2022) (4)
Abstract CT008: Phase I study of the alpha specific PI3-Kinase inhibitor BYL719 and the poly (ADP-Ribose) polymerase (PARP) inhibitor olaparib in recurrent ovarian and breast cancer: Analysis of the dose escalation and ovarian cancer expansion cohort (2017) (4)
Growth Factors Bind Receptor Tyrosine Kinases to Stimulate Cell Survival, Cell Division, Cell Growth, and Cytoskeletal Rearrangement (2003) (4)
GLUT5 (SLC2A5) enables fructose-mediated proliferation independent of ketohexokinase (2020) (4)
A murine genomic DNA fragment amplifies ouabain-induced Na,K-ATPase alpha/beta-subunit mRNA up-regulation and confers ouabain resistance. (1993) (4)
Somatic Mutations of PIK 3 R 1 Promote Gliomagenesis (2012) (4)
A murine genomic DNA fragment amplifies ouabain-induced Na,K-ATPase alpha/beta-subunit mRNA up-regulation and confers ouabain resistance. (1993) (4)
Tubular Cell Dropout in Preimplantation Deceased Donor Biopsies as a Predictor of Delayed Graft Function (2021) (4)
Using Imaging Mass Cytometry to Define Cell Identities and Interactions in Human Tissues (2021) (4)
ATM and lymphoid malignancies; use of oriented peptide libraries to identify novel substrates of ATM critical in downstream signaling pathways. (1999) (3)
[12] - Phosphatidylinositol 3-Kinase (1993) (3)
Abstract 33: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate (2010) (3)
Suppression of insulin feedback enhances the efficacy of PI3K inhibitors (2018) (3)
The Active Site Structure of Na,K-ATPase: Location of a Specific Fluorescein Isothiocyanate-Reactive Site (1983) (3)
SIRT3 Is a Novel Metabolic Driver of and Therapeutic Target for Chemotherapy Resistant Dlbcls (2017) (3)
Membrane Lipids Speak to Histones. (2017) (3)
PI3-Kinases: Role in Signal Transduction (2000) (3)
Abstract CT232: SU2C Phase Ib study of the PI3K-alpha inhibitor BYL719 (alpelisib) with letrozole in ER+/HER2-metastatic breast cancer (2015) (3)
Principles of Cell Signaling (2013) (3)
Phosphoinositide kinase activity and transformation. (1986) (3)
Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain (2020) (3)
Lipid research picks up speed on the slopes of Taos. (2002) (3)
ATP Produces Two Cai Responses in Rat Parotid Cells (1990) (3)
PIK3IP1 Inhibition of PI3K in G1 Arrest Induced By CDK4 Inhibition Reprograms MCL for Ibrutinib Therapy (2016) (3)
-Dependent Activation of the mTORC2 Kinase Complex (2015) (3)
Differential Dependence On Aerobic Glycolysis In Normal and Malignant Hematopoietic Stem and Progenitor Cells To Sustain Daughter Cell Production (2013) (3)
The PI3K regulatory subunit p85α can exert tumor suppressor properties through negative regulation of growth factor signalling (2011) (3)
Correction for Taniguchi et al., Phosphoinositide 3-kinase regulatory subunit p85α suppresses insulin action via positive regulation of PTEN (2016) (3)
Workshops in Fluid and Electrolyte Disorders (1995) (3)
Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy (2020) (3)
The plasma membrane (Mg2+)-dependent adenosine triphosphatase from the human erythrocyte is not an ion pump (2005) (2)
Purification and characterization of human erythrocyte phosphatidylinositol 4-kinase (2005) (2)
The ion transporter Na+-K+-ATPase enables pathological B cell survival in the kidney microenvironment of lupus nephritis (2023) (2)
SARS-CoV-2 hijacks p38β/MAPK11 to promote virus replication (2021) (2)
Abstract GS6-06: A neoadjuvant trial with letrozole identifiesPRR11in the 17q23 amplicon as a mechanism of resistance to endocrine therapy in ER-positive breast cancer (2020) (2)
The role of lipid-derived second messengers in cell growth and transformation. (1987) (2)
Development and external validation of a diagnostic model for biopsy-proven acute interstitial nephritis using electronic health record data. (2021) (2)
Discovery and Characterization of a Novel Allosteric Small-Molecule Inhibitor of NADP+-Dependent Malic Enzyme 1 (2022) (2)
Erratum to Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2, [Cell Reports 4, 2013, 830-841] (2015) (2)
Abstract KN01: Keynote Lecture: PI 3-kinase links obesity, insulin resistance, and cancer (2018) (2)
PTEN loss as a context-dependent determinant of patient outcomes in obese and non-obese endometrioid endometrial cancer patients. (2013) (2)
Abstract NG03: Chromosomal instability promotes metastasis through a cytosolic DNA response (2018) (2)
Abstract P3-07-41: Genomic alterations indicative of a luminal A subtype associate with clinical benefit to buparlisib and letrozole in endocrine-resistant ER+/HER2– metastatic breast cancer (2016) (2)
Author Correction: Fatty acid synthesis is required for breast cancer brain metastasis (2021) (2)
Targeting the PI5P4K lipid kinase family in cancer using novel covalent inhibitors (2019) (2)
Sizing up a growing field (2004) (2)
Extracellular ATP Gates a Ca2+‐Permeable Nonselective Cation Channel in Rat Parotid Acinar Cells (1990) (2)
Limited Environmental Serine Confers Sensitivity to PHGDH Inhibition in Brain Metastasis (2020) (2)
Synthesis and Activity of C 11-Modified Wortmannin Probes for PI 3 Kinase (2)
Abstract 5497: Cabozantinib eradicatesde novocastrate-resistant PTEN/p53 deficient murine prostate cancer via activation of neutrophil-mediated anti-tumor innate immunity (2015) (2)
Expression of c-ret promotes morphogenesis and cell survival in mIMCD-3 cells. (1999) (1)
Erratum: Acetate fuels the cancer engine (Cell (2014) 159 (1492-1494)) (2015) (1)
Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2 (2023) (1)
Abstract IA01: Targeting phosphoinositide 3-kinase for cancer therapy (2015) (1)
Homeostasis Enzyme Bifunctionality in Glucose Switching and Its Circumvention by A Fundamental Trade-off in Covalent Computational Biology: (2014) (1)
Author Correction: A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer (2020) (1)
D2-07: Mechanisms of activating PI3K signaling in lung cancers that become resistant EGFR tyrosine kinase inhibitors (2007) (1)
Phosphatidylinositol kinases and cell transformation. (1986) (1)
Pancreatic cancers depend on a non-canonical glutamine metabolism pathway (2014) (1)
A topical report on the design principles of metabolism (2018) (1)
Characterization of Temporospatial Distribution of Renal Tubular Casts by Nephron Tracking after Ischemia Reperfusion Injury. (2022) (1)
CHARACTERIZATION OF A PLASMA MEMBRANE KINASE WHICH SPECIFICALLY PHOSPHORYLATES THE (NA,K)PUMP (1983) (1)
Oncogenic in Mammary Epithelial Cells Mutations Are PIK 3 CA Associated − Breast Cancer (2005) (1)
Phosphatidylinositol 4-kinases. Assays and product analysis. (1998) (1)
Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase (Proceedings of the National Academy of Sciences of the United States of America (2009) 103, 45, (16882-16887) 10.1073/pnas. 0607984103) (2009) (1)
Development of Inhibitors of PIP4K2 As a Treatment for Patients with Hematologic Malignancies (2018) (1)
Abstract A33: Utilizing insulin the treatment of prostate cancer with BKM120 abrogates the therapeutic effect of PI3K pathway inhibition (2015) (1)
Inhibition of Phosphatidylinositol-5-Phosphate 4-Kinases (PI5P4Kα and β) Inhibits Proliferation and Radiosensitizes Triple Negative Breast Cancer Cells Harboring p53 Mutations (2015) (1)
Erratum: Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKCλ/ζ (Cell Metabolism (2006) 3 (343-353)) (2016) (1)
PI3K-Akt-mTOR Signaling in Cancer and Cancer Therapeutics (2016) (1)
Role of Na+ andCa2+ Fluxes in Terminal Differentiation of Murine Erythroleukemia Cells (1983) (1)
Abstract NG16: DoublePIK3CAmutations incisincrease oncogenicity and sensitivity to PI3Kα inhibitors (2020) (1)
Abstract CT338: Combination of a PI3K- and a PARP-inhibitor to treat high-grade serous ovarian or triple-negative breast cancer (2014) (1)
Pancreatic cancers depend on a non-canonical glutamine metabolism pathway (2014) (1)
Yonghao Yu Substrate That Negatively Regulates Insulin Signaling Phosphoproteomic Analysis Identifies Grb 10 as an mTORC 1 (2011) (1)
Phosphoinositide 3-Kinase regulates glycolysis through mobilization of Aldolase A from the actin cytoskeleton (2014) (1)
Abstract LB-255: A mass spectrometry platform to quantitatively profile cancer cell metabolism from cells, tumors, and fixed tissue (2011) (1)
PD-142 ErbB-3 mediates PI3K activity in gefitinib-sensitive non-smallcell lung cancer cell lines (2005) (1)
Seeking out the sweet spot in cancer therapeutics: an interview with Lewis Cantley (2016) (1)
1954P A pan-cancer analysis of double PIK3CA mutations (2020) (1)
Abstract 2808: Characterization of KRAS rearrangements in metastatic prostate cancer (2011) (1)
PI5P4Kα supports prostate cancer metabolism and exposes a survival vulnerability during androgen receptor inhibition (2023) (1)
Class IA phosphatidylinositol 3-kinases are indispensable for osteoclast function by regulating cytoskeletal organization and cell death (2009) (1)
IgA vasculitis complicated by acute kidney failure with thrombotic microangiopathy: successful use of eculizumab (2021) (1)
Histone Methylation-Adenosylmethionine and S Influence of Threonine Metabolism on (1)
PIK 3 CA C 2 domain deletions hyperactivate phosphoinositide 3-kinase ( PI 3 K ) , generate oncogene dependence and are exquisitely sensitive to PI 3 Kα inhibitors (2017) (1)
Growth and survival signaling by lipid kinases (2008) (1)
Cancer, metabolism, fructose, artificial sweeteners, and going cold turkey on sugar (2014) (1)
Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine (2018) (1)
Getting Knit-PI3Ky: PIK3CA Mutation Status to Direct Multimodality Therapy? (2009) (1)
Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85a subunit (signal transductionyGTPase-activating proteinyx-ray crystallographyyCdc42Hs) (1996) (1)
Non-conserved metabolic regulation by LKB1 distinguishes human and mouse lung adenocarcinoma (2021) (1)
Perianeurysmal retroperitoneal fibrosis presenting as acute kidney injury: A case report. (2021) (1)
Erratum: BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of pi3k (Cell Metabolism (2014:20:73-84)) (2014) (1)
Marine source ω-3 fatty acid, docosahexaenoic acid (DHA), inhibits human colorectal cancer growth through multiple mechanisms depending on the mutational status of p53 protein (2005) (1)
EXTH-36. PI3K INHIBITION IN CONJUNCTION WITH THE KETOGENIC DIET REDUCES GROWTH AND NEUROINFLAMMATION IN PEDIATRIC HIGH-GRADE GLIOMA (2019) (1)
Abstract TS2-1: The complexity of targeting PI3K for cancer therapy (2019) (1)
Comparison of the Na+ Pump and the Ouabain-Resistant K+ Transport System with Other Metal Ion Transport ATPases (1986) (1)
Faculty Opinions recommendation of Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. (2011) (1)
The PI3K Pathway in Colorectal Cancers (2013) (1)
PI 3-kinase and disease (2014) (1)
Diverse Hotspot Thermal Profiling Methods Detect Phosphorylation-Dependent Changes in Protein Stability (2021) (1)
The lipid products of phosphatidylinositol 3-kinase mediate chemotaxis via protein kinase C (1995) (1)
Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression (2022) (1)
The lipid products of phosphatidylinositol 3-kinase mediate chemotaxis via protein kinase C (1995) (1)
708: A Phase Ib study of BKM120 combined with abiraterone acetate for castrate-resistant, metastatic prostate cancer (2014) (1)
Chapter 11 B Lymphocyte Differentiation: Role of Phosphoinositides, C Kinase, and Na+-H+ Exchange (1986) (1)
A Mass Spectrometry Platform to Quantitatively Profile Cancer Cell Metabolism from Cell Lines to Tissues. (2010) (0)
Abstract 1081: Non-random genomic alterations in BRCA1-related breast cancer (2015) (0)
Crystal structure of PIP4KIIBETA I368A complex with AMP (2015) (0)
Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase (2019) (0)
PIP 4 Ks Suppress Insulin S ignaling through a Catalytic-Independent Mechanism Graphical (2019) (0)
Methods of treating cancer resistant to ErbB doctor mites (2008) (0)
Abstract 4714: Targeting p53 mutant cancers through inhibition of the phosphatidylinositol-5-phosphate 4-kinases (2015) (0)
Phosphatidylinositol 3-kinase: A Novel Signal Transduction Pathway? (1992) (0)
Abstract B034: Determination of KRAS- and ERK-regulated phosphoproteomes in KRAS-mutant cancers (2023) (0)
Live cold to grow old? Thermogenesis to fight cancer (2022) (0)
Figure 3, [A) SDS-PAGE run under non-reducing...]. (2013) (0)
Reply to A Drewnowski et al, O Devinsky, D A Booth and E L Gibson, and D J Millward. (2022) (0)
Development of potent and selective degraders of PI5P4Kγ. (2022) (0)
Cancer Discovery at one year: the editors' interim analysis. (2012) (0)
14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (1999) (0)
Figure 1, Pyruvate kinase-luciferase coupled assay (2010) (0)
Maintenance of Pluripotent Stem Cells is Influenced by Ser/Thr Metabolism (2014) (0)
Abstract P3-03-01: DoublePIK3CAmutations incisdrive oncogene addiction and enhance sensitivity to PI3K alpha inhibitors in breast cancer (2020) (0)
Crystal structure of PIP4KIIBETA T201M complex with AMP (2015) (0)
Figure 6, ML285-bound crystal structure of human pyruvate kinase M2 (PDB code: 3GR4) (2013) (0)
The Structural Basis for Specificity in Protein-Tyrosine Kinase Signaling (1996) (0)
Crystal structure of PIP4KIIBETA complex with AMPPNP (2015) (0)
Figure 8, [A) Intracellular ROS levels measured...]. (2013) (0)
Abstract CT418: A Phase Ib study of BKM120 combined with abiraterone acetate for castrate-resistant, metastatic prostate cancer (2014) (0)
PTEN PATHWAYS & TARGETS (2010) (0)
Abstract 2062: Evaluating the effect of tumor necrosis on glycolytic flux and cell survival in glioblastoma (2019) (0)
O-009 Differential effects of gefitinib and cetuximab on EGFR mutant non-small cell lung cancers (NSCLC) cell lines (2005) (0)
Obesity promotes breast epithelium DNA damage in BRCA mutation carriers (2022) (0)
Abstract 3858: Feasibility and efficacy of a precision treatment approach for triple-negative breast cancer in mouse models (2016) (0)
Figure 2, [A) Hypoxia and exogenous oxidants...]. (2013) (0)
Cell Metabolism Previews PI 3 K Enters Beta-Testing (0)
Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone (2015) (0)
DDRE-22. TARGETING SERINE SYNTHESIS IN BRAIN METASTASIS (2021) (0)
Age-induced accumulation of methylmalonic acid promotes tumour progression (2020) (0)
P11.63 PI3K inhibition in conjunction with the ketogenic diet reduces growth and neuroinflammation in pediatric high-grade glioma (2019) (0)
Quantitative proteomics identification of potential protein biomarkers of early recovery after kidney transplant (591.5) (2014) (0)
Integrated Systems and Technologies Using Tandem Mass Spectrometry in Targeted Mode to Identify Activators of Class IA PI 3 K in Cancer (2011) (0)
The PI3K-LKB1 Pathway (2016) (0)
CHAPTER 11 – Principles of Cell Signaling (2008) (0)
14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 1) (1999) (0)
Cell and molecular physiology. Modulation of membrane transport systems (1988) (0)
Loss of the tumour suppressor inositol polyphosphate 4-phosphatase type II in ovarian cancer-implications for therapy (2012) (0)
Phosphoinositide biology – messages from lipids (2000) (0)
Abstract B04: NRF2 regulates serine biosynthesis in pancreatic ductal adenocarcinoma (2016) (0)
A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas (2021) (0)
Therapeutic Effects of Metformin The Kinase LKB 1 Mediates Glucose Homeostasis in Liver and (2012) (0)
Increased insulin sensitivity i subunit of phosphoinositide (2016) (0)
The Lymphatic System in Kidney Disease. (2023) (0)
Abstract 794: Pan-cancer proteogenomic analysis reveals functional mechanisms underlying DNA repair deficiencies (2022) (0)
cell morphogenesis The chemokine KC regulates HGF-stimulated epithelial (2016) (0)
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. (2022) (0)
Abstract PO-051: Radiation therapy enhances the presentation of phosphopeptides by MHC-I on cancer cells (2021) (0)
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. (2022) (0)
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. (2022) (0)
[Table, Probe Chemical Characterization]. (2011) (0)
Modulation de la phosphoinositide phosphate kinase de type ii$g(b) (2003) (0)
Targeting insulin feedback to enhance alpelisib (TIFA): A phase II randomized trial in metastatic, PIK3CA-mutant, hormone receptor–positive breast cancer. (2022) (0)
Crystal structure of PIP4KIIBETA (2015) (0)
1 3 D bioengineered neural tissue generated from patient-derived iPSCs develops time-1 dependent phenotypes and transcriptional features of Alzheimer ’ s disease 2 3 (2022) (0)
Harlequin ichthyosis unmasked: a defect of lipid transport (2005) (0)
Table 4, SAR of selected thieno[3,2-b]pyrrole[3,2-d]pyridazinones (2011) (0)
Abstract C112: Cabozantinib eradicates advanced murine prostate cancer by activating anti-tumor innate immunity (2015) (0)
The Role of p204 in Kidney Injury (2015) (0)
Longitudinal biomarkers and kidney disease progression after acute kidney injury. (2023) (0)
Abstract 5121: A targeted approach to identify activators of class IA phosphoinositide-3-kinase in cancers using tandem mass spectrometry (2011) (0)
Genetic Heterogeneity and Tissue-specific Patterns of Tumors with Multiple PIK3CA Mutations (2023) (0)
Abstract A51: Oncogenic Kras is required for pancreatic tumor maintenance through the regulation of anabolic glucose metabolism. (2012) (0)
Abstract PR13: Pancreatic tumor stem cells resistant to inhibition of oncogenic signaling are dependent on mitochondrial function (2015) (0)
mIMCD-3細胞での形態形成と細胞生存を促進するc-retの発現 (1999) (0)
Vascular endothelial growth factor (VEGF) isoform attenuates hyperoxic injury of embryonic lung via a Flk1–neuropilin (Nrp)-1–protein kinase C (PKC) dependent pathway (2013) (0)
Phosphoinositide 3- Kinase and disease (2012) (0)
A ‘fast’er way to treat breast cancer (2020) (0)
Faculty of 1000 evaluation for Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer. (2011) (0)
Abstract 1772:PIK3CAC2 domain deletions hyperactivate PI3K, generate oncogene dependence and are exquisitely sensitive to PI3Kα inhibitors (2017) (0)
Abstract IA21: Combination treatments that include PI3K-inhibitors for the treatment of triple-negative breast cancer (2015) (0)
Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation (2019) (0)
Abstract OT1-4-02: Phase I study of the combination of BKM120 and olaparib for the treatment of high grade serous ovarian cancer (HGSC) and triple negative breast cancer (TNBC) (2013) (0)
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor. (2023) (0)
Abstract NG05: Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53 null tumors (2014) (0)
Polycystin 2 is increased in disease to protect against stress-induced cell death (2020) (0)
Authors' Reply: Most Arginase-1 Positive Cells Are Likely Injured S3 Proximal Tubular Cells Carrying Upregulated Phagocytotic Capacity rather than M2 Macrophages-Too Many To Be True. (2022) (0)
Abstract IA12: Coordination of mRNA processing, translation, and metabolism by mTORC1 (2020) (0)
Abstract 981: A genetic-metabolic axis of metastatic liver organotropism (2022) (0)
Interferon activated gene 204 (Ifi204) protects against bone loss in experimental periodontitis. (2022) (0)
An Overview of Renal Development (2009) (0)
Crystal structure of PIP4KIIBETA F205L complex with AMP (2015) (0)
Abstract MS1-1: Targeting PI3K (2012) (0)
Evolution of host protease interactions among SARS-CoV-2 variants of concern and related coronaviruses (2022) (0)
Targeting chromosomal instability and downstream cytosolic dna signaling for cancer treatment (2018) (0)
Abstract LB-161: Metformin increases lipolytic metabolism and PEDF expression in prostate cancer cells (2012) (0)
PI 3-KINASE KNOCKOUT MICE: ROLE OF p85α IN B CELL DEVELOPMENT AND PROLIFERATION (1999) (0)
Molecular Oncology: PI3K (2013) (0)
Lewis C. Cantley (2009) (0)
Radiation-Induced Activation of Innate Immune Pathways from Errors in Mitosis (2017) (0)
Mutation and functional analysis of PIK3CA and PIK3R1 in endometrial cancer (2011) (0)
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. (2022) (0)
Phosphatidyl Inositol (4,5)P2 Marks Megakaryocyte Internal Membranes and Is Associated with Megakaryocyte Maturation and Platelet Release. (2005) (0)
AMP-Kinase mediates regulation of glomerular volume and podocyte survival (2021) (0)
Abstract LB-365: Effective use of PI3K/MTOR and MEK inhibitors prior to hormone ablative therapy in PTEN-loss driven murine prostate cancer (2012) (0)
Vascular Endothelial Growth Factor (VEGF) Attenuates Hyperoxia Via Neuropilin-1 (nrp)-Protein Kinase C (pkc) Dependent Pathway In Explanted Embryonic Lung (2011) (0)
14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 2) (1999) (0)
Abstract 4165: Myc vs. Akt therapy in RapidCap, a GEM model for metastatic prostate cancer (2016) (0)
160 Cancer-associated IDH1 and IDH2 mutations: therapeutic opportunities (2010) (0)
527 Impaird Kit- but not FcεRI-mediated mast cell activation in the absence of regulatory subunits encoded by the phosphoinositide 3-kinase (PI3K) p85α gene (2000) (0)
Membrane biochemistry of the ouabain-resistant potassium transport system. (1987) (0)
Abstract C60: Vitamin C inhibits the survival and growth of colorectal cancer cells with KRAS or BRAF mutations (2013) (0)
The Phosphatidylinositol 3‐Kinase Pathway in Human Malignancies (2015) (0)
Abstract SY34-01: Biomarkers for predicting response to PI3K inhibitors (2011) (0)
RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer (2023) (0)
Figure 4, PBS Buffer Stability of NCGC00185939/CID-4547230 (2011) (0)
Characterization of PXK as a Protein Involved in Epidermal Growth Factor Receptor Trafﬁcking (cid:1) (2010) (0)
Figure 3, PBS Buffer Stability of NCGC00186527/CID-44246498 (2011) (0)
CS-33 * DISCOVERY OF A p53-INDEPENDENT SUPPRESSOR OF SENESCENCE OF GLIOBLASTOMA MULTIFORME (2014) (0)
Abstract 16: Patterns and regulation of post translational modifications in cancer (2021) (0)
Differential Immediate Early Gene Expression Induced by (2001) (0)
Abstract 2650: PI 3-Kinase inhibitors enhance the synthetic lethality of Parp inhibitors (2015) (0)
Introduction: Understanding Human AKI. (2018) (0)
Editorial Note to: Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply. (2021) (0)
Kidney and Electrolyte Disturbances (2000) (0)
The p85 (cid:2) Regulatory Subunit of Phosphoinositide 3-Kinase Potentiates c-Jun N-Terminal Kinase-Mediated Insulin Resistance (cid:1) † (2007) (0)
Stefan Wuchty , of Knowledge The Increasing Dominance of Teams in Production (2009) (0)
Abstract 159: Analysis of resistance to the combination of a PI3K- and Parp-inhibitor using a genomic sequencing approach (2016) (0)
27A Targeting the PI3K/mTOR pathway in genetically engineered mouse models of advanced prostate cancer (2010) (0)
OBSERVATION AKT 1 Overexpression in Endothelial Cells Leads to the Development of Cutaneous Vascular Malformations In Vivo (2007) (0)
Physical and Functional Interactions between SH 2 and SH 3 Domains of the Src Family Protein Tyrosine Kinase p 59 fi 5 (0)
Abstract 4588: Identification of CDCP1 as a HIF-2α target gene involved in the regulation of cancer cell migration and metastasis. (2013) (0)
Author Correction: Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer (2022) (0)
Reply from Lewis Cantley (1986) (0)
105 INVITED The role of PI3K in cancer (2007) (0)
P13.18 Inhibition of epidermal growth factor receptor and platelet-derived growth factor receptor-alpha exerts synergistic efficacy in glioblastoma (2021) (0)
P13.07 Cysteine induces glioblastoma cytotoxicity through mitochondrial reductive stress (2021) (0)
EXTH-12. INHIBITION OF EPIDERMAL GROWTH FACTOR RECEPTOR AND PLATELET-DERIVED GROWTH FACTOR RECEPTOR-ALPHA EXERTS SYNERGISTIC EFFICACY IN GLIOBLASTOMA (2021) (0)
Abstract 3175: Methylmalonic acid in TME signaling (2022) (0)
PI 3-kinase and disease (2014) (0)
Abstract 1789: NAK associated protein 1/ NAP1 is required for mitosis and cytokinesis through TBK1 activation (2023) (0)
FSMP-10. CYSTEINE INDUCES CYTOTOXICITY IN GLIOBLASTOMA THROUGH MITOCHONDRIAL HYDROGEN PEROXIDE PRODUCTION (2021) (0)
Abstract 2951: Vitamin C is selectively toxic to cancer cells harboring KRAS or BRAF mutations by targeting GAPDH (2014) (0)
Abstract LB-188: Positive regulation of the Ras oncogene by ubiquitination (2010) (0)
B . canadensis Campanian Hadrosaur Biomolecular Characterization and Protein Sequences of the (2012) (0)
Abstract 162: Identification of novel targets of Serine/arginine-rich protein-specific kinase 2 (2022) (0)
Abstract IA-2: PI3‐Kinase and cancer metabolism (2009) (0)
Correction: PIK3CA C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3Kα Inhibitors (2019) (0)
The Hallmarks of a Cancer Discovery. (2023) (0)
DDRE-07. FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS (2021) (0)
Abstract IA14: Autophagy, metabolism, and pancreatic cancer. (2012) (0)
Phase 2 study of buparlisib (BKM120), a pan-class I PI3K inhibitor, in patients with metastatic triple-negative breast cancer (2020) (0)
STRUCTURE OF BCR-HOMOLOGY (BH) DOMAIN (1997) (0)
Downstream Effectors Through the Activation of Distinct Herpes Simplex Virus-Induced Cell Death Resistance to Encephalomyocarditis and Phosphatidylinositol 3-Kinase Confers (2001) (0)
Abstract 5712: Nutrient scarcity confers breast cancer brain metastasis sensitivity to serine synthesis pathway inhibition (2020) (0)
The C2 Domain of PKC is a new Phospho-Tyrosine Binding Domain (2005) (0)
TAMI-38. CYSTEINE-PROMOTING COMPOUNDS INDUCE MITOCHONDRIAL TOXICITY IN GLIOBLASTOMA THROUGH ALTERED PYRUVATE AND SERINE METABOLISM (2020) (0)
Table 3, SAR of selected N,N-bisarylsulfonamides (2011) (0)
Identification of SARS-CoV-2 inhibitors using lung and colonic organoids (2020) (0)
compound PARP / PI 3 K inhibition Vulnerabilities of PTEN-p 53-deficient prostate cancers to (2014) (0)
Crystal structure of PIP4KIIBETA N203A complex with AMP (2015) (0)
Publisher Correction: Suppression of insulin feedback enhances the efficacy of PI3K inhibitors (2018) (0)
1234 Vitamin C as a potential treatment for melanoma (2018) (0)
Phosphatidylinositol pathways in growth and transformation (1990) (0)
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. (2022) (0)
Using Departments of Pathology And (2011) (0)
PI 3—kinase and cancer metabolism (2012) (0)
Role of the PI 3-kinase signaling pathway in cell regulation and human disease (2010) (0)
Pr R moprevention Meets Glucose Control (2010) (0)
Na+ and Ca2+ Fluxes and Differentiation of Transformed Cells (1985) (0)
Figure 4, Purified recombinant PKM2 was treated with either A) DMSO or B) 1 μM ML285 followed by H2O2 for 30 minutes, diluted 100-fold and PK activity was assayed (2013) (0)
Role of Phosphatidylinositol 3-Kinase in Growth Factor and Oncogene Signaling (1993) (0)
Methodes et reactifs permettant de reguler l'expression genique (2000) (0)
Ras Activity Regulation by Monoubiquitination (2013) (0)
Abstract LB-418: Targeting the PI3K/mTOR pathway in genetically engineered mouse models of prostate cancer (2011) (0)
Crystal structure of PIP4KIIBETA complex with AMP (2015) (0)
Abstract 4979: Cabozantinib eradicates advanced murine prostate cancer by activating neutrophil-mediated anti-tumor innate immunity (2016) (0)
From meetings (1988) (0)
Targeting PI3K Remains Complex in Cancer Therapy (2018) (0)
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. (2022) (0)
The role of ion fluxes in hematopoietic cell differentiation. (1985) (0)
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. (2022) (0)
Methods for treating cancer resistant to ErbB therapeutics (2008) (0)
PIK3CA and MAP3K1 alterations imply luminal A status and are associated with clinical benefit from pan-PI3K inhibitor buparlisib and letrozole in ER+ metastatic breast cancer (2019) (0)
Obesity, Insulin Resistance and Cancer: The PI3K connection (2018) (0)
Program at a Glance (2022) (0)
Abstract 1625: CUB domain-containing protein 1 (CDCP1) promotes metastatic phenotype in pancreatic ductal adenocarcinoma (2016) (0)
Abstract IA22: PI3K and cancer metabolism (2013) (0)
Abstract B09: Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation (2015) (0)
(acidification of coated vesicles/endocytosis/receptors) (2016) (0)
Lessons in signal transduction from a DNA tumor virus (1995) (0)
Abstract 3917: DoublePIK3CAmutations incisenhance oncogene activation and sensitivity to PI3K alpha inhibitors in breast cancer (2019) (0)
Epinephrine inhibits PI3K alpha via the Hippo kinases (2022) (0)
Faculty Opinions recommendation of Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene. (2011) (0)
Abstract IA08: PI3K- and PARP-inhibitors for the treatment of women cancers. (2016) (0)
Abstract 2636: Myc vs. Akt therapy in RapidCap, a GEM model for metastatic prostate cancer (2015) (0)
Abstract SY12-01: PI 3-kinase and cancer metabolism (2016) (0)
NAK associated protein 1/NAP1 is required for mitosis and cytokinesis by activating TBK1 (2023) (0)
Faculty Opinions recommendation of HIF-1 mediates the Warburg effect in clear cell renal carcinoma. (2011) (0)
Table 1, Final optimized 1536-well assay protocol (2011) (0)
Abstract 12839: Cardiac-Specific Deletion of RhoA Results in the Development of Cardiac Hypertrophy via Effects on the Erk/MAPK and PI3K/Akt pathways (2010) (0)
Figure 8, Critical Workflow to Lead to in vivo studies of HPykM2 activators (2011) (0)
Cancer evention esearch pective rspective on Memmott et al . , p . 1066 Pr R moprevention Meets Glucose Control (2010) (0)
INCREASE IN [Ca2+]i IN CULTURED HUMAN KERATINOCYTES BY 1,25(OH)2D3 IS CALCIUM DEPENDENT AND COINCIDES WITH AN INCREASE IN PHOSPHATIDYLINOSITOL METABOLISM. (1988) (0)
I (cid:1) B Kinase (cid:2) Phosphorylation of TRAF4 Downregulates Innate Immune Signaling (2012) (0)
Abstract 956: Receptor tyrosine kinases, not KRAS, activate PI3K in KRAS mutant colorectal cancers (2011) (0)
Abstract IA08: Reprogramming human cancer cells in CDK4/6 inhibitor therapy (2016) (0)
Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide production (2021) (0)
Methods of treating resistant cancer therapeutic agents ERBB (2008) (0)
Blocking ActRIIB signaling and restoring appetite reverses cachexia and improves survival in mice with lung cancer (2021) (0)
Leukemogenic Tyrosine Kinases Inhibit PKM2 to Promote the Warburg Effect and Tumor Growth (2010) (0)
MP46-10 UTILIZING INSULIN IN THE TREATMENT OF PROSTATE CANCER WITH BKM120 ABROGATES THE THERAPEUTIC EFFECT OF PI3K PATHWAY INHIBITION (2015) (0)
A Decade of Cancer Discovery. (2021) (0)
Table 5, SAR of selected tetrahydroquinoline-sulfonamides (2011) (0)
SAT-LB057 High-Fructose Corn Syrup Enhances Intestinal Tumor Growth in Mice (2019) (0)
Abstract A21: Compound PIK3CA mutations support a mutational dose-response model for oncogene activation and response to PI3K inhibitor targeted therapy in breast cancer (2020) (0)
Activateurs de la pyruvate kinase m2 et procédé de traitement d'une maladie (2008) (0)
AMP-Activated Protein Kinase and Cancer Cell Metabolism (2011) (0)
Figure 2, PBS Buffer Stability of NCGC00185916/CID-44543605 (2011) (0)
Figure 7, [A) [1-14C]glucose flux through PPP...]. (2013) (0)
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. (2022) (0)
Age-induced methylmalonic acid accumulation promotes tumor progression and aggressiveness (2020) (0)
Minireview Blocks Apoptosis (1997) (0)
Abstract 34: Oncogenic tyrosine kinases phosphorylate and inhibit PKM2 to provide a metabolic advantage to tumor growth (2010) (0)
The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation (2018) (0)
LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma (2023) (0)
Abstract OP-03: PI 3-Kinase, AMPK, and Cancer (2012) (0)
43 Targeting PI3K: where are we? (2010) (0)
PI 3-kinase and disease (2012) (0)
Figure 1, Previously reported PKM2 activator ML probes (2013) (0)
Methionine-Labeled Proteins in CHO / IR Cells (0)
Abstract A078: Towards understanding noncanonical phosphatidylinositol kinases in the maintenance of prostate metabolism (2018) (0)
Abstract 4265: Derivation and characterization of endometrial cancer cells resistant to phosphatidylinositol-3-kinase (PI3K) pathway inhibitors. (2013) (0)
Pyruvate kinase M2 deficiency promotes a brown fat-like program in white adipocytes (2012) (0)
Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader. (2023) (0)
Pyruvate kinase inhibitors and disease treatment methods (2007) (0)
Contributors to Volume 18 (1993) (0)
New and revised textbooks (2004) (0)
Figure 5, [A) ML285 shows a dose-response...]. (2013) (0)
Activation directe de la kinase activee par l'amp reposant sur l'utilisation de la kinase lkb1, suppresseur de tumeurs (2004) (0)
The primary pathway from PI 3 K to mTORC 1 : switching on Rheb (2016) (0)
Abstract 3514: A genetic-metabolic circuit of liver-specific metastatic organotropism (2023) (0)
GLUT5 (SLC2A5) enables fructose-mediated proliferation independent of ketohexokinase (2021) (0)

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